Cerebral blood flow studies in the diagnosis and management of intrauterine growth restriction

Current Opinion in Obstetrics and Gynecology

Volumn 25, Issue 2, 2013, Pages 138-144

  Hernandez Andrade, Edgar ^a,b   Stampalija, Tamara ^c   Figueras, Francesc ^d  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INSTITUTO NACIONAL DE PERINATOLOGÍA   (Mexico)

^c UNIVERSITY OF MILAN   (Italy)

^d UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Doppler; fetal brain vasodilatation; intrauterine growth restriction; neurological outcome

Indexed keywords

CARBON DIOXIDE;

ABDOMINAL CIRCUMFERENCE; ANTHROPOMETRIC PARAMETERS; BLOOD VOLUME; BRAIN BLOOD FLOW; BRAIN HEMORRHAGE; CEREBRAL PALSY; DOPPLER FLOWMETRY; ENCEPHALOMALACIA; FETUS WEIGHT; FRACTIONAL MOVING BLOOD VOLUME; GESTATION PERIOD; HUMAN; INTRAUTERINE GROWTH RETARDATION; NEUROLOGICAL COMPLICATION; PERINATAL MORBIDITY; PERINATAL MORTALITY; PH; PRIORITY JOURNAL; REVIEW; SMALL FOR DATE INFANT; SURVIVAL; UMBILICAL ARTERY; VASODILATATION;

BLOOD FLOW VELOCITY; CEREBROVASCULAR CIRCULATION; FEMALE; FETAL GROWTH RETARDATION; HUMANS; PLACENTAL INSUFFICIENCY; PREGNANCY; PULSATILE FLOW; ULTRASONOGRAPHY, PRENATAL; UMBILICAL ARTERIES; VASODILATION;

EID: 84874947645     PISSN: 1040872X     EISSN: 1473656X     Source Type: Journal    
DOI: 10.1097/GCO.0b013e32835e0e9c     Document Type: Review

References (64)

