Superoxide produced by Kupffer cells is an essential effector in concanavalin A-induced hepatitis in mice

Hepatology

Volumn 48, Issue 6, 2008, Pages 1979-1988

  Nakashima, Hiroyuki ^a   Kinoshita, Manabu ^a   Nakashima, Masahiro ^a   Habu, Yoshiko ^a   Shono, Satoshi ^a   Uchida, Takefumi ^a   Shinomiya, Nariyoshi ^a   Seki, Shuhji ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; CD68 ANTIGEN; CD69 ANTIGEN; CONCANAVALIN A; FAS LIGAND; FASL ANTIBODY; GADOLINIUM CHLORIDE; GAMMA INTERFERON; OXYGEN RADICAL; PROTEIN ANTIBODY; REACTIVE OXYGEN METABOLITE; SCAVENGER; SUPEROXIDE; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ANTIBODY; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; CD68 PROTEIN, MOUSE; CYTOKINE; DIFFERENTIATION ANTIGEN; GADOLINIUM; LEUKOCYTE ANTIGEN; TUMOR NECROSIS FACTOR ALPHA;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; C57BL 6 MOUSE; CELL INTERACTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; HEPATITIS; KUPFFER CELL; LIVER CELL; LIVER INJURY; LYMPHOCYTE DEPLETION; LYMPHOCYTE FUNCTION; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; ANIMAL; C57BL MOUSE; CELL COMMUNICATION; DISEASE MODEL; METABOLISM; PATHOLOGY; T LYMPHOCYTE; TOXIC HEPATITIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CELL COMMUNICATION; CONCANAVALIN A; CYTOKINES; DISEASE MODELS, ANIMAL; GADOLINIUM; HEPATITIS, TOXIC; INTERFERON-GAMMA; KILLER CELLS, NATURAL; KUPFFER CELLS; MALE; MICE; MICE, INBRED C57BL; REACTIVE OXYGEN SPECIES; SUPEROXIDES; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 58149388313     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.22561     Document Type: Article

References (43)

