메뉴 건너뛰기




Volumn 8, Issue 1, 2013, Pages 3-14

Identification of driver mutations in lung cancer: First step in personalized cancer

Author keywords

ALK; EGFR; Mutation; NSCLC; Personalized

Indexed keywords

AFATINIB; ANAPLASTIC LYMPHOMA KINASE; B RAF KINASE; CARBOPLATIN; CISPLATIN; CRIZOTINIB; DASATINIB; DISCOIDIN DOMAIN RECEPTOR 2; DOCETAXEL; EML4 ALK PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERLOTINIB; FIBROBLAST GROWTH FACTOR RECEPTOR 1; GEFITINIB; GEMCITABINE; HYBRID PROTEIN; K RAS PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PACLITAXEL; PEMETREXED; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE LKB1; PROTEIN RET; SCATTER FACTOR RECEPTOR; SOMATOMEDIN C; TRANSCRIPTION FACTOR SOX2; TRASTUZUMAB; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

EID: 84874934597     PISSN: 17762596     EISSN: 1776260X     Source Type: Journal    
DOI: 10.1007/s11523-013-0263-z     Document Type: Article
Times cited : (25)

References (102)
  • 1
    • 49049089802 scopus 로고    scopus 로고
    • Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer
    • 18506025 10.1200/JCO.2007.15.0375 1:CAS:528:DC%2BD1cXpvVWmtLg%3D
    • Scagliotti GV, Parikh P, von Pawel J, Biesma B, Vansteenkiste J, Manegold C et al (2008) Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 26(21):3543-3551
    • (2008) J Clin Oncol , vol.26 , Issue.21 , pp. 3543-3551
    • Scagliotti, G.V.1    Parikh, P.2    Von Pawel, J.3    Biesma, B.4    Vansteenkiste, J.5    Manegold, C.6
  • 2
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • 17167137 10.1056/NEJMoa061884 1:CAS:528:DC%2BD28XhtlWqsbzI
    • Sandler A, Gray R, Perry MC, Brahmer J, Schiller JH, Dowlati A et al (2006) Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 355(24):2542-2550
    • (2006) N Engl J Med , vol.355 , Issue.24 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3    Brahmer, J.4    Schiller, J.H.5    Dowlati, A.6
  • 3
    • 79251490374 scopus 로고    scopus 로고
    • New driver mutations in non-small-cell lung cancer
    • 21277552 10.1016/S1470-2045(10)70087-5 1:CAS:528:DC%2BC3MXht12ns74%3D
    • Pao W, Girard N (2011) New driver mutations in non-small-cell lung cancer. Lancet Oncol 12(2):175-180
    • (2011) Lancet Oncol , vol.12 , Issue.2 , pp. 175-180
    • Pao, W.1    Girard, N.2
  • 4
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • 15118125 10.1126/science.1099314 1:CAS:528:DC%2BD2cXksVGmsbs%3D
    • Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S et al (2004) EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304(5676):1497-1500
    • (2004) Science , vol.304 , Issue.5676 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3    Tracy, S.4    Greulich, H.5    Gabriel, S.6
  • 5
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • 15118073 10.1056/NEJMoa040938 1:CAS:528:DC%2BD2cXktF2js7c%3D
    • Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW et al (2004) Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350(21):2129-2139
    • (2004) N Engl J Med , vol.350 , Issue.21 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3    Gurubhagavatula, S.4    Okimoto, R.A.5    Brannigan, B.W.6
  • 6
    • 84866934606 scopus 로고    scopus 로고
    • Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: Updated results from a phase 1 study
    • 22954507 10.1016/S1470-2045(12)70344-3 1:CAS:528:DC%2BC38XhsVCjsb3E
    • Camidge DR, Bang YJ, Kwak EL, Iafrate AJ, Varella-Garcia M, Fox SB et al (2012) Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study. Lancet Oncol 13(10):1011-1019
    • (2012) Lancet Oncol , vol.13 , Issue.10 , pp. 1011-1019
    • Camidge, D.R.1    Bang, Y.J.2    Kwak, E.L.3    Iafrate, A.J.4    Varella-Garcia, M.5    Fox, S.B.6
  • 7
    • 33845444046 scopus 로고    scopus 로고
    • Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
    • 17151364 10.1056/NEJMoa062867 1:CAS:528:DC%2BD28Xht12ntrzM
    • Druker BJ, Guilhot F, O'Brien SG, Gathmann I, Kantarjian H, Gattermann N et al (2006) Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 355(23):2408-2417
    • (2006) N Engl J Med , vol.355 , Issue.23 , pp. 2408-2417
    • Druker, B.J.1    Guilhot, F.2    O'Brien, S.G.3    Gathmann, I.4    Kantarjian, H.5    Gattermann, N.6
  • 8
    • 33847323129 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations in lung cancer
    • 17318210 10.1038/nrc2088 1:CAS:528:DC%2BD2sXitVGrsbo%3D
    • Sharma SV, Bell DW, Settleman J, Haber DA (2007) Epidermal growth factor receptor mutations in lung cancer. Nat Rev Cancer 7(3):169-181
    • (2007) Nat Rev Cancer , vol.7 , Issue.3 , pp. 169-181
    • Sharma, S.V.1    Bell, D.W.2    Settleman, J.3    Haber, D.A.4
  • 9
    • 0027159063 scopus 로고
    • Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung
    • 7683573 1:CAS:528:DyaK3sXkvFamtLg%3D
    • Rusch V, Baselga J, Cordon-Cardo C, Orazem J, Zaman M, Hoda S et al (1993) Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung. Cancer Res 53(10 Suppl):2379-2385
    • (1993) Cancer Res , vol.53 , Issue.10 SUPPL. , pp. 2379-2385
    • Rusch, V.1    Baselga, J.2    Cordon-Cardo, C.3    Orazem, J.4    Zaman, M.5    Hoda, S.6
  • 10
    • 39749191925 scopus 로고    scopus 로고
    • Epidermal growth factor receptor immunohistochemistry: Comparison of antibodies and cutoff points to predict benefit from gefitinib in a phase 3 placebo-controlled study in advanced nonsmall-cell lung cancer
    • 18219661 10.1002/cncr.23282 1:CAS:528:DC%2BD1cXjs1eqsLc%3D
    • Hirsch FR, Dziadziuszko R, Thatcher N, Mann H, Watkins C, Parums DV et al (2008) Epidermal growth factor receptor immunohistochemistry: comparison of antibodies and cutoff points to predict benefit from gefitinib in a phase 3 placebo-controlled study in advanced nonsmall-cell lung cancer. Cancer 112(5):1114-1121
    • (2008) Cancer , vol.112 , Issue.5 , pp. 1114-1121
    • Hirsch, F.R.1    Dziadziuszko, R.2    Thatcher, N.3    Mann, H.4    Watkins, C.5    Parums, D.V.6
  • 11
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
    • 15329413 10.1073/pnas.0405220101 1:CAS:528:DC%2BD2cXnvFems70%3D
    • Pao W, Miller V, Zakowski M, Doherty J, Politi K, Sarkaria I et al (2004) EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci USA 101(36):13306-13311
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.36 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3    Doherty, J.4    Politi, K.5    Sarkaria, I.6
  • 12
    • 20044364940 scopus 로고    scopus 로고
    • Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
    • 15741570 10.1093/jnci/dji055 1:CAS:528:DC%2BD2MXitV2jsb4%3D
    • Shigematsu H, Lin L, Takahashi T, Nomura M, Suzuki M, Wistuba II et al (2005) Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 97(5):339-346
    • (2005) J Natl Cancer Inst , vol.97 , Issue.5 , pp. 339-346
    • Shigematsu, H.1    Lin, L.2    Takahashi, T.3    Nomura, M.4    Suzuki, M.5    Wistuba, I.I.6
  • 13
    • 33645052711 scopus 로고    scopus 로고
    • Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features
    • 16533793 10.1158/1078-0432.CCR-05-1981 1:CAS:528:DC%2BD28XitVGmsb8%3D
    • Tam IY, Chung LP, Suen WS, Wang E, Wong MC, Ho KK et al (2006) Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features. Clin Cancer Res 12(5):1647-1653
    • (2006) Clin Cancer Res , vol.12 , Issue.5 , pp. 1647-1653
    • Tam, I.Y.1    Chung, L.P.2    Suen, W.S.3    Wang, E.4    Wong, M.C.5    Ho, K.K.6
  • 14
    • 84862823259 scopus 로고    scopus 로고
    • Molecular pathology of lung cancer: Key to personalized medicine
    • 22282308 10.1038/modpathol.2011.215 1:CAS:528:DC%2BC38Xjt1Wqt7w%3D
    • Cheng L, Alexander RE, Maclennan GT, Cummings OW, Montironi R, Lopez-Beltran A et al (2012) Molecular pathology of lung cancer: key to personalized medicine. Mod Pathol 25(3):347-369
    • (2012) Mod Pathol , vol.25 , Issue.3 , pp. 347-369
    • Cheng, L.1    Alexander, R.E.2    Maclennan, G.T.3    Cummings, O.W.4    Montironi, R.5    Lopez-Beltran, A.6
