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Volumn 10, Issue 1, 2009, Pages 35-45

Pharmacotherapy in post-traumatic stress disorder: Evidence from randomized controlled trials

Author keywords

Adrenergic antagonist; Anticonvulsant; Antipsychotic; Pharmacotherapy; Post traumatic stress disorder; Randomized controlled trial; SSRI; Treatment

Indexed keywords

ALPRAZOLAM; AMFEBUTAMONE; AMITRIPTYLINE; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ATYPICAL ANTIPSYCHOTIC AGENT; BENZODIAZEPINE DERIVATIVE; BROFAROMINE; CITALOPRAM; CYCLOSERINE; DESIPRAMINE; FLUOXETINE; IMIPRAMINE; LAMOTRIGINE; MIRTAZAPINE; MONOAMINE OXIDASE INHIBITOR; NEFAZODONE; PAROXETINE; PHENELZINE; PLACEBO; SEROTONIN NORADRENALIN REUPTAKE INHIBITOR; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; TEMAZEPAM; TIAGABINE; TOPIRAMATE; TRICYCLIC ANTIDEPRESSANT AGENT; UNINDEXED DRUG; VALPROIC ACID; VENLAFAXINE;

EID: 58449116017     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (31)

References (86)
  • 2
    • 0034757360 scopus 로고    scopus 로고
    • Post-traumatic stress disorder: Findings from the Australian National Survey of Mental Health and Well-being
    • Creamer M, Burgess P, McFarlane AC: Post-traumatic stress disorder: Findings from the Australian National Survey of Mental Health and Well-being. Psychol Med (2001) 31(7):1237-1247.
    • (2001) Psychol Med , vol.31 , Issue.7 , pp. 1237-1247
    • Creamer, M.1    Burgess, P.2    McFarlane, A.C.3
  • 3
    • 22044441228 scopus 로고    scopus 로고
    • Anxiety disorders associated with suicidal ideation and suicide attempts in the National Comorbidity Survey
    • Sareen J, Houlahan T, Cox BJ, Asmundson GJ: Anxiety disorders associated with suicidal ideation and suicide attempts in the National Comorbidity Survey. J Nerv Ment Dis (2005) 193(7):450-454.
    • (2005) J Nerv Ment Dis , vol.193 , Issue.7 , pp. 450-454
    • Sareen, J.1    Houlahan, T.2    Cox, B.J.3    Asmundson, G.J.4
  • 4
    • 67649364676 scopus 로고    scopus 로고
    • Impairment in role functioning in mental and chronic medical disorders in the United States: Results from the National Comorbidity Survey Replication
    • doi:10.1038/mp.2008.13
    • Druss BG, Hwang I, Petukhova M, Sampson NA, Wang PS, Kessler RC: Impairment in role functioning in mental and chronic medical disorders in the United States: Results from the National Comorbidity Survey Replication. Mol Psychiatry (2008):doi:10.1038/mp.2008.13.
    • (2008) Mol Psychiatry
    • Druss, B.G.1    Hwang, I.2    Petukhova, M.3    Sampson, N.A.4    Wang, P.S.5    Kessler, R.C.6
  • 5
    • 0035068598 scopus 로고    scopus 로고
    • Brunello N, Davidson JR, Deahl M, Kessler RC, Mendlewicz J, Racagni G, Shalev AY, Zohar J: Posttraumatic stress disorder: Diagnosis and epidemiology, comorbidity and social consequences, biology and treatment. Neuropsychobiology (2001) 43(3):150-162. • Despite being published in 2001, this is a comprehensive review of PTSD epidemiology, neurobiology and treatment that remains relevant.
    • Brunello N, Davidson JR, Deahl M, Kessler RC, Mendlewicz J, Racagni G, Shalev AY, Zohar J: Posttraumatic stress disorder: Diagnosis and epidemiology, comorbidity and social consequences, biology and treatment. Neuropsychobiology (2001) 43(3):150-162. • Despite being published in 2001, this is a comprehensive review of PTSD epidemiology, neurobiology and treatment that remains relevant.
  • 6
    • 0004235298 scopus 로고    scopus 로고
    • American Psychiatric Association: 4th edition. American Psychiatric Publishing Inc, Arlington, VA, USA
    • American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders: DSM-IV-TR 4th edition. American Psychiatric Publishing Inc, Arlington, VA, USA (2000).
    • (2000) Diagnostic and Statistical Manual of Mental Disorders: DSM-IV-TR
  • 7
    • 33646134113 scopus 로고    scopus 로고
    • Neria Y, Gross R, Olfson M, Gameroff MJ, Wickramaratne P, Das A, Pilowsky D, Feder A, Blanco C, Marshall RD, Lantigua R et al: Posttraumatic stress disorder in primary care one year after the 9/11 attacks. Gen Hosp Psychiatry (2006) 28(3):213-222. • This paper described a systematic sampling of an adult primary care population in New York City with high rates of exposure to trauma from the September 11th (9/11) terror attacks. Factors associated with higher rates of PTSD symptomology included ethnicity, immigrant status, marital status, family psychiatric history and presence of pre-9/11 trauma.
    • Neria Y, Gross R, Olfson M, Gameroff MJ, Wickramaratne P, Das A, Pilowsky D, Feder A, Blanco C, Marshall RD, Lantigua R et al: Posttraumatic stress disorder in primary care one year after the 9/11 attacks. Gen Hosp Psychiatry (2006) 28(3):213-222. • This paper described a systematic sampling of an adult primary care population in New York City with high rates of exposure to trauma from the September 11th (9/11) terror attacks. Factors associated with higher rates of PTSD symptomology included ethnicity, immigrant status, marital status, family psychiatric history and presence of pre-9/11 trauma.
