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Volumn 35, Issue 2, 2013, Pages 251-257

Relationship between azathioprine dosage and thiopurine metabolites in pediatric ibd patients: Identification of covariables using multilevel analysis

Author keywords

azathioprine dosage; inflammatory bowel disease; multilevel analysis; pediatric; thiopurine metabolites

Indexed keywords

6 METHYLTHIOINOSINE; ALANINE AMINOTRANSFERASE; AZATHIOPRINE; INFLIXIMAB; THIOGUANINE DERIVATIVE;

EID: 84875143574     PISSN: 01634356     EISSN: 15363694     Source Type: Journal    
DOI: 10.1097/FTD.0b013e318282c3a6     Document Type: Article
Times cited : (16)

References (44)
  • 1
    • 84873027788 scopus 로고    scopus 로고
    • In: Walker WA, Goulet O, Kleinman RE, eds. 4th ed. Hamilton, Canada: BC Decker
    • Griffiths AM, Hugot JP. Crohn disease. In: Walker WA, Goulet O, Kleinman RE, eds. Pediatric Gastrointestinal Disease. 4th ed. Hamilton, Canada: BC Decker; 2004: 789-824.
    • (2004) Crohn Disease , pp. 789-824
    • Griffiths, A.M.1    Hugot, J.P.2
  • 2
    • 67650999864 scopus 로고    scopus 로고
    • Ulcerative colitis
    • In: Walker WA, Goulet O, Kleinman RE, eds.. Hamilton, Canada: BC Decker
    • Leichtner AM, Higuchi L. Ulcerative colitis. In: Walker WA, Goulet O, Kleinman RE, eds. Pediatric Gastrointestinal Disease. Hamilton, Canada: BC Decker; 2004: 825-849.
    • (2004) Pediatric Gastrointestinal Disease , pp. 825-849
    • Leichtner, A.M.1    Higuchi, L.2
  • 3
    • 79952191733 scopus 로고    scopus 로고
    • Difficulties and possibilities with thiopurine therapy in inflammatory bowel disease-proceedings of the first thiopurine task force meeting
    • van Asseldonk DP, Sanderson J, de Boer NKH, et al. Difficulties and possibilities with thiopurine therapy in inflammatory bowel disease-proceedings of the first thiopurine task force meeting. Dig Liver Dis. 2011; 43: 270-276.
    • (2011) Dig Liver Dis. , vol.43 , pp. 270-276
    • Van Asseldonk, D.P.1    Sanderson, J.2    De Boer, N.K.H.3
  • 6
    • 4544239107 scopus 로고    scopus 로고
    • Thiopurine drug adverse effects in a population of New Zealand patients with inflammatory bowel disease
    • Gearry RB, Barclay ML, Burt MJ, et al. Thiopurine drug adverse effects in a population of New Zealand patients with inflammatory bowel disease. Pharmacoepidemiol Drug Saf. 2004; 13: 563-567.
    • (2004) PharmacoepiDemiol Drug Saf. , vol.13 , pp. 563-567
    • Gearry, R.B.1    Barclay, M.L.2    Burt, M.J.3
  • 7
    • 0036202803 scopus 로고    scopus 로고
    • 6-MP metabolite profiles proviDe a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease
    • Dubinsky MC, Yang H, Hassard PV, et al. 6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease. Gastroenterology. 2002; 122: 904-915.
    • (2002) Gastroenterology. , vol.122 , pp. 904-915
    • Dubinsky, M.C.1    Yang, H.2    Hassard, P.V.3
  • 8
    • 46049093818 scopus 로고    scopus 로고
    • Increased dosing requirements for 6-mercaptopurine and azathioprine in inflammatory bowel disease patients six years and younger
    • Grossman AB, Noble AJ, Mamula P, et al. Increased dosing requirements for 6-mercaptopurine and azathioprine in inflammatory bowel disease patients six years and younger. Inflamm Bowel Dis. 2008; 14: 750-755.
    • (2008) Inflamm Bowel Dis. , vol.14 , pp. 750-755
    • Grossman, A.B.1    Noble, A.J.2    Mamula, P.3
  • 9
    • 80053982932 scopus 로고    scopus 로고
    • Evaluating the use of metabolite measurement in children receiving treatment with a thiopurine
    • Armstrong L, Sharif JA, Galloway P, et al. Evaluating the use of metabolite measurement in children receiving treatment with a thiopurine. Aliment Pharmacol Ther. 2011; 34: 1106-1114.
