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Volumn 55, Issue 10, 2012, Pages 2800-2810

Systemic inflammation in childhood obesity: Circulating inflammatory mediators and activated CD14++ monocytes

Author keywords

Adipokines; Childhood obesity; Inflammation; Insulin resistance; Monocytes

Indexed keywords

ADIPOCYTOKINE; CD14 ANTIGEN; CHEMERIN; EPIDERMAL GROWTH FACTOR; INSULIN; LEPTIN; LIGAND; LIPOPOLYSACCHARIDE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR RECEPTOR 2;

EID: 84866071750     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2641-y     Document Type: Article
Times cited : (95)

References (49)
  • 1
    • 79957920754 scopus 로고    scopus 로고
    • Inflammatory links between obesity and metabolic disease
    • 21633179 10.1172/JCI57132 1:CAS:528:DC%2BC3MXnsVais7Y%3D
    • Lumeng CN, Saltiel AR (2011) Inflammatory links between obesity and metabolic disease. J Clin Invest 121:2111-2117
    • (2011) J Clin Invest , vol.121 , pp. 2111-2117
    • Lumeng, C.N.1    Saltiel, A.R.2
  • 2
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • DOI 10.1038/nature05485, PII NATURE05485
    • Hotamisligil GS (2006) Inflammation and metabolic disorders. Nature 444:860-867 (Pubitemid 46024993)
    • (2006) Nature , vol.444 , Issue.7121 , pp. 860-867
    • Hotamisligil, G.S.1
  • 3
    • 79151484704 scopus 로고    scopus 로고
    • Adipokines in inflammation and metabolic disease
    • 21252989 10.1038/nri2921 1:CAS:528:DC%2BC3MXotlSgsg%3D%3D
    • Ouchi N, Parker JL, Lugus JJ, Walsh K (2011) Adipokines in inflammation and metabolic disease. Nat Rev Immunol 11:85-97
    • (2011) Nat Rev Immunol , vol.11 , pp. 85-97
    • Ouchi, N.1    Parker, J.L.2    Lugus, J.J.3    Walsh, K.4
  • 4
    • 79151478555 scopus 로고    scopus 로고
    • Type 2 diabetes as an inflammatory disease
    • 21233852 10.1038/nri2925 1:CAS:528:DC%2BC3MXlsFehtQ%3D%3D
    • Donath MY, Shoelson SE (2011) Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 11:98-107
    • (2011) Nat Rev Immunol , vol.11 , pp. 98-107
    • Donath, M.Y.1    Shoelson, S.E.2
  • 5
    • 69249205739 scopus 로고    scopus 로고
    • Obesity, inflammation, and atherosclerosis
    • 19399028 10.1038/nrcardio.2009.55 1:CAS:528:DC%2BD1MXmsVCmsbg%3D
    • Rocha VZ, Libby P (2009) Obesity, inflammation, and atherosclerosis. Nat Rev Cardiol 6:399-409
    • (2009) Nat Rev Cardiol , vol.6 , pp. 399-409
    • Rocha, V.Z.1    Libby, P.2
  • 6
    • 67650169799 scopus 로고    scopus 로고
    • Adiponectin levels and risk of type 2 diabetes: A systematic review and meta-analysis
    • 19584347 10.1001/jama.2009.976 1:CAS:528:DC%2BD1MXosVSruro%3D
    • Li S, Shin HJ, Ding EL, van Dam RM (2009) Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA 302:179-188
    • (2009) JAMA , vol.302 , pp. 179-188
    • Li, S.1    Shin, H.J.2    Ding, E.L.3    Van Dam, R.M.4
  • 7
    • 0037097415 scopus 로고    scopus 로고
    • Comparison of numbers of circulating blood monocytes in men grouped by body mass index (<25, 25 to <30, ≥30)
    • DOI 10.1016/S0002-9149(02)02366-4, PII S0002914902023664
    • Kullo IJ, Hensrud DD, Allison TG (2002) Comparison of numbers of circulating blood monocytes in men grouped by body mass index (<25, 25 to <30, > or =30). Am J Cardiol 89:1441-1443 (Pubitemid 34607793)
    • (2002) American Journal of Cardiology , vol.89 , Issue.12 , pp. 1441-1443
    • Kullo, I.J.1    Hensrud, D.D.2    Allison, T.G.3
  • 8
    • 4644338458 scopus 로고    scopus 로고