  • 8
    • 0030855073 scopus 로고    scopus 로고
    • Full and partial posttraumatic stress disorder: Findings from a community survey
    • Stein MB, Walker JR, Hazen AL, Forde DR: Full and partial posttraumatic stress disorder: Findings from a community survey. Am J Psychiatry (1997) 154(8):1114-1119.
    • (1997) Am J Psychiatry , vol.154 , Issue.8 , pp. 1114-1119
    • Stein, M.B.1    Walker, J.R.2    Hazen, A.L.3    Forde, D.R.4
  • 11
    • 0002931135 scopus 로고
    • CGI: Clinical Global Impressions
    • National Institute of Mental Health:, Guy W, Bonato RR Eds, National Institute of Mental Health, Bethesda, MD, USA
    • National Institute of Mental Health: CGI: Clinical Global Impressions. In: Manual for the ECDEU Assessment Battery Volume 2. Guy W, Bonato RR (Eds), National Institute of Mental Health, Bethesda, MD, USA (1970):12.1-12.6.
    • (1970) Manual for the ECDEU Assessment Battery , vol.2
  • 12
    • 0018777479 scopus 로고
    • Impact of event scale: A measure of subjective stress
    • Horowitz M, Wilner N, Alvarez W: Impact of event scale: A measure of subjective stress. Psychosom Med (1979) 41(3):209-218.
    • (1979) Psychosom Med , vol.41 , Issue.3 , pp. 209-218
    • Horowitz, M.1    Wilner, N.2    Alvarez, W.3
  • 14
    • 58449083123 scopus 로고    scopus 로고
    • Committee on Treatment of Posttraumatic Stress Disorder, Institute of Medicine: Treatment of Posttraumatic Stress Disorder: An Assessment of the Evidence. The National Academies Press, Washington DC, USA (2008). •• This is the Institute of Medicine committee report on the treatment of PTSD, including a systematic analysis of pharmacotherapeutic trials in chapter 3, with tables listing populations studied, outcome measures, handling of dropouts, changes in outcome measure scores, statistical significance for changes in outcome measures and principal limitations of the clinical trials.
    • Committee on Treatment of Posttraumatic Stress Disorder, Institute of Medicine: Treatment of Posttraumatic Stress Disorder: An Assessment of the Evidence. The National Academies Press, Washington DC, USA (2008). •• This is the Institute of Medicine committee report on the treatment of PTSD, including a systematic analysis of pharmacotherapeutic trials in chapter 3, with tables listing populations studied, outcome measures, handling of dropouts, changes in outcome measure scores, statistical significance for changes in outcome measures and principal limitations of the clinical trials.
  • 15
    • 58449109826 scopus 로고    scopus 로고
    • Post-traumatic stress disorder (PTSD): The management of PTSD in adults and children in primary and secondary care. National Institute for Clinical Excellence, London, UK (2005). http://www.nice.org.uk/nicemedia/pdf/ CG026NICEguideline.pdf •• PTSD treatment guidelines commissioned by the UK's National Institute for Clinical Excellence recommend that pharmacotherapy is not used as routine first-line treatment for adults, with trauma-focused psychological therapy as the preferred treatment option. This is based on an a priori requirement of a standardized mean difference ≤ -0.5 as an indicator of a clinically meaningful difference between drug and placebo.
    • Post-traumatic stress disorder (PTSD): The management of PTSD in adults and children in primary and secondary care. National Institute for Clinical Excellence, London, UK (2005). http://www.nice.org.uk/nicemedia/pdf/ CG026NICEguideline.pdf •• PTSD treatment guidelines commissioned by the UK's National Institute for Clinical Excellence recommend that pharmacotherapy is not used as routine first-line treatment for adults, with trauma-focused psychological therapy as the preferred treatment option. This is based on an a priori requirement of a standardized mean difference ≤ -0.5 as an indicator of a clinically meaningful difference between drug and placebo.
  • 16
    • 0034565065 scopus 로고    scopus 로고
    • Stein DJ, Ipser JC, Seedat S: Pharmacotherapy for post traumatic stress disorder (PTSD). Cochrane Database Syst Rev (2006) 1:CD002795. •• This systematic review and meta-analysis of controlled, randomized pharmacotherapeutic trials for PTSD includes 35 short-term (≤ 14 weeks) trials. Objectives were to estimate the effects of drug treatment in reducing PTSD symptoms, determine the more efficacious drug classes, and identify clinical and methodological factors predicting treatment response.
    • Stein DJ, Ipser JC, Seedat S: Pharmacotherapy for post traumatic stress disorder (PTSD). Cochrane Database Syst Rev (2006) 1:CD002795. •• This systematic review and meta-analysis of controlled, randomized pharmacotherapeutic trials for PTSD includes 35 short-term (≤ 14 weeks) trials. Objectives were to estimate the effects of drug treatment in reducing PTSD symptoms, determine the more efficacious drug classes, and identify clinical and methodological factors predicting treatment response.