    • (2011) Aliment Pharmacol Ther. , vol.34 , pp. 1106-1114
    • Armstrong, L.1    Sharif, J.A.2    Galloway, P.3
  • 10
    • 0026758498 scopus 로고
    • The clinical pharmacology of 6-mercaptopurine
    • Lennard L. The clinical pharmacology of 6-mercaptopurine. Eur J Clin Pharmacol. 1992; 43: 329-339.
    • (1992) Eur J Clin Pharmacol. , vol.43 , pp. 329-339
    • Lennard, L.1
  • 11
    • 0018822866 scopus 로고
    • Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity
    • Weinshilboum RM, Sladek SL. Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet. 1980; 32: 651-662.
    • (1980) Am J Hum Genet. , vol.32 , pp. 651-662
    • Weinshilboum, R.M.1    Sladek, S.L.2
  • 12
    • 0242464926 scopus 로고    scopus 로고
    • CD28-DepenDent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes
    • Tiede I, Fritz G, Strand S, et al. CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes. J Clin Invest. 2003; 111: 1133-1145.
    • (2003) J Clin Invest. , vol.111 , pp. 1133-1145
    • Tiede, I.1    Fritz, G.2    Strand, S.3
  • 13
    • 33748787999 scopus 로고    scopus 로고
    • Pharmacogenetics, drug-metabolizing enzymes, and clinical practice
    • Gardiner SJ, Begg EJ. Pharmacogenetics, drug-metabolizing enzymes, and clinical practice. Pharmacol Rev. 2006; 58: 521-590.
    • (2006) Pharmacol Rev. , vol.58 , pp. 521-590
    • Gardiner, S.J.1    Begg, E.J.2
  • 15
    • 0034067784 scopus 로고    scopus 로고
    • Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease
    • Dubinsky MC, Lamothe S, Yang HY, et al. Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease. Gastroenterology. 2000; 118: 705-713.
    • (2000) Gastroenterology. , vol.118 , pp. 705-713
    • Dubinsky, M.C.1    Lamothe, S.2    Yang, H.Y.3
  • 16
    • 0035037706 scopus 로고    scopus 로고
    • Utilisation of erythrocyte 6-thioguanine metabolite levels to optimise azathioprine therapy in patients with inflammatory bowel disease
    • Cuffari C, Hunt S, Bayless T. Utilisation of erythrocyte 6-thioguanine metabolite levels to optimise azathioprine therapy in patients with inflammatory bowel disease. Gut. 2001; 48: 642-646.
    • (2001) Gut. , vol.48 , pp. 642-646
    • Cuffari, C.1    Hunt, S.2    Bayless, T.3
  • 17
    • 34047125345 scopus 로고    scopus 로고
    • Thiopurine metabolite monitoring in paediatric inflammatory bowel disease
    • Ooi CY, Bohane TD, Lee D, et al. Thiopurine metabolite monitoring in paediatric inflammatory bowel disease. Aliment Pharmacol Ther. 2007; 25: 941-947.
    • (2007) Aliment Pharmacol Ther. , vol.25 , pp. 941-947
    • Ooi, C.Y.1    Bohane, T.D.2    Lee, D.3
  • 18
    • 33646011261 scopus 로고    scopus 로고
    • Association of 6-Thioguanine nucleotiDe levels and inflammatory bowel disease activity: A meta-analysis
    • Osterman MT, Kundu R, Lichtenstein GR, et al. Association of 6-Thioguanine nucleotide levels and inflammatory bowel disease activity: a meta-analysis. Gastroenterology. 2006; 130: 1047-1053.
    • (2006) Gastroenterology. , vol.130 , pp. 1047-1053
    • Osterman, M.T.1    Kundu, R.2    Lichtenstein, G.R.3
  • 19
    • 27744461917 scopus 로고    scopus 로고
    • Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease
    • Gearry RB, Barclay ML. Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease. J Gastroenterol Hepatol. 2005; 20: 1149-1157.