1. Rudolph AM, Heymann MA. Circulatory changes during growth in the fetal lamb. Circ Res 1970; 26:289-299.
2. Teitel D, Sidi D, Bernstein D, et al. Chronic hypoxemia in the newborn lamb, cardiovascular, hematopoietic, and growth adaptations. Pediatr Res 1985; 19:1004-1010.
3. Sidi D, Kuipers JR, Teitel D, et al. Developmental changes in oxygenation and circulatory responses to hypoxemia in lambs. Am J Physiol 1983; 245:H674-H682.
4. Arbeille P, Roncin A, Berson M, et al. Exploration of the fetal cerebral blood flow by duplex Doppler-linear array system in normal and pathological pregnancies. Ultrasound Med Biol 1987; 13:329-337.
5. Wladimiroff JW, Tonge HM, Stewart PA. Doppler ultrasound assessment of cerebral blood flow in the human fetus. Br J Obstet Gynaecol 1986; 93:471-475.
6. van den Wijngaard JA, Groenenberg IA, Wladimiroff JW, Hop WC. Cerebral Doppler ultrasound of the human fetus. Br J Obstet Gynaecol 1989; 96:845-849.
7. Malamitsi-Puchner A, Nikolaou KE, Puchner KP. Intrauterine growth restriction, brain-sparing effect, and neurotrophins. Ann N Y Acad Sci 2006; 1092:293-296.
8. Marsal K. Intrauterine growth restriction. Curr Opin Obstet Gynecol 2002; 14:127-135.
9. Marsal K. Obstetric management of intrauterine growth restriction. Best Pract Res Clin Obstet Gynaecol 2009; 23:857-870.
10. Soothill PW, Bobrow CS, Holmes R. Small for gestational age is not a diagnosis. Ultrasound Obstet Gynecol 1999; 13:225-228.
11. Kuban KC, Allred EN, O'Shea TM, et al. Cranial ultrasound lesions in the NICU predict cerebral palsy at age 2 years in children born at extremely low gestational age. J Child Neurol 2009; 24:63-72.
12. Laughon M, O'Shea MT, Allred EN, et al. Chronic lung disease and developmental delay at 2 years of age in children born before 28 weeks' gestation. Pediatrics 2009; 124:637-648.
13. Hernandez-Andrade E, Crispi F, Benavides-Serralde JA, et al. Contribution of the myocardial performance index and aortic isthmus blood flow index to predicting mortality in preterm growth-restricted fetuses. Ultrasound Obstet Gynecol 2009; 34:430-436.
14. Alfirevic Z, Stampalija T, Gyte GM. Fetal and umbilical Doppler ultrasound in high-risk pregnancies. Cochrane Database Syst Rev 2010: CD007529.
15. Stampalija T, Alfirevic Z, Gyte G. Doppler in obstetrics: evidence from randomized trials. Ultrasound Obstet Gynecol 2010; 36:779-780.
16. Turan S, Miller J, Baschat AA. Integrated testing and management in fetal growth restriction. Semin Perinatol 2008; 32:194-200.
17. Turan OM, Turan S, Gungor S, et al. Progression of Doppler abnormalities in intrauterine growth restriction. Ultrasound Obstet Gynecol 2008; 32:160-167.
18. Akalin-Sel T, Nicolaides KH, Peacock J, Campbell S. Doppler dynamics and their complex interrelation with fetal oxygen pressure, carbon dioxide pressure, and pH in growth-retarded fetuses. Obstet Gynecol 1994; 84:439-444.
19. Figueras F, Lanna M, Palacio M, et al. Middle cerebral artery Doppler indices at different sites: prediction of umbilical cord gases in prolonged pregnancies. Ultrasound Obstet Gynecol 2004; 24:529-533.
20. Vyas S, Nicolaides KH, Bower S, Campbell S. Middle cerebral artery flow velocity waveforms in fetal hypoxaemia. Br J Obstet Gynaecol 1990; 97:797-803.
21. Hecher K, Snijders R, Campbell S, Nicolaides K. Fetal venous, intracardiac, and arterial blood flow measurements in intrauterine growth retardation: relationship with fetal blood gases. Am J Obstet Gynecol 1995; 173:10-15.
22. Madazli R, Sen C, Uludag S, Ocak V. Doppler dynamics: their clinical significance and relationship with fetal blood gases and pH measurements. J Obstet Gynaecol 2001; 21:448-452.
23. Cheema R, Dubiel M, Gudmundsson S. Signs of fetal brain sparing are not related to umbilical cord blood gases at birth. Early Hum Dev 2009; 85:467-470.
24. Brodszki J, Morsing E, Malcus P, et al. Early intervention in management of very preterm growth-restricted fetuses: 2-year outcome of infants delivered on fetal indication before 30 gestational weeks. Ultrasound Obstet Gynecol 2009; 34:288-296.
