메뉴 건너뛰기




Volumn 12, Issue 3, 2013, Pages 295-305

Neutralization of prolactin receptor function by monoclonal antibody LFA102, a novel potential therapeutic for the treatment of breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; LETROZOLE; MONOCLONAL ANTIBODY LFA102; NEUTRALIZING ANTIBODY; PROLACTIN RECEPTOR; UNCLASSIFIED DRUG;

EID: 84874919434     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-12-0886     Document Type: Article
Times cited : (55)

References (48)
  • 1
    • 34248190678 scopus 로고    scopus 로고
    • A prospective study of plasma prolactin concentrations and risk of premenopausal and postmenopausal breast cancer
    • Tworoger SS, Eliassen AH, Sluss P, Hankinson SE. A prospective study of plasma prolactin concentrations and risk of premenopausal and postmenopausal breast cancer. J Clin Oncol 2007;25: 1482-8.
    • (2007) J Clin Oncol , vol.25 , pp. 1482-1488
    • Tworoger, S.S.1    Eliassen, A.H.2    Sluss, P.3    Hankinson, S.E.4
  • 5
    • 15444353990 scopus 로고    scopus 로고
    • Increased expression of prolactin receptor gene assessed by quantitative polymerase chain reaction in human breast tumors versus normal breast tissues
    • Touraine P, Martini JF, Zafrani B, Durand JC, Labaille F, Malet C, et al. Increased expression of prolactin receptor gene assessed by quantitative polymerase chain reaction in human breast tumors versus normal breast tissues. J Clin Endocrinol Metab 1998;83: 667-74.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 667-674
    • Touraine, P.1    Martini, J.F.2    Zafrani, B.3    Durand, J.C.4    Labaille, F.5    Malet, C.6
  • 6
    • 79953754929 scopus 로고    scopus 로고
    • Growth hormone signaling in human T47D breast cancer cells: Potential role for a growth hormone receptor-prolactin receptor complex
    • Xu J, Zhang Y, Berry PA, Jiang J, Lobie PE, Langenheim JF, et al. Growth hormone signaling in human T47D breast cancer cells: potential role for a growth hormone receptor-prolactin receptor complex. Mol Endocrinol 2011;25: 597-610.
    • (2011) Mol Endocrinol , vol.25 , pp. 597-610
    • Xu, J.1    Zhang, Y.2    Berry, P.A.3    Jiang, J.4    Lobie, P.E.5    Langenheim, J.F.6
  • 8
    • 0242267055 scopus 로고    scopus 로고
    • Src mediates prolactin-dependent proliferation of T47D and MCF7 cells via the activation of focal adhesion kinase/Erk1/2 and phosphatidylinositol 3-kinase pathways
    • Acosta JJ, Munoz RM, Gonzalez L, Subtil-Rodriguez A, Dominguez- Caceres MA, Garcia-Martinez JM, et al. Src mediates prolactin-dependent proliferation of T47D and MCF7 cells via the activation of focal adhesion kinase/Erk1/2 and phosphatidylinositol 3-kinase pathways. Mol Endocrinol 2003;17: 2268-82.
    • (2003) Mol Endocrinol , vol.17 , pp. 2268-2282
    • Acosta, J.J.1    Munoz, R.M.2    Gonzalez, L.3    Subtil-Rodriguez, A.4    Dominguez-Caceres, M.A.5    Garcia-Martinez, J.M.6
  • 9
    • 80051473568 scopus 로고    scopus 로고
    • Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells
    • Aksamitiene E, Achanta S, Kolch W, Kholodenko BN, Hoek JB, Kiyatkin A. Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells. Cell Signal 2011;23: 1794-805.
    • (2011) Cell Signal , vol.23 , pp. 1794-1805
    • Aksamitiene, E.1    Achanta, S.2    Kolch, W.3    Kholodenko, B.N.4    Hoek, J.B.5    Kiyatkin, A.6
  • 10
    • 34547441513 scopus 로고    scopus 로고
    • The Janus kinase 2 is required for expression and nuclear accumulation of cyclin D1 in proliferating mammary epithelial cells
    • Sakamoto K, Creamer BA, Triplett AA, Wagner KU. The Janus kinase 2 is required for expression and nuclear accumulation of cyclin D1 in proliferating mammary epithelial cells. Mol Endocrinol 2007;21: 1877-92.