1. Tiegs G, Hentschel J, Wendel A. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J Clin Invest 1992;90:196-203.
2. Mizuhara H, O'Neill E, Seki N, Ogawa T, Kusunoki C, Otsuka K, et al. T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6. J Exp Med 1994;179:1529-1537.
3. Gantner F, Leist M, Lohse AW, Germann PG, Tiegs G. Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor. HEPATOLOGY 1995;21:190-198.
4. Kusters S, Tiegs G, Alexopoulou L, Pasparakis M, Douni E, Kunstle G, et al. In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis. Eur J Immunol 1997;27:2870-2875.
5. Kusters S, Gantner F, Kunstle G, Tiegs G. Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A. Gastroenterology 1996;111:462-471.
6. Mizuhara H, Uno M, Seki N, Yamashita M, Yamaoka M, Ogawa T, et al. Critical involvement of interferon gamma in the pathogenesis of T-cell activation-associated hepatitis and regulatory mechanisms of interleukin-6 for the manifestations of hepatitis. HEPATOLOGY 1996;23:1608-1615.
7. Toyabe S, Seki S, Iiai T, Takeda K, Shirai K, Watanabe H, et al. Requirement of IL-4 and liver NK1+ T cells for concanavalin A-induced hepatic injury in mice. J Immunol 1997;159:1537-1542.
8. Kaneko Y, Harada M, Kawano T, Yamashita M, Shibata Y, Gejyo F, et al. Augmentation of Valpha14NKTcell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis. J Exp Med 2000;191:105-114.
9. Takeda K, Hayakawa Y, Van Kaer L, Matsuda H, Yagita H, Okumura K. Critical contribution of liver natural killer T cells to a murine model of hepatitis. Proc Natl Acad Sci U S A 2000;97:5498-5503.
10. Seino K, Kayagaki N, Takeda K, Fukao K, Okumura K, Yagita H. Contribution of Fas ligand to T cell-mediated hepatic injury in mice. Gastroenterology 1997;113:1315-1322.
11. Ksontini R, Colagiovanni DB, Josephs MD, Edwards CK 3rd, Tannahill CL, Solorzano CC, et al. Disparate roles for TNF-alpha and Fas ligand in concanavalin A-induced hepatitis. J Immunol 1998;160:4082-4089.
12. Streetz K, Fregien B, Plumpe J, Korber K, Kubicka S, Sass G, et al. Dissection of the intracellular pathways in hepatocytes suggests a role for Jun kinase and IFN regulatory factor-1 in Con A-induced liver failure. J Immunol 2001;167:514-523.
13. Okamoto T, Maeda O, Tsuzuike N, Hara K. Effect of gadolinium chloride treatment on concanavalin A-induced cytokine mRNA expression in mouse liver. Jpn J Pharmacol 1998;78:101-103.
14. Schumann J, Wolf D, Pahl A, Brune K, Papadopoulos T, van Rooijen N, et al. Importance of Kupffer cells for T-cell-dependent liver injury in mice. Am J Pathol 2000;157:1671-1683.
15. Nakamura K, Okada M, Yoneda M, Takamoto S, Nakade Y, Tamori K, et al. Macrophage inflammatory protein-2 induced by TNF-alpha plays a pivotal role in concanavalin A-induced liver injury in mice. J Hepatol 2001;35:217-224.
16. Tiegs G. T cells, NKT cells, and NK cells in an experimental model of autoimmune hepatitis. In: Gershwin ME, Vierling JM, Manns MP, eds. Liver Immunology. Philadelphia, PA: Hanley & Belfus Inc.; 2003:171-183.
17. Kinoshita M, Uchida T, Nakashima H, Ono S, Seki S, Hiraide H. Opposite effects of enhanced tumor necrosis factor-alpha production from Kupffer cells by gadolinium chloride on liver injury/mortality in endotoxemia of normal and partially hepatectomized mice. Shock 2005;23:65-72.
18. Nakashima H, Inui T, Habu Y, Kinoshita M, Nagao S, Kawaguchi A, et al. Activation of mouse natural killer T cells accelerates liver regeneration after partial hepatectomy. Gastroenterology 2006;131:1573-1583.
19. Kobayashi E, Motoki K, Uchida T, Fukushima H, Koezuka Y. KRN7000, a novel immunomodulator, and its antitumor activities. Oncol Res 1995; 7:529-534.
20. Morita M, Motoki K, Akimoto K, Natori T, Sakai T, Sawa E, et al. Structure-activity relationship of alpha-galactosylceramides against B16-bearing mice. J Med Chem 1995;38:2176-2187.
21. Dobashi H, Seki S, Habu Y, Ohkawa T, Takeshita S, Hiraide H, et al. Activation of mouse liver natural killer cells and NK1.1(+) T cells by bacterial superantigen-primed Kupffer cells. HEPATOLOGY&RTF-SCAPSSTART;& rtf-scaps-end; 1999;30: 430-436.
22. Naidenko OV, Maher JK, Ernst WA, Sakai T, Modlin RL, Kronenberg M. Binding and antigen presentation of ceramide-containing glycolipids by soluble mouse and human CD1d molecules. J Exp Med 1999;190:1069-1080.