  • 15
    • 0034954124 scopus 로고    scopus 로고
    • The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapy
    • 11484948 10.1023/A:1011177318162 1:STN:280:DC%2BD38%2FislSktw%3D%3D
    • Pedersen MW, Meltorn M, Damstrup L, Poulsen HS (2001) The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapy. Ann Oncol 12(6):745-760
    • (2001) Ann Oncol , vol.12 , Issue.6 , pp. 745-760
    • Pedersen, M.W.1    Meltorn, M.2    Damstrup, L.3    Poulsen, H.S.4
  • 16
    • 17844390172 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and non-small-cell lung cancer: Current knowledge and future directions
    • 15767641 10.1200/JCO.2005.07.799 1:CAS:528:DC%2BD2MXjvVyktLc%3D
    • Pao W, Miller VA (2005) Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and non-small-cell lung cancer: current knowledge and future directions. J Clin Oncol 23(11):2556-2568
    • (2005) J Clin Oncol , vol.23 , Issue.11 , pp. 2556-2568
    • Pao, W.1    Miller, V.A.2
  • 17
    • 20244388126 scopus 로고    scopus 로고
    • Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence
    • 15738541 10.1200/JCO.2005.00.992 1:CAS:528:DC%2BD2MXjvVyktLs%3D
    • Mitsudomi T, Kosaka T, Endoh H, Horio Y, Hida T, Mori S et al (2005) Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence. J Clin Oncol 23(11):2513-2520
    • (2005) J Clin Oncol , vol.23 , Issue.11 , pp. 2513-2520
    • Mitsudomi, T.1    Kosaka, T.2    Endoh, H.3    Horio, Y.4    Hida, T.5    Mori, S.6
  • 18
    • 27244451321 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer
    • 15998907 10.1200/JCO.2005.01.0793 1:CAS:528:DC%2BD2MXhtFCrsb3P
    • Takano T, Ohe Y, Sakamoto H, Tsuta K, Matsuno Y, Tateishi U et al (2005) Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer. J Clin Oncol 23(28):6829-6837
    • (2005) J Clin Oncol , vol.23 , Issue.28 , pp. 6829-6837
    • Takano, T.1    Ohe, Y.2    Sakamoto, H.3    Tsuta, K.4    Matsuno, Y.5    Tateishi, U.6
  • 19
    • 79960702788 scopus 로고    scopus 로고
    • Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer in Asia (IPASS)
    • 21670455 10.1200/JCO.2010.33.4235 1:CAS:528:DC%2BC3MXhtVOqsLnO
    • Fukuoka M, Wu YL, Thongprasert S, Sunpaweravong P, Leong SS, Sriuranpong V et al (2011) Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer in Asia (IPASS). J Clin Oncol 29(21):2866-2874
    • (2011) J Clin Oncol , vol.29 , Issue.21 , pp. 2866-2874
    • Fukuoka, M.1    Wu, Y.L.2    Thongprasert, S.3    Sunpaweravong, P.4    Leong, S.S.5    Sriuranpong, V.6
  • 20
    • 69949186250 scopus 로고    scopus 로고
    • Screening for epidermal growth factor receptor mutations in lung cancer
    • 19692684 10.1056/NEJMoa0904554 1:CAS:528:DC%2BD1MXhtVOqsL7M
    • Rosell R, Moran T, Queralt C, Porta R, Cardenal F, Camps C et al (2009) Screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med 361(10):958-967
    • (2009) N Engl J Med , vol.361 , Issue.10 , pp. 958-967
    • Rosell, R.1    Moran, T.2    Queralt, C.3    Porta, R.4    Cardenal, F.5    Camps, C.6
  • 21
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • 19692680 10.1056/NEJMoa0810699 1:CAS:528:DC%2BD1MXhtVygsbfK
    • Mok TS, Wu YL, Thongprasert S, Yang CH, Chu DT, Saijo N et al (2009) Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 361(10):947-957
    • (2009) N Engl J Med , vol.361 , Issue.10 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3    Yang, C.H.4    Chu, D.T.5    Saijo, N.6
  • 22
    • 72449160988 scopus 로고    scopus 로고
    • A randomized phase III study of gefitinib (IRESSATM) versus standard chemotherapy (gemcitabine plus cisplatin) as a first-line treatment for never-smokers with advanced or metastatic adenocarcinoma of the lung
    • Abstract PRS.4
    • Lee JS, Park K, Kim SW, Lee DH, Kim HT, Ham JY (2009) A randomized phase III study of gefitinib (IRESSATM) versus standard chemotherapy (gemcitabine plus cisplatin) as a first-line treatment for never-smokers with advanced or metastatic adenocarcinoma of the lung. J Thorac Oncol 4(9 suppl1):S283-S284, Abstract PRS.4
    • (2009) J Thorac Oncol , vol.4 , Issue.9 SUPPL. 1
    • Lee, J.S.1    Park, K.2    Kim, S.W.3    Lee, D.H.4    Kim, H.T.5    Ham, J.Y.6
  • 23
    • 77953930730 scopus 로고    scopus 로고
    • Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
    • 20573926 10.1056/NEJMoa0909530 1:CAS:528:DC%2BC3cXot1Gjt7Y%3D
    • Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H et al (2010) Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med 362(25):2380-2388
    • (2010) N Engl J Med , vol.362 , Issue.25 , pp. 2380-2388
    • Maemondo, M.1    Inoue, A.2    Kobayashi, K.3    Sugawara, S.4    Oizumi, S.5    Isobe, H.6
  • 24
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
    • 20022809 10.1016/S1470-2045(09)70364-X 1:CAS:528:DC%2BC3cXhtlGgtbo%3D
    • Mitsudomi T, Morita S, Yatabe Y, Negoro S, Okamoto I, Tsurutani J et al (2010) Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol 11(2):121-128
    • (2010) Lancet Oncol , vol.11 , Issue.2 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3    Negoro, S.4    Okamoto, I.5    Tsurutani, J.6
  • 25
    • 79960889662 scopus 로고    scopus 로고
    • Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study
    • 21783417 10.1016/S1470-2045(11)70184-X 1:CAS:528:DC%2BC3MXpslKhsbY%3D
    • Zhou C, Wu YL, Chen G, Feng J, Liu XQ, Wang C et al (2011) Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol 12(8):735-742
    • (2011) Lancet Oncol , vol.12 , Issue.8 , pp. 735-742
    • Zhou, C.1    Wu, Y.L.2    Chen, G.3    Feng, J.4    Liu, X.Q.5    Wang, C.6
  • 26
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial
    • 22285168 10.1016/S1470-2045(11)70393-X 1:CAS:528:DC%2BC38XjsVCgsbk%3D
    • Rosell R, Carcereny E, Gervais R, Vergnenegre A, Massuti B, Felip E et al (2012) Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol 13(3):239-246
    • (2012) Lancet Oncol , vol.13 , Issue.3 , pp. 239-246
    • Rosell, R.1    Carcereny, E.2    Gervais, R.3    Vergnenegre, A.4    Massuti, B.5    Felip, E.6
  • 27
    • 84866655838 scopus 로고    scopus 로고
    • LUX-Lung 3: A randomized, open-label, phase III study of afatinib versus pemetrexed and cisplatin as first-line treatment for patients with advanced adenocarcinoma of the lung harboring EGFR-activating mutations
    • abstr LBA7500
    • Yang J-C, Schuler M-H, Yamamoto N, O'Byrne K-J, Hirsh V, Mok T et al. (2012) LUX-Lung 3: a randomized, open-label, phase III study of afatinib versus pemetrexed and cisplatin as first-line treatment for patients with advanced adenocarcinoma of the lung harboring EGFR-activating mutations. J Clin Oncol 30 (suppl; abstr LBA7500)
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Yang, J.-C.1    Schuler, M.-H.2    Yamamoto, N.3    O'Byrne, K.-J.4    Hirsh, V.5    Mok, T.6
  • 28
    • 77953541527 scopus 로고    scopus 로고
    • Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: A multicentre, randomised, placebo-controlled phase 3 study
    • 20493771 10.1016/S1470-2045(10)70112-1 1:CAS:528:DC%2BC3cXntVCksb0%3D
    • Cappuzzo F, Ciuleanu T, Stelmakh L, Cicenas S, Szczesna A, Juhasz E et al (2010) Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study. Lancet Oncol 11(6):521-529
    • (2010) Lancet Oncol , vol.11 , Issue.6 , pp. 521-529
    • Cappuzzo, F.1    Ciuleanu, T.2    Stelmakh, L.3    Cicenas, S.4    Szczesna, A.5    Juhasz, E.6
  • 29
    • 84856299168 scopus 로고    scopus 로고
    • Efficacy and safety of PF299804 as first-line treatment of patients with advanced NSCLC selected for activating mutation of epidermal growth factor receptor (EGFR)
    • [abstract LBA18])
    • Mok T, Spigel D, Park K, Socinski M, Tung S, Kim D-W et al. (2010) Efficacy and safety of PF299804 as first-line treatment of patients with advanced NSCLC selected for activating mutation of epidermal growth factor receptor (EGFR). Annals Oncol 21 ((suppl. 8): [abstract LBA18].)
