Effects of Δ40p53, an isoform of p53 lacking the N-terminus, on transactivation capacity of the tumor suppressor protein p53

BMC Cancer

Volumn 13, Issue , 2013, Pages

  Hafsi, Hind ^a   Santos Silva, Daniela ^a   Courtois Cox, Stéphanie ^b   Hainaut, Pierre ^a,c  

^a INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^b Cancer Research Center   (France)

^c INTERNATIONAL PREVENTION RESEARCH INSTITUTE   (France)

Author keywords

40p53; Hdm2; Isoforms; Oligomerization; P53

Indexed keywords

CELL PROTEIN; DELTA40P53 PROTEIN; ISOPROTEIN; MONOMER; PROTEIN MDM2; PROTEIN P53; TETRAMER; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; BREAST CANCER; CANCER CELL CULTURE; CELL STRAIN HCT116; COMPLEX FORMATION; CONTROLLED STUDY; DNA PROTEIN COMPLEX; DOWN REGULATION; EXPRESSION VECTOR; HUMAN; HUMAN CELL; OLIGOMERIZATION; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; TRANSACTIVATION; TRANSCRIPTION REGULATION; WESTERN BLOTTING; WILD TYPE;

ALTERNATIVE SPLICING; ANIMALS; CELL LINE, TUMOR; HUMANS; MICE; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-MDM2; RNA, MESSENGER; TRANS-ACTIVATORS; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84875059314     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-13-134     Document Type: Article

References (24)

1. Hainaut P, Wiman KG. 30 years and a long way into p53 research. Lancet Oncol 2009, 10:913-919. 10.1016/S1470-2045(09)70198-6, 19717093.
2. Marine JC, Lozano G. Mdm2-mediated ubiquitylation: p53 and beyond. Cell Death Differ 2010, 17:93-102. 10.1038/cdd.2009.68, 19498444.
3. Hollstein M, Hainaut P. Massively regulated genes: the example of TP53. J Pathol 2010, 220:164-173.
4. Hafsi H, Hainaut P. Redox Control and Interplay Between p53 Isoforms: Roles in the Regulation of Basal p53 Levels, Cell Fate, and Senescence. Antioxid Redox Signal 2011, 15:1655-1667. 10.1089/ars.2010.3771, 21194382.
5. Vousden KH, Prives C. Blinded by the Light: The Growing Complexity of p53. Cell 2009, 137:413-431. 10.1016/j.cell.2009.04.037, 19410540.
6. Oren M. Decision making by p53: life, death and cancer. Cell Death Differ 2003, 10:431-442. 10.1038/sj.cdd.4401183, 12719720.
7. Marcel V, Dichtel-Danjoy ML, Sagne C, Hafsi H, Ma D, Ortiz-Cuaran S, Olivier M, Hall J, Mollereau B, Hainaut P, Bourdon JC. Biological functions of p53 isoforms through evolution: lessons from animal and cellular models. Cell Death Differ 2011, 18:1815-1824. 10.1038/cdd.2011.120, 3214904, 21941372.
8. Khoury MP, Bourdon JC. p53 Isoforms: An Intracellular Microprocessor?. Genes Cancer 2011, 2:453-465. 10.1177/1947601911408893, 3135639, 21779513.
9. Courtois S, Verhaegh G, North S, Luciani MG, Lassus P, Hibner U, Oren M, Hainaut P. DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53. Oncogene 2002, 21:6722-6728.
10. Yin Y, Stephen CW, Luciani MG, Fahraeus R. p53 Stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products. Nat Cell Biol 2002, 4:462-467. 10.1038/ncb801, 12032546.
11. Ghosh A, Stewart D, Matlashewski G. Regulation of human p53 activity and cell localization by alternative splicing. Mol Cell Biol 2004, 24:7987-7997. 10.1128/MCB.24.18.7987-7997.2004, 515058, 15340061.
12. Ray PS, Grover R, Das S. Two internal ribosome entry sites mediate the translation of p53 isoforms. EMBO Rep 2006, 7:404-410. 1456917, 16440000.
13. Maier B, Gluba W, Bernier B, Turner T, Mohammad K, Guise T, Sutherland A, Thorner M, Scrable H. Modulation of mammalian life span by the short isoform of p53. Genes Dev 2004, 18:306-319. 10.1101/gad.1162404, 338283, 14871929.
14. Pehar M, O'Riordan KJ, Burns-Cusato M, Andrzejewski ME, del Alcazar CG, Burger C, Scrable H, Puglielli L. Altered longevity-assurance activity of p53:p44 in the mouse causes memory loss, neurodegeneration and premature death. Aging Cell 2010, 9:174-190. 10.1111/j.1474-9726.2010.00547.x, 2848983, 20409077.
15. Davidson WR, Kari C, Ren Q, Daroczi B, Dicker AP, Rodeck U. Differential regulation of p53 function by the N-terminal DeltaNp53 and Delta113p53 isoforms in zebrafish embryos. BMC Dev Biol 2010, 10:102. 10.1186/1471-213X-10-102, 2958959, 20929554.
16. Band V, Zajchowski D, Swisshelm K, Trask D, Kulesa V, Cohen C, Connolly J, Sager R. Tumor progression in four mammary epithelial cell lines derived from the same patient. Cancer Res 1990, 50:7351-7357.
17. Brattain MG, Fine WD, Khaled FM, Thompson J, Brattain DE. Heterogeneity of malignant cells from a human colonic carcinoma. Cancer Res 1981, 41:1751-1756.
18. Marcel V, Vijayakumar V, Fernandez-Cuesta L, Hafsi H, Sagne C, Hautefeuille A, Olivier M, Hainaut P. p53 regulates the transcription of its Delta 133p53 isoform through specific response elements contained within the TP53 P2 internal promoter. Oncogene 2010, 29:2691-2700. 10.1038/onc.2010.26, 20190805.
19. Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B. Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 1992, 358:80-83. 10.1038/358080a0, 1614537.
20. Verhaegh GW, Richard MJ, Hainaut P. Regulation of p53 by metal ions and by antioxidants: dithiocarbamate down-regulates p53 DNA-binding activity by increasing the intracellular level of copper. Mol Cell Biol 1997, 17:5699-5706. 232418, 9315628.
21. Chan WM, Siu WY, Lau A, Poon RY. How many mutant p53 molecules are needed to inactivate a tetramer?. Mol Cell Biol 2004, 24:3536-3551. 10.1128/MCB.24.8.3536-3551.2004, 381690, 15060172.
22. Kubbutat MH, Jones SN, Vousden KH. Regulation of p53 stability by Mdm2. Nature 1997, 387:299-303. 10.1038/387299a0, 9153396.
23. Ungewitter E, Scrable H. Delta40p53 controls the switch from pluripotency to differentiation by regulating IGF signaling in ESCs. Genes Dev 2010, 24:2408-2419. 10.1101/gad.1987810, 2964751, 21041409.
24. Fujita K, Mondal AM, Horikawa I, Nguyen GH, Kumamoto K, Sohn JJ, Bowman ED, Mathe EA, Schetter AJ, Pine SR. p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence. Nat Cell Biol 2009, 11:1135-1142. 10.1038/ncb1928, 2802853, 19701195.