    • Circulating mononuclear cells in the obese are in a proinflammatory state
    • DOI 10.1161/01.CIR.0000142055.53122.FA
    • Ghanim H, Aljada A, Hofmeyer D, Syed T, Mohanty P, Dandona P (2004) Circulating mononuclear cells in the obese are in a proinflammatory state. Circulation 110:1564-1571 (Pubitemid 39297977)
    • (2004) Circulation , vol.110 , Issue.12 , pp. 1564-1571
    • Ghanim, H.1    Aljada, A.2    Hofmeyer, D.3    Syed, T.4    Mohanty, P.5    Dandona, P.6
  • 9
    • 33847789122 scopus 로고    scopus 로고
    • The CD14+ CD16+ blood monocytes: Their role in infection and inflammation
    • DOI 10.1189/jlb.0806510
    • Ziegler-Heitbrock L (2007) The CD14+ CD16+ blood monocytes: their role in infection and inflammation. J Leukoc Biol 81:584-592 (Pubitemid 46393535)
    • (2007) Journal of Leukocyte Biology , vol.81 , Issue.3 , pp. 584-592
    • Ziegler-Heitbrock, L.1
  • 10
    • 80051567423 scopus 로고    scopus 로고
    • Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets
    • 21653326 10.1182/blood-2010-12-326355 1:CAS:528:DC%2BC3MXhtVCnurbO
    • Wong KL, Tai JJ, Wong WC et al (2011) Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets. Blood 118:e16-e31
    • (2011) Blood , vol.118
    • Wong, K.L.1    Tai, J.J.2    Wong, W.C.3
  • 11
    • 80053181958 scopus 로고    scopus 로고
    • SuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subset
    • 21803849 10.1182/blood-2011-01-326827 1:CAS:528:DC%2BC3MXht1Ogu7vF
    • Zawada AM, Rogacev KS, Rotter B et al (2011) SuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subset. Blood 118:e50-e61
    • (2011) Blood , vol.118
    • Zawada, A.M.1    Rogacev, K.S.2    Rotter, B.3
  • 12
    • 80052962325 scopus 로고    scopus 로고
    • CD14dimCD16+ and CD14∈+∈CD16+ monocytes in obesity and during weight loss: Relationships with fat mass and subclinical atherosclerosis
    • 21799175 10.1161/ATVBAHA.111.230979 1:CAS:528:DC%2BC3MXhtFGls7fE
    • Poitou C, Dalmas E, Renovato M et al (2011) CD14dimCD16+ and CD14∈+∈CD16+ monocytes in obesity and during weight loss: relationships with fat mass and subclinical atherosclerosis. Arterioscler Thromb Vasc Biol 31:2322-2330
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 2322-2330
    • Poitou, C.1    Dalmas, E.2    Renovato, M.3
  • 13
    • 76349109659 scopus 로고    scopus 로고
    • Monocyte heterogeneity in obesity and subclinical atherosclerosis
    • 19687164 10.1093/eurheartj/ehp308 1:CAS:528:DC%2BC3cXhslOgtr0%3D
    • Rogacev KS, Ulrich C, Blomer L et al (2010) Monocyte heterogeneity in obesity and subclinical atherosclerosis. Eur Heart J 31:369-376
    • (2010) Eur Heart J , vol.31 , pp. 369-376
    • Rogacev, K.S.1    Ulrich, C.2    Blomer, L.3
  • 14
    • 74249084928 scopus 로고    scopus 로고
    • Unbalanced M1/M2 phenotype of peripheral blood monocytes in obese diabetic patients: Effect of pioglitazone
    • 20040670 10.2337/dc09-1315
    • Satoh N, Shimatsu A, Himeno A et al (2010) Unbalanced M1/M2 phenotype of peripheral blood monocytes in obese diabetic patients: effect of pioglitazone. Diabetes Care 33:e7
    • (2010) Diabetes Care , vol.33 , pp. 7
    • Satoh, N.1    Shimatsu, A.2    Himeno, A.3
  • 15
    • 75149191888 scopus 로고    scopus 로고
    • Obesity and low-grade inflammation: A paediatric perspective
    • 19845868 10.1111/j.1467-789X.2009.00674.x 1:CAS:528:DC%2BC3cXivVejtLc%3D
    • Tam CS, Clement K, Baur LA, Tordjman J (2010) Obesity and low-grade inflammation: a paediatric perspective. Obes Rev 11:118-126
    • (2010) Obes Rev , vol.11 , pp. 118-126
