Granzyme A Produced by γ9δ2 T Cells Induces Human Macrophages to Inhibit Growth of an Intracellular Pathogen

PLoS Pathogens

Volumn 9, Issue 1, 2013, Pages

  Spencer, Charles T ^a,c   Abate, Getahun ^a   Sakala, Isaac G ^a,d   Xia, Mei ^a   Truscott, Steven M ^a,e   Eickhoff, Christopher S ^a   Linn, Rebecca ^a   Blazevic, Azra ^a   Metkar, Sunil S ^b   Peng, Guangyong ^a   Froelich, Christopher J ^b   Hoft, Daniel F ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

^c UNIVERSITY OF TEXAS AT EL PASO   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e WILLIAM BEAUMONT HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GRANZYME A; LENTIVIRUS VECTOR; SHORT HAIRPIN RNA; TUMOR NECROSIS FACTOR ALPHA;

ANTIMICROBIAL ACTIVITY; APOPTOSIS; ARTICLE; BACTERIAL INFECTION; CELL CONTACT; CELL DIVISION; CONTROLLED STUDY; FLOW CYTOMETRY; GAMMA DELTA T LYMPHOCYTE; GROWTH INHIBITION; HUMAN; HUMAN CELL; INFLAMMATION; MONOCYTE; MYCOBACTERIUM; NONHUMAN; NORMAL HUMAN; PATHOGENESIS;

CELLS, CULTURED; GENE EXPRESSION REGULATION, BACTERIAL; GENE KNOCKDOWN TECHNIQUES; GRANZYMES; HOST-PATHOGEN INTERACTIONS; HUMANS; MACROPHAGES; MONOCYTES; MYCOBACTERIUM; NEUTRALIZATION TESTS; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; RNA, SMALL INTERFERING; T-LYMPHOCYTE SUBSETS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84875069292     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003119     Document Type: Article

References (34)

