Effect of S-allylcysteine, A sulphur containing amino acid on iron metabolism in streptozotocin induced diabetic rats

Journal of Trace Elements in Medicine and Biology

Volumn 27, Issue 2, 2013, Pages 143-147

  Saravanan, Ganapathy ^a   Ponmurugan, Ponnusamy ^b   Begum, Mustapha Shabana ^c  

^a K S RANGASAMY COLLEGE OF ARTS AND SCIENCE AUTONOMOUS   (India)

^b K S RANGASAMY COLLEGE OF TECHNOLOGY   (India)

^c MUTHAYAMMAL COLLEGE OF ARTS AND SCIENCE   (India)

Author keywords

Aminolevulinic acid dehydratase; Diabetes; Heme oxygenase; S allylcysteine

Indexed keywords

AMINO ACID; BILIRUBIN; FERRITIN; GLICLAZIDE; GLUCOSE; HEME OXYGENASE; INSULIN; IRON; PORPHOBILINOGEN SYNTHASE; REACTIVE OXYGEN METABOLITE; S ALLYLCYSTEINE; STREPTOZOCIN; SULFUR; TRANSFERRIN;

ANIMAL EXPERIMENT; ARTICLE; BILIRUBIN BLOOD LEVEL; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; EXPERIMENTAL DIABETES MELLITUS; FERRITIN BLOOD LEVEL; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; IRON BLOOD LEVEL; IRON METABOLISM; KIDNEY; LIVER; MALE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; TRANSFERRIN BLOOD LEVEL;

AMINOLEVULINIC ACID; ANIMALS; BLOOD GLUCOSE; CYSTEINE; DIABETES MELLITUS, EXPERIMENTAL; FERRITINS; HEME OXYGENASE (DECYCLIZING); INSULIN; IRON; KIDNEY; LIVER; MALE; RATS; RATS, WISTAR; SULFUR; TRANSFERRIN;

ALLIUM SATIVUM; RATTUS;

EID: 84875101451     PISSN: 0946672X     EISSN: 18783252     Source Type: Journal    
DOI: 10.1016/j.jtemb.2012.07.009     Document Type: Article

References (41)

