Comparison between 5-aminosalicylic acid (5-ASA) and para-aminosalicylic acid (4-PAS) as potential protectors against Mn-induced neurotoxicity

Biological Trace Element Research

Volumn 152, Issue 1, 2013, Pages 113-116

  Santos, Dinamene ^a   Batoreu, M Camila ^a   Aschner, Michael ^b   Marreilha Dos Santos, Ana P ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Blood brain barrier; Endothelium; Manganese; Neuroprotection; Neurotoxicity; RBE4 cells

Indexed keywords

AMINOSALICYLIC ACID; LACTATE DEHYDROGENASE; MANGANESE; MESALAZINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; CYTOTOXICITY; ENDOTHELIUM CELL; ENZYME RELEASE; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; RAT; SUPERNATANT;

AMINOSALICYLIC ACID; ANALYSIS OF VARIANCE; ANIMALS; BRAIN; CELL LINE; CELL SURVIVAL; CHLORIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; HUMANS; L-LACTATE DEHYDROGENASE; MANGANESE; MANGANESE COMPOUNDS; MANGANESE POISONING; MESALAMINE; NEUROPROTECTIVE AGENTS; RATS;

RATTUS;

EID: 84874935537     PISSN: 01634984     EISSN: 15590720     Source Type: Journal    
DOI: 10.1007/s12011-012-9597-0     Document Type: Article

References (34)