    • (2007) Mol Endocrinol , vol.21 , pp. 1877-1892
    • Sakamoto, K.1    Creamer, B.A.2    Triplett, A.A.3    Wagner, K.U.4
  • 11
    • 77950873516 scopus 로고    scopus 로고
    • Prolactin enhances insulin-like growth factor i receptor phosphorylation by decreasing its association with the tyrosine phosphatase SHP-2 in MCF-7 breast cancer cells
    • Carver KC, Piazza TM, Schuler LA. Prolactin enhances insulin-like growth factor I receptor phosphorylation by decreasing its association with the tyrosine phosphatase SHP-2 in MCF-7 breast cancer cells. J Biol Chem 2010;285: 8003-12.
    • (2010) J Biol Chem , vol.285 , pp. 8003-8012
    • Carver, K.C.1    Piazza, T.M.2    Schuler, L.A.3
  • 12
    • 42049116315 scopus 로고    scopus 로고
    • Prolactin does not require insulin-like growth factor intermediates but synergizes with insulin-like growth factor i in human breast cancer cells
    • Carver KC, Schuler LA. Prolactin does not require insulin-like growth factor intermediates but synergizes with insulin-like growth factor I in human breast cancer cells. Mol Cancer Res 2008;6: 634-43.
    • (2008) Mol Cancer Res , vol.6 , pp. 634-643
    • Carver, K.C.1    Schuler, L.A.2
  • 13
    • 33845528355 scopus 로고    scopus 로고
    • Prolactin modulates phosphorylation, signaling and trafficking of epidermal growth factor receptor in human T47D breast cancer cells
    • Huang Y, Li X, Jiang J, Frank SJ. Prolactin modulates phosphorylation, signaling and trafficking of epidermal growth factor receptor in human T47D breast cancer cells. Oncogene 2006;25: 7565-76.
    • (2006) Oncogene , vol.25 , pp. 7565-7576
    • Huang, Y.1    Li, X.2    Jiang, J.3    Frank, S.J.4
  • 14
    • 59649112705 scopus 로고    scopus 로고
    • Estrogen receptor-alpha mediates the epidermal growth factor-stimulated prolactin expression and release in lactotrophs
    • Ben-Jonathan N, Chen S, Dunckley JA, LaPensee C, Kansra S. Estrogen receptor-alpha mediates the epidermal growth factor-stimulated prolactin expression and release in lactotrophs. Endocrinology 2009;150: 795-802.
    • (2009) Endocrinology , vol.150 , pp. 795-802
    • Ben-Jonathan, N.1    Chen, S.2    Dunckley, J.A.3    Lapensee, C.4    Kansra, S.5
  • 15
    • 0034721797 scopus 로고    scopus 로고
    • Constitutive tyrosine phosphorylation of ErbB-2 via Jak2 by autocrine secretion of prolactin in human breast cancer
    • Yamauchi T, Yamauchi N, Ueki K, Sugiyama T, Waki H, Miki H, et al. Constitutive tyrosine phosphorylation of ErbB-2 via Jak2 by autocrine secretion of prolactin in human breast cancer. J Biol Chem 2000;275: 33937-44.
    • (2000) J Biol Chem , vol.275 , pp. 33937-33944
    • Yamauchi, T.1    Yamauchi, N.2    Ueki, K.3    Sugiyama, T.4    Waki, H.5    Miki, H.6
  • 16
    • 0022978393 scopus 로고
    • Prospective randomized trial concerning hyper- and normoprolactinemia and the use of bromoergocryptine in patients with metastatic breast cancer
    • Fritze D, Queisser W, Schmid H, Kaufmann M, Massner B, Westerhausen M, et al. Prospective randomized trial concerning hyper- and normoprolactinemia and the use of bromoergocryptine in patients with metastatic breast cancer. Onkologie 1986;9: 305-12.
    • (1986) Onkologie , vol.9 , pp. 305-312
    • Fritze, D.1    Queisser, W.2    Schmid, H.3    Kaufmann, M.4    Massner, B.5    Westerhausen, M.6
  • 17
    • 0023891112 scopus 로고
    • Bromocriptine in chemotherapy-resistant metastatic breast cancer. Results of the GO-MC-BROMO 282 AIO study
    • Holtkamp W, Nagel GA. [Bromocriptine in chemotherapy-resistant, metastatic breast cancer. Results of the GO-MC-BROMO 2/82 AIO Study]. Onkologie 1988;11: 121-7.