  • 17
    • 33846954439 scopus 로고    scopus 로고
    • Bisson JI, Ehlers A, Matthews R, Pilling S, Richards D, Turner S: Psychological treatments for chronic post-traumatic stress disorder. Systematic review and meta-analysis. Br J Psychiatry (2007) 190:97-104. •• A meta-analysis of 38 RCTs of psychotherapies for the treatment of PTSD. Trauma-focused cognitive-behavioral therapy, and eye-movement desensitization and reprocessing were observed to be superior to other psychotherapeutic strategies.
    • Bisson JI, Ehlers A, Matthews R, Pilling S, Richards D, Turner S: Psychological treatments for chronic post-traumatic stress disorder. Systematic review and meta-analysis. Br J Psychiatry (2007) 190:97-104. •• A meta-analysis of 38 RCTs of psychotherapies for the treatment of PTSD. Trauma-focused cognitive-behavioral therapy, and eye-movement desensitization and reprocessing were observed to be superior to other psychotherapeutic strategies.
  • 19
    • 34548248084 scopus 로고    scopus 로고
    • Psychobiological mechanisms of resilience: Relevance to prevention and treatment of stress-related psychopathology
    • Haglund ME, Nestadt PS, Cooper NS, Southwick SM, Charney DS: Psychobiological mechanisms of resilience: Relevance to prevention and treatment of stress-related psychopathology. Dev Psychopathol (2007) 19(3):889-920.
    • (2007) Dev Psychopathol , vol.19 , Issue.3 , pp. 889-920
    • Haglund, M.E.1    Nestadt, P.S.2    Cooper, N.S.3    Southwick, S.M.4    Charney, D.S.5
  • 20
    • 34748854338 scopus 로고    scopus 로고
    • Yehuda R, LeDoux J: Response variation following trauma: A translational neuroscience approach to understanding PTSD. Neuron (2007) 56(1):19-32. • This is a thorough review of the neurobiology of PTSD and the roles of preclinical models for improving the understanding of PTSD development as it contrasts with resilience in the face of trauma. Treatment interventions derived from preclinical models, such as those involving fear memory consolidation and extinction, are discussed.
    • Yehuda R, LeDoux J: Response variation following trauma: A translational neuroscience approach to understanding PTSD. Neuron (2007) 56(1):19-32. • This is a thorough review of the neurobiology of PTSD and the roles of preclinical models for improving the understanding of PTSD development as it contrasts with resilience in the face of trauma. Treatment interventions derived from preclinical models, such as those involving fear memory consolidation and extinction, are discussed.
  • 23
    • 33645102671 scopus 로고    scopus 로고
    • Group VDCPGW, Washington DC, USA
    • Management of post-traumatic stress. Group VDCPGW, Washington DC, USA (2003). http://www.oqp.med.va.gov/cpg/PTSD/PTSD-Base.htm
    • (2003) Management of post-traumatic stress
  • 24
    • 0037239124 scopus 로고    scopus 로고
    • Adjunctive risperidone treatment in post-traumatic stress disorder: A preliminary controlled trial of effects on comorbid psychotic symptoms
    • Hamner MB, Faldowski RA, Ulmer HG, Frueh BC, Huber MG, Arana GW: Adjunctive risperidone treatment in post-traumatic stress disorder: A preliminary controlled trial of effects on comorbid psychotic symptoms. Int Clin Psychopharmacol (2003) 18(1):1-8.
    • (2003) Int Clin Psychopharmacol , vol.18 , Issue.1 , pp. 1-8
    • Hamner, M.B.1    Faldowski, R.A.2    Ulmer, H.G.3    Frueh, B.C.4    Huber, M.G.5    Arana, G.W.6
  • 25
    • 38349128467 scopus 로고    scopus 로고
    • Divalproex in the treatment of posttraumatic stress disorder: A randomized, double-blind, placebo-controlled trial in a veteran population
    • Davis LL, Davidson JR, Ward LC, Bartolucci A, Bowden CL, Petty F: Divalproex in the treatment of posttraumatic stress disorder: A randomized, double-blind, placebo-controlled trial in a veteran population. J Clin Psychopharmacol (2008) 28(1):84-88.
    • (2008) J Clin Psychopharmacol , vol.28 , Issue.1 , pp. 84-88
    • Davis, L.L.1    Davidson, J.R.2    Ward, L.C.3    Bartolucci, A.4    Bowden, C.L.5    Petty, F.6
  • 26
    • 0037380689 scopus 로고    scopus 로고
    • Low-dose risperidone as adjunctive therapy for irritable aggression in posttraumatic stress disorder
    • Monnelly EP, Ciraulo DA, Knapp C, Keane T: Low-dose risperidone as adjunctive therapy for irritable aggression in posttraumatic stress disorder. J Clin Psychopharmacol (2003) 23(2):193-196.
    • (2003) J Clin Psychopharmacol , vol.23 , Issue.2 , pp. 193-196
    • Monnelly, E.P.1    Ciraulo, D.A.2    Knapp, C.3    Keane, T.4
  • 27
    • 0035141923 scopus 로고    scopus 로고
    • A preliminary study of bupropion sustained-release for smoking cessation in patients with chronic posttraumatic stress disorder
    • Hertzberg MA, Moore SD, Feldman ME, Beckham JC: A preliminary study of bupropion sustained-release for smoking cessation in patients with chronic posttraumatic stress disorder. J Clin Psychopharmacol (2001) 21(1):94-98.