23. Matsuda JL, Naidenko OV, Gapin L, Nakayama T, Taniguchi M, Wang CR, et al. Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. J Exp Med 2000;192:741-754.
24. Setsukinai K, Urano Y, Kakinuma K, Majima HJ, Nagano T. Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species. J Biol Chem 2003;278:3170-3175.
25. Kayagaki N, Yamaguchi N, Nagao F, Matsuo S, Maeda H, Okumura K, et al. Polymorphism of murine Fas ligand that affects the biological activity. Proc Natl Acad Sci U S A 1997;94:3914-3919.
26. Yamamoto T, Yuki S, Watanabe T, Mitsuka M, Saito KI, Kogure K. Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia. Brain Res 1997;762: 240-242.
27. Watanabe T, Yuki S, Egawa M, Nishi H. Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions. J Pharmacol Exp Ther 1994;268:1597-1604.
28. Igarashi R, Hoshino J, Takenaga M, Kawai S, Morizawa Y, Yasuda A, et al. Lecithinization of superoxide dismutase potentiates its protective effect against Forssman antiserum-induced elevation in guinea pig airway resistance. J Pharmacol Exp Ther 1992;262:1214-1219.
29. Koo DD, Welsh KI, West NE, Channon KM, Penington AJ, Roake JA, et al. Endothelial cell protection against ischemia/reperfusion injury by lecithinized superoxide dismutase. Kidney Int 2001;60:786-796.
30. Nakauchi K, Ikata T, Katoh S, Hamada Y, Tsuchiya K, Fukuzawa K. Effects of lecithinized superoxide dismutase on rat spinal cord injury. J Neurotrauma 1996;13:573-582.
31. Nakano M, Sugioka K, Ushijima Y, Goto T. Chemiluminescence probe with Cypridina luciferin analog, 2-methyl-6-phenyl-3,7-dihydroimidazo [1,2-a]pyrazin-3-one, for estimating the ability of human granulocytes to generate O2. Anal Biochem 1986;159:363-369.
32. Inui T, Nakashima H, Habu Y, Nakagawa R, Fukasawa M, Kinoshita M, et al. Neutralization of tumor necrosis factor abrogates hepatic failure induced by alpha-galactosylceramide without attenuating its antitumor effect in aged mice. J Hepatol 2005;43:670-678.
33. Inui T, Nakagawa R, Ohkura S, Habu Y, Koike Y, Motoki K, et al. Age-associated augmentation of the synthetic ligand- mediated function of mouse NK1.1 ag(+) T cells: their cytokine production and hepatotoxicity in vivo and in vitro. J Immunol 2002;169:6127-6132.
34. Crowe NY, Uldrich AP, Kyparissoudis K, Hammond KJ, Hayakawa Y, Sidobre S, et al. Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells. J Immunol 2003;171:4020-4027.
35. Wilson MT, Johansson C, Olivares-Villagomez D, Singh AK, Stanic AK, Wang CR, et al. The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion. Proc Natl Acad Sci U S A 2003;100:10913-10918.
36. Habu Y, Uchida T, Inui T, Nakashima H, Fukasawa M, Seki S. Enhancement of the synthetic ligand-mediated function of liver NK1.1Ag+T cells in mice by interleukin-12 pretreatment. Immunology 2004;113:35-43.
37. Liu P, McGuire GM, Fisher MA, Farhood A, Smith CW, Jaeschke H. Activation of Kupffer cells and neutrophils for reactive oxygen formation is responsible for endotoxin-enhanced liver injury after hepatic ischemia. Shock 1995;3:56-62.
38. Bautista AP, Meszaros K, Bojta J, Spitzer JJ. Superoxide anion generation in the liver during the early stage of endotoxemia in rats. J Leukoc Biol 1990;48:123-128.
39. Rymsa B, Wang JF, de Groot H. O2 - release by activated Kupffer cells upon hypoxia-reoxygenation. Am J Physiol 1991;261:G602-607.
40. Jaeschke H, Bautista AP, Spolarics Z, Spitzer JJ. Superoxide generation by neutrophils and Kupffer cells during in vivo reperfusion after hepatic ischemia in rats. J Leukoc Biol 1992;52:377-382.
41. Hardonk MJ, Dijkhuis FW, Hulstaert CE, Koudstaal J. Heterogeneity of rat liver and spleen macrophages in gadolinium chloride-induced elimination and repopulation. J Leukoc Biol 1992;52:296-302.
42. Kono H, Fujii H, Asakawa M, Yamamoto M, Maki A, Matsuda M, et al. Functional heterogeneity of the kupffer cell population is involved in the mechanism of gadolinium chloride in rats administered endotoxin. J Surg Res 2002;106:179-187.
43. Nakagawa R, Nagafune I, Tazunoki Y, Ehara H, Tomura H, Iijima R, et al. Mechanisms of the antimetastatic effect in the liver and of the hepatocyte injury induced by alpha-galactosylceramide in mice. J Immunol 2001;166: 6578-6584.