    • Tam, C.S.1    Clement, K.2    Baur, L.A.3    Tordjman, J.4
  • 16
    • 0035234153 scopus 로고    scopus 로고
    • Low-grade systemic inflammation in overweight children
    • 11134477 10.1542/peds.107.1.e13 1:STN:280:DC%2BD3M%2FpsVaisQ%3D%3D
    • Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB (2001) Low-grade systemic inflammation in overweight children. Pediatrics 107:E13
    • (2001) Pediatrics , vol.107 , pp. 13
    • Visser, M.1    Bouter, L.M.2    McQuillan, G.M.3    Wener, M.H.4    Harris, T.B.5
  • 17
    • 77950569526 scopus 로고    scopus 로고
    • Multiple markers of inflammation and weight status: Cross-sectional analyses throughout childhood
    • 20194272 10.1542/peds.2009-2182
    • Skinner AC, Steiner MJ, Henderson FW, Perrin EM (2010) Multiple markers of inflammation and weight status: cross-sectional analyses throughout childhood. Pediatrics 125:e801-e809
    • (2010) Pediatrics , vol.125
    • Skinner, A.C.1    Steiner, M.J.2    Henderson, F.W.3    Perrin, E.M.4
  • 18
    • 77951283646 scopus 로고    scopus 로고
    • IL-6, IL-8 and IL-10 levels in healthy weight and overweight children
    • 20190550 10.1159/000277632 1:CAS:528:DC%2BC3cXhslOhtbk%3D
    • Tam CS, Garnett SP, Cowell CT et al (2010) IL-6, IL-8 and IL-10 levels in healthy weight and overweight children. Horm Res Paediatr 73:128-134
    • (2010) Horm Res Paediatr , vol.73 , pp. 128-134
    • Tam, C.S.1    Garnett, S.P.2    Cowell, C.T.3
  • 19
    • 79953796176 scopus 로고    scopus 로고
    • Adolescent BMI trajectory and risk of diabetes versus coronary disease
    • 21470009 10.1056/NEJMoa1006992 1:CAS:528:DC%2BC3MXkvVCms70%3D
    • Tirosh A, Shai I, Afek A et al (2011) Adolescent BMI trajectory and risk of diabetes versus coronary disease. N Engl J Med 364:1315-1325
    • (2011) N Engl J Med , vol.364 , pp. 1315-1325
    • Tirosh, A.1    Shai, I.2    Afek, A.3
  • 20
    • 84855692008 scopus 로고    scopus 로고
    • Childhood obesity and risk of the adult metabolic syndrome: A systematic review
    • 10.1038/ijo.2011.186 1:CAS:528:DC%2BC38XntF2muw%3D%3D
    • Lloyd LJ, Langley-Evans SC, McMullen S (2012) Childhood obesity and risk of the adult metabolic syndrome: a systematic review. Int J Obes (Lond) 36:1-11
    • (2012) Int J Obes (Lond) , vol.36 , pp. 1-11
    • Lloyd, L.J.1    Langley-Evans, S.C.2    McMullen, S.3
  • 21
    • 77955240000 scopus 로고    scopus 로고
    • A multiplex immunoassay for human adipokine profiling
    • 20530731 10.1373/clinchem.2010.146118 1:CAS:528:DC%2BC3cXhtVahsb7L
    • Schipper HS, de Jager W, van Dijk ME et al (2010) A multiplex immunoassay for human adipokine profiling. Clin Chem 56:1320-1328
    • (2010) Clin Chem , vol.56 , pp. 1320-1328
    • Schipper, H.S.1    De Jager, W.2    Van Dijk, M.E.3
  • 22
    • 77956475219 scopus 로고    scopus 로고
    • Standardized single-platform assay for human monocyte subpopulations: Lower CD14∈+∈CD16++ monocytes in females
    • 20662093
    • Heimbeck I, Hofer TP, Eder C et al (2010) Standardized single-platform assay for human monocyte subpopulations: lower CD14∈+∈CD16++ monocytes in females. Cytometry A 77:823-830
    • (2010) Cytometry A , vol.77 , pp. 823-830
    • Heimbeck, I.1    Hofer, T.P.2    Eder, C.3
  • 23
    • 81055144889 scopus 로고    scopus 로고
    • Increase in prevalence of overweight in Dutch children and adolescents: A comparison of nationwide growth studies in 1980, 1997 and 2009
    • 22110687 10.1371/journal.pone.0027608