    • (2010) Annals Oncol , vol.21 , Issue.SUPPL. 8
    • Mok, T.1    Spigel, D.2    Park, K.3    Socinski, M.4    Tung, S.5    Kim, D.-W.6
  • 30
    • 13844317894 scopus 로고    scopus 로고
    • EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
    • 15728811 10.1056/NEJMoa044238 1:CAS:528:DC%2BD2MXhsFCiurk%3D
    • Kobayashi S, Boggon TJ, Dayaram T, Janne PA, Kocher O, Meyerson M et al (2005) EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med 352(8):786-792
    • (2005) N Engl J Med , vol.352 , Issue.8 , pp. 786-792
    • Kobayashi, S.1    Boggon, T.J.2    Dayaram, T.3    Janne, P.A.4    Kocher, O.5    Meyerson, M.6
  • 31
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • 15737014 10.1371/journal.pmed.0020073
    • Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF et al (2005) Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2(3):e73
    • (2005) PLoS Med , vol.2 , Issue.3 , pp. 73
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3    Riely, G.J.4    Somwar, R.5    Zakowski, M.F.6
  • 32
    • 78649518887 scopus 로고    scopus 로고
    • A phase II study of BIBW 2992 in patients with adenocarcinoma of the lung and activating EGFR mutations (LUX-Lung 2)
    • (suppl; abstr 7521)
    • Yang C, Shih J, Su W, Hsia T, Tsai C, Ou SI et al (2010) A phase II study of BIBW 2992 in patients with adenocarcinoma of the lung and activating EGFR mutations (LUX-Lung 2). J Clin Oncol 28:15s (suppl; abstr 7521)
    • (2010) J Clin Oncol , vol.28
    • Yang, C.1    Shih, J.2    Su, W.3    Hsia, T.4    Tsai, C.5    Ou, S.I.6
  • 33
    • 84873677937 scopus 로고    scopus 로고
    • Activity of afatinib/cetuximab in patients (pts) with EGFR mutant non-small cell lung cancer (NSCLC) and acquired resistance (AR) to EGFR inhibitors
    • abst 12270
    • Janjigian Y, smit EF, Horn L, Groen JJM, Camidge DR, Gettinger S (2012) Activity of afatinib/cetuximab in patients (pts) with EGFR mutant non-small cell lung cancer (NSCLC) and acquired resistance (AR) to EGFR inhibitors. ESMO, abst 12270
    • (2012) ESMO
    • Janjigian, Y.1    Smit, E.F.2    Horn, L.3    Jjm, G.4    Camidge, D.R.5    Gettinger, S.6
  • 34
    • 33748074447 scopus 로고    scopus 로고
    • Presence of epidermal growth factor receptor gene T790M mutation as a minor clone in non-small cell lung cancer
    • 16912157 10.1158/0008-5472.CAN-06-1951 1:CAS:528:DC%2BD28XotFWqsbo%3D
    • Inukai M, Toyooka S, Ito S, Asano H, Ichihara S, Soh J et al (2006) Presence of epidermal growth factor receptor gene T790M mutation as a minor clone in non-small cell lung cancer. Cancer Res 66(16):7854-7858
    • (2006) Cancer Res , vol.66 , Issue.16 , pp. 7854-7858
    • Inukai, M.1    Toyooka, S.2    Ito, S.3    Asano, H.4    Ichihara, S.5    Soh, J.6
  • 35
    • 47949114668 scopus 로고    scopus 로고
    • Detection of mutations in EGFR in circulating lung-cancer cells
    • 18596266 10.1056/NEJMoa0800668 1:CAS:528:DC%2BD1cXovFSqtbc%3D
    • Maheswaran S, Sequist LV, Nagrath S, Ulkus L, Brannigan B, Collura CV et al (2008) Detection of mutations in EGFR in circulating lung-cancer cells. N Engl J Med 359(4):366-377
    • (2008) N Engl J Med , vol.359 , Issue.4 , pp. 366-377
    • Maheswaran, S.1    Sequist, L.V.2    Nagrath, S.3    Ulkus, L.4    Brannigan, B.5    Collura, C.V.6
  • 36
    • 46749156706 scopus 로고    scopus 로고
    • Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins
    • 18568074 1:CAS:528:DC%2BD1cXot1Onurk%3D
    • Guix M, Faber AC, Wang SE, Olivares MG, Song Y, Qu S et al (2008) Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins. J Clin Invest 118(7):2609-2619
    • (2008) J Clin Invest , vol.118 , Issue.7 , pp. 2609-2619
    • Guix, M.1    Faber, A.C.2    Wang, S.E.3    Olivares, M.G.4    Song, Y.5    Qu, S.6
  • 37
    • 38049150665 scopus 로고    scopus 로고
    • MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
    • 18093943 10.1073/pnas.0710370104 1:CAS:528:DC%2BD1cXktlyhsg%3D%3D
    • Bean J, Brennan C, Shih JY, Riely G, Viale A, Wang L et al (2007) MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci USA 104(52):20932-20937
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.52 , pp. 20932-20937
    • Bean, J.1    Brennan, C.2    Shih, J.Y.3    Riely, G.4    Viale, A.5    Wang, L.6
  • 38
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • 17463250 10.1126/science.1141478 1:CAS:528:DC%2BD2sXltlOjt7g%3D
    • Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO et al (2007) MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316(5827):1039-1043
    • (2007) Science , vol.316 , Issue.5827 , pp. 1039-1043
    • Engelman, J.A.1    Zejnullahu, K.2    Mitsudomi, T.3    Song, Y.4    Hyland, C.5    Park, J.O.6
  • 40
    • 52049099853 scopus 로고    scopus 로고
    • PIK3CA mutations and copy number gains in human lung cancers
    • 18757405 10.1158/0008-5472.CAN-07-5084 1:CAS:528:DC%2BD1cXhtVCrs7%2FK
    • Yamamoto H, Shigematsu H, Nomura M, Lockwood WW, Sato M, Okumura N et al (2008) PIK3CA mutations and copy number gains in human lung cancers. Cancer Res 68(17):6913-6921
    • (2008) Cancer Res , vol.68 , Issue.17 , pp. 6913-6921
    • Yamamoto, H.1    Shigematsu, H.2    Nomura, M.3    Lockwood, W.W.4    Sato, M.5    Okumura, N.6
  • 41
    • 0037029712 scopus 로고    scopus 로고
    • Evaluation of HER-2/neu gene amplification and protein expression in non-small cell lung carcinomas
    • 11986780 10.1038/sj.bjc.6600286 1:CAS:528:DC%2BD38XkvVKjsb8%3D
    • Hirsch FR, Varella-Garcia M, Franklin WA, Veve R, Chen L, Helfrich B et al (2002) Evaluation of HER-2/neu gene amplification and protein expression in non-small cell lung carcinomas. Br J Cancer 86(9):1449-1456
    • (2002) Br J Cancer , vol.86 , Issue.9 , pp. 1449-1456
    • Hirsch, F.R.1    Varella-Garcia, M.2    Franklin, W.A.3    Veve, R.4    Chen, L.5    Helfrich, B.6
  • 42
    • 84858002759 scopus 로고    scopus 로고
    • Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu
    • 22325357 10.1016/j.lungcan.2012.01.008
    • De Greve J, Teugels E, Geers C, Decoster L, Galdermans D, De Mey J et al (2012) Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu. Lung Cancer 76(1):123-127
    • (2012) Lung Cancer , vol.76 , Issue.1 , pp. 123-127
    • De Greve, J.1    Teugels, E.2    Geers, C.3    Decoster, L.4    Galdermans, D.5    De Mey, J.6
  • 43
    • 33745057881 scopus 로고    scopus 로고
    • HER2 mutation and response to trastuzumab therapy in non-small-cell lung cancer
    • 16775247 10.1056/NEJMc060020 1:CAS:528:DC%2BD28Xlsl2ru7w%3D
