Optimal ratio of transcription factors for somatic cell reprogramming

Journal of Biological Chemistry

Volumn 287, Issue 43, 2012, Pages 36273-36282

  Nagamatsu, Go ^a,c   Saito, Shigeru ^b,d   Kosaka, Takeo ^a   Takubo, Keiyo ^a   Kinoshita, Taisuke ^a   Oya, Mototsugu ^a   Horimoto, Katsuhisa ^b,e   Suda, Toshio ^a  

^a KEIO UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d INFOCOM Corporation   (Japan)

^e SHANGHAI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINES; EXPRESSION LEVELS; G-PROTEIN COUPLED RECEPTORS; GENE EXPRESSION PROFILES; MICROARRAY ANALYSIS; MOLECULAR BASIS; MOUSE EMBRYONIC FIBROBLASTS; PATHWAY ANALYSIS; PLURIPOTENT; PROMOTER ACTIVITIES; SIGNATURE GENES; SOMATIC CELLS; TAGGING SYSTEMS;

CELL CULTURE; EFFICIENCY; TRANSCRIPTION FACTORS;

CELLS;

G PROTEIN COUPLED RECEPTOR; KRUPPEL LIKE FACTOR 4; MONOCYTE CHEMOTACTIC PROTEIN 1; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR SOX2;

ANIMAL CELL; ARTICLE; CELL SELECTION; CONTROLLED STUDY; EMBRYO; FIBROBLAST; GENE EXPRESSION PROFILING; MICROARRAY ANALYSIS; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; SIGNAL TRANSDUCTION; SOMATIC CELL; UPREGULATION;

ANIMALS; CELL DEDIFFERENTIATION; CELLS, CULTURED; EMBRYO, MAMMALIAN; FIBROBLASTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; INDUCED PLURIPOTENT STEM CELLS; MICE; MICE, TRANSGENIC; PROTO-ONCOGENE PROTEINS; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 84867809581     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.380683     Document Type: Article

References (32)