    • (2005) J Gastroenterol Hepatol. , vol.20 , pp. 1149-1157
    • Gearry, R.B.1    Barclay, M.L.2
  • 20
    • 77957601118 scopus 로고    scopus 로고
    • Optimizing thiopurine therapy: More weight to the metabolite argument
    • Gibson PR, Gearry RB. Optimizing thiopurine therapy: more weight to the metabolite argument. J Gastroenterol Hepatol. 2010; 25: 1592-1594.
    • (2010) J Gastroenterol Hepatol. , vol.25 , pp. 1592-1594
    • Gibson, P.R.1    Gearry, R.B.2
  • 21
    • 2542639314 scopus 로고    scopus 로고
    • Pharmacokinetics of 6-Mercap topurine in patients with inflammatory bowel disease: Implications for therapy
    • Derijks LJ, Gilissen LP, Engels LG, et al. Pharmacokinetics of 6-Mercap topurine in patients with inflammatory bowel disease: implications for therapy. Ther Drug Monit. 2004; 26: 311-318.
    • (2004) Ther Drug Monit. , vol.26 , pp. 311-318
    • Derijks, L.J.1    Gilissen, L.P.2    Engels, L.G.3
  • 22
    • 4644241128 scopus 로고    scopus 로고
    • Azathioprine formulation optimizes metabolite profile in inflammatory bowel disease
    • Stevens T, Achkar JP, Easley K, et al. Azathioprine formulation optimizes metabolite profile in inflammatory bowel disease. Aliment Pharmacol Ther. 2004; 20: 601-606.
    • (2004) Aliment Pharmacol Ther. , vol.20 , pp. 601-606
    • Stevens, T.1    Achkar, J.P.2    Easley, K.3
  • 23
    • 0034771188 scopus 로고    scopus 로고
    • Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease
    • Lowry PW, Franklin CL, Weaver AL, et al. Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease. Gut. 2001; 49: 665-670.
    • (2001) Gut. , vol.49 , pp. 665-670
    • Lowry, P.W.1    Franklin, C.L.2    Weaver, A.L.3
  • 24
    • 9644291462 scopus 로고    scopus 로고
    • Assessment of thiopurine methyltransferase and metabolite formation during thiopurine therapy: Results from a large Swedish patient population
    • Hindorf U, Peterson C, Almer S. Assessment of thiopurine methyltransferase and metabolite formation during thiopurine therapy: results from a large Swedish patient population. Ther Drug Monit. 2004; 26: 673-678.
    • (2004) Ther Drug Monit. , vol.26 , pp. 673-678
    • Hindorf, U.1    Peterson, C.2    Almer, S.3
  • 25
    • 52149099443 scopus 로고    scopus 로고
    • Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease
    • Ansari A, Arenas M, Greenfield SM, et al. Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease. Aliment Pharmacol Ther. 2008; 28: 973-983.
    • (2008) Aliment Pharmacol Ther. , vol.28 , pp. 973-983
    • Ansari, A.1    Arenas, M.2    Greenfield, S.M.3
  • 26
    • 33745650894 scopus 로고    scopus 로고
    • Adverse events leading to modification of therapy in a large cohort of patients with inflammatory bowel disease
    • Hindorf U, Lindqvist M, Hildebrand H, et al. Adverse events leading to modification of therapy in a large cohort of patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2006; 24: 331-342.
    • (2006) Aliment Pharmacol Ther. , vol.24 , pp. 331-342
    • Hindorf, U.1    Lindqvist, M.2    Hildebrand, H.3
  • 27
    • 84862233680 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of thiopurine metabolites in adult thiopurine tolerant IBD patients on maintenance therapy
    • Gilissen LP, Wong DR, Engels LG, et al. Therapeutic drug monitoring of thiopurine metabolites in adult thiopurine tolerant IBD patients on maintenance therapy. J Crohns Colitis. 2012; 6: 698-707.
    • (2012) J Crohns Colitis. , vol.6 , pp. 698-707
    • Gilissen, L.P.1    Wong, D.R.2    Engels, L.G.3
  • 28
    • 0035134907 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of azathioprine and 6-mercaptopurine metabolites in Crohn disease
    • Balaiche J, Desager JP, Horsmans Y, et al. Therapeutic drug monitoring of azathioprine and 6-mercaptopurine metabolites in Crohn disease. Scand J Gastroenterol. 2001; 36: 71-76.
