The role of hypothermia in the regulation of blood glutamate levels in naive rats

Journal of Neurosurgical Anesthesiology

Volumn 25, Issue 2, 2013, Pages 174-183

  Boyko, Matthew ^a   Kuts, Ruslan ^a   Gruenbaum, Benjamin F ^a   Melamed, Israel ^a   Gruenbaum, Shaun E ^b   Klein, Moti ^a   Shapira, Yoram ^a   Zlotnik, Alexander ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

glutamate; glutamate oxaloacetate transaminase (GOT); glutamate pyruvate transaminase (GPT); hypothermia; neuroprotection

Indexed keywords

2 OXOGLUTARIC ACID; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GLUTAMIC ACID; ISOFLURANE;

AMINO ACID BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; HYPOTHERMIA; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; REDUCTION; REGULATORY MECHANISM;

ALANINE TRANSAMINASE; ANESTHESIA, GENERAL; ANESTHETICS, INHALATION; ANIMALS; ASPARTATE AMINOTRANSFERASES; BODY TEMPERATURE; GLUTAMIC ACID; HYPOTHERMIA, INDUCED; ISOFLURANE; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84875051618     PISSN: 08984921     EISSN: 15371921     Source Type: Journal    
DOI: 10.1097/ANA.0b013e31827ee0ac     Document Type: Article

References (42)