    • Cappuzzo F, Bemis L, Varella-Garcia M (2006) HER2 mutation and response to trastuzumab therapy in non-small-cell lung cancer. N Engl J Med 354(24):2619-2621
    • (2006) N Engl J Med , vol.354 , Issue.24 , pp. 2619-2621
    • Cappuzzo, F.1    Bemis, L.2    Varella-Garcia, M.3
  • 44
    • 78049451972 scopus 로고    scopus 로고
    • Personalizing therapy in an epidermal growth factor receptor-tyrosine kinase inhibitor-resistant non-small-cell lung cancer using PF-00299804 and trastuzumab
    • 20679607 10.1200/JCO.2010.29.3126 1:CAS:528:DC%2BC3cXhtl2ks7jM
    • Kelly RJ, Carter C, Giaccone G (2010) Personalizing therapy in an epidermal growth factor receptor-tyrosine kinase inhibitor-resistant non-small-cell lung cancer using PF-00299804 and trastuzumab. J Clin Oncol 28(28):e507-e510
    • (2010) J Clin Oncol , vol.28 , Issue.28
    • Kelly, R.J.1    Carter, C.2    Giaccone, G.3
  • 45
    • 0031035052 scopus 로고    scopus 로고
    • Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system
    • 9053841 10.1038/sj.onc.1200849 1:CAS:528:DyaK2sXht1ensbs%3D
    • Iwahara T, Fujimoto J, Wen D, Cupples R, Bucay N, Arakawa T et al (1997) Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system. Oncogene 14(4):439-449
    • (1997) Oncogene , vol.14 , Issue.4 , pp. 439-449
    • Iwahara, T.1    Fujimoto, J.2    Wen, D.3    Cupples, R.4    Bucay, N.5    Arakawa, T.6
  • 46
    • 0028198206 scopus 로고
    • Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma
    • 8122112 10.1126/science.8122112 1:CAS:528:DyaK2cXis1aks7Y%3D
    • Morris SW, Kirstein MN, Valentine MB, Dittmer KG, Shapiro DN, Saltman DL et al (1994) Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science 263(5151):1281-1284
    • (1994) Science , vol.263 , Issue.5151 , pp. 1281-1284
    • Morris, S.W.1    Kirstein, M.N.2    Valentine, M.B.3    Dittmer, K.G.4    Shapiro, D.N.5    Saltman, D.L.6
  • 47
    • 34547638047 scopus 로고    scopus 로고
    • Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
    • 17625570 10.1038/nature05945 1:CAS:528:DC%2BD2sXosVSrtrs%3D
    • Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S et al (2007) Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 448(7153):561-566
    • (2007) Nature , vol.448 , Issue.7153 , pp. 561-566
    • Soda, M.1    Choi, Y.L.2    Enomoto, M.3    Takada, S.4    Yamashita, Y.5    Ishikawa, S.6
  • 48
    • 48549098388 scopus 로고    scopus 로고
    • Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer
    • 18593892 10.1158/0008-5472.CAN-07-6158 1:CAS:528:DC%2BD1cXnvFOqsbY%3D
    • Choi YL, Takeuchi K, Soda M, Inamura K, Togashi Y, Hatano S et al (2008) Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer. Cancer Res 68(13):4971-4976
    • (2008) Cancer Res , vol.68 , Issue.13 , pp. 4971-4976
    • Choi, Y.L.1    Takeuchi, K.2    Soda, M.3    Inamura, K.4    Togashi, Y.5    Hatano, S.6
  • 49
    • 37549060017 scopus 로고    scopus 로고
    • EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers
    • 18166835 10.1097/JTO.0b013e31815e8b60
    • Inamura K, Takeuchi K, Togashi Y, Nomura K, Ninomiya H, Okui M et al (2008) EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers. J Thorac Oncol 3(1):13-17
    • (2008) J Thorac Oncol , vol.3 , Issue.1 , pp. 13-17
    • Inamura, K.1    Takeuchi, K.2    Togashi, Y.3    Nomura, K.4    Ninomiya, H.5    Okui, M.6
  • 50
    • 70349336416 scopus 로고    scopus 로고
    • Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK
    • 19667264 10.1200/JCO.2009.22.6993 1:CAS:528:DC%2BD1MXht1WisbvF
    • Shaw AT, Yeap BY, Mino-Kenudson M, Digumarthy SR, Costa DB, Heist RS et al (2009) Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol 27(26):4247-4253
    • (2009) J Clin Oncol , vol.27 , Issue.26 , pp. 4247-4253
    • Shaw, A.T.1    Yeap, B.Y.2    Mino-Kenudson, M.3    Digumarthy, S.R.4    Costa, D.B.5    Heist, R.S.6
  • 51
    • 78049425319 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
    • 20979469 10.1056/NEJMoa1006448 1:CAS:528:DC%2BC3cXhtlKitL%2FO
    • Kwak EL, Bang YJ, Camidge DR, Shaw AT, Solomon B, Maki RG et al (2010) Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 363(18):1693-1703
    • (2010) N Engl J Med , vol.363 , Issue.18 , pp. 1693-1703
    • Kwak, E.L.1    Bang, Y.J.2    Camidge, D.R.3    Shaw, A.T.4    Solomon, B.5    Maki, R.G.6
  • 52
    • 84856990335 scopus 로고    scopus 로고
    • Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer
    • 22235099 10.1158/1078-0432.CCR-11-2906 1:CAS:528:DC%2BC38Xjt1Wksro%3D
    • Doebele RC, Pilling AB, Aisner DL, Kutateladze TG, Le AT, Weickhardt AJ et al (2012) Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer. Clin Cancer Res 18(5):1472-1482
    • (2012) Clin Cancer Res , vol.18 , Issue.5 , pp. 1472-1482
    • Doebele, R.C.1    Pilling, A.B.2    Aisner, D.L.3    Kutateladze, T.G.4    Le, A.T.5    Weickhardt, A.J.6
  • 53
    • 70349342712 scopus 로고    scopus 로고
    • EML4-ALK: Honing in on a new target in non-small-cell lung cancer
    • 19667260 10.1200/JCO.2009.23.6661 1:CAS:528:DC%2BD1MXht1WisbvE
    • Horn L, Pao W (2009) EML4-ALK: honing in on a new target in non-small-cell lung cancer. J Clin Oncol 27(26):4232-4235
    • (2009) J Clin Oncol , vol.27 , Issue.26 , pp. 4232-4235
    • Horn, L.1    Pao, W.2
  • 54
    • 84865431278 scopus 로고    scopus 로고
    • Results of a global phase II study with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC)
    • abstr 7533
    • Kim D-W, Ahn M-J, Shi Y, De Pas T-M, Yang P-C, Riely G-J et al. (2012) Results of a global phase II study with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC). J Clin Oncol 30 (suppl; abstr 7533)
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Kim, D.-W.1    Ahn, M.-J.2    Shi, Y.3    De Pas, T.-M.4    Yang, P.-C.5    Riely, G.-J.6
  • 55
    • 84872569905 scopus 로고    scopus 로고
    • Phase III study of crizotinib versus pemetrexed or docetaxel chemotherapy in patients with advanced ALKpositive non-small cell lung cancer (NSCLC) (PROFILE 1007)
    • Shaw AT, Kim D-W, Nakagawa K, Seto TC, L., Ahn M-J, Tassell V et al. (2012) Phase III study of crizotinib versus pemetrexed or docetaxel chemotherapy in patients with advanced ALKpositive non-small cell lung cancer (NSCLC) (PROFILE 1007) ESMO congress abst: LBA1
    • (2012) ESMO Congress Abst: LBA1
    • Shaw, A.T.1    Kim, D.-W.2    Nakagawa, K.3    Seto, T.C.L.4    Ahn, M.-J.5    Tassell, V.6
  • 57
    • 78049426513 scopus 로고    scopus 로고
    • EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors
    • 20979473 10.1056/NEJMoa1007478 1:CAS:528:DC%2BC3cXhtlKitL%2FJ