    • Schonbeck Y, Talma H, van Dommelen P et al (2011) Increase in prevalence of overweight in Dutch children and adolescents: a comparison of nationwide growth studies in 1980, 1997 and 2009. PLoS One 6:e27608
    • (2011) PLoS One , vol.6 , pp. 27608
    • Schonbeck, Y.1    Talma, H.2    Van Dommelen, P.3
  • 24
    • 0034611996 scopus 로고    scopus 로고
    • Establishing a standard definition for child overweight and obesity worldwide: International survey
    • Cole TJ, Bellizzi MC, Flegal KM, Dietz WH (2000) Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 320:1240-1243 (Pubitemid 30240471)
    • (2000) British Medical Journal , vol.320 , Issue.7244 , pp. 1240-1243
    • Cole, T.J.1    Bellizzi, M.C.2    Flegal, K.M.3    Dietz, W.H.4
  • 25
    • 79959701357 scopus 로고    scopus 로고
    • Comparison of several anthropometric indices with insulin resistance proxy measures among European adolescents: The Helena Study
    • 21052739 10.1007/s00431-010-1322-4
    • Kondaki K, Grammatikaki E, Pavon DJ et al (2011) Comparison of several anthropometric indices with insulin resistance proxy measures among European adolescents: The Helena Study. Eur J Pediatr 170:731-739
    • (2011) Eur J Pediatr , vol.170 , pp. 731-739
    • Kondaki, K.1    Grammatikaki, E.2    Pavon, D.J.3
  • 26
    • 72449201976 scopus 로고    scopus 로고
    • Association of existing diabetes, gestational diabetes and glycosuria in pregnancy with macrosomia and offspring body mass index, waist and fat mass in later childhood: Findings from a prospective pregnancy cohort
    • 19841891 10.1007/s00125-009-1560-z 1:CAS:528:DC%2BD1MXhsFantLnJ
    • Lawlor DA, Fraser A, Lindsay RS et al (2010) Association of existing diabetes, gestational diabetes and glycosuria in pregnancy with macrosomia and offspring body mass index, waist and fat mass in later childhood: findings from a prospective pregnancy cohort. Diabetologia 53:89-97
    • (2010) Diabetologia , vol.53 , pp. 89-97
    • Lawlor, D.A.1    Fraser, A.2    Lindsay, R.S.3
  • 27
    • 84856810474 scopus 로고    scopus 로고
    • Altered plasma adipokine levels and in vitro adipocyte differentiation in pediatric type 1 diabetes
    • 22112811 10.1210/jc.2011-1858 1:STN:280:DC%2BC383gs1ymsQ%3D%3D
    • Verrijn Stuart AA, Schipper HS, Tasdelen I et al (2012) Altered plasma adipokine levels and in vitro adipocyte differentiation in pediatric type 1 diabetes. J Clin Endocrinol Metab 97:463-472
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 463-472
    • Verrijn Stuart, A.A.1    Schipper, H.S.2    Tasdelen, I.3
  • 28
    • 79961151517 scopus 로고    scopus 로고
    • Toll-like receptor 2 and 4 stimulation elicits an enhanced inflammatory response in human obese patients with atherosclerosis
    • 10.1042/CS20100601 1:CAS:528:DC%2BC3MXmtl2rsbY%3D
    • Scholtes VP, Versteeg D, de Vries JP et al (2011) Toll-like receptor 2 and 4 stimulation elicits an enhanced inflammatory response in human obese patients with atherosclerosis. Clin Sci (Lond) 121:205-214
    • (2011) Clin Sci (Lond) , vol.121 , pp. 205-214
    • Scholtes, V.P.1    Versteeg, D.2    De Vries, J.P.3
  • 29
    • 0001677717 scopus 로고
    • Controlling the false discovery ratea practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y (1995) Controlling the false discovery ratea practical and powerful approach to multiple testing. J Roy Stat Soc B Methodological 57:289-300
    • (1995) J Roy Stat Soc B Methodological , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 30