1. Beetz S, Marischen L, Kabelitz D, Wesch D, (2007) Human γδ T cells: candidates for the development of immunotherapeutic strategies. Immunology Research 37: 97-111.
2. Morita CT, Jin C, Sarikonda G, Wang H, (2007) Nonpeptide antigens, presentation mechanisms, and immunological memory of human Vγ2Vδ2 T cells: discriminating friend from foe through the recognition of prenyl pyrophosphate antigens. Immunological Reviews 215: 59-76.
3. Constant P, Davodeau F, Peyrat MA, Poquet Y, Puzo G, et al. (1994) Stimulation of human γδ T cells by nonpeptidic mycobacterial ligands. Science 264: 267-270.
4. Abate G, Eslick J, Newman FK, Frey SE, Belshe RB, et al. (2005) Flow-cytometric detection of vaccinia-induced memory effector CD4+, CD8+, and γδ TCR+ T cells capable of antigen-specific expansion and effector functions. Journal of Infectious Diseases 192: 1362-1371.
5. Hoft DF, Babusis E, Worku S, Spencer CT, Lottenbach K, et al. (2011) Live and inactivated influenza vaccines induce similar humoral responses, but only live vaccines induce diverse T cell responses in young children. Journal of Infectious Diseases 204: 845-853.
6. Hoft DF, Brown RM, Roodman ST, (1998) Bacille Calmette-Guérin vaccination enhances human γδ T cell responsiveness to mycobacteria suggestive of a memory-like phenotype. Journal of Immunology 161: 1045-1054.
7. Spencer CT, Abate G, Blazevic A, Hoft DF, (2008) Only a subset of phosphoantigen-responsive γ9δ2 T cells mediate protective tuberculosis immunity. Journal of Immunology 181: 4471-4484.
8. Dieli F, Troye-Blomberg M, Ivanyi J, Fournie JJ, Bonneville M, et al. (2000) Vg9Vd2 T lymphocytes reduce the viability of intracellular Mycobacterium tuberculosis. European Journal of Immunology 30: 1512-1519.
9. Dieli F, Troye-Blomberg M, Ivanyi J, Fournie JJ, Krensky AM, et al. (2001) Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by Vg9Vd2 T lymphocytes. Journal of Infectious Diseases 184: 1082-1085.
10. Oliaro J, Dudal S, Liautard J, Andrault JB, Liautard JP, et al. (2005) Vg9Vd2 T cells use a combination of mechanisms to limit the spread of the pathogenic bacteria Brucella. Journal of Leukocyte Biology 77: 652-660.
11. Metkar SS, Menaa C, Pardo J, Wang B, Wallich R, et al. (2008) Human and mouse granzyme A induce a proinflammatory cytokine response. Immunity 29: 720-733.
12. Thurner B, Roder C, Dieckmann D, Heuer M, Kruse M, et al. (1999) Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application. Journal of Immunological Methods 223: 1-15.
13. Neighbour PA, Huberman HS, (1982) Sr++-induced inhibition of human natural killer (NK) cell-mediated cytotoxicity. Journal of Immunology 128: 1236-1240.
14. Blommaart EF, Krause U, Schellens JP, Vreeling-Sindelarova H, Meijer AJ, (1997) The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. European Journal of Biochemistry 243: 240-246.
15. Seglen PO, Gordon PB, (1982) 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proceedings of the National Academy of Sciences 79: 1889-1892.
16. Zhu H, Fearnhead HO, Cohen GM, (1995) An ICE-like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells. FEBS Letters 374: 303-308.
17. Hanna WL, Zhang X, Turbov J, Winkler U, Hudig D, et al. (1993) Rapid purification of cationic granule proteases: application to human granzymes. Protein Expression and Purification 4: 398-404.
18. Worku S, Hoft DF, (2003) Differential effects of control and antigen-specific T cells on intracellular mycobacterial growth. Infection and Immunity 71: 1763-1773.
19. Peng G, Guo Z, Kiniwa Y, Voo Ks, Peng W, et al. (2005) Toll-Like Receptor 8-Mediated Reversal of CD4+ Regulatory T Cell Function. Science 309: 1380-1384.
20. Allison TJ, Winter CC, Fournie JJ, Bonneville M, Garboczi DN, (2001) Structure of a human γδ-cell antigen receptor. Nature 411: 820-824.
21. Boom WH, Chervenak KA, Mincek MA, Ellner JJ, (1992) Role of the mononuclear phagocyte as an antigen-presenting cell for human γ/δ T cells activated by live Mycobacterium tuberculosis. Infection and Immunity 60: 3480-3488.
22. Rojas RE, Torres M, Fournie JJ, Harding CV, Boom WH, (2002) Phosphoantigen presentation by macrophages to Mycobacterium tuberculosis-reactive Vγ9Vδ2+ T cells: modulation by chloroquine. Infection and Immunity 70: 4019-4027.
23. Burk MR, Mori L, De Libero G, (1995) Human Vγ9Vδ2 cells are stimulated in a cross-reactive fashion by a variety of phosphorylated metabolites. European Journal of Immunology 25: 2052-2058.
24. Evans PS, Enders PJ, Yin C, Ruckwardt TJ, Malkovsky M, et al. (2001) In vitro stimulation with a non-peptidic alkylphosphate expands cells expressing Vγ2-Jδ1.2/Vδ2 T-cell receptors. Immunology 104: 19-27.
25. Martino A, Casetti R, Sacchi A, Poccia F, (2007) Central memory Vg9Vd2 T lymphocytes primed and expanded by Bacille Calmette-Guérin-infected dendritic cells kill mycobacterial-infected monocytes. Journal of Immunology 179: 3057-3064.
26. Ottones F, Dornand J, Naroeni A, Liautard JP, Favero J, (2000) Vγ9Vδ2 T cells impair intracellular multiplication of Brucella suis in autologous monocytes through soluble factor release and contact-dependent cytotoxic effect. Journal of Immunology 165: 7133-7139.
27. Wang L, Kamath A, Das H, Li L, Bukowski JF, (2001) Antibacterial effect of human Vg2Vd2 T cells in vivo. Journal of Clinical Investigation 108: 1349-1357.
28. Lee J, Choi K, Olin MR, Cho SN, Molitor TW, (2004) γδ T cells in immunity induced by Mycobacterium bovis bacillus Calmette-Guérin vaccination. Infection and Immunity 72: 1504-1511.
29. Tsukaguchi K, Balaji KN, Boom WH, (1995) CD4+ αβ T cell and γδ T cell responses to Mycobacterium tuberculosis. Journal of Immunology 154: 1786-1796.
30. Bodnar KA, Serbina NV, Flynn JL, (2001) Fate of Mycobacterium tuberculosis within murine dendritic cells. Infection and Immunity 69: 800-809.
31. Cooper AM, Dalton DK, Stewart TA, Griffin JP, Russell DG, et al. (1993) Disseminated tuberculosis in IFN-γ gene-disrupted mice. Journal of Experimental Medicine 178: 2243-2247.
32. Flynn JL, Chan J, Triebold KJ, Dalton DK, Stewart TA, et al. (1993) An essential role for IFN-gamma in resistance to Mycobacterium tuberculosis infection. Journal of Experimental Medicine 178: 2249-2254.
33. Ottenhoff TH, Kumararatne D, Casanova JL, (1998) Novel human immunodeficiencies reveal the essential role of type-I cytokines in immunity to intracellular bacteria. Immunology Today 19: 491-494.
34. Li H, Luo K, Pauza CD, (2008) TNF-alpha is a positive regulatory factor for human Vγ2 Vδ2 T cells. Journal of Immunolgy 181: 7131-7137.