    • Choi YL, Soda M, Yamashita Y, Ueno T, Takashima J, Nakajima T et al (2010) EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors. N Engl J Med 363(18):1734-1739
    • (2010) N Engl J Med , vol.363 , Issue.18 , pp. 1734-1739
    • Choi, Y.L.1    Soda, M.2    Yamashita, Y.3    Ueno, T.4    Takashima, J.5    Nakajima, T.6
  • 58
    • 80052793410 scopus 로고    scopus 로고
    • A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors
    • 21791641 10.1158/0008-5472.CAN-11-1340 1:CAS:528:DC%2BC3MXhtFKntb3K
    • Sasaki T, Koivunen J, Ogino A, Yanagita M, Nikiforow S, Zheng W et al (2011) A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors. Cancer Res 71(18):6051-6060
    • (2011) Cancer Res , vol.71 , Issue.18 , pp. 6051-6060
    • Sasaki, T.1    Koivunen, J.2    Ogino, A.3    Yanagita, M.4    Nikiforow, S.5    Zheng, W.6
  • 59
    • 84863338079 scopus 로고    scopus 로고
    • ROS1 rearrangements define a unique molecular class of lung cancers
    • 22215748 10.1200/JCO.2011.35.6345 1:CAS:528:DC%2BC38XntV2lsbg%3D
    • Bergethon K, Shaw AT, Ou SH, Katayama R, Lovly CM, McDonald NT et al (2012) ROS1 rearrangements define a unique molecular class of lung cancers. J Clin Oncol 30(8):863-870
    • (2012) J Clin Oncol , vol.30 , Issue.8 , pp. 863-870
    • Bergethon, K.1    Shaw, A.T.2    Ou, S.H.3    Katayama, R.4    Lovly, C.M.5    McDonald, N.T.6
  • 60
    • 77955096407 scopus 로고    scopus 로고
    • KRAS mutations and resistance to EGFR-TKIs treatment in patients with non-small cell lung cancer: A meta-analysis of 22 studies
    • 20022659 10.1016/j.lungcan.2009.11.020
    • Mao C, Qiu LX, Liao RY, Du FB, Ding H, Yang WC et al (2010) KRAS mutations and resistance to EGFR-TKIs treatment in patients with non-small cell lung cancer: a meta-analysis of 22 studies. Lung Cancer 69(3):272-278
    • (2010) Lung Cancer , vol.69 , Issue.3 , pp. 272-278
    • Mao, C.1    Qiu, L.X.2    Liao, R.Y.3    Du, F.B.4    Ding, H.5    Yang, W.C.6
  • 61
    • 53249145767 scopus 로고    scopus 로고
    • Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma
    • 18794081 10.1158/1078-0432.CCR-08-0646 1:CAS:528:DC%2BD1cXhtFaitrrK
    • Riely GJ, Kris MG, Rosenbaum D, Marks J, Li A, Chitale DA et al (2008) Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma. Clin Cancer Res 14(18):5731-5734
    • (2008) Clin Cancer Res , vol.14 , Issue.18 , pp. 5731-5734
    • Riely, G.J.1    Kris, M.G.2    Rosenbaum, D.3    Marks, J.4    Li, A.5    Chitale, D.A.6
  • 62
    • 52749099497 scopus 로고    scopus 로고
    • Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: A systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer
    • 18804418 10.1016/S1470-2045(08)70206-7 1:CAS:528:DC%2BD1cXhtFOmurvJ
    • Linardou H, Dahabreh IJ, Kanaloupiti D, Siannis F, Bafaloukos D, Kosmidis P et al (2008) Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer. Lancet Oncol 9(10):962-972
    • (2008) Lancet Oncol , vol.9 , Issue.10 , pp. 962-972
    • Linardou, H.1    Dahabreh, I.J.2    Kanaloupiti, D.3    Siannis, F.4    Bafaloukos, D.5    Kosmidis, P.6
  • 63
    • 15744372810 scopus 로고    scopus 로고
    • KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib
    • 15696205 10.1371/journal.pmed.0020017
    • Pao W, Wang TY, Riely GJ, Miller VA, Pan Q, Ladanyi M et al (2005) KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS Med 2(1):e17
    • (2005) PLoS Med , vol.2 , Issue.1 , pp. 17
    • Pao, W.1    Wang, T.Y.2    Riely, G.J.3    Miller, V.A.4    Pan, Q.5    Ladanyi, M.6
  • 64
    • 79960894047 scopus 로고    scopus 로고
    • Molecular biomarkers in non-small-cell lung cancer: A retrospective analysis of data from the phase 3 FLEX study
    • 21782507 10.1016/S1470-2045(11)70189-9
    • O'Byrne KJ, Gatzemeier U, Bondarenko I, Barrios C, Eschbach C, Martens UM et al (2011) Molecular biomarkers in non-small-cell lung cancer: a retrospective analysis of data from the phase 3 FLEX study. Lancet Oncol 12(8):795-805
    • (2011) Lancet Oncol , vol.12 , Issue.8 , pp. 795-805
    • O'Byrne, K.J.1    Gatzemeier, U.2    Bondarenko, I.3    Barrios, C.4    Eschbach, C.5    Martens, U.M.6
  • 65
    • 80755181069 scopus 로고    scopus 로고
    • Prospective molecular marker analyses of EGFR and KRAS from a randomized, placebo-controlled study of erlotinib maintenance therapy in advanced non-small-cell lung cancer
    • 21969500 10.1200/JCO.2010.31.8162 1:CAS:528:DC%2BC3MXhs1CisLzP
    • Brugger W, Triller N, Blasinska-Morawiec M, Curescu S, Sakalauskas R, Manikhas GM et al (2011) Prospective molecular marker analyses of EGFR and KRAS from a randomized, placebo-controlled study of erlotinib maintenance therapy in advanced non-small-cell lung cancer. J Clin Oncol 29(31):4113-4120
    • (2011) J Clin Oncol , vol.29 , Issue.31 , pp. 4113-4120
    • Brugger, W.1    Triller, N.2    Blasinska-Morawiec, M.3    Curescu, S.4    Sakalauskas, R.5    Manikhas, G.M.6
  • 66
    • 52049090365 scopus 로고    scopus 로고
    • Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21
    • 18626007 10.1200/JCO.2007.14.8924 1:CAS:528:DC%2BD1cXhtF2it7bF
    • Zhu CQ, da Cunha SG, Ding K, Sakurada A, Cutz JC, Liu N et al (2008) Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21. J Clin Oncol 26(26):4268-4275
    • (2008) J Clin Oncol , vol.26 , Issue.26 , pp. 4268-4275
    • Zhu, C.Q.1    Da Cunha, S.G.2    Ding, K.3    Sakurada, A.4    Cutz, J.C.5    Liu, N.6
  • 67
    • 54549094903 scopus 로고    scopus 로고
    • Somatic mutations affect key pathways in lung adenocarcinoma
    • 18948947 10.1038/nature07423 1:CAS:528:DC%2BD1cXht1yju73J
    • Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, Cibulskis K et al (2008) Somatic mutations affect key pathways in lung adenocarcinoma. Nature 455(7216):1069-1075
    • (2008) Nature , vol.455 , Issue.7216 , pp. 1069-1075
    • Ding, L.1    Getz, G.2    Wheeler, D.A.3    Mardis, E.R.4    McLellan, M.D.5    Cibulskis, K.6
  • 68
    • 84866182159 scopus 로고    scopus 로고
    • Phase II double-blind, randomized study of selumetinib (SEL) plus docetaxel (DOC) versus DOC plus placebo as second-line treatment for advanced KRAS mutant non-small cell lung cancer (NSCLC)
    • abstr 7503 (30)
    • Pasi A. Janne, Alice Tsang Shaw, Jose Rodrigues Pereira, Gaelle Jeannin, Johan Vansteenkiste, Carlos H. Barrios et al. (2012) Phase II double-blind, randomized study of selumetinib (SEL) plus docetaxel (DOC) versus DOC plus placebo as second-line treatment for advanced KRAS mutant non-small cell lung cancer (NSCLC). J Clin Oncol suppl; abstr 7503 (30)
    • (2012) J Clin Oncol , Issue.SUPPL.