1. Neslihan Toyran, Peter Lasch, Dieter Naumann Early alterations in myocardia and vessels of the diabetic rat heart: an FTIR microspectroscopic study. Biochem J 2006, 397:427-436.
2. WHO. Prevalence of diabetes worldwide. Available from: [accessed 06.06.10]. http://www.who.int/mediacentre/factsheets/fs312/en/index.html.
3. IDA. Diabetes Atlas. 4th ed. Available from: ; 2009. http://www.diabetesatlas.org/.
4. Fugh-Berman A. Herbs and dietary supplements in the prevention and treatment of cardiovascular disease. Prev Cardiol 2000, 3:24-32.
5. Schlyer S., Horuk R. I want a new drug: G-protein-coupled receptors in drug development. Drug Discov Today 2006, 11:481-493.
6. Rangkadilok N., Sitthimonchai S., Worasuttayangkurn L., Mahidol C., Ruchirawat M., Satayavivad J. Evaluation of free radical scavenging and antityrosinase activities of standardized longan fruit extract. Food Chem Toxicol 2007, 45:328-336.
7. Numagami Y., Ohnishi S.T. S-allylcysteine inhibits free radical production, lipid peroxidation and neuronal damage in rat brain ischemia. J Nutr 2001, 131:1100S-1105S.
8. Saravanan G., Ponmurugan P., Senthil kumar G.P., Rajarajan T. Antidiabetic properties of S-allyl cysteine, a garlic component on streptozotocin-induced diabetes in rats. J Appl Biomed 2009, 7:151-159.
9. Saravanan G., Ponmurugan P., Senthil kumar G.P., Rajarajan T. Modulatory effect of S-allylcysteine on glucose metabolism in streptozotocin induced diabetic rats. J Funct Food 2009, 1:336-340.
10. Saravanan G., Ponmurugan P. Ameliorative potential of S-allyl cysteine on oxidative stress in STZ induced diabetic rats. Chem Biol Int 2011, 189:100-106.
11. Kaleem M., Asif M., Ahmed Q., Bano B. Antidiabetic and antioxidant activity of Annona squamosa extract in streptozotozin induced diabetic rats. Singapore Med J 2006, 47:670-675.
12. Pulido N., Suarez A., Casanova B. Glyclazide treatment of streptozotocin diabetic rats restores GLUT4 protein content and basal glucose uptake in skeletal muscle. Metabolism 1997, 46:10-13.
13. Sassa S., Porphyria A.L.A.D. Semin Liver Dis 1998, 18:95-101.
14. Trakshel G.M., Kutty R.K., Maines M.D. Purification and characterization of the major constitutive form of testicular heme oxygenase. The noninducible isoform. J Biol Chem 1986, 261:11131-11137.
15. Saravanan G, Ponmurugan P. Ameliorative potential of S-allylcysteine: effect on lipid profile and changes in tissue fatty acid composition in experimental diabetes. Exp Toxicol Pathol, doi:10.1016/j.etp.2010.12.007.
16. Saravanan G., Ponmurugan P. Beneficial effect of S-allylcysteine (SAC) on blood glucose and pancreatic antioxidant system in streptozotocin diabetic rats. Plant Foods Hum Nutr 2010, 65:374-378.
17. Wu K.K., Huan Y. Streptozotocin-induced diabetic models in mice and rats. Curr Protoc Pharmacol 2008, 40:1-5.
18. Palsamy P., Subramanian S. Resveratrol, a natural phytoalexin, normalizes hyperglycemia in streptozotocin-nicotinamide induced experimental diabetic rats. Biomed Pharmacother 2008, 62:598-605.
19. Puntarulo S. Iron oxidative stress and human health. Mol Aspects Med 2005, 26:299-312.
20. Goswami T., Rolfs A., Hediger M.A. Iron transport: emerging roles in health and disease. Biochem Cell Biol 2002, 80:679-689.
21. Gutteridge J.M.C. Iron promoters of the Fenton reaction and lipid peroxidation can be released from hemoglobin by peroxides. FEBS Lett 1986, 201:291-295.
22. Fernandez-Real J.M., Lopez-Bermejo A., Ricart W. Cross-talk between iron metabolism and diabetes. Diabetes 2002, 51:2348-3235.
23. Baynes J.W. Role of oxidative stress in development of complications in diabetes. Diabetes 1991, 40:405-412.
24. Jehn M., Clark J.M., Guallar E. Serum ferritin and risk of the metabolic syndrome in U.S. adults. Diabetes Care 2004, 27:2422e8.
25. 2 as a mediator for DNA fragmentation. Diabetes 1991, 40:1141-1145.
26. Moumita Roy, Subhrojit Sen, Abhay Sankar Chakraborti Action of pelargonidin on hyperglycemia and oxidative damage in diabetic rats: implication for glycation-induced hemoglobin modification. Life Sci 2008, 82:1102-1110.
27. Vallejo S., Angulo J., Peiró C., Navado J., Sánchez-ferrer A., Petidier R., et al. Highly glycated oxyhaemoglobin impairs nitric oxide relaxations in human mesenteric microvessels. Diabetologia 2000, 43:83-90.
28. Ford E.S., Cogswell M.E. Diabetes and serum ferritin concentration among US adults. Diabetes Care 1999, 22:1978-1983.
29. Sheu W.H., Chen Y.T., Lee W.J., Wang C.W., Lin L.Y. A relationship between serum ferritin and the insulin resistance syndrome is present in non-diabetic women but not in non-diabetic men. Clin Endocrinol (Oxf) 2003, 58:380-385.
30. Shi Z., Hu X., Yuan B., Pan X., Meyer H.E., Holmboe-Ottesen G. Association between serum ferritin, hemoglobin, iron intake, and diabetes in adults in Jiangsu, China. Diabetes Care 2006, 29:1878-1883.
31. Gabay C., Kushner I. Acute-phase proteins other systemic responses to inflammation. Engl J N. Med 1999, 340:448-454.
32. Jarnum S., Lassen N.A. Albumin and transferrin metabolism in infectious and toxic diseases. Scand J Clin Lab Invest 1961, 13:357-368.
33. De Block C.E., Van Campenhout C.M., De Leeuw I.H., Keenoy B.M., Martin M., Van Hoof V., et al. Soluble transferrin receptor level: a new marker of iron deficiency anemia, a common manifestation of gastric autoimmunity in type 1 diabetes. Diabetes Care 2000, 23:1384-1388.
34. O'Donnell M.J., Martin P., Florkowski C.M., Toop M.J., Chapman C., Holder R., et al. Urinary transferrin excretion in type-1 (insulin-dependent) diabetes-mellitus. Diabet Med 1991, 8:657-661.
35. Telci A., Cakatay U., Kayali R., Erdoĝan C., Orhan Y., Sivas A., et al. Oxidative protein damage in plasma of type 2 diabetic patients. Horm Metab Res 2000, 32:40-43.
36. Buelow R., Tullius S.G., Volk H.D. Protection of grafts by hemoxygenase-1 and its toxic product carbon monoxide. Am J Transplant 2001, 1:313-315.
37. Dennery P.A., Spitz D.R., Yang G., Tatarov A., Lee C.S., Shegog M.L., et al. Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2. J Clin Invest 1998, 101:1001-1011.
38. Nath K.A., Haggard J.J., Croatt A.J., Grande J.P., Poss K.D., Alam J. The indispensability of heme oxygenase-1 in protecting against acute heme protein-induced toxicity in vivo. Am J Pathol 2000, 156:1527-1535.
39. Nogueira C.W., Soares F.A., Nascimento P.C., Muller D., Rocha J.B.T. 2,3-Dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid increase mercury and cadmium-induced inhibition of delta-aminolevulinate dehydratase. Toxicology 2003, 184:85-95.
40. Brito V.B., Folmer V., Soares J.C., Silveira I.D., Rocha J.B. Long-term sucrose and glucose consumption decreases the delta-aminolevulinate dehydratase activity in mice. Nutrition 2007, 23:818-826.
41. Kade I.J., Borges V.C., Savegnago L., Ibukun E.O., Zeni G., Nogueira C.W., et al. Effect of oral administration of diphenyl diselenide on antioxidant status, and activity of delta aminolevulinic acid dehydratase and isoforms of lactate dehydrogenase, in streptozotocin-induced diabetic rats. Cell Biol Toxicol 2009, 25:415-424.