    • 70149102924 scopus 로고    scopus 로고
    • Differential cytokine profiles in juvenile idiopathic arthritis subtypes revealed by cluster analysis
    • 10.1093/rheumatology/kep125
    • van den Ham HJ, de Jager W, Bijlsma JW, Prakken BJ, de Boer RJ (2009) Differential cytokine profiles in juvenile idiopathic arthritis subtypes revealed by cluster analysis. Rheumatol (Oxford) 48:899-905
    • (2009) Rheumatol (Oxford) , vol.48 , pp. 899-905
    • Van Den Ham, H.J.1    De Jager, W.2    Bijlsma, J.W.3    Prakken, B.J.4    De Boer, R.J.5
  • 32
    • 33745612095 scopus 로고    scopus 로고
    • Pvclust: An R package for assessing the uncertainty in hierarchical clustering
    • DOI 10.1093/bioinformatics/btl117
    • Suzuki R, Shimodaira H (2006) Pvclust: an R package for assessing the uncertainty in hierarchical clustering. Bioinformatics 22:1540-1542 (Pubitemid 43985330)
    • (2006) Bioinformatics , vol.22 , Issue.12 , pp. 1540-1542
    • Suzuki, R.1    Shimodaira, H.2
  • 33
    • 21344454662 scopus 로고    scopus 로고
    • Assessing the predictive accuracy of QUICKI as a surrogate index for insulin sensitivity using a calibration model
    • DOI 10.2337/diabetes.54.7.1914
    • Chen H, Sullivan G, Quon MJ (2005) Assessing the predictive accuracy of QUICKI as a surrogate index for insulin sensitivity using a calibration model. Diabetes 54:1914-1925 (Pubitemid 40911252)
    • (2005) Diabetes , vol.54 , Issue.7 , pp. 1914-1925
    • Chen, H.1    Sullivan, G.2    Quon, M.J.3
  • 34
    • 33645538262 scopus 로고    scopus 로고
    • Relationship between different fasting-based insulin sensitivity indices in obese children and adolescents
    • 16607927 10.1515/JPEM.2006.19.3.259
    • Gunczler P, Lanes R (2006) Relationship between different fasting-based insulin sensitivity indices in obese children and adolescents. J Pediatr Endocrinol Metab 19:259-265
    • (2006) J Pediatr Endocrinol Metab , vol.19 , pp. 259-265
    • Gunczler, P.1    Lanes, R.2
  • 35
    • 0030964490 scopus 로고    scopus 로고
    • Serum leptin levels in normal children: Relationship to age, gender, body mass index, pituitary-gonadal hormones, and pubertal stage
    • DOI 10.1210/jc.82.9.2849
    • Garcia-Mayor RV, Andrade MA, Rios M, Lage M, Dieguez C, Casanueva FF (1997) Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadal hormones, and pubertal stage. J Clin Endocrinol Metab 82:2849-2855 (Pubitemid 27385638)
    • (1997) Journal of Clinical Endocrinology and Metabolism , vol.82 , Issue.9 , pp. 2849-2855
    • Garcia-Mayor, R.V.1    Andrade, M.A.2    Rios, M.3    Lage, M.4    Dieguez, C.5    Casanueva, F.F.6
  • 36
    • 70349564487 scopus 로고    scopus 로고
    • Regulation of the migration and survival of monocyte subsets by chemokine receptors and its relevance to atherosclerosis
    • 19759373 10.1161/ATVBAHA.108.180505 1:CAS:528:DC%2BD1MXhtFWhur%2FP
    • Gautier EL, Jakubzick C, Randolph GJ (2009) Regulation of the migration and survival of monocyte subsets by chemokine receptors and its relevance to atherosclerosis. Arterioscler Thromb Vasc Biol 29:1412-1418
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 1412-1418
    • Gautier, E.L.1    Jakubzick, C.2    Randolph, G.J.3
  • 38
    • 78049314118 scopus 로고    scopus 로고
    • Chemerin: At the crossroads of inflammation and obesity
    • 20817486 10.1016/j.tem.2010.08.001 1:CAS:528:DC%2BC3cXhtlKltL7F
    • Ernst MC, Sinal CJ (2010) Chemerin: at the crossroads of inflammation and obesity. Trends Endocrinol Metab 21:660-667