25. Hartung J, Kalache KD, Heyna C, et al. Outcome of 60 neonates who had ARED flow prenatally compared with a matched control group of appropriatefor-gestational age preterm neonates. Ultrasound Obstet Gynecol 2005; 25:566-572.
26. Scherjon S, Briet J, Oosting H, Kok J. The discrepancy between maturation of visual-evoked potentials and cognitive outcome at five years in very preterm infants with and without hemodynamic signs of fetal brain-sparing. Pediatrics 2000; 105:385-391.
27. van den Broek AJ, Kok JH, Houtzager BA, Scherjon SA. Behavioural problems at the age of eleven years in preterm-born children with or without fetal brain sparing: a prospective cohort study. Early Hum Dev 2010; 86:379-384.
28. Leppanen M, Ekholm E, Palo P, et al., and the PIPARI Study Group. Abnormal antenatal Doppler velocimetry and cognitive outcome in very-low-birth-weight infants at 2 years of age. Ultrasound Obstet Gynecol 2010; 36:178-185.
29. Ertan AK, Tanriverdi HA, Meier M, Schmidt W. Perinatal risk factors for neonatal intracerebral hemorrhage in preterm infants. Eur J Obstet Gynecol Reprod Biol 2006; 127:29-34.
30. von Beckerath AK, Kollmann M, Rotky-Fast C, et al. Perinatal complications and long-term neurodevelopmental outcome of infants with intrauterine growth restriction. Am J Obstet Gynecol 2012; 15. doi: 10.1016.
31. Turan OM, Turan S, Berg C, et al. Duration of persistent abnormal ductus venosus flow and its impact on perinatal outcome in fetal growth restriction. Ultrasound Obstet Gynecol 2011; 38:295-302.
32. Padilla-Gomes NF, Enriquez G, Acosta-Rojas R, et al. Prevalence of neonatal ultrasound brain lesions in premature infants with and without intrauterine growth restriction. Acta Paediatr 2007; 96:1582-1587.
33. Mari G, Hanif F, Kruger M, et al. Middle cerebral artery peak systolic velocity: a new Doppler parameter in the assessment of growth-restricted fetuses. Ultrasound Obstet Gynecol 2007; 29:310-316.
34. Figueroa-Diesel H, Hernandez-Andrade E, Acosta-Rojas R, et al. Doppler changes in the main fetal brain arteries at different stages of hemodynamic adaptation in severe intrauterine growth restriction. Ultrasound Obstet Gynecol 2007; 30:297-302.
35. Konje JC, Bell SC, Taylor DJ. Abnormal Doppler velocimetry and blood flow volume in the middle cerebral artery in very severe intrauterine growth restriction: is the occurrence of reversal of compensatory flow too late? BJOG 2001; 108:973-979.
36. Benavides-Serralde A, Scheier M, Cruz-Martinez R, et al. Changes in central and peripheral circulation in intrauterine growth-restricted fetuses at different stages of umbilical artery flow deterioration: new fetal cardiac and brain parameters. Gynecol Obstet Invest 2011; 71:274-280.
37. Tideman E, Marsal K, Ley D. Cognitive function in young adults following intrauterine growth restriction with abnormal fetal aortic blood flow. Ultrasound Obstet Gynecol 2007; 29:614-618.
38. Martin L, Ley D, Marsal K, Hellstrom A. Visual function in young adults following intrauterine growth retardation. J Pediatr Ophthalmol Strabismus 2004; 41:212-218.
39. Hellstrom A, Dahlgren J, Marsal K, Ley D. Abnormal retinal vascular morphology in young adults following intrauterine growth restriction. Pediatrics 2004; 113:e77-e80.
40. Figueras F, Cruz-Martinez R, Sanz-Cortes M, et al. Neurobehavioral outcomes in preterm, growth-restricted infants with and without prenatal advanced signs of brain-sparing. Ultrasound Obstet Gynecol 2011; 38:288-294.
41. Neilson JP, Alfirevic Z. Doppler ultrasound for fetal assessment in high-risk pregnancies. Cochrane Database Syst Rev 2000: CD000073.
42. Chang TC, Robson SC, Spencer JA, Gallivan S. Prediction of perinatal morbidity at term in small fetuses: comparison of fetal growth and Doppler ultrasound. Br J Obstet Gynaecol 1994; 101:422-427.
43. Doctor BA, O'Riordan MA, Kirchner HL, et al. Perinatal correlates and neonatal outcomes of small for gestational age infants born at term gestation. Am J Obstet Gynecol 2001; 185:652-659.
44. McCowan LM, Harding JE, Stewart AW. Umbilical artery Doppler studies in small for gestational age babies reflect disease severity. BJOG 2000; 107:916-925.