1. Barnes PJ, Karin M (1997) Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336:1066-1071
2. Blanc P (1990) Poisoning and drug overdose. Appleton & Lange, Norwalk
3. Bressler JP, Olivi L, Cheong JH, Kim Y, Bannona D (2004) Divalent metal transporter 1 in lead and cadmium transport. Ann N Y Acad Sci 1012:142-152
4. Cotzias GC, Horiuchi K, Fuenzalida S, Mena I (1968) Chronic manganese poisoning. Clearance of tissue manganese concentrations with persistance of the neurological picture. Neurology 18:376-382
5. Demeuse P, Kerkhofs A, Struys-Ponsar C, Knoops B, Remacle C, van den Bosch de Aguilar P (2002) Compartmentalized coculture of rat brain endothelial cells and astrocytes: a syngenic model to study the blood-brain barrier. J Neurosci Methods 121:21-31
6. dos Santos AP, Milatovic D, Au C, Yin Z, Batoreu MC, Aschner M (2010) Rat brain endothelial cells are a target of manganese toxicity. Brain Res 1326:152-161
7. Durieu-Trautmann O, Federici C, Creminon C, Foignant-Chaverot N, Roux F, Claire M, Strosberg AD, Couraud PO (1993) Nitric oxide and endothelin secretion by brain microvessel endothelial cells: regulation by cyclic nucleotides. J Cell Physiol 155:104-111
8. Fitzwater SP, Sechler GA, Jave O, Coronel J, Mendoza A, Gilman RH, Friedland JS, Moore DA (2013) Second-line anti-TB drug concentrations for susceptibility testing in the MODS assay. Eur Respir J. doi: 10.1183/09031936.00059812
9. Goncalves E, Almeida LM, Dinis TC (1998) Antioxidant activity of 5-aminosalicylic acid against peroxidation of phosphatidylcholine liposomes in the presence of alpha-tocopherol: a synergistic interaction? Free Radic Res 29:53-66
10. Herrero Hernandez E, Discalzi G, Valentini C, Venturi F, Chio A, Carmellino C, Rossi L, Sacchetti A, Pira E (2006) Follow-up of patients affected by manganese-induced Parkinsonism after treatment with CaNa2EDTA. Neurotoxicology 27:333-339
11. Kanski J, Lauderback C, Butterfield DA (2001) 5-Aminosalicylic acid protection against oxidative damage to synaptosomal membranes by alkoxyl radicals in vitro. Neurochem Res 26:23-29
12. Koller WC, Lyons KE, Truly W (2004) Effect of levodopa treatment for parkinsonism in welders: a double-blind study. Neurology 62:730-733
13. Legrand C, Bour JM, Jacob C, Capiaumont J, Martial A, Marc A, Wudtke M, Kretzmer G, Demangel C, Duval D et al (1992) Lactate dehydrogenase (LDH) activity of the cultured eukaryotic cells as marker of the number of dead cells in the medium [corrected]. J Biotechnol 25:231-243
14. Marreilha dos Santos AP, Santos D, Au C, Milatovic D, Aschner M, Batoreu MC (2008) Antioxidants prevent the cytotoxicity of manganese in RBE4 cells. Brain Res 1236:200-205
15. Mergler D, Baldwin M, Belanger S, Larribe F, Beuter A, Bowler R, Panisset M, Edwards R, de Geoffroy A, Sassine MP, Hudnell K (1999) Manganese neurotoxicity, a continuum of dysfunction: results from a community based study. Neurotoxicology 20:327-342
16. Milatovic D, Aschner M (2009) Measurement of isoprostanes as markers of oxidative stress in neuronal tissue. Curr Protoc Toxicol, Chapter 12 Unit 12 14
17. Milatovic D, Zaja-Milatovic S, Gupta RC, Yu Y, Aschner M (2009) Oxidative damage and neurodegeneration in manganese-induced neurotoxicity. Toxicol Appl Pharmacol 240:219-225
18. Miles AM, Grisham MB (1994) Antioxidant properties of aminosalicylates. Methods Enzymol 234:555-572
19. Pearson DC, Jourd'heuil D, Meddings JB (1996) The anti-oxidant properties of 5-aminosalicylic acid. Free Radic Biol Med 21:367-373
20. Prabhakaran K, Ghosh D, Chapman GD, Gunasekar PG (2008) Molecular mechanism of manganese exposure-induced dopaminergic toxicity. Brain Res Bull 76:361-367
21. Ramesh GT, Ghosh D, Gunasekar PG (2002) Activation of early signaling transcription factor, NF-kappaB following low-level manganese exposure. Toxicol Lett 136:151-158
22. Roels H, Sarhan MJ, Hanotiau I, de Fays M, Genet P, Bernard A, Buchet JP, Lauwerys R (1985) Preclinical toxic effects of manganese in workers from a Mn salts and oxides producing plant. Sci Total Environ 42:201-206
23. Rosenstock L, Cullen M (1994) Metals and related compounds. In: Rosenstock L, Cullen M (eds) Textbook of clinical and occupational and environmental medicine. Saunders, Philadelphia
24. Roux F, Durieu-Trautmann O, Chaverot N, Claire M, Mailly P, Bourre JM, Strosberg AD, Couraud PO (1994) Regulation of gamma-glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells. J Cell Physiol 159:101-113
25. Sadek AH, Rauch R, Schulz PE (2003) Parkinsonism due to manganism in a welder. Int J Toxicol 22:393-401
26. Santos AP, Lucas RL, Andrade V, Mateus ML, Milatovic D, Aschner M, Batoreu MC (2012) Protective effects of ebselen (Ebs) and para-aminosalicylic acid (PAS) against manganese (Mn)-induced neurotoxicity. Toxicol Appl Pharmacol 258:394-402
27. Santos D, Milatovic D, Andrade V, Batoreu MC, Aschner M, Marreilha dos Santos AP (2012) The inhibitory effect of manganese on acetylcholinesterase activity enhances oxidative stress and neuroinflammation in the rat brain. Toxicology 292:90-98
28. Svartz N (1988) Sulfasalazine: II. Some notes on the discovery and development of salazopyrin. Am J Gastroenterol 83:497-503
29. UKPAR (2009) Pentasa slow release tablets 1 g. ed. M.a. H.P. R. Agency, 19. United Kingdom: Ferring Pharmaceuticals Limited
30. Valentine JF (2001) Mesalamine induces manganese superoxide dismutase in rat intestinal epithelial cell lines and in vivo. Am J Physiol Gastrointest Liver Physiol 281:G1044-G1050
31. Yppolito R, Pappano N, Debattista N, Miskoski S, Bertolotti SG, Garcia NA (2002) On the antioxidant properties of therapeutic drugs: quenching of singlet molecular oxygen by aminosalicylic acids. Redox Rep 7:229-233
32. Zhang D, He X, Huang S, Li Y (2001) Effect of manganese exposure on brain development in postnatal mice. Wei Sheng Yan Jiu 30:260-262
33. Zhao F, Cai T, Liu M, Zheng G, Luo W, Chen J (2009) Manganese induces dopaminergic neurodegeneration via microglial activation in a rat model of manganism. Toxicol Sci 107:156-164
34. Zheng W, Jiang YM, Zhang Y, Jiang W, Wang X, Cowan DM (2009) Chelation therapy of manganese intoxication with para-aminosalicylic acid (PAS) in Sprague-Dawley rats. Neurotoxicology 30:240-248