    • (2001) J Clin Psychopharmacol , vol.21 , Issue.1 , pp. 94-98
    • Hertzberg, M.A.1    Moore, S.D.2    Feldman, M.E.3    Beckham, J.C.4
  • 28
    • 15944378164 scopus 로고    scopus 로고
    • Sertraline in the treatment of co-occurring alcohol dependence and posttraumatic stress disorder
    • Brady KT, Sonne S, Anton RF, Randall CL, Back SE, Simpson K: Sertraline in the treatment of co-occurring alcohol dependence and posttraumatic stress disorder. Alcohol Clin Exp Res (2005) 29(3):395-401.
    • (2005) Alcohol Clin Exp Res , vol.29 , Issue.3 , pp. 395-401
    • Brady, K.T.1    Sonne, S.2    Anton, R.F.3    Randall, C.L.4    Back, S.E.5    Simpson, K.6
  • 29
    • 0037081437 scopus 로고    scopus 로고
    • Pitman RK, Sanders KM, Zusman RM, Healy AR, Cheema F, Lasko NB, Cahill L, Orr SP: Pilot study of secondary prevention of posttraumatic stress disorder with propranolol. Biol Psychiatry (2002) 51(2):189-192. • This small pilot RCT for PTSD prevention with propranolol treatment (initiated within 6 h of the index trauma) did not demonstrate a significant effect of propranolol on PTSD development. However, propranolol did appear to have an effect on the reduction of physiological activation upon challenge with trauma-specific mental imagery.
    • Pitman RK, Sanders KM, Zusman RM, Healy AR, Cheema F, Lasko NB, Cahill L, Orr SP: Pilot study of secondary prevention of posttraumatic stress disorder with propranolol. Biol Psychiatry (2002) 51(2):189-192. • This small pilot RCT for PTSD prevention with propranolol treatment (initiated within 6 h of the index trauma) did not demonstrate a significant effect of propranolol on PTSD development. However, propranolol did appear to have an effect on the reduction of physiological activation upon challenge with trauma-specific mental imagery.
  • 30
    • 0034639954 scopus 로고    scopus 로고
    • Efficacy and safety of sertraline treatment of posttraumatic stress disorder: A randomized controlled trial
    • Brady K, Pearlstein T, Asnis GM, Baker D, Rothbaum B, Sikes CR, Farfel GM: Efficacy and safety of sertraline treatment of posttraumatic stress disorder: A randomized controlled trial. J Am Med Assoc (2000) 283(14):1837-1844.
    • (2000) J Am Med Assoc , vol.283 , Issue.14 , pp. 1837-1844
    • Brady, K.1    Pearlstein, T.2    Asnis, G.M.3    Baker, D.4    Rothbaum, B.5    Sikes, C.R.6    Farfel, G.M.7
  • 31
    • 0035022587 scopus 로고    scopus 로고
    • Multicenter, double-blind comparison of sertraline and placebo in the treatment of posttraumatic stress disorder
    • Davidson JR, Rothbaum BO, van der Kolk BA, Sikes CR, Farfel GM: Multicenter, double-blind comparison of sertraline and placebo in the treatment of posttraumatic stress disorder. Arch Gen Psychiatry (2001) 58(5):485-492.
    • (2001) Arch Gen Psychiatry , vol.58 , Issue.5 , pp. 485-492
    • Davidson, J.R.1    Rothbaum, B.O.2    van der Kolk, B.A.3    Sikes, C.R.4    Farfel, G.M.5
  • 32
    • 34249698975 scopus 로고    scopus 로고
    • Randomized, double-blind comparison of sertraline and placebo for posttraumatic stress disorder in a Department of Veterans Affairs setting
    • Friedman MJ, Marmar CR, Baker DG, Sikes CR, Farfel GM: Randomized, double-blind comparison of sertraline and placebo for posttraumatic stress disorder in a Department of Veterans Affairs setting. J Clin Psychiatry (2007) 68(5):711-720.
    • (2007) J Clin Psychiatry , vol.68 , Issue.5 , pp. 711-720
    • Friedman, M.J.1    Marmar, C.R.2    Baker, D.G.3    Sikes, C.R.4    Farfel, G.M.5
  • 34
    • 0035189776 scopus 로고    scopus 로고
    • Efficacy and safety of paroxetine treatment for chronic PTSD: A fixed-dose, placebo-controlled study
    • Marshall RD, Beebe KL, Oldham M, Zaninelli R: Efficacy and safety of paroxetine treatment for chronic PTSD: A fixed-dose, placebo-controlled study. Am J Psychiatry (2001) 158(12):1982-1988.
    • (2001) Am J Psychiatry , vol.158 , Issue.12 , pp. 1982-1988
    • Marshall, R.D.1    Beebe, K.L.2    Oldham, M.3    Zaninelli, R.4
  • 37
    • 0035196193 scopus 로고    scopus 로고
    • Paroxetine in the treatment of chronic posttraumatic stress disorder: Results of a placebo-controlled, flexible-dosage trial
    • Tucker P, Zaninelli R, Yehuda R, Ruggiero L, Dillingham K, Pitts CD: Paroxetine in the treatment of chronic posttraumatic stress disorder: Results of a placebo-controlled, flexible-dosage trial. J Clin Psychiatry (2001) 62(11):860-868.