1. Erecinska M, Thoresen M, Silver IA. Effects of hypothermia on energy metabolism in Mammalian central nervous system. J Cereb Blood Flow Metab. 2003;23:513-530
2. Lampe JW, Becker LB. State of the art in therapeutic hypothermia. Annu Rev Med. 2011;62:79-93
3. Kentner R, Rollwagen FM, Prueckner S, et al. Effects of mild hypothermia on survival and serum cytokines in uncontrolled hemorrhagic shock in rats. Shock. 2002;17:521-526
4. Berger C, Schabitz WR, Georgiadis D, et al. Effects of hypothermia on excitatory amino acids and metabolism in stroke patients: a microdialysis study. Stroke. 2002;33:519-524
5. Berger C, Schabitz WR, Wolf M, et al. Hypothermia and brainderived neurotrophic factor reduce glutamate synergistically in acute stroke. Exp Neurol. 2004;185:305-312
6. Castillo J, Davalos A, Naveiro J, et al. Neuroexcitatory amino acids and their relation to infarct size and neurological deficit in ischemic stroke. Stroke. 1996;27:1060-1065
7. Castillo J, Davalos A, Noya M. Progression of ischaemic stroke and excitotoxic aminoacids. Lancet. 1997;349:79-83
8. Johnston MV, Trescher WH, Ishida A, et al. Neurobiology of hypoxic-ischemic injury in the developing brain. Pediatr Res. 2001;49:735-741
9. Zauner A, Bullock R, Kuta AJ, et al. Glutamate release and cerebral blood flow after severe human head injury. Acta Neurochir Suppl. 1996;67:40-44
10. Ferrarese C, Aliprandi A, Tremolizzo L, et al. Increased glutamate in CSF and plasma of patients with HIV dementia. Neurology. 2001;57:671-675
11. Shaw PJ, Forrest V, Ince PG, et al. CSF and plasma amino acid levels in motor neuron disease: elevation of CSF glutamate in a subset of patients. Neurodegeneration. 1995;4:209-216
12. Spranger M, Krempien S, Schwab S, et al. Excess glutamate in the cerebrospinal fluid in bacterial meningitis. J Neurol Sci. 1996;143: 126-131
13. Koura SS, Doppenberg EM, Marmarou A, et al. Relationship between excitatory amino acid release and outcome after severe human head injury. Acta Neurochir Suppl. 1998;71:244-246
14. Zhang H, Zhang X, Zhang T, et al. Excitatory amino acids in cerebrospinal fluid of patients with acute head injuries. Clin Chem. 2001;47:1458-1462
15. Boyko M, Zlotnik A, Gruenbaum BF, et al. Pyruvate's blood glutamate scavenging activity contributes to the spectrum of its neuroprotective mechanisms in a rat model of stroke. Eur J Neurosci. 2011;34:1432-1441
16. O'Kane RL, Martinez-Lopez I, DeJoseph MR, et al. Na(+)- dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) of the blood-brain barrier. A mechanism for glutamate removal. J Biol Chem. 1999;274:31891-31895
17. Teichberg VI, Cohen-Kashi-Malina K, Cooper I, et al. Homeostasis of glutamate in brain fluids: an accelerated brain-to-blood efflux of excess glutamate is produced by blood glutamate scavenging and offers protection from neuropathologies. Neuroscience. 2009;158:301-308
18. Zlotnik A, Gruenbaum SE, Artru AA, et al. The neuroprotective effects of oxaloacetate in closed head injury in rats is mediated by its blood glutamate scavenging activity: evidence from the use of maleate. J Neurosurg Anesthesiol. 2009;21:235-241
19. Zlotnik A, Gurevich B, Cherniavsky E, et al. The contribution of the blood glutamate scavenging activity of pyruvate to its neuroprotective properties in a rat model of closed head injury. Neurochem Res. 2008;33:1044-1050
20. Zlotnik A, Gurevich B, Tkachov S, et al. Brain neuroprotection by scavenging blood glutamate. Exp Neurol. 2007;203:213-220
21. Zlotnik A, Klin Y, Kotz R, et al. Regulation of blood L-glutamate levels by stress as a possible brain defense mechanism. Exp Neurol. 2010;224:465-471
22. Campos F, Rodriguez-Yanez M, Castellanos M, et al. Blood levels of glutamate oxaloacetate transaminase are more strongly associated with good outcome in acute ischaemic stroke than glutamate pyruvate transaminase levels. Clin Sci (Lond). 2011;121: 11-17
23. Campos F, Sobrino T, Ramos-Cabrer P, et al. Neuroprotection by glutamate oxaloacetate transaminase in ischemic stroke: an experimental study. J Cereb Blood Flow Metab. 2011;31:1378-1386
24. Campos F, Sobrino T, Ramos-Cabrer P, et al. High blood glutamate oxaloacetate transaminase levels are associated with good functional outcome in acute ischemic stroke. J Cereb Blood Flow Metab. 2011;31:1387-1393
25. Castellanos M, Sobrino T, Pedraza S, et al. High plasma glutamate concentrations are associated with infarct growth in acute ischemic stroke. Neurology. 2008;71:1862-1868
26. Tisherman SA. Hypothermia and injury. Curr Opin Crit Care. 2004;10:512-519
27. Tang XN, Liu L, Yenari MA. Combination therapy with hypothermia for treatment of cerebral ischemia. J Neurotrauma. 2009;26:325-331
28. Graham LT Jr, Aprison MH. Fluorometric determination of aspartate, glutamate, and gamma-aminobutyrate in nerve tissue using enzymic methods. Anal Biochem. 1966;15:487-497
29. Teichberg VI. From the liver to the brain across the blood-brain barrier. Proc Natl Acad Sci USA. 2007;104:7315-7316
30. Winfree CJ, Baker CJ, Connolly ES Jr, et al. Mild hypothermia reduces penumbral glutamate levels in the rat permanent focal cerebral ischemia model. Neurosurgery. 1996;38:1216-1222
31. Zornow MH. Inhibition of glutamate release: a possible mechanism of hypothermic neuroprotection. J Neurosurg Anesthesiol. 1995;7:148-151
32. Bissonnette B, Pellerin L, Ravussin P, et al. Deep hypothermia and rewarming alters glutamate levels and glycogen content in cultured astrocytes. Anesthesiology. 1999;91:1763-1769
33. Ehrlich MP, McCullough JN, Zhang N, et al. Effect of hypothermia on cerebral blood flow and metabolism in the pig. Ann Thorac Surg. 2002;73:191-197
34. Blair E, Hook R, Tolley H, et al. Serum glutamic oxalacetic transaminase content in hypothermia. Science. 1961;133:105-106
35. Filho JC, Hazel SJ, Anderstam B, et al. Effect of protein intake on plasma and erythrocyte free amino acids and serum IGF-I and IGFBP-1 levels in rats. Am J Physiol. 1999;277:E693-E701
36. Altland PD, Highman B, Sellner RG. Serum enzyme and tissue changes in shaven rabbits exposed to cold. Cryobiology. 1974;11: 296-304
37. Arakawa H, Kodama H, Matsuoka N, et al. Stress increases plasma enzyme activity in rats: differential effects of adrenergic and cholinergic blockades. J Pharmacol Exp Ther. 1997;280:1296-1303
38. Roti Roti JL. Cellular responses to hyperthermia (40-46 degrees C): cell killing and molecular events. Int J Hyperthermia. 2008;24:3-15
39. Zlotnik A, Gurevich B, Artru AA, et al. The effect of hyperthermia on blood glutamate levels. Anesth Analg. 2010;111:1497-1504
40. Campos F, Perez-Mato M, Agulla J, et al. Glutamate excitoxicity is the key molecular mechanism which is influenced by body temperature during the acute phase of brain stroke. PLoS One. 2012;7:e44191
41. Teichberg VI. GOT to rid the body of excess glutamate. J Cereb Blood Flow Metab. 2011;31:1376-1377
42. Gottlieb M, Wang Y, Teichberg VI. Blood-mediated scavenging of cerebrospinal fluid glutamate. J Neurochem. 2003;87:119-126