    • (1988) Onkologie , vol.11 , pp. 121-127
    • Holtkamp, W.1    Nagel, G.A.2
  • 19
    • 0030621563 scopus 로고    scopus 로고
    • Prolactin as an autocrine/paracrine factor in breast tissue
    • Clevenger CV, Plank TL. Prolactin as an autocrine/paracrine factor in breast tissue. J Mammary Gland Biol Neoplasia 1997;2: 59-68.
    • (1997) J Mammary Gland Biol Neoplasia , vol.2 , pp. 59-68
    • Clevenger, C.V.1    Plank, T.L.2
  • 21
    • 80052019392 scopus 로고    scopus 로고
    • Overexpression of P53 protein and local hGH, IGF-I, IGFBP-3, IGFBP- 2 and PRL secretion by human breast cancer explants
    • Milewicz T, Rys J, Wojtowicz A, Stochmal E, Jach R, Krzysiek J, et al. Overexpression of P53 protein and local hGH, IGF-I, IGFBP-3, IGFBP- 2 and PRL secretion by human breast cancer explants. Neuro Endocrinol Lett 2011;32: 328-33.
    • (2011) Neuro Endocrinol Lett , vol.32 , pp. 328-333
    • Milewicz, T.1    Rys, J.2    Wojtowicz, A.3    Stochmal, E.4    Jach, R.5    Krzysiek, J.6
  • 22
    • 80053499096 scopus 로고    scopus 로고
    • Tumor expression of human growth hormone and human prolactin predict a worse survival outcome in patients with mammary or endometrial carcinoma
    • Wu ZS, Yang K, Wan Y, Qian PX, Perry JK, Chiesa J, et al. Tumor expression of human growth hormone and human prolactin predict a worse survival outcome in patients with mammary or endometrial carcinoma. J Clin Endocrinol Metab 2011;96:E1619-29.
    • (2011) J Clin Endocrinol Metab , vol.96
    • Wu, Z.S.1    Yang, K.2    Wan, Y.3    Qian, P.X.4    Perry, J.K.5    Chiesa, J.6
  • 23
    • 3142707259 scopus 로고    scopus 로고
    • Activation of signal transducer and activator of transcription 5 in human prostate cancer is associated with high histological grade
    • Li H, Ahonen TJ, Alanen K, Xie J, LeBaron MJ, Pretlow TG, et al. Activation of signal transducer and activator of transcription 5 in human prostate cancer is associated with high histological grade. Cancer Res 2004;64: 4774-82.
    • (2004) Cancer Res , vol.64 , pp. 4774-4782
    • Li, H.1    Ahonen, T.J.2    Alanen, K.3    Xie, J.4    Lebaron, M.J.5    Pretlow, T.G.6
  • 24
    • 0034864156 scopus 로고    scopus 로고
    • S179D-human PRL, a pseudophosphorylated human PRL analog, is an agonist and not an antagonist
    • Bernichtein S, Kinet S, Jeay S, Llovera M, Madern D, Martial JA, et al. S179D-human PRL, a pseudophosphorylated human PRL analog, is an agonist and not an antagonist. Endocrinology 2001;142: 3950-63.
    • (2001) Endocrinology , vol.142 , pp. 3950-3963
    • Bernichtein, S.1    Kinet, S.2    Jeay, S.3    Llovera, M.4    Madern, D.5    Martial, J.A.6
  • 25
    • 18844447250 scopus 로고    scopus 로고
    • Development and potential clinical uses of human prolactin receptor antagonists
    • Goffin V, Bernichtein S, Touraine P, Kelly PA. Development and potential clinical uses of human prolactin receptor antagonists. Endocr Rev 2005;26: 400-22.
    • (2005) Endocr Rev , vol.26 , pp. 400-422
    • Goffin, V.1    Bernichtein, S.2    Touraine, P.3    Kelly, P.A.4
  • 26
    • 0031790107 scopus 로고    scopus 로고
    • Development of recombinant human prolactin receptor antagonists by molecular mimicry of the phosphorylated hormone
    • Chen TJ,KuoCB, TsaiKF, LiuJW,ChenDY,WalkerAM.Development of recombinant human prolactin receptor antagonists by molecular mimicry of the phosphorylated hormone. Endocrinology 1998;139: 609-16.