    • Janne, P.A.1    Tsang Shaw, A.2    Rodrigues Pereira, J.3    Jeannin, G.4    Vansteenkiste, J.5    Barrios, C.H.6
  • 69
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • 12068308 10.1038/nature00766 1:CAS:528:DC%2BD38XkvVagsLo%3D
    • Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S et al (2002) Mutations of the BRAF gene in human cancer. Nature 417(6892):949-954
    • (2002) Nature , vol.417 , Issue.6892 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3    Stephens, P.4    Edkins, S.5    Clegg, S.6
  • 70
    • 79956316170 scopus 로고    scopus 로고
    • Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations
    • 21483012 10.1200/JCO.2010.33.1280
    • Paik PK, Arcila ME, Fara M, Sima CS, Miller VA, Kris MG et al (2011) Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations. J Clin Oncol 29(15):2046-2051
    • (2011) J Clin Oncol , vol.29 , Issue.15 , pp. 2046-2051
    • Paik, P.K.1    Arcila, M.E.2    Fara, M.3    Sima, C.S.4    Miller, V.A.5    Kris, M.G.6
  • 71
    • 33751084640 scopus 로고    scopus 로고
    • PIK3CA mutation status in Japanese lung cancer patients
    • 16930767 10.1016/j.lungcan.2006.07.006
    • Kawano O, Sasaki H, Endo K, Suzuki E, Haneda H, Yukiue H et al (2006) PIK3CA mutation status in Japanese lung cancer patients. Lung Cancer 54(2):209-215
    • (2006) Lung Cancer , vol.54 , Issue.2 , pp. 209-215
    • Kawano, O.1    Sasaki, H.2    Endo, K.3    Suzuki, E.4    Haneda, H.5    Yukiue, H.6
  • 72
    • 84866894408 scopus 로고    scopus 로고
    • Comprehensive genomic characterization of squamous cell lung cancers
    • 10.1038/nature11404 1:CAS:528:DC%2BC38XhtlWqu7fN
    • Hammerman PS, Hayes DN, Wilkerson MD, Schultz N, Bose R, Chu A et al (2012) Comprehensive genomic characterization of squamous cell lung cancers. Nature 489(7417):519-525
    • (2012) Nature , vol.489 , Issue.7417 , pp. 519-525
    • Hammerman, P.S.1    Hayes, D.N.2    Wilkerson, M.D.3    Schultz, N.4    Bose, R.5    Chu, A.6
  • 73
    • 34548485621 scopus 로고    scopus 로고
    • PIK3CA gene amplification in Japanese non-small cell lung cancer
    • 17681398 10.1016/j.lungcan.2007.06.020
    • Kawano O, Sasaki H, Okuda K, Yukiue H, Yokoyama T, Yano M et al (2007) PIK3CA gene amplification in Japanese non-small cell lung cancer. Lung Cancer 58(1):159-160
    • (2007) Lung Cancer , vol.58 , Issue.1 , pp. 159-160
    • Kawano, O.1    Sasaki, H.2    Okuda, K.3    Yukiue, H.4    Yokoyama, T.5    Yano, M.6
  • 74
    • 34547172596 scopus 로고    scopus 로고
    • A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
    • 17611497 10.1038/nature05933 1:CAS:528:DC%2BD2sXotFajtbk%3D
    • Carpten JD, Faber AL, Horn C, Donoho GP, Briggs SL, Robbins CM et al (2007) A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 448(7152):439-444
    • (2007) Nature , vol.448 , Issue.7152 , pp. 439-444
    • Carpten, J.D.1    Faber, A.L.2    Horn, C.3    Donoho, G.P.4    Briggs, S.L.5    Robbins, C.M.6
  • 75
    • 41849132829 scopus 로고    scopus 로고
    • Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung
    • 18256540 10.4161/cc.7.5.5485 1:CAS:528:DC%2BD1cXlvFensbs%3D
    • Malanga D, Scrima M, De Marco C, Fabiani F, De Rosa N, De Gisi S et al (2008) Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung. Cell Cycle 7(5):665-669
    • (2008) Cell Cycle , vol.7 , Issue.5 , pp. 665-669
    • Malanga, D.1    Scrima, M.2    De Marco, C.3    Fabiani, F.4    De Rosa, N.5    De Gisi, S.6
  • 76
    • 0036094196 scopus 로고    scopus 로고
    • Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation
    • 12006535 1:CAS:528:DC%2BD38XksVWjsr8%3D
    • Soria JC, Lee HY, Lee JI, Wang L, Issa JP, Kemp BL et al (2002) Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation. Clin Cancer Res 8(5):1178-1184
    • (2002) Clin Cancer Res , vol.8 , Issue.5 , pp. 1178-1184
    • Soria, J.C.1    Lee, H.Y.2    Lee, J.I.3    Wang, L.4    Issa, J.P.5    Kemp, B.L.6
  • 77
    • 13944276728 scopus 로고    scopus 로고
    • Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer
    • 15735036 10.1158/0008-5472.CAN-04-2650 1:CAS:528:DC%2BD2MXhsFKqtLo%3D
    • Ma PC, Jagadeeswaran R, Jagadeesh S, Tretiakova MS, Nallasura V, Fox EA et al (2005) Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer. Cancer Res 65(4):1479-1488
    • (2005) Cancer Res , vol.65 , Issue.4 , pp. 1479-1488
    • Ma, P.C.1    Jagadeeswaran, R.2    Jagadeesh, S.3    Tretiakova, M.S.4    Nallasura, V.5    Fox, E.A.6
  • 78
    • 80051974548 scopus 로고    scopus 로고
    • Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer
    • 21768463 10.1200/JCO.2010.34.0570 1:CAS:528:DC%2BC3MXht1ajsrnL
    • Sequist LV, von Pawel J, Garmey EG, Akerley WL, Brugger W, Ferrari D et al (2011) Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer. J Clin Oncol 29(24):3307-3315
    • (2011) J Clin Oncol , vol.29 , Issue.24 , pp. 3307-3315
    • Sequist, L.V.1    Von Pawel, J.2    Garmey, E.G.3    Akerley, W.L.4    Brugger, W.5    Ferrari, D.6
  • 79
    • 80052511675 scopus 로고    scopus 로고
    • Final efficacy results from OAM4558g, a randomized phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC
    • abstr 7505
    • Spigel DR, Ervin TJ, Ramlau R, Daniel DB, Goldschmidt JH, Blumenschein GR et al. (2011) Final efficacy results from OAM4558g, a randomized phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC. J Clin Oncol 29 (suppl; abstr 7505)
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Spigel, D.R.1    Ervin, T.J.2    Ramlau, R.3    Daniel, D.B.4    Goldschmidt, J.H.5    Blumenschein, G.R.6
  • 80
    • 79955458487 scopus 로고    scopus 로고
    • Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification
    • 21623265 10.1097/JTO.0b013e31821528d3
    • Ou SH, Kwak EL, Siwak-Tapp C, Dy J, Bergethon K, Clark JW et al (2011) Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification. J Thorac Oncol 6(5):942-946
    • (2011) J Thorac Oncol , vol.6 , Issue.5 , pp. 942-946