1. Takahashi, K., and Yamanaka, S. (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676 (Pubitemid 44233629)
2. Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., and Yamanaka, S. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872 (Pubitemid 350138099)
3. Hanna, J., Wernig, M., Markoulaki, S., Sun, C. W., Meissner, A., Cassady, J. P., Beard, C., Brambrink, T., Wu, L. C., Townes, T. M., and Jaenisch, R. (2007) Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science 318, 1920-1923
4. Wernig, M., Zhao, J. P., Pruszak, J., Hedlund, E., Fu, D., Soldner, F., Broccoli, V., Constantine-Paton, M., Isacson, O., and Jaenisch, R. (2008) Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson disease. Proc. Natl. Acad. Sci. U.S.A. 105, 5856-5861 (Pubitemid 351758462)
5. Miura, K., Okada, Y., Aoi, T., Okada, A., Takahashi, K., Okita, K., Nakagawa, M., Koyanagi, M., Tanabe, K., Ohnuki, M., Ogawa, D., Ikeda, E., Okano, H., and Yamanaka, S. (2009) Variation in the safety of induced pluripotent stem cell lines. Nat. Biotechnol. 27, 743-745
6. Stadtfeld, M., Maherali, N., Breault, D. T., and Hochedlinger, K. (2008) Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell 2, 230-240
7. Araki, R., Jincho, Y., Hoki, Y., Nakamura, M., Tamura, C., Ando, S., Kasama, Y., and Abe, M. (2010) Conversion of ancestral fibroblasts to induced pluripotent stem cells. Stem Cells 28, 213-220
8. Okita, K., Ichisaka, T., and Yamanaka, S. (2007) Generation of germline-competent induced pluripotent stem cells. Nature 448, 313-317 (Pubitemid 47080336)
9. Han, D. W., Greber, B., Wu, G., Tapia, N., Araúzo-Bravo, M. J., Ko, K., Bernemann, C., Stehling, M., and Schöler, H. R. (2011) Direct reprogramming of fibroblasts into epiblast stem cells. Nat. Cell Biol. 13, 66-71
10. Efe, J. A., Hilcove, S., Kim, J., Zhou, H., Ouyang, K., Wang, G., Chen, J., and Ding, S. (2011) Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nat. Cell Biol. 13, 215-222
11. Nagamatsu, G., Kosaka, T., Kawasumi, M., Kinoshita, T., Takubo, K., Akiyama, H., Sudo, T., Kobayashi, T., Oya, M., and Suda, T. (2011) A germ cell-specific gene, Prmt5, works in somatic cell reprogramming. J. Biol. Chem. 286, 10641-10648
12. Hasegawa, K., Cowan, A. B., Nakatsuji, N., and Suemori, H. (2007) Efficient multicistronic expression of a transgene in human embryonic stem cells. Stem Cells 25, 1707-1712 (Pubitemid 47121848)
13. + T cells into the Th2 lineage by repressing GATA3 expression. J. Exp. Med. 198, 51-61
14. Yamasaki, S., Ishikawa, E., Sakuma, M., Ogata, K., Sakata-Sogawa, K., Hiroshima, M., Wiest, D. L., Tokunaga, M., and Saito, T. (2006) Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development. Nat. Immunol. 7, 67-75 (Pubitemid 41823870)
15. Takahashi, K., Okita, K., Nakagawa, M., and Yamanaka, S. (2007) Induction of pluripotent stem cells from fibroblast cultures. Nat. Protoc. 2, 3081-3089
16. Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., and Mesirov, J. P. (2005) Gene set enrichment analysis. A knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. U.S.A. 102, 15545-15550 (Pubitemid 41528093)
17. Boyle, E. I., Weng, S., Gollub, J., Jin, H., Botstein, D., Cherry, J. M., and Sherlock, G. (2004) GO::TermFinder. Open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genes. Bioinformatics 20, 3710-3715 (Pubitemid 40136825)
18. Szabo, E., Rampalli, S., Risueño, R. M., Schnerch, A., Mitchell, R., Fiebig- Comyn, A., Levadoux-Martin, M., and Bhatia, M. (2010) Direct conversion of human fibroblasts to multilineage blood progenitors. Nature 468, 521-526
19. Ying, Q. L., Wray, J., Nichols, J., Batlle-Morera, L., Doble, B., Woodgett, J., Cohen, P., and Smith, A. (2008) The ground state of embryonic stem cell self-renewal. Nature 453, 519-523 (Pubitemid 351733324)
20. Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J., and Melton, D. A. (2008) In vivo reprogramming of adult pancreatic exocrine cells to beta cells. Nature 455, 627-632
21. Sekiya, S., and Suzuki, A. (2011) Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors. Nature 475, 390-393
22. Wang, Y., Chen, J., Hu, J. L., Wei, X. X., Qin, D., Gao, J., Zhang, L., Jiang, J., Li, J. S., Liu, J., Lai, K. Y., Kuang, X., Zhang, J., Pei, D., and Xu, G. L. (2011) Reprogramming of mouse and human somatic cells by high-performance engineered factors. EMBO Rep. 12, 373-378
23. Hirai, H., Tani, T., Katoku-Kikyo, N., Kellner, S., Karian, P., Firpo, M., and Kikyo, N. (2011) Radical acceleration of nuclear reprogramming by chromatin remodeling with the transactivation domain of MyoD. Stem Cells 29, 1349-1361
24. Niwa, H., Miyazaki, J., and Smith, A. G. (2000) Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation, or self-renewal of ES cells. Nat. Genet. 24, 372-376 (Pubitemid 30187435)
25. Yamaguchi, S., Hirano, K., Nagata, S., and Tada, T. (2011) Sox2 expression effects on direct reprogramming efficiency as determined by alternative somatic cell fate. Stem Cell Res. 6, 177-186
26. Lin, Z., Perez, P., Lei, D., Xu, J., Gao, X., and Bao, J. (2011) Two-phase analysis of molecular pathways underlying induced pluripotent stem cell induction. Stem Cells 29, 1963-1974
27. Chen, T., Yuan, D., Wei, B., Jiang, J., Kang, J., Ling, K., Gu, Y., Li, J., Xiao, L., and Pei, G. (2010) E-cadherin-mediated cell-cell contact is critical for induced pluripotent stem cell generation. Stem Cells 28, 1315-1325
28. Redmer, T., Diecke, S., Grigoryan, T., Quiroga-Negreira, A., Birchmeier, W., and Besser, D. (2011) E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming. EMBO Rep. 12, 720-726
29. Hasegawa, Y., Takahashi, N., Forrest, A. R., Shin, J. W., Kinoshita, Y., Suzuki, H., and Hayashizaki, Y. (2011) CC chemokine ligand 2 and leukemia inhibitory factor cooperatively promote pluripotency in mouse induced pluripotent cells. Stem Cells 29, 1196-1205
30. Xu, P. F., Zhu, K. Y., Jin, Y., Chen, Y., Sun, X. J., Deng, M., Chen, S. J., Chen, Z., and Liu, T. X. (2010) Setdb2 restricts dorsal organizer territory and regulates left-right asymmetry through suppressing fgf8 activity. Proc. Natl. Acad. Sci. U.S.A. 107, 2521-2526
31. Hamamoto, R., Furukawa, Y., Morita, M., Iimura, Y., Silva, F. P., Li, M., Yagyu, R., and Nakamura, Y. (2004) SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. Nat. Cell Biol. 6, 731-740 (Pubitemid 39144478)
32. Stec, I., van Ommen, G. J., and den Dunnen, J. T. (2001) WHSC1L1, on human chromosome 8p11.2, closely resembles WHSC1 and maps to a duplicated region shared with 4p16.3. Genomics 76, 5-8 (Pubitemid 32744617)