Properties and Molecular Determinants of the Natural Flavone Acacetin for Blocking hKv4.3 Channels

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Wu, Hui Jun ^a   Sun, Hai Ying ^a   Wu, Wei ^a   Zhang, Yan Hui ^a   Qin, Guo Wei ^b   Li, Gui Rong ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACACETIN; ALANINE; ISOLEUCINE; MUTANT PROTEIN; POTASSIUM CHANNEL; POTASSIUM CHANNEL KV4.3; THREONINE; UNCLASSIFIED DRUG; VALINE;

ARTICLE; CELL STRAIN HEK293; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; IC 50; MOLECULAR BIOLOGY; MUTAGENESIS; POTASSIUM CURRENT; PROTEIN EXPRESSION; VOLTAGE CLAMP; WHOLE CELL;

BINDING SITES; FLAVONES; HEK293 CELLS; HUMANS; KINETICS; MUTAGENESIS, SITE-DIRECTED; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; RECOMBINANT PROTEINS; SHAL POTASSIUM CHANNELS;

EID: 84875198067     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057864     Document Type: Article

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