    • Ou, S.H.1    Kwak, E.L.2    Siwak-Tapp, C.3    Dy, J.4    Bergethon, K.5    Clark, J.W.6
  • 81
    • 34748845413 scopus 로고    scopus 로고
    • Prevalence and specificity of LKB1 genetic alterations in lung cancers
    • 17384680 10.1038/sj.onc.1210418 1:CAS:528:DC%2BD2sXps12nur0%3D
    • Matsumoto S, Iwakawa R, Takahashi K, Kohno T, Nakanishi Y, Matsuno Y et al (2007) Prevalence and specificity of LKB1 genetic alterations in lung cancers. Oncogene 26(40):5911-5918
    • (2007) Oncogene , vol.26 , Issue.40 , pp. 5911-5918
    • Matsumoto, S.1    Iwakawa, R.2    Takahashi, K.3    Kohno, T.4    Nakanishi, Y.5    Matsuno, Y.6
  • 82
    • 78649679778 scopus 로고    scopus 로고
    • Roles of fibroblast growth factor receptors in carcinogenesis
    • 21047773 10.1158/1541-7786.MCR-10-0168 1:CAS:528:DC%2BC3cXhsVOktLnF
    • Haugsten EM, Wiedlocha A, Olsnes S, Wesche J (2010) Roles of fibroblast growth factor receptors in carcinogenesis. Mol Cancer Res 8(11):1439-1452
    • (2010) Mol Cancer Res , vol.8 , Issue.11 , pp. 1439-1452
    • Haugsten, E.M.1    Wiedlocha, A.2    Olsnes, S.3    Wesche, J.4
  • 83
    • 78650451788 scopus 로고    scopus 로고
    • Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
    • 21160078 10.1126/scitranslmed.3001451 1:CAS:528:DC%2BC3MXhsFWisLc%3D
    • Weiss J, Sos ML, Seidel D, Peifer M, Zander T, Heuckmann JM et al (2010) Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer. Sci Transl Med 2(62):62ra93
    • (2010) Sci Transl Med , vol.2 , Issue.62
    • Weiss, J.1    Sos, M.L.2    Seidel, D.3    Peifer, M.4    Zander, T.5    Heuckmann, J.M.6
  • 84
    • 77952309862 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor 1 (IGF1R) gene copy number is associated with survival in operable non-small-cell lung cancer: A comparison between IGF1R fluorescent in situ hybridization, protein expression, and mRNA expression
    • 20351332 10.1200/JCO.2009.24.6611
    • Dziadziuszko R, Merrick DT, Witta SE, Mendoza AD, Szostakiewicz B, Szymanowska A et al (2010) Insulin-like growth factor receptor 1 (IGF1R) gene copy number is associated with survival in operable non-small-cell lung cancer: a comparison between IGF1R fluorescent in situ hybridization, protein expression, and mRNA expression. J Clin Oncol 28(13):2174-2180
    • (2010) J Clin Oncol , vol.28 , Issue.13 , pp. 2174-2180
    • Dziadziuszko, R.1    Merrick, D.T.2    Witta, S.E.3    Mendoza, A.D.4    Szostakiewicz, B.5    Szymanowska, A.6
  • 85
    • 66349091290 scopus 로고    scopus 로고
    • Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer
    • 19380445 10.1200/JCO.2008.19.9331 1:CAS:528:DC%2BD1MXmvVOhsb4%3D
    • Karp DD, Paz-Ares LG, Novello S, Haluska P, Garland L, Cardenal F et al (2009) Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer. J Clin Oncol 27(15):2516-2522
    • (2009) J Clin Oncol , vol.27 , Issue.15 , pp. 2516-2522
    • Karp, D.D.1    Paz-Ares, L.G.2    Novello, S.3    Haluska, P.4    Garland, L.5    Cardenal, F.6
  • 86
    • 77956227862 scopus 로고    scopus 로고
    • Randomized, open label, phase III trial of figitumumab in combinations with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC)
    • abstract 7500
    • Jassem J LC, Karp DD (2010) Randomized, open label, phase III trial of figitumumab in combinations with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC). J Clin Oncol 28 (15suppl):abstract 7500
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL.
    • Jassem, J.L.C.1    Karp, D.D.2
  • 87
    • 84866709500 scopus 로고    scopus 로고
    • Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer
    • 22328973 10.1158/2159-8274.CD-11-0005 1:CAS:528:DC%2BC3MXpsVylsbg%3D
    • Hammerman PS, Sos ML, Ramos AH, Xu C, Dutt A, Zhou W et al (2011) Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. Cancer Discov 1(1):78-89
    • (2011) Cancer Discov , vol.1 , Issue.1 , pp. 78-89
    • Hammerman, P.S.1    Sos, M.L.2    Ramos, A.H.3    Xu, C.4    Dutt, A.5    Zhou, W.6
  • 88
    • 77952505658 scopus 로고    scopus 로고
    • SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas
    • 20126410 10.1371/journal.pone.0008960
    • Hussenet T, Dali S, Exinger J, Monga B, Jost B, Dembele D et al (2010) SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas. PLoS One 5(1):e8960
    • (2010) PLoS One , vol.5 , Issue.1 , pp. 8960
    • Hussenet, T.1    Dali, S.2    Exinger, J.3    Monga, B.4    Jost, B.5    Dembele, D.6
  • 89
    • 70350641014 scopus 로고    scopus 로고
    • SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas
    • 19801978 10.1038/ng.465 1:CAS:528:DC%2BD1MXht1Wgsb3M
    • Bass AJ, Watanabe H, Mermel CH, Yu S, Perner S, Verhaak RG et al (2009) SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet 41(11):1238-1242
    • (2009) Nat Genet , vol.41 , Issue.11 , pp. 1238-1242
    • Bass, A.J.1    Watanabe, H.2    Mermel, C.H.3    Yu, S.4    Perner, S.5    Verhaak, R.G.6
  • 90
    • 84857929267 scopus 로고    scopus 로고
    • KIF5B-RET fusions in lung adenocarcinoma
    • 22327624 10.1038/nm.2644 1:CAS:528:DC%2BC38XitFaltb8%3D
    • Kohno T, Ichikawa H, Totoki Y, Yasuda K, Hiramoto M, Nammo T et al (2012) KIF5B-RET fusions in lung adenocarcinoma. Nat Med 18(3):375-377
    • (2012) Nat Med , vol.18 , Issue.3 , pp. 375-377
    • Kohno, T.1    Ichikawa, H.2    Totoki, Y.3    Yasuda, K.4    Hiramoto, M.5    Nammo, T.6
  • 91
    • 84870748688 scopus 로고    scopus 로고
    • RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer
    • 23150706 10.1200/JCO.2012.44.1477 1:CAS:528:DC%2BC3sXhsV2kt7g%3D
    • Wang R, Hu H, Pan Y, Li Y, Ye T, Li C et al (2012) RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer. J Clin Oncol 30(35):4352-4359
    • (2012) J Clin Oncol , vol.30 , Issue.35 , pp. 4352-4359
    • Wang, R.1    Hu, H.2    Pan, Y.3    Li, Y.4    Ye, T.5    Li, C.6
  • 92
    • 0037115405 scopus 로고    scopus 로고
    • ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases
    • 12499271 1:CAS:528:DC%2BD3sXhtV2jsw%3D%3D