    • (2001) J Clin Psychiatry , vol.62 , Issue.11 , pp. 860-868
    • Tucker, P.1    Zaninelli, R.2    Yehuda, R.3    Ruggiero, L.4    Dillingham, K.5    Pitts, C.D.6
  • 39
    • 33846851960 scopus 로고    scopus 로고
    • A randomized clinical trial of eye movement desensitization and reprocessing (EMDR), fluoxetine, and pill placebo in the treatment of posttraumatic stress disorder: Treatment effects and long-term maintenance
    • van der Kolk BA, Spinazzola J, Blaustein ME, Hopper JW, Hopper EK, Korn DL, Simpson WB: A randomized clinical trial of eye movement desensitization and reprocessing (EMDR), fluoxetine, and pill placebo in the treatment of posttraumatic stress disorder: Treatment effects and long-term maintenance. J Clin Psychiatry (2007) 68(1):37-46.
    • (2007) J Clin Psychiatry , vol.68 , Issue.1 , pp. 37-46
    • van der Kolk, B.A.1    Spinazzola, J.2    Blaustein, M.E.3    Hopper, J.W.4    Hopper, E.K.5    Korn, D.L.6    Simpson, W.B.7
  • 40
    • 0036218753 scopus 로고    scopus 로고
    • Double-blind placebo-controlled pilot study of sertraline in military veterans with posttraumatic stress disorder
    • Zohar J, Amital D, Miodownik C, Kotler M, Bleich A, Lane RM, Austin C: Double-blind placebo-controlled pilot study of sertraline in military veterans with posttraumatic stress disorder. J Clin Psychopharmacol (2002) 22(2):190-195.
    • (2002) J Clin Psychopharmacol , vol.22 , Issue.2 , pp. 190-195
    • Zohar, J.1    Amital, D.2    Miodownik, C.3    Kotler, M.4    Bleich, A.5    Lane, R.M.6    Austin, C.7
  • 41
    • 3042666168 scopus 로고    scopus 로고
    • Can physiologic assessment and side effects tease out differences in PTSD trials? A double-blind comparison of citalopram, sertraline, and placebo
    • Tucker P, Potter-Kimball R, Wyatt DB, Parker DE, Burgin C, Jones DE, Masters BK: Can physiologic assessment and side effects tease out differences in PTSD trials? A double-blind comparison of citalopram, sertraline, and placebo. Psychopharmacol Bull (2003) 37(3):135-149.
    • (2003) Psychopharmacol Bull , vol.37 , Issue.3 , pp. 135-149
    • Tucker, P.1    Potter-Kimball, R.2    Wyatt, D.B.3    Parker, D.E.4    Burgin, C.5    Jones, D.E.6    Masters, B.K.7
  • 42
    • 0035190261 scopus 로고    scopus 로고
    • Efficacy of sertraline in preventing relapse of posttraumatic stress disorder: Results of a 28-week double-blind, placebo-controlled study
    • Davidson J, Pearlstein T, Londborg P, Brady KT, Rothbaum B, Bell J, Maddock R, Hegel MT, Farfel G: Efficacy of sertraline in preventing relapse of posttraumatic stress disorder: Results of a 28-week double-blind, placebo-controlled study. Am J Psychiatry (2001) 158(12):1974- 1981.
    • (2001) Am J Psychiatry , vol.158 , Issue.12 , pp. 1974-1981
    • Davidson, J.1    Pearlstein, T.2    Londborg, P.3    Brady, K.T.4    Rothbaum, B.5    Bell, J.6    Maddock, R.7    Hegel, M.T.8    Farfel, G.9
  • 43
    • 15444375594 scopus 로고    scopus 로고
    • Maintenance therapy with fluoxetine in posttraumatic stress disorder: A placebo-controlled discontinuation study
    • Davidson JR, Connor KM, Hertzberg MA, Weisler RH, Wilson WH, Payne VM: Maintenance therapy with fluoxetine in posttraumatic stress disorder: A placebo-controlled discontinuation study. J Clin Psychopharmacol (2005) 25(2):166-169.
    • (2005) J Clin Psychopharmacol , vol.25 , Issue.2 , pp. 166-169
    • Davidson, J.R.1    Connor, K.M.2    Hertzberg, M.A.3    Weisler, R.H.4    Wilson, W.H.5    Payne, V.M.6
  • 45
    • 0036794843 scopus 로고    scopus 로고
    • Fluoxetine v. placebo in prevention of relapse in post-traumatic stress disorder
    • Martenyi F, Brown EB, Zhang H, Koke SC, Prakash A: Fluoxetine v. placebo in prevention of relapse in post-traumatic stress disorder. Br J Psychiatry (2002) 181:315-320.
    • (2002) Br J Psychiatry , vol.181 , pp. 315-320
    • Martenyi, F.1    Brown, E.B.2    Zhang, H.3    Koke, S.C.4    Prakash, A.5
  • 46
    • 33749362591 scopus 로고    scopus 로고
    • Davidson J, Baldwin D, Stein DJ, Kuper E, Benattia I, Ahmed S, Pedersen R, Musgnung J: Treatment of posttraumatic stress disorder with venlafaxine extended release: A 6-month randomized controlled trial. Arch Gen Psychiatry (2006) 63(10):1158-1165. • This is an example of a large, multicenter trial in which efficacy was demonstrated. Effect sizes for selected outcome measures are available, and results are compared with outcomes from other large pharmacotherapy RCTs for the treatment of PTSD.
    • Davidson J, Baldwin D, Stein DJ, Kuper E, Benattia I, Ahmed S, Pedersen R, Musgnung J: Treatment of posttraumatic stress disorder with venlafaxine extended release: A 6-month randomized controlled trial. Arch Gen Psychiatry (2006) 63(10):1158-1165. • This is an example of a large, multicenter trial in which efficacy was demonstrated. Effect sizes for selected outcome measures are available, and results are compared with outcomes from other large pharmacotherapy RCTs for the treatment of PTSD.
