Successful treatment with atomoxetine of an adolescent boy with attention deficit/hyperactivity disorder, extreme obesity, and reduced melanocortin 4 receptor function

Obesity Facts

Volumn 6, Issue 1, 2013, Pages 109-115

  Pott, Wilfried ^a   Albayrak, Özgür ^b   Hinney, Anke ^b   Hebebrand, Johannes ^b   Pauli Pott, Ursula ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Appetite control; Brain derived neurotrophic factor; Methylphenidate; Pharmacogenetics; Weight loss

Indexed keywords

ATOMOXETINE; MELANOCORTIN 4 RECEPTOR;

ADOLESCENT; ARTICLE; ATTENTION DEFICIT DISORDER; CASE REPORT; DRUG DOSE INCREASE; GENE MUTATION; HUMAN; LIFESTYLE MODIFICATION; MALE; OBESITY; PRIORITY JOURNAL; DRUG DOSE REDUCTION; FEEDING BEHAVIOR; HETEROZYGOSITY; STRUCTURED INTERVIEW; TREATMENT OUTCOME; TREATMENT RESPONSE; WEIGHT GAIN; WEIGHT REDUCTION;

ADOLESCENT; ADRENERGIC UPTAKE INHIBITORS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; DNA MUTATIONAL ANALYSIS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MUTATION; OBESITY; PHENOTYPE; PROPYLAMINES; RECEPTOR, MELANOCORTIN, TYPE 4; RISK REDUCTION BEHAVIOR; TREATMENT OUTCOME; WEIGHT LOSS;

EID: 84875152868     PISSN: 16624025     EISSN: 16624033     Source Type: Journal    
DOI: 10.1159/000348792     Document Type: Article

References (54)