45. Cruz-Martinez R, Figueras F, Oros D, et al. Cerebral blood perfusion and neurobehavioral performance in full-term small-for-gestational-age fetuses. Am J Obstet Gynecol 2009; 201:474e1-7.
46. Figueras F, Oros D, Cruz-Martinez R, et al. Neurobehavior in term, small-forgestational age infants with normal placental function. Pediatrics 2009; 124:e934-e941.
47. Arcangeli T, Thilaganathan B, Hooper R, et al. Neurodevelopmental delay in small babies at term: a systematic review. Ultrasound Obstet Gynecol 2012; 40:267-275.
48. Oros D, Figueras F, Cruz-Martinez R, et al. Longitudinal changes in uterine, umbilical and fetal cerebral Doppler indices in late-onset small-for-gestational age fetuses. Ultrasound Obstet Gynecol 2011; 37:191-195.
49. Eixarch E, Meler E, Iraola A, et al. Neurodevelopmental outcome in 2-year-old infants who were small-for-gestational age term fetuses with cerebral blood flow redistribution. Ultrasound Obstet Gynecol 2008; 32:894-899.
50. Hershkovitz R, Kingdom JC, Geary M, Rodeck CH. Fetal cerebral blood flow redistribution in late gestation: identification of compromise in small fetuses with normal umbilical artery Doppler. Ultrasound Obstet Gynecol 2000; 15:209-212.
51. Cruz-Martinez R, Figueras F, Hernandez-Andrade E, et al. Fetal brain Doppler to predict cesarean delivery for nonreassuring fetal status in term small-forgestational-age fetuses. Obstet Gynecol 2011; 117:618-626.
52. Boers KE, Vijgen SM, Bijlenga D, et al. Induction versus expectant monitoring for intrauterine growth restriction at term: randomised equivalence trial (DIGITAT). BMJ 2010; 341:c7087.
53. Boers KE, van Wyk L, van der Post JA, et al. Neonatal morbidity after induction vs. expectant monitoring in intrauterine growth restriction at term: a subanalysis of the DIGITAT RCT. Am J Obstet Gynecol 2012; 206:344e1-7.
54. Oros D, Figueras F, Cruz-Martinez R, et al. Middle versus anterior cerebral artery Doppler for the prediction of perinatal outcome and neonatal neurobehavior in term small-for-gestational-age fetuses with normal umbilical artery Doppler. Ultrasound Obstet Gynecol 2010; 35:456-461.
55. Gramellini D, Folli MC, Raboni S, et al. Cerebral-umbilical Doppler ratio as a predictor of adverse perinatal outcome. Obstet Gynecol 1992; 79:416-420.
56. Arbeille P, Maulik D, Fignon A, et al. Assessment of the fetal PO2 changes by cerebral and umbilical Doppler on lamb fetuses during acute hypoxia. Ultrasound Med Biol 1995; 21:861-870.
57. Cruz-Martinez R, Figueras F, Hernandez-Andrade E, et al. Longitudinal brain perfusion changes in near-term small-for-gestational-age fetuses as measured by spectral Doppler indices or by fractional moving blood volume. Am J Obstet Gynecol 2010; 203:42 e1-6.
58. Roza SJ, Steegers EA, Verburg BO, et al. What is spared by fetal brainsparing? Fetal circulatory redistribution and behavioral problems in the general population. Am J Epidemiol 2008; 168:1145-1152.
59. Dubiel M, Gunnarsson GO, Gudmundsson S. Blood redistribution in the fetal brain during chronic hypoxia. Ultrasound Obstet Gynecol 2002; 20:117-121.
60. Raine-Fenning NJ, Nordin NM, Ramnarine KV, et al. Determining the relationship between three-dimensional power Doppler data and true blood flow characteristics: an in-vitro flow phantom experiment. Ultrasound Obstet Gynecol 2008; 32:540-550.
61. Rubin JM, Adler RS, Fowlkes JB, et al. Fractional moving blood volume: estimation with power Doppler US. Radiology 1995; 197:183-190.
62. Rubin JM, Bude RO, Fowlkes JB, et al. Normalizing fractional moving blood volume estimates with power Doppler US: defining a stable intravascular point with the cumulative power distribution function. Radiology 1997; 205:757-765.
63. Hernandez-Andrade E, Jansson T, Ley D, et al. Validation of fractional moving blood volume measurement with power Doppler ultrasound in an experimental sheep model. Ultrasound Obstet Gynecol 2004; 23:363-368.
64. Hernandez-Andrade E, Figueroa-Diesel H, Jansson T, et al. Changes in regional fetal cerebral blood flow perfusion in relation to hemodynamic deterioration in severely growth-restricted fetuses. Ultrasound Obstet Gynecol 2008; 32:71-76.