  • 47
    • 33744482833 scopus 로고    scopus 로고
    • Venlafaxine extended release in posttraumatic stress disorder: A sertraline- and placebo-controlled study
    • Davidson J, Rothbaum BO, Tucker P, Asnis G, Benattia I, Musgnung JJ: Venlafaxine extended release in posttraumatic stress disorder: A sertraline- and placebo-controlled study. J Clin Psychopharmacol (2006) 26(3):259-267.
    • (2006) J Clin Psychopharmacol , vol.26 , Issue.3 , pp. 259-267
    • Davidson, J.1    Rothbaum, B.O.2    Tucker, P.3    Asnis, G.4    Benattia, I.5    Musgnung, J.J.6
  • 48
    • 2442649125 scopus 로고    scopus 로고
    • A placebo-controlled study of nefazodone for the treatment of chronic posttraumatic stress disorder: A preliminary study
    • Davis LL, Jewell ME, Ambrose S, Farley J, English B, Bartolucci A, Petty F: A placebo-controlled study of nefazodone for the treatment of chronic posttraumatic stress disorder: A preliminary study. J Clin Psychopharmacol (2004) 24(3):291-297.
    • (2004) J Clin Psychopharmacol , vol.24 , Issue.3 , pp. 291-297
    • Davis, L.L.1    Jewell, M.E.2    Ambrose, S.3    Farley, J.4    English, B.5    Bartolucci, A.6    Petty, F.7
  • 49
    • 0036304914 scopus 로고    scopus 로고
    • Hepatic adverse reactions associated with nefazodone
    • Stewart DE: Hepatic adverse reactions associated with nefazodone. Can J Psychiatry (2002) 47(4):375-377.
    • (2002) Can J Psychiatry , vol.47 , Issue.4 , pp. 375-377
    • Stewart, D.E.1
  • 52
    • 0021934319 scopus 로고
    • Tricyclics: Possible treatment for posttraumatic stress disorder
    • Falcon S, Ryan C, Chamberlain K, Curtis G: Tricyclics: Possible treatment for posttraumatic stress disorder. J Clin Psychiatry (1985) 46(9):385-388.
    • (1985) J Clin Psychiatry , vol.46 , Issue.9 , pp. 385-388
    • Falcon, S.1    Ryan, C.2    Chamberlain, K.3    Curtis, G.4
  • 53
    • 0019514821 scopus 로고
    • Treatment of traumatic war neurosis with phenelzine
    • Hogben GL, Cornfield RB: Treatment of traumatic war neurosis with phenelzine. Arch Gen Psychiatry (1981) 38(4):440-445.
    • (1981) Arch Gen Psychiatry , vol.38 , Issue.4 , pp. 440-445
    • Hogben, G.L.1    Cornfield, R.B.2
  • 54
    • 0023895894 scopus 로고
    • A controlled trial of phenelzine in posttraumatic stress disorder
    • Shestatzky M, Greenberg D, Lerer B: A controlled trial of phenelzine in posttraumatic stress disorder. Psychiatry Res (1988) 24(2):149-155.
    • (1988) Psychiatry Res , vol.24 , Issue.2 , pp. 149-155
    • Shestatzky, M.1    Greenberg, D.2    Lerer, B.3
  • 55
    • 0025756382 scopus 로고
    • Pharmacotherapy for posttraumatic stress disorder using phenelzine or imipramine
    • Kosten TR, Frank JB, Dan E, McDougle CJ, Giller EL Jr: Pharmacotherapy for posttraumatic stress disorder using phenelzine or imipramine. J Nerv Ment Dis (1991) 179(6):366-370.
    • (1991) J Nerv Ment Dis , vol.179 , Issue.6 , pp. 366-370
    • Kosten, T.R.1    Frank, J.B.2    Dan, E.3    McDougle, C.J.4    Giller Jr, E.L.5
  • 56
    • 0025215353 scopus 로고    scopus 로고
    • Davidson J, Kudler H, Smith R, Mahorney SL, Lipper S, Hammett E, Saunders WB, Cavenar JO Jr: Treatment of posttraumatic stress disorder with amitriptyline and placebo. Arch Gen Psychiatry (1990) 47(3):259-266. •• This paper includes a review of the PTSD pharmacotherapy literature from the 1980s and a systematic discussion of numerous methodological problems with the clinical trials conducted during that decade.
    • Davidson J, Kudler H, Smith R, Mahorney SL, Lipper S, Hammett E, Saunders WB, Cavenar JO Jr: Treatment of posttraumatic stress disorder with amitriptyline and placebo. Arch Gen Psychiatry (1990) 47(3):259-266. •• This paper includes a review of the PTSD pharmacotherapy literature from the 1980s and a systematic discussion of numerous methodological problems with the clinical trials conducted during that decade.
  • 62
    • 33847679030 scopus 로고    scopus 로고
    • Efficacy and safety of topiramate monotherapy in civilian posttraumatic stress disorder: A randomized, double-blind, placebo-controlled study
    • Tucker P, Trautman RP, Wyatt DB, Thompson J, Wu SC, Capece JA, Rosenthal NR: Efficacy and safety of topiramate monotherapy in civilian posttraumatic stress disorder: A randomized, double-blind, placebo-controlled study. J Clin Psychiatry (2007) 68(2):201-206.