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 660-667
    • Ernst, M.C.1    Sinal, C.J.2
  • 39
    • 13644255622 scopus 로고    scopus 로고
    • Serum levels of soluble tumor necrosis factor-α receptor 2 are linked to insulin resistance and glucose intolerance in children
    • Gupta A, Ten S, Anhalt H (2005) Serum levels of soluble tumor necrosis factor-alpha receptor 2 are linked to insulin resistance and glucose intolerance in children. J Pediatr Endocrinol Metab 18:75-82 (Pubitemid 40227875)
    • (2005) Journal of Pediatric Endocrinology and Metabolism , vol.18 , Issue.1 , pp. 75-82
    • Gupta, A.1    Ten, S.2    Anhalt, H.3
  • 40
    • 80052531958 scopus 로고    scopus 로고
    • Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) controls adipogenesis in obesity in mice and in humans
    • 21437772 10.1007/s00125-011-2093-9 1:CAS:528:DC%2BC3MXlslWgurw%3D
    • Meissburger B, Stachorski L, Roder E, Rudofsky G, Wolfrum C (2011) Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) controls adipogenesis in obesity in mice and in humans. Diabetologia 54:1468-1479
    • (2011) Diabetologia , vol.54 , pp. 1468-1479
    • Meissburger, B.1    Stachorski, L.2    Roder, E.3    Rudofsky, G.4    Wolfrum, C.5
  • 41
    • 73249148728 scopus 로고    scopus 로고
    • EGFR tyrosine kinase inhibitor (PD153035) improves glucose tolerance and insulin action in high-fat diet-fed mice
    • 19696185 10.2337/db08-0506 1:CAS:528:DC%2BD1MXhsFKlu77J
    • Prada PO, Ropelle ER, Mourao RH et al (2009) EGFR tyrosine kinase inhibitor (PD153035) improves glucose tolerance and insulin action in high-fat diet-fed mice. Diabetes 58:2910-2919
    • (2009) Diabetes , vol.58 , pp. 2910-2919
    • Prada, P.O.1    Ropelle, E.R.2    Mourao, R.H.3
  • 42
    • 84859538216 scopus 로고    scopus 로고
    • Chemerin as a mediator between obesity and vascular inflammation in children
    • 22438234 10.1210/jc.2011-2937 1:CAS:528:DC%2BC38Xlslynsbg%3D
    • Landgraf K, Friebe D, Ullrich T et al (2012) Chemerin as a mediator between obesity and vascular inflammation in children. J Clin Endocrinol Metab 97:E556-E564
    • (2012) J Clin Endocrinol Metab , vol.97
    • Landgraf, K.1    Friebe, D.2    Ullrich, T.3
  • 46
    • 77954946392 scopus 로고    scopus 로고
    • Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b
    • 20639876 10.1038/ni.1908 1:CAS:528:DC%2BC3cXovFCnt7Y%3D
    • Han C, Jin J, Xu S, Liu H, Li N, Cao X (2010) Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b. Nat Immunol 11:734-742
    • (2010) Nat Immunol , vol.11 , pp. 734-742
    • Han, C.1    Jin, J.2    Xu, S.3    Liu, H.4    Li, N.5    Cao, X.6
  • 47
    • 79953161490 scopus 로고    scopus 로고
    • Effects of the gut microbiota on obesity and glucose homeostasis
    • 21353592 10.1016/j.tem.2011.01.002 1:CAS:528:DC%2BC3MXkt1eitr8%3D
    • Greiner T, Backhed F (2011) Effects of the gut microbiota on obesity and glucose homeostasis. Trends Endocrinol Metab 22:117-123
    • (2011) Trends Endocrinol Metab , vol.22 , pp. 117-123
    • Greiner, T.1    Backhed, F.2
  • 49
    • 79955487247 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice
    • 21490391 10.1172/JCI43378 1:CAS:528:DC%2BC3MXlvFKnt7Y%3D
    • Holland WL, Bikman BT, Wang LP et al (2011) Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J Clin Invest 121:1858-1870
    • (2011) J Clin Invest , vol.121 , pp. 1858-1870
    • Holland, W.L.1    Bikman, B.T.2    Wang, L.P.3


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