    • (1998) Endocrinology , vol.139 , pp. 609-616
    • Chen, T.J.1    Kuo, C.B.2    Tsai, K.F.3    Liu, J.W.4    Chen, D.Y.5    Walker, A.M.6
  • 27
    • 0032758264 scopus 로고    scopus 로고
    • A human prolactin antagonist, hPRL-G129R, inhibits breast cancer cell proliferation through induction of apoptosis
    • Chen WY, Ramamoorthy P, Chen N, Sticca R, Wagner TE. A human prolactin antagonist, hPRL-G129R, inhibits breast cancer cell proliferation through induction of apoptosis. Clin Cancer Res 1999;5: 3583-93.
    • (1999) Clin Cancer Res , vol.5 , pp. 3583-3593
    • Chen, W.Y.1    Ramamoorthy, P.2    Chen, N.3    Sticca, R.4    Wagner, T.E.5
  • 28
    • 40249111487 scopus 로고    scopus 로고
    • From bench to bedside: Future potential for the translation of prolactin inhibitors as breast cancer therapeutics
    • Clevenger CV, Zheng J, Jablonski EM, Galbaugh TL, Fang F. From bench to bedside: future potential for the translation of prolactin inhibitors as breast cancer therapeutics. J Mammary Gland Biol Neoplasia 2008;13: 147-56.
    • (2008) J Mammary Gland Biol Neoplasia , vol.13 , pp. 147-156
    • Clevenger, C.V.1    Zheng, J.2    Jablonski, E.M.3    Galbaugh, T.L.4    Fang, F.5
  • 29
    • 84856720066 scopus 로고    scopus 로고
    • The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation: Insight from structures of the prolactin receptor
    • Dagil R, Knudsen MJ, Olsen JG, O'Shea C, Franzmann M, Goffin V, et al. The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation: insight from structures of the prolactin receptor. Structure 2012;20: 270-82.
    • (2012) Structure , vol.20 , pp. 270-282
    • Dagil, R.1    Knudsen, M.J.2    Olsen, J.G.3    O'Shea, C.4    Franzmann, M.5    Goffin, V.6
  • 31
    • 78049441033 scopus 로고    scopus 로고
    • Structural characterization of the stem-stem dimerization interface between prolactin receptor chains complexed with the natural hormone
    • van AJ, Zhang C, Tallet E, Raynal B, Hoos S, Baron B, et al. Structural characterization of the stem-stem dimerization interface between prolactin receptor chains complexed with the natural hormone. J Mol Biol 2010;404: 112-26.
    • (2010) J Mol Biol , vol.404 , pp. 112-126
    • Van Aj Zhang, C.1    Tallet, E.2    Raynal, B.3    Hoos, S.4    Baron, B.5
  • 32
    • 0029991439 scopus 로고    scopus 로고
    • Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer
    • Baselga J, Tripathy D, Mendelsohn J, Baughman S, Benz CC, Dantis L, et al. Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer. J Clin Oncol 1996;14: 737-44.
    • (1996) J Clin Oncol , vol.14 , pp. 737-744
    • Baselga, J.1    Tripathy, D.2    Mendelsohn, J.3    Baughman, S.4    Benz, C.C.5    Dantis, L.6
  • 33
    • 0034455797 scopus 로고    scopus 로고
    • Rescue of preimplantatory egg development and embryo implantation in prolactin receptor-deficient mice after progesterone administration
    • Binart N, Helloco C, Ormandy CJ, Barra J, Clement-Lacroix P, Baran N, et al. Rescue of preimplantatory egg development and embryo implantation in prolactin receptor-deficient mice after progesterone administration. Endocrinology 2000;141: 2691-7.
    • (2000) Endocrinology , vol.141 , pp. 2691-2697
    • Binart, N.1    Helloco, C.2    Ormandy, C.J.3    Barra, J.4    Clement-Lacroix, P.5    Baran, N.6
  • 35
    • 0028156792 scopus 로고
    • The use of severe combined immunodeficiency mice to study the metabolism of human immunoglobulin G
    • Zuckier LS, Georgescu L, Chang CJ, Scharff MD, Morrison SL. The use of severe combined immunodeficiency mice to study the metabolism of human immunoglobulin G. Cancer 1994;73 Suppl: 794-9.
