Highly glycated oxyhaemoglobin impairs nitric oxide relaxations in human mesenteric microvessels

Diabetologia

Volumn 43, Issue 1, 2000, Pages 83-90

  Vallejo, S ^a   Angulo, J ^a   Peiro C ^b   Nevado, J ^b   Sanchez Ferrer A ^a   Petidier, R ^a   Sanchez Ferrer C F ^b   Rodriguez Manas L ^a  

^a HOSPITAL UNIVERSITARIO DE GETAFE   (Spain)

^b AUTONOMOUS UNIVERSITY OF MADRID   (Spain)

Author keywords

Antioxidants; Endothelial dysfunction; Glycated haemoglobin; Human microvessels; Nitric oxide; Superoxide anions

Indexed keywords

ASCORBIC ACID; BRADYKININ; CATALASE; DIMETHYLTHIOUREA; GLIBENCLAMIDE; GLICLAZIDE; GLYCOSYLATED HEMOGLOBIN; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; OXYHEMOGLOBIN; POTASSIUM CHLORIDE; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; MESENTERY BLOOD VESSEL; PRIORITY JOURNAL; VASODILATATION;

EID: 0034091902     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050011     Document Type: Article

References (32)

1. 1. Fortes ZB, Leme JG, Scivoletto R (1983) Vascular reactivity in diabetes mellitus: role of the endothelial cells. Br J Pharmacol 79: 771-781
2. 2. Calvier A, Collier J, Vallance P (1992) Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes. J Clin Invest 90: 2548-2554
3. 3. Bucala R, Tracey KJ, Cerami A (1991) Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilation in experimental diabetes. J Clin Invest 87: 432-438
4. 4. Rodríguez-Mañas L, Arribas S, Girón C, Villamor J, Sánchez-Ferrer CF, Marín J (1993) Interference of glycosylated human hemoglobin with endothelium-dependent responses. Circulation 88: 2111-2116
5. 5. Angulo J, Sánchez-Ferrer CF, Peiró C, Marín J, Rodríguez-Mañas L (1996) Impairment of endothelium-dependent relaxation by increasing percentages of glycosylated human hemoglobin. Possible mechanisms involved. Hypertension 28: 583-592
6. 6. Dacie J, Lewis SM (1984) Practical hematology, 6th edn. Churchill Livingstone, Edinburgh
7. 7. Tietz NW (1990) Clinical guide to laboratory tests, 2nd edn. Saunders, Philadelphia
8. 8. Angulo J, Rodríguez-Mañas L, Peiró C, Neira M, Marín J, Sánchez-Ferrer C (1998) Impairment of nitric oxide-mediated relaxations in anaesthetized autoperfused streptozotocin-induced diabetic rats. Naunyn Schmiedebergs Arch Pharmacol 356: 529-537
9. 9. Rodríguez-Mañas L, Angulo J, Peiró C et al. (1998) Endothelial dysfunction and metabolic control in streptozotocin-induced diabetic rats. Br J Pharmacol 123: 1495-1502
10. 10. Palmer KJ, Brogden RN (1993) Gliclazide. An update of its pharmacological properties and therapeutic efficacy in non-insulin dependent diabetes mellitus. Drugs 46: 92-125
11. 11. Scott NA, Jennings PE, Brown J, Belch JJF (1991) Gliclazide: a free radical scavenger. Eur J Pharmacol 208: 175-177
12. 12. Jennings PE, Scott NA, Santabadi AR, Belch JJF (1992) Effects of gliclazide on platelet reactivity and free radicals in type II diabetic patients: clinical assessments. Metabolism 41: 36-39
13. 13. Mulvany MJ, Halpern W (1977) Contractile properties of small arterial resistance arteries in spontaneously hypertensive and normotensive rats. Circ Res 4: 19-26
14. 14. Ohlmann P, Martínez MC, Schneider F, Stoclet JC, Andriantsitohaina R (1997) Characterization of endothelium-derived relaxing factors released by bradykinin in human resistance arteries. Br J Pharmacol 121: 657-664
15. 15. Kemp BK, Cocks TM (1997) Evidence that mechanisms dependent and independent of nitric oxide mediate endothelium-dependent relaxation to bradykinin in human small resistance-like coronary arteries. Br J Pharmacol 120: 757-762
16. 16. Ceriello A, Quatraro A, Giugliano D (1993) Diabetes mellitus and hypertension: the possible role of hyperglycaemia through oxidative stress. Diabetologia 36: 265-266
17. 17. Giugliano D, Ceriello A, Paolisso G (1996) Oxidative stress and diabetic vascular complications. Diabetes Care 19: 257-267
18. 18. Tesfamariam B (1994) Free radicals in diabetic endothelial cell dysfunction. Free Radic Biol Med 16: 383-391
19. 19. Domínguez C, Ruiz E, Gussinye M, Carrascosa A (1998) Oxidative stress at onset and in early stages of type I diabetes in children and adolescents. Diabetes Care 21: 1736-1742
20. 20. Mullarkey CJ, Edelstein D, Brownlee M (1990) Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes. Biochem Biophys Res Commun 173: 932-939
21. 21. Pagano PJ, Griswold MC, Ravel D, Cohen RA (1998) Vascular action of the hypoglycaemic agent gliclazide in diabetic rabbits. Diabetologia 41: 9-15
22. 22. Calvier A, Collier J, Vallance P (1992) Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes. J Clin Invest 90: 2548-2554
23. 23. Cohen RA (1993) Dysfunction of vascular endothelium in diabetes mellitus. Circulation 87:[Suppl V]:V67-V76
24. 24. Pieper GM (1998) Review of alterations in endothelial nitric oxide production in diabetes. Protective role of arginine on endothelial dysfunction. Hypertension 31: 1047-1060
25. 25. Kamata K, Miyata N, Kasuya Y (1989) Involvement of endothelial cells in relaxation and contraction responses of the aorta to isoproterenol in naive and streptozotocininduced diabetic rats. J Pharmacol Exp Ther 249: 890-894
26. 26. Durante W, Sen AK, Sunahara FA (1988) Impairment of endothelium-dependent relaxation in aortae from spontaneously diabetic rats. Br J Pharmacol 94: 463-468
27. 27. Jovanovic L, Peterson CM (1981) The clinical utility of glycosylated hemoglobin. Am J Med 70: 331-337
28. 28. The Diabetes Control and Complications Trials Research Group (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329: 977-986
29. 29. UK Prospective Diabetes Study (UKPDS) Group (1998) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352: 837-853
30. 30. Hongo K, Ogawa H, Kassel NF et al. (1988) Comparison of intraluminal and extraluminal-inhibitory effects of hemoglobin on endothelium-dependent relaxation of rabbit basilar artery. Stroke 19: 1550-1555
31. 31. Stary HC, Blankenhorn DH, Chandler AB et al. (1992) A definition of the intima of human arteries and of its atherosclerosis-prone regions. A report from the Committee on Vascular Lesions of the Council on Atherosclerosis, American Heart Association. Circulation 85: 391-405
32. 32. Faivre-Fiorina B, Caron A, Fassot C et al. (1999) Presence of hemoglobin inside aortic cells after cell-free hemoglobin administration in guinea-pigs. Am J Physiol 276: H766-H770