    • Carlomagno F, Vitagliano D, Guida T, Ciardiello F, Tortora G, Vecchio G et al (2002) ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases. Cancer Res 62(24):7284-7290
    • (2002) Cancer Res , vol.62 , Issue.24 , pp. 7284-7290
    • Carlomagno, F.1    Vitagliano, D.2    Guida, T.3    Ciardiello, F.4    Tortora, G.5    Vecchio, G.6
  • 93
    • 79957857433 scopus 로고    scopus 로고
    • The BATTLE trial: Personalizing therapy for lung cancer
    • 22586319 10.1158/2159-8274.CD-10-0010 1:CAS:528:DC%2BC3MXpsVylsb0%3D
    • Kim ES, Herbst RS, Wistuba II, Lee JJ, Blumenschein GR Jr, Tsao A et al (2011) The BATTLE trial: personalizing therapy for lung cancer. Cancer Discov 1(1):44-53
    • (2011) Cancer Discov , vol.1 , Issue.1 , pp. 44-53
    • Kim, E.S.1    Herbst, R.S.2    Wistuba, I.I.3    Lee, J.J.4    Blumenschein, Jr.G.R.5    Tsao, A.6
  • 94
    • 80555139776 scopus 로고    scopus 로고
    • Identification of driver mutations in tumor specimens from 1000 patients with lung adenocarcinoma: The NCI's Lung Cancer Mutation Consortium (LCMC)
    • abstract CRA 7506
    • Kris MG, Johnson BE, DJ K (2011) Identification of driver mutations in tumor specimens from 1000 patients with lung adenocarcinoma: the NCI's Lung Cancer Mutation Consortium (LCMC). J Clin Oncol 29:(Suppl, abstract CRA 7506)
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Kris, M.G.1    Johnson, B.E.2    Dj, K.3
  • 95
    • 84874937534 scopus 로고    scopus 로고
    • Upfront genomic testing for patients with non-small cell lung cancer (NSCLC) receiving first-line platinum-based regimen: Preliminary result of the MSN study
    • Planchard D, A. Rahal, L. Lacroix, M. Ngocamus, N. Auger, P. Saulnier et al. (2012) Upfront genomic testing for patients with non-small cell lung cancer (NSCLC) receiving first-line platinum-based regimen: preliminary result of the MSN study. ESMO-ELCC Abst: 810
    • (2012) ESMO-ELCC Abst: 810
    • Planchard, D.1    Rahal, A.2    Lacroix, L.3    Ngocamus, M.4    Auger, N.5    Saulnier, P.6
  • 96
    • 84864450130 scopus 로고    scopus 로고
    • Tumour molecular profiling for deciding therapy-the French initiative
    • 22777058 10.1038/nrclinonc.2012.42 1:CAS:528:DC%2BC38XhtFansrnJ
    • Nowak F, Soria JC, Calvo F (2012) Tumour molecular profiling for deciding therapy-the French initiative. Nat Rev Clin Oncol 9(8):479-486
    • (2012) Nat Rev Clin Oncol , vol.9 , Issue.8 , pp. 479-486
    • Nowak, F.1    Soria, J.C.2    Calvo, F.3
  • 97
    • 84860532031 scopus 로고    scopus 로고
    • Squamous cell carcinoma of the lung: Molecular subtypes and therapeutic opportunities
    • 22407829 10.1158/1078-0432.CCR-11-2370 1:CAS:528:DC%2BC38XmsFejur4%3D
    • Perez-Moreno P, Brambilla E, Thomas R, Soria JC (2012) Squamous cell carcinoma of the lung: molecular subtypes and therapeutic opportunities. Clin Cancer Res 18(9):2443-2451
    • (2012) Clin Cancer Res , vol.18 , Issue.9 , pp. 2443-2451
    • Perez-Moreno, P.1    Brambilla, E.2    Thomas, R.3    Soria, J.C.4
  • 98
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • 22397650 10.1056/NEJMoa1113205 1:CAS:528:DC%2BC38XktFOgtbw%3D
    • Gerlinger M, Rowan AJ, Horswell S, Larkin J, Endesfelder D, Gronroos E et al (2012) Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 366(10):883-892
    • (2012) N Engl J Med , vol.366 , Issue.10 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3    Larkin, J.4    Endesfelder, D.5    Gronroos, E.6
  • 99
    • 84864045330 scopus 로고    scopus 로고
    • EGFR mutation heterogeneity and the mixed response to EGFR tyrosine kinase inhibitors of lung adenocarcinomas
    • 22673630 10.1634/theoncologist.2011-0385
    • Chen ZY, Zhong WZ, Zhang XC, Su J, Yang XN, Chen ZH et al (2012) EGFR mutation heterogeneity and the mixed response to EGFR tyrosine kinase inhibitors of lung adenocarcinomas. Oncologist 17(7):978-985
    • (2012) Oncologist , vol.17 , Issue.7 , pp. 978-985
    • Chen, Z.Y.1    Zhong, W.Z.2    Zhang, X.C.3    Su, J.4    Yang, X.N.5    Chen, Z.H.6
  • 100
    • 51449101924 scopus 로고    scopus 로고
    • Comparison of EGFR and K-RAS gene status between primary tumours and corresponding metastases in NSCLC
    • 19238633 10.1038/sj.bjc.6604629 1:CAS:528:DC%2BD1cXhtV2jurrP
    • Kalikaki A, Koutsopoulos A, Trypaki M, Souglakos J, Stathopoulos E, Georgoulias V et al (2008) Comparison of EGFR and K-RAS gene status between primary tumours and corresponding metastases in NSCLC. Br J Cancer 99(6):923-929
    • (2008) Br J Cancer , vol.99 , Issue.6 , pp. 923-929
    • Kalikaki, A.1    Koutsopoulos, A.2    Trypaki, M.3    Souglakos, J.4    Stathopoulos, E.5    Georgoulias, V.6
  • 101
    • 68049088934 scopus 로고    scopus 로고
    • EGFR/KRAS/BRAF mutations in primary lung adenocarcinomas and corresponding locoregional lymph node metastases
    • 19584155 10.1158/1078-0432.CCR-09-0089 1:CAS:528:DC%2BD1MXosV2lt7o%3D
    • Schmid K, Oehl N, Wrba F, Pirker R, Pirker C, Filipits M (2009) EGFR/KRAS/BRAF mutations in primary lung adenocarcinomas and corresponding locoregional lymph node metastases. Clin Cancer Res 15(14):4554-4560
    • (2009) Clin Cancer Res , vol.15 , Issue.14 , pp. 4554-4560
    • Schmid, K.1    Oehl, N.2    Wrba, F.3    Pirker, R.4    Pirker, C.5    Filipits, M.6
  • 102
    • 43649099401 scopus 로고    scopus 로고
    • Intratumor heterogeneity of epidermal growth factor receptor mutations in lung cancer and its correlation to the response to gefitinib
    • 18325048 10.1111/j.1349-7006.2008.00782.x 1:CAS:528:DC%2BD1cXlslCrtr4%3D
    • Taniguchi K, Okami J, Kodama K, Higashiyama M, Kato K (2008) Intratumor heterogeneity of epidermal growth factor receptor mutations in lung cancer and its correlation to the response to gefitinib. Cancer Sci 99(5):929-935
    • (2008) Cancer Sci , vol.99 , Issue.5 , pp. 929-935
    • Taniguchi, K.1    Okami, J.2    Kodama, K.3    Higashiyama, M.4    Kato, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.