1. Kromeyer-Hauschild K, Wabitsch M, Kunze D, Geller D, Geiss H.C, Hesse V, von Hippel A, Jaeger U, Johnsen D, Korte W, Menner K, Muller G, Muller JM, Niemann-Pilatus A, Remer T, Schaefer F, Wittchen HU, Zabransky S, Zellner K, Ziegler A, Hebebrand J: Percentiles of body mass index in children and adolescents evaluated from different regional German studies. Monatsschr Kinderheilkd 2001; 149: 807-818
2. Hinney A, Hohmann S, Geller F, Vogel C, Hess C, Wermter AK, Brokamp B, Goldschmidt H, Siegfried W, Remschmidt H, Schafer H, Gudermann T, Hebebrand J: Melanocortin-4 receptor gene: Case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity. J Clin Endocrinol Metab 2003; 88: 4258-4267
3. Hinney A, Bettecken T, Tarnow P, Brumm H, Reichwald K, Lichtner P, Scherag A, Nguyen TT, Schlumberger P, Rief W, Vollmert C, Illig T, Wichmann HE, Schafer H, Platzer M, Biebermann H, Meitinger T, Hebebrand J: Prevalence, spectrum, and functional characterization of melanocortin-4 receptor gene mutations in a representative population-based sample and obese adults from Germany. J Clin Endocrinol Metab 2006; 91: 1761- 1769
4. Reinehr T, Hebebrand J, Friedel S, Toschke AM, Brumm H, Biebermann H, Hinney A: Lifestyle intervention in obese children with variations in the melanocortin 4 receptor gene. Obesity (Silver Spring) 2009; 17: 382-389
5. Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, Williamson D, Ryan N: Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): Initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 1997; 36: 980-988
6. American Psychiatric Association: Manual of Mental Disorders - DSM-IV-TR. Washington, D.C., American Psychiatric Association, 2000
7. Zimmermann P, Fimm B: Testbatterie zur Aufmerksamkeitsprüfung. Psytest, 2012. www.psytest.net/index. php?page=TAP-2-2
8. Brickenkamp R: Test d2 - Aufmerksamkeits-Belastungs-Test. Handanweisung. Göttingen, Hogrefe, 2002
9. Weiß RH: Grundintelligenztest Skala 2 (CFT 20) mit Wortschatztest (WS) und Zahlenfolgentest (ZF). Handanweisung, 4, überarbeitete Auflage. Göttingen, Westermann Test, 1998
10. Johnson WG, Kirk AA, Reed AE: Adolescent version of the questionnaire of eating and weight patterns: Reliability and gender differences. Int J Eat Disord 2001; 29: 94-96
11. Pauli-Pott U, Albayrak O, Hebebrand J, Pott W: Does inhibitory control capacity in overweight and obese children and adolescents predict success in a weight-reduction program? Eur Child Adolesc Psychiatry 2010; 19: 135-141
12. Pauli-Pott U, Albayrak O, Hebebrand J, Pott W: Association between inhibitory control capacity and body weight in overweight and obese children and adolescents: Dependence on age and inhibitory control component. Child Neuropsychol 2010; 16: 592-603
13. Summerbell CD, Ashton V, Campbell KJ, Edmunds L, Kelly S, Waters E: Interventions for treating obesity in children. Cochrane Database Syst Rev 2003; 3:CD001872
14. Albayrak O, Albrecht B, Scherag S, Barth N, Hinney A, Hebebrand J: Successful methylphenidate treatment of early onset extreme obesity in a child with a melanocortin-4 receptor gene mutation and attention deficit/hyperactivity disorder. Eur J Pharmacol 2011; 660: 165-170
15. Santini F, Maffei M, Ceccarini G, Pelosini C, Scartabelli G, Rosellini V, Chiellini C, Marsili A, Lisi S, Tonacchera M, Agretti P, Chiovato L, Mammoli C, Vitti P, Pinchera A: Genetic screening for melanocortin-4 receptor mutations in a cohort of Italian obese patients: Description and functional characterization of a novel mutation. J Clin Endocrinol Metab 2004; 89: 904-908
16. Cortese S, Vincenzi B: Obesity and ADHD: Clinical and neurobiological implications. Curr Top Behav Neurosci 2012; 9: 199-218
17. Agranat-Meged AN, Deitcher C, Goldzweig G, Leibenson L, Stein M, Galili-Weisstub E: Childhood obesity and attention deficit/hyperactivity disorder: A newly described comorbidity in obese hospitalized children. Int J Eat Disord 2005; 37: 357-359