    • (2007) J Clin Psychiatry , vol.68 , Issue.2 , pp. 201-206
    • Tucker, P.1    Trautman, R.P.2    Wyatt, D.B.3    Thompson, J.4    Wu, S.C.5    Capece, J.A.6    Rosenthal, N.R.7
  • 63
    • 39649093687 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of augmentation topiramate for chronic combat-related posttraumatic stress disorder
    • Lindley SE, Carlson EB, Hill K: A randomized, double-blind, placebo-controlled trial of augmentation topiramate for chronic combat-related posttraumatic stress disorder. J Clin Psychopharmacol (2007) 27(6):677-681.
    • (2007) J Clin Psychopharmacol , vol.27 , Issue.6 , pp. 677-681
    • Lindley, S.E.1    Carlson, E.B.2    Hill, K.3
  • 64
    • 33846229999 scopus 로고    scopus 로고
    • The efficacy and tolerability of tiagabine in adult patients with post-traumatic stress disorder
    • Davidson JR, Brady K, Mellman TA, Stein MB, Pollack MH: The efficacy and tolerability of tiagabine in adult patients with post-traumatic stress disorder. J Clin Psychopharmacol (2007) 27(1):85-88.
    • (2007) J Clin Psychopharmacol , vol.27 , Issue.1 , pp. 85-88
    • Davidson, J.R.1    Brady, K.2    Mellman, T.A.3    Stein, M.B.4    Pollack, M.H.5
  • 65
    • 0025352832 scopus 로고
    • Core symptoms of posttraumatic stress disorder unimproved by alprazolam treatment
    • Braun P, Greenberg D, Dasberg H, Lerer B: Core symptoms of posttraumatic stress disorder unimproved by alprazolam treatment. J Clin Psychiatry (1990) 51(6):236-238.
    • (1990) J Clin Psychiatry , vol.51 , Issue.6 , pp. 236-238
    • Braun, P.1    Greenberg, D.2    Dasberg, H.3    Lerer, B.4
  • 70
    • 0036789143 scopus 로고    scopus 로고
    • Adjunctive olanzapine for SSRI-resistant combat-related PTSD: A double-blind, placebo-controlled study
    • Stein MB, Kline NA, Matloff JL: Adjunctive olanzapine for SSRI-resistant combat-related PTSD: A double-blind, placebo-controlled study. Am J Psychiatry (2002) 159(10):1777-1779.
    • (2002) Am J Psychiatry , vol.159 , Issue.10 , pp. 1777-1779
    • Stein, M.B.1    Kline, N.A.2    Matloff, J.L.3
  • 71
    • 44849108132 scopus 로고    scopus 로고
    • Placebo-controlled trial of risperidone augmentation for selective serotonin reuptake inhibitor-resistant civilian posttraumatic stress disorder
    • Rothbaum BO, Killeen TK, Davidson JR, Brady KT, Connor KM, Heekin MH: Placebo-controlled trial of risperidone augmentation for selective serotonin reuptake inhibitor-resistant civilian posttraumatic stress disorder. J Clin Psychiatry (2008) 69(4):520-525.
    • (2008) J Clin Psychiatry , vol.69 , Issue.4 , pp. 520-525
    • Rothbaum, B.O.1    Killeen, T.K.2    Davidson, J.R.3    Brady, K.T.4    Connor, K.M.5    Heekin, M.H.6
  • 72
    • 14644423248 scopus 로고    scopus 로고
    • Adjunctive risperidone in the treatment of chronic combat-related posttraumatic stress disorder
    • Bartzokis G, Lu PH, Turner J, Mintz J, Saunders CS: Adjunctive risperidone in the treatment of chronic combat-related posttraumatic stress disorder. Biol Psychiatry (2005) 57(5):474-479.
    • (2005) Biol Psychiatry , vol.57 , Issue.5 , pp. 474-479
    • Bartzokis, G.1    Lu, P.H.2    Turner, J.3    Mintz, J.4    Saunders, C.S.5
  • 73
    • 13744255491 scopus 로고    scopus 로고
    • A preliminary study of risperidone in the treatment of posttraumatic stress disorder related to childhood abuse in women
    • Reich DB, Winternitz S, Hennen J, Watts T, Stanculescu C: A preliminary study of risperidone in the treatment of posttraumatic stress disorder related to childhood abuse in women. J Clin Psychiatry (2004) 65(12):1601-1606.
    • (2004) J Clin Psychiatry , vol.65 , Issue.12 , pp. 1601-1606
    • Reich, D.B.1    Winternitz, S.2    Hennen, J.3    Watts, T.4    Stanculescu, C.5
  • 74
    • 0016441344 scopus 로고
    • Facilitation of time-dependent memory processes with posttrial epinephrine injections
    • Gold PE, Van Buskirk RB: Facilitation of time-dependent memory processes with posttrial epinephrine injections. Behav Biol (1975) 13(2):145-153.
    • (1975) Behav Biol , vol.13 , Issue.2 , pp. 145-153
    • Gold, P.E.1    Van Buskirk, R.B.2
  • 75
    • 0030474255 scopus 로고    scopus 로고
    • Involvement of the amygdala in memory storage: Interaction with other brain systems
    • McGaugh JL, Cahill L, Roozendaal B: Involvement of the amygdala in memory storage: Interaction with other brain systems. Proc Natl Acad Sci USA (1996) 93(24):13508-13514.
