Induction of pluripotent stem cells from primordial germ cells by single reprogramming factors

Stem Cells

Volumn 31, Issue 3, 2013, Pages 479-487

  Nagamatsu, Go ^a   Kosaka, Takeo ^b   Saito, Shigeru ^c,d   Honda, Hiroaki ^e   Takubo, Keiyo ^a   Kinoshita, Taisuke ^a   Akiyama, Hideo ^f   Sudo, Tetsuo ^f   Horimoto, Katsuhisa ^c,g   Oya, Mototsugu ^b   Suda, Toshio ^a  

^a KEIO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^d INFOCOM Corporation   (Japan)

^e HIROSHIMA UNIVERSITY   (Japan)

^f Toray New Frontiers Research Laboratories   (Japan)

^g SHANGHAI UNIVERSITY   (China)

Author keywords

Germline; Microarray; Pluripotent stem cells; Reprogramming

Indexed keywords

B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; ERAS PROTEIN; KRUPPEL LIKE FACTOR 2; KRUPPEL LIKE FACTOR 4; KRUPPEL LIKE FACTOR 5; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; EMBRYONIC STEM CELL; ENDODERM; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; MESODERM; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PLURIPOTENT STEM CELL; PRIMORDIAL GERM CELL; SOMATIC CELL; TERATOMA;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GERM CELLS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED ICR; MICE, NUDE; MICE, TRANSGENIC; NUCLEAR REPROGRAMMING;

EID: 84874920929     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1303     Document Type: Article

References (37)

1. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126: 663-676.
2. Takahashi K, Tanabe K, Ohnuki M et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131: 861-872.
3. Hanna J, Wernig M, Markoulaki S et al. Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science 2007;318: 1920-1923.
4. Stadtfeld M, Maherali N, Breault DT et al. Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell 2008;2: 230-240.
5. Masaki H, Ishikawa T, Takahashi S et al. Heterogeneity of pluripotent marker gene expression in colonies generated in human iPS cell induction culture. Stem Cell Res 2007;1: 105-115.
6. Nagamatsu G, Saito S, Kosaka T et al. Optimal ratio of transcription factors for somatic cell reprogramming. J Biol Chem 2012;287: 36273-36282.
7. Nakagawa M, Koyanagi M, Tanabe K et al. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotechnol 2008;26: 101-106.
8. Nakagawa M, Takizawa N, Narita M et al. Promotion of direct reprogramming by transformation-deficient Myc. Proc Natl Acad Sci USA 2010;107: 14152-14157.
9. Matsui Y, Zsebo K, Hogan BL. Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture. Cell 1992;70: 841-847.
10. Kanatsu-Shinohara M, Inoue K, Lee J et al. Generation of pluripotent stem cells from neonatal mouse testis. Cell 2004;119: 1001-1012.
11. Nagamatsu G, Kosaka T, Kawasumi M et al. A germ cell specific gene, Prmt5 works as somatic cell reprogramming. J Biol Chem 2011; 2011: 26.
12. Okita K, Ichisaka T, Yamanaka S. Generation of germline-competent induced pluripotent stem cells. Nature 2007;448: 313-317.
13. Kinoshita T, Nagamatsu G, Kosaka T et al. Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells. Biochem Biophys Res Commun 2011;2011: 6.
14. Boyle EI, Weng S, Gollub J et al. GO::TermFinder-open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genes. Bioinformatics 2004;20: 3710-3715.
15. Feng B, Jiang J, Kraus P et al. Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nat Cell Biol 2009;11: 197-203.
16. Durcova-Hills G, Adams IR, Barton SC et al. The role of exogenous fibroblast growth factor-2 on the reprogramming of primordial germ cells into pluripotent stem cells. Stem Cells 2006;24: 1441-1449.
17. Tesar PJ, Chenoweth JG, Brook FA et al. New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature 2007;448: 196-199.
18. Yang J, van Oosten AL, Theunissen TW et al. Stat3 activation is limiting for reprogramming to ground state pluripotency. Cell Stem Cell 2010;7: 319-328.
19. Labosky PA, Barlow DP, Hogan BL. Mouse embryonic germ (EG) cell lines: Transmission through the germline and differences in the methylation imprint of insulin-like growth factor 2 receptor (Igf2r) gene compared with embryonic stem (ES) cell lines. Development 1994;120: 3197-3204.
20. Shovlin TC, Durcova-Hills G, Surani A et al. Heterogeneity in imprinted methylation patterns of pluripotent embryonic germ cells derived from pre-migratory mouse germ cells. Dev Biol 2008;313: 674-681.
21. Tanaka SS, Toyooka Y, Akasu R et al. The mouse homolog of Drosophila Vasa is required for the development of male germ cells. Genes Dev 2000;14: 841-853.
22. Vincent SD, Dunn NR, Sciammas R et al. The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse. Development 2005;132: 1315-1325.
23. Nagamatsu G, Kosaka T, Saito S et al. Tracing the conversion process for primordial germ cells to pluripotent stem cells in mice. Biol Reprod 2012;14: 14.
24. Guo G, Yang J, Nichols J et al. Klf4 reverts developmentally programmed restriction of ground state pluripotency. Development 2009;136: 1063-1069.
25. Kim K, Doi A, Wen B et al. Epigenetic memory in induced pluripotent stem cells. Nature 2010;467: 285-290.
26. Kim JB, Zaehres H, Wu G et al. Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. Nature 2008;454: 646-650.
27. Masui S, Nakatake Y, Toyooka Y et al. Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells. Nat Cell Biol 2007;9: 625-635.
28. Niwa H, Miyazaki J, Smith AG. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 2000;24: 372-376.
29. Wang Y, Chen J, Hu JL et al. Reprogramming of mouse and human somatic cells by high-performance engineered factors. EMBO Rep 2011;12: 373-378.
30. Hirai H, Tani T, Katoku-Kikyo N et al. Radical acceleration of nuclear reprogramming by chromatin remodeling with the transactivation domain of MyoD. Stem Cells 2011;29: 1349-1361.
31. Hirata T, Amano T, Nakatake Y et al. Zscan4 transiently reactivates early embryonic genes during the generation of induced pluripotent stem cells. Sci Rep 2012;2.
32. Toyooka Y, Shimosato D, Murakami K et al. Identification and characterization of subpopulations in undifferentiated ES cell culture. Development 2008;135: 909-918.
33. Chambers I, Silva J, Colby D et al. Nanog safeguards pluripotency and mediates germline development. Nature 2007;450: 1230-1234.
34. Zhao J, Kim KA, Abo A. Tipping the balance: Modulating the Wnt pathway for tissue repair. Trends Biotechnol 2009;27: 131-136.
35. Marson A, Foreman R, Chevalier B et al. Wnt signaling promotes reprogramming of somatic cells to pluripotency: Cell Stem Cell 2008; 3: 132-135.
36. Sato N, Meijer L, Skaltsounis L et al. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med 2004;10: 55-63.
37. de Lau W, Barker N, Low TY et al. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature 2011;476: 293-297.