    • (2001) Scand J Gastroenterol. , vol.36 , pp. 71-76
    • Balaiche, J.1    Desager, J.P.2    Horsmans, Y.3
  • 29
    • 3543150184 scopus 로고    scopus 로고
    • Indicators of clinical response to treatment with six-mercaptopurine or azathioprine in patients with inflammatory bowel disease
    • Achkar JP, Stevens T, Easley K, et al. Indicators of clinical response to treatment with six-mercaptopurine or azathioprine in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2004; 10: 339-345.
    • (2004) Inflamm Bowel Dis. , vol.10 , pp. 339-345
    • Achkar, J.P.1    Stevens, T.2    Easley, K.3
  • 30
    • 0242383310 scopus 로고    scopus 로고
    • Drug interaction between infliximab and azathioprine in patients with Crohn's disease
    • Roblin X, Serre-Debeauvais F, Phelip JM, et al. Drug interaction between infliximab and azathioprine in patients with Crohn's disease. Aliment Pharmacol Ther. 2003; 18: 917-925.
    • (2003) Aliment Pharmacol Ther. , vol.18 , pp. 917-925
    • Roblin, X.1    Serre-Debeauvais, F.2    Phelip, J.M.3
  • 31
    • 85027912855 scopus 로고    scopus 로고
    • Infliximab treatment induces levels of the active azathioprine metabolite TGTP in Crohn's disease
    • Teichgräber U, Atreya I, Atreya R, et al. Infliximab treatment induces levels of the active azathioprine metabolite TGTP in Crohn's disease. Inflamm Bowel Dis. 2012.
    • (2012) Inflamm Bowel Dis.
    • Teichgräber, U.1    Atreya, I.2    Atreya, R.3
  • 32
    • 0021245463 scopus 로고
    • Childhood lymphoblastic leukaemia: Sex difference in 6-mercaptopurine utilization
    • Lilleyman JS, Lennard L, Rees CA, et al. Childhood lymphoblastic leukaemia: sex difference in 6-mercaptopurine utilization. Br J Cancer. 1984; 49: 703-707.
    • (1984) Br J Cancer. , vol.49 , pp. 703-707
    • Lilleyman, J.S.1    Lennard, L.2    Rees, C.A.3
  • 33
    • 0030041584 scopus 로고    scopus 로고
    • Long-term follow-up of patients with Crohn's disease treated with azathioprine or 6-mercaptopurine
    • Bouhnik Y, Scemama G, Taï R, et al. Long-term follow-up of patients with Crohn's disease treated with azathioprine or 6-mercaptopurine. Lancet. 1996; 347: 215-219.
    • (1996) Lancet. , vol.347 , pp. 215-219
    • Bouhnik, Y.1    Scemama, G.2    Taï, R.3
  • 34
    • 0032367178 scopus 로고    scopus 로고
    • Multilevel analysis of repeated measures data
    • Van Der LR. Multilevel analysis of repeated measures data. Qual Quant. 1998; 32: 15-29.
    • (1998) Qual Quant. , vol.32 , pp. 15-29
    • Van Der, L.R.1
  • 35
    • 0032874716 scopus 로고    scopus 로고
    • Lack of effect of intravenous administration on time to respond to azathioprine for steroid-treated Crohn's disease
    • Sandborn WJ, Tremaine WJ, Wolf DC, et al. Lack of effect of intravenous administration on time to respond to azathioprine for steroid-treated Crohn's disease. Gastroenterology. 1999; 117: 527-535.
    • (1999) Gastroenterology. , vol.117 , pp. 527-535
    • Sandborn, W.J.1    Tremaine, W.J.2    Wolf, D.C.3
  • 36
    • 78649515217 scopus 로고    scopus 로고
    • Steady-state of azathioprine during initiation treatment of pediatric inflammatory bowel disease
    • Pozler O, Chládek J, Malý J, et al. Steady-state of azathioprine during initiation treatment of pediatric inflammatory bowel disease. J Crohns Colitis. 2010; 4: 623-628.
    • (2010) J Crohns Colitis. , vol.4 , pp. 623-628
    • Pozler, O.1    Chládek, J.2    Malý, J.3
  • 37
    • 0031889642 scopus 로고    scopus 로고
    • Simultaneous Determination of 6-thioguanine and methyl 6-mercaptopurine nucleotiDes of azathioprine in red blood cells by HPLC
    • Dervieux T, Boulieu R. Simultaneous determination of 6-thioguanine and methyl 6-mercaptopurine nucleotides of azathioprine in red blood cells by HPLC. Clin Chem. 1998; 44: 551-555.