18. Erermis S, Cetin N, Tamar M, Bukusoglu N, Akdeniz F, Goksen D: Is obesity a risk factor for psychopathology among adolescents? Pediatr Int 2004; 46: 296-301
19. Altfas JR: Prevalence of attention deficit/hyperactivity disorder among adults in obesity treatment. BMC Psychiatry 2002; 2: 9
20. Fleming JP, Levy LD, Levitan RD: Symptoms of attention deficit hyperactivity disorder in severely obese women. Eat Weight Disord 2002; 10:e10-13
21. Biederman J, Faraone SV, Monuteaux MC, Plunkett EA, Gifford J, Spencer T: Growth deficits and attentiondeficit/hyperactivity disorder revisited: Impact of gender, development, and treatment. Pediatrics 2003; 111: 1010-1016
22. Curtin C, Bandini LG, Perrin EC, Tybor DJ, Must A: Prevalence of overweight in children and adolescents with attention deficit hyperactivity disorder and autism spectrum disorders: A chart review. BMC Pediatr 2005; 5: 48
23. Faraone SV, Biederman J, Monuteaux M, Spencer T: Long-term effects of extended-release mixed amphetamine salts treatment of attention-deficit/ hyperactivity disorder on growth. J Child Adolesc Psychopharmacol 2005; 15: 191-202
24. Holtkamp K, Konrad K, Müller B, Heussen N, Herpertz S, Herpertz-Dahlmann B, Hebebrand J: Overweight and obesity in children with attention-deficit/hyperactivity disorder. Int J Obes (Lond) 2004; 28: 685-689
25. Hubel R, Jass J, Marcus A, Laessle RG: Overweight and basal metabolic rate in boys with attention-deficit/hyperactivity disorder. Eat Weight Disord 2006; 11: 139-146
26. Ptacek R, Kuzelova H, Paclt I, Zukov I, Fischer S: Anthropometric changes in non-medicated ADHD boys. Neuro Endocrinol Lett 2009; 30: 377-381
27. Spencer TJ, Biederman J, Harding M, O'Donnell D, Faraone SV, Wilens TE: Growth deficits in ADHD children revisited: Evidence for disorder-associated growth delays? J Am Acad Child Adolesc Psychiatry 1996; 35: 1460-1469
28. Swanson J, Greenhill L, Wigal T, Kollins S, Stehli A, Davies M, Chuang S, Vitiello B, Skrobala A, Posner K, Abikoff H, Oatis M, McCracken J, McGough J, Riddle M, Ghuman J, Cunningham C, Wigal S: Stimulant-related reductions of growth rates in the PATS. J Am Acad Child Adolesc Psychiatry 2006; 45: 1304-1313
29. Anderson SE, Cohen P, Naumova EN, Must A: Relationship of childhood behavior disorders to weight gain from childhood into adulthood. Ambul Pediatr 2006; 6: 297-301
30. Chen AY, Kim SE, Houtrow AJ, Newacheck PW: Prevalence of obesity among children with chronic conditions. Obesity (Silver Spring) 2010; 18: 210-213
31. Erhart M, Herpertz-Dahlmann B, Wille N, Sawitzky-Rose B, Holling H, Ravens-Sieberer U: Examining the relationship between attention-deficit/ hyperactivity disorder and overweight in children and adolescents. Eur Child Adolesc Psychiatry 2012; 21: 39-49
32. Lam LT, Yang L: Overweight/obesity and attention deficit and hyperactivity disorder tendency among adolescents in China. Int J Obes (Lond) 2007; 31: 584-590
33. Fuemmeler BF, Ostbye T, Yang C, McClernon FJ, Kollins SH: Association between attention-deficit/hyperactivity disorder symptoms and obesity and hypertension in early adulthood: A population-based study. Int J Obes (Lond) 2011; 35: 852-862
34. Waring E, Lapane KL: Overweight in children and adolescents in relation to attention-deficit/hyperactivity disorder: Results from a national sample. Pediatrics 2008; 122:e1-e6
35. de Zwaan M, Gruss B, Muller A, Philipsen A, Graap H, Martin A, Glaesmer H, Hilbert A: Association between obesity and adult attention-deficit/ hyperactivity disorder in a German community-based sample. Obes Facts 2011; 4: 204-211
36. Pagoto SL, Curtin C, Lemon SC, Bandini LG, Schneider KL, Bodenlos JS, Ma Y: Association between adult attention deficit/hyperactivity disorder and obesity in the US population. Obesity (Silver Spring) 2009; 17: 539-544