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.24 , pp. 13508-13514
    • McGaugh, J.L.1    Cahill, L.2    Roozendaal, B.3
  • 76
    • 38049049257 scopus 로고    scopus 로고
    • Pharmacotherapy to prevent PTSD: Results from a randomized controlled proof-of-concept trial in physically injured patients
    • Stein MB, Kerridge C, Dimsdale JE, Hoyt DB: Pharmacotherapy to prevent PTSD: Results from a randomized controlled proof-of-concept trial in physically injured patients. J Trauma Stress (2007) 20(6):923-932.
    • (2007) J Trauma Stress , vol.20 , Issue.6 , pp. 923-932
    • Stein, M.B.1    Kerridge, C.2    Dimsdale, J.E.3    Hoyt, D.B.4
  • 78
    • 0021359925 scopus 로고
    • Effects of methoxamine, and α-1 adrenoceptor agonist, and prazosin, an α-1 antagonist, on the stages of the sleep-waking cycle in the cat
    • Hilakivi I, Leppavuori A: Effects of methoxamine, and α-1 adrenoceptor agonist, and prazosin, an α-1 antagonist, on the stages of the sleep-waking cycle in the cat. Acta Physiol Scand (1984) 120(3):363-372.
    • (1984) Acta Physiol Scand , vol.120 , Issue.3 , pp. 363-372
    • Hilakivi, I.1    Leppavuori, A.2
  • 79
    • 33947587104 scopus 로고    scopus 로고
    • Raskind MA, Peskind ER, Hoff DJ, Hart KL, Holmes HA, Warren D, Shofer J, O'Connell J, Taylor F, Gross C, Rohde K et al: A parallel group placebo controlled study of prazosin for trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder. Biol Psychiatry (2007) 61(8):928-934. • In this RCT, prazosin demonstrated large effect sizes for reduction of trauma nightmares, improved sleep quality and improved global clinical status in a veteran patient group with chronic PTSD.
    • Raskind MA, Peskind ER, Hoff DJ, Hart KL, Holmes HA, Warren D, Shofer J, O'Connell J, Taylor F, Gross C, Rohde K et al: A parallel group placebo controlled study of prazosin for trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder. Biol Psychiatry (2007) 61(8):928-934. • In this RCT, prazosin demonstrated large effect sizes for reduction of trauma nightmares, improved sleep quality and improved global clinical status in a veteran patient group with chronic PTSD.
  • 80
    • 39449113662 scopus 로고    scopus 로고
    • Prazosin effects on objective sleep measures and clinical symptoms in civilian trauma posttraumatic stress disorder: A placebo-controlled study
    • Taylor FB, Martin P, Thompson C, Williams J, Mellman TA, Gross C, Peskind ER, Raskind MA: Prazosin effects on objective sleep measures and clinical symptoms in civilian trauma posttraumatic stress disorder: A placebo-controlled study. Biol Psychiatry (2008) 63(6):629-632.
    • (2008) Biol Psychiatry , vol.63 , Issue.6 , pp. 629-632
    • Taylor, F.B.1    Martin, P.2    Thompson, C.3    Williams, J.4    Mellman, T.A.5    Gross, C.6    Peskind, E.R.7    Raskind, M.A.8
  • 83
    • 0030746976 scopus 로고    scopus 로고
    • Enhanced dexamethasone suppression of plasma cortisol in adult women traumatized by childhood sexual abuse
    • Stein MB, Yehuda R, Koverola C, Hanna C: Enhanced dexamethasone suppression of plasma cortisol in adult women traumatized by childhood sexual abuse. Biol Psychiatry (1997) 42(8):680-686.
    • (1997) Biol Psychiatry , vol.42 , Issue.8 , pp. 680-686
    • Stein, M.B.1    Yehuda, R.2    Koverola, C.3    Hanna, C.4
  • 84
    • 36248950082 scopus 로고    scopus 로고
    • Adrenal stress hormones, amygdala activation, and memory for emotionally arousing experiences
    • Roozendaal B, Barsegyan A, Lee S: Adrenal stress hormones, amygdala activation, and memory for emotionally arousing experiences. Prog Brain Res (2008) 167:79-97.
    • (2008) Prog Brain Res , vol.167 , pp. 79-97
    • Roozendaal, B.1    Barsegyan, A.2    Lee, S.3
  • 85
    • 0035894630 scopus 로고    scopus 로고
    • The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder in survivors
    • Schelling G, Briegel J, Roozendaal B, Stoll C, Rothenhausler HB, Kapfhammer HP: The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder in survivors. Biol Psychiatry (2001) 50(12):978-985.
    • (2001) Biol Psychiatry , vol.50 , Issue.12 , pp. 978-985
    • Schelling, G.1    Briegel, J.2    Roozendaal, B.3    Stoll, C.4    Rothenhausler, H.B.5    Kapfhammer, H.P.6
  • 86
    • 34247192167 scopus 로고    scopus 로고
    • Post-traumatic stress disorder and post-traumatic stress symptoms following critical illness in medical intensive care unit patients: Assessing the magnitude of the problem
    • Jackson JC, Hart RP, Gordon SM, Hopkins RO, Girard TD, Ely EW: Post-traumatic stress disorder and post-traumatic stress symptoms following critical illness in medical intensive care unit patients: Assessing the magnitude of the problem. Crit Care (2007) 11(1):R27.
    • (2007) Crit Care , vol.11 , Issue.1
    • Jackson, J.C.1    Hart, R.P.2    Gordon, S.M.3    Hopkins, R.O.4    Girard, T.D.5    Ely, E.W.6


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