    • (1998) Clin Chem. , vol.44 , pp. 551-555
    • Dervieux, T.1    Boulieu, R.2
  • 38
    • 0035043156 scopus 로고    scopus 로고
    • Phenotype Determination of thiopurine methyltransferase in erythrocytes by HPLC
    • Boulieu R, Sauviat M, Dervieux T, et al. Phenotype determination of thiopurine methyltransferase in erythrocytes by HPLC. Clin Chem. 2001; 47: 956-958.
    • (2001) Clin Chem. , vol.47 , pp. 956-958
    • Boulieu, R.1    Sauviat, M.2    Dervieux, T.3
  • 39
    • 33846235123 scopus 로고    scopus 로고
    • Thiopurine methyltransferase activity is correlated with azathioprine metabolite levels in patients with inflammatory bowel disease in clinical gastroenterology practice
    • Bloomfeld RS, Bickston SJ, Levine ME, et al. Thiopurine methyltransferase activity is correlated with azathioprine metabolite levels in patients with inflammatory bowel disease in clinical gastroenterology practice. J Appl Res. 2006; 6: 282-287.
    • (2006) J Appl Res. , vol.6 , pp. 282-287
    • Bloomfeld, R.S.1    Bickston, S.J.2    Levine, M.E.3
  • 40
    • 78649710356 scopus 로고    scopus 로고
    • Allopurinol might improve response to azathioprine and 6-mercaptopurine by correcting an unfavorable metabolite ratio
    • Gardiner SJ, Gearry RB, Burt MJ, et al. Allopurinol might improve response to azathioprine and 6-mercaptopurine by correcting an unfavorable metabolite ratio. J Gastroenterol Hepatol. 2011; 26: 49-54.
    • (2011) J Gastroenterol Hepatol. , vol.26 , pp. 49-54
    • Gardiner, S.J.1    Gearry, R.B.2    Burt, M.J.3
  • 41
    • 70449482129 scopus 로고    scopus 로고
    • Thiopurine methyltransferase and thiopurine metabolite testing in patients with inflammatory bowel disease who are taking thiopurine drugs
    • Sheffield LJ, Irving P, Gupta A, et al. Thiopurine methyltransferase and thiopurine metabolite testing in patients with inflammatory bowel disease who are taking thiopurine drugs. Pharmacogenomics. 2009; 10: 1091-1099.
    • (2009) Pharmacogenomics. , vol.10 , pp. 1091-1099
    • Sheffield, L.J.1    Irving, P.2    Gupta, A.3
  • 42
    • 0028269944 scopus 로고
    • Mercaptopurine metabolism and risk of relapse in childhood lymphoblastic leukaemia
    • Lilleyman JS, Lennard L. Mercaptopurine metabolism and risk of relapse in childhood lymphoblastic leukaemia. Lancet. 1994; 343: 1188-1190.
    • (1994) Lancet. , vol.343 , pp. 1188-1190
    • Lilleyman, J.S.1    Lennard, L.2
  • 43
    • 34247213437 scopus 로고    scopus 로고
    • Thiopurine methyltransferase activity in Spain: A study of 14, 545 patients
    • Gisbert J, Gomollón F, Cara C, et al. Thiopurine methyltransferase activity in Spain: a study of 14, 545 patients. Dig Dis Sci. 2007; 52: 1262-1269.
    • (2007) Dig Dis Sci. , vol.52 , pp. 1262-1269
    • Gisbert, J.1    Gomollón, F.2    Cara, C.3
  • 44
    • 79958779611 scopus 로고    scopus 로고
    • Pre-analytic and analytic sources of variations in thiopurine methyltransferase activity measurement in patients prescribed thiopurine-based drugs: A systematic review
    • Loit E, Tricco AC, Tsouros S, et al. Pre-analytic and analytic sources of variations in thiopurine methyltransferase activity measurement in patients prescribed thiopurine-based drugs: a systematic review. Clin Biochem. 2011; 44: 751-757.
    • (2011) Clin Biochem. , vol.44 , pp. 751-757
    • Loit, E.1    Tricco, A.C.2    Tsouros, S.3


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