37. Braet C, Claus L, Verbeken S, Van Vlierberghe L: Impulsivity in overweight children. Eur Child Adolesc Psychiatry 2007; 16: 473-483
38. Mustillo S, Worthman C, Erkanli A, Keeler G, Angold A, Costello EJ: Obesity and psychiatric disorder: Developmental trajectories. Pediatrics 2003; 111: 851-859
39. Dubnov-Raz G, Perry A, Berger I: Body mass index of children with attention-deficit/hyperactivity disorder. J Child Neurol 2011; 26: 302-308
40. Cortese S, Isnard P, Frelut ML, Michel G, Quantin L, Guedeney A, Falissard B, Acquaviva E, Dalla Bernardina B, Mouren MC: Association between symptoms of attention-deficit/hyperactivity disorder and bulimic behaviors in a clinical sample of severely obese adolescents. Int J Obes (Lond) 2007; 31: 340-346
41. Agranat-Meged A, Ghanadri Y, Eisenberg I, Ben Neriah Z, Kieselstein-Gross E, Mitrani-Rosenbaum S: Attention deficit hyperactivity disorder in obese melanocortin-4-receptor (MC4R) deficient subjects: A newly described expression of MC4R deficiency. Am J Med Genet B Neuropsychiatr Genet 2008; 147B:1547-1553
42. Davis C, Levitan RD, Smith M, Tweed S, Curtis C: Associations among overeating, overweight, and attention deficit/hyperactivity disorder: A structural equation modelling approach. Eating Behaviors 2006; 7: 266-274
43. Appelhans BM: Neurobehavioral inhibition of reward-driven feeding: Implications for dieting and obesity. Obesity (Silver Spring) 2009; 17: 640-647
44. Rothemund Y, Preuschhof C, Bohner G, Bauknecht HC, Klingebiel R, Flor H, Klapp BF: Differential activation of the dorsal striatum by high-calorie visual food stimuli in obese individuals. Neuroimage 2007; 37: 410-421
45. Stoeckel LE, Weller RE, Cook EW 3rd, Twieg DB, Knowlton RC, Cox JE: Widespread reward-system activation in obese women in response to pictures of high-calorie foods. Neuroimage 2008; 41: 636-647
46. Volkow ND, Wang GJ, Telang F, Fowler JS, Thanos PK, Logan J, Alexoff D, Ding YS, Wong C, Ma Y, Pradhan K: Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: Possible contributing factors. Neuroimage 2008; 42: 1537-1543
47. Cortese S, Angriman M, Maffeis C, Isnard P, Konofal E, Lecendreux M, Purper-Ouakil D, Vincenzi B, Bernardina BD, Mouren MC: Attention-deficit/ hyperactivity disorder (ADHD) and obesity: A systematic review of the literature. Crit Rev Food Sci Nutr 2008; 48: 524-537
48. Cui H, Mason BL, Lee C, Nishi A, Elmquist JK, Lutter M: Melanocortin 4 receptor signaling in dopamine 1 receptor neurons is required for procedural memory learning. Physiol Behav 2012; 106: 201-210
49. Garnock-Jones KP, Keating GM: Atomoxetine: A review of its use in attention-deficit hyperactivity disorder in children and adolescents. Paediatr Drugs 2009; 11: 203-226
50. Michelson D, Faries D, Wernicke J, Kelsey D, Kendrick K, Sallee FR, Spencer T: Atomoxetine in the treatment of children and adolescents with attention-deficit/hyperactivity disorder: A randomized, placebo-controlled, dose-response study. Pediatrics 2001; 108:E83
51. Sayk F, Heutling D, Dodt C, Iwen KA, Wellhoner JP, Scherag S, Hinney A, Hebebrand J, Lehnert H: Sympathetic function in human carriers of melanocortin-4 receptor gene mutations. J Clin Endocrinol Metab 2010; 95: 1998-2002
52. Greenfield JR, Miller JW, Keogh JM, Henning E, Satterwhite JH, Cameron GS, Astruc B, Mayer JP, Brage S, See TC, Lomas DJ, O'Rahilly S, Farooqi IS: Modulation of blood pressure by central melanocortinergic pathways. N Engl J Med 2009; 360: 44-52
53. Gadde KM, Yonish GM, Wagner HR Jr, Foust MS, Allison DB: Atomoxetine for weight reduction in obese women: A preliminary randomised controlled trial. Int J Obes (Lond) 2006; 30: 1138-1142
54. McElroy SL, Guerdjikova A, Kotwal R, Welge JA, Nelson EB, Lake KA, Keck PE Jr, Hudson JI: Atomoxetine in the treatment of binge-eating disorder: A randomized placebo-controlled trial. J Clin Psychiatry 2007; 68: 390- 398