    • (1994) Cancer , vol.73 , Issue.SUPPL. , pp. 794-799
    • Zuckier, L.S.1    Georgescu, L.2    Chang, C.J.3    Scharff, M.D.4    Morrison, S.L.5
  • 36
    • 0028095487 scopus 로고
    • Immunocytochemical localization of prolactin receptors in rat liver cells: I. Dependence on sex and sex steroids
    • Smirnova OV, Petraschuk OM, Kelly PA. Immunocytochemical localization of prolactin receptors in rat liver cells: I. Dependence on sex and sex steroids. Mol Cell Endocrinol 1994;105: 77-81.
    • (1994) Mol Cell Endocrinol , vol.105 , pp. 77-81
    • Smirnova, O.V.1    Petraschuk, O.M.2    Kelly, P.A.3
  • 37
    • 0023191190 scopus 로고
    • Role of serum in the prolactin responsiveness of MCF-7 human breast cancer cells in long-term tissue culture
    • Biswas R, Vonderhaar BK. Role of serum in the prolactin responsiveness of MCF-7 human breast cancer cells in long-term tissue culture. Cancer Res 1987;47: 3509-14.
    • (1987) Cancer Res , vol.47 , pp. 3509-3514
    • Biswas, R.1    Vonderhaar, B.K.2
  • 38
    • 63849281305 scopus 로고    scopus 로고
    • Insensitivity of human prolactin receptors to nonhuman prolactins: Relevance for experimental modeling of prolactin receptor-expressing human cells
    • Utama FE, Tran TH, Ryder A, LeBaron MJ, Parlow AF, Rui H. Insensitivity of human prolactin receptors to nonhuman prolactins: relevance for experimental modeling of prolactin receptor-expressing human cells. Endocrinology 2009;150: 1782-90.
    • (2009) Endocrinology , vol.150 , pp. 1782-1790
    • Utama, F.E.1    Tran, T.H.2    Ryder, A.3    Lebaron, M.J.4    Parlow, A.F.5    Rui, H.6
  • 39
    • 33645213701 scopus 로고    scopus 로고
    • Human prolactin receptors are insensitive to mouse prolactin: Implications for xenotransplant modeling of human breast cancer in mice
    • Utama FE, LeBaron MJ, Neilson LM, Sultan AS, Parlow AF, Wagner KU, et al.Human prolactin receptors are insensitive to mouse prolactin: implications for xenotransplant modeling of human breast cancer in mice. J Endocrinol 2006;188: 589-601.
    • (2006) J Endocrinol , vol.188 , pp. 589-601
    • Utama, F.E.1    Lebaron, M.J.2    Neilson, L.M.3    Sultan, A.S.4    Parlow, A.F.5    Wagner, K.U.6
  • 40
    • 0027230575 scopus 로고
    • Anti-tumor and endocrine effects of non-steroidal aromatase inhibitors on estrogen- dependent rat mammary tumors
    • Schieweck K, Bhatnagar AS, Batzl C, Lang M. Anti-tumor and endocrine effects of non-steroidal aromatase inhibitors on estrogen- dependent rat mammary tumors. J Steroid Biochem Mol Biol 1993;44: 633-6.
    • (1993) J Steroid Biochem Mol Biol , vol.44 , pp. 633-636
    • Schieweck, K.1    Bhatnagar, A.S.2    Batzl, C.3    Lang, M.4
  • 41
    • 0030690027 scopus 로고    scopus 로고
    • The relevance of preclinical models to the treatment of postmenopausal breast cancer
    • Dukes M. The relevance of preclinical models to the treatment of postmenopausal breast cancer. Oncology 1997;54 Suppl 2: 6-10.
    • (1997) Oncology , vol.54 , Issue.SUPPL. 2 , pp. 6-10
    • Dukes, M.1
  • 42
    • 0036550062 scopus 로고    scopus 로고
    • In vivo studies of the anti-tumor effects of a human prolactin antagonist, hPRLG129R
    • Chen NY, Holle L, Li W, Peirce SK, Beck MT, Chen WY. In vivo studies of the anti-tumor effects of a human prolactin antagonist, hPRLG129R. Int J Oncol 2002;20: 813-8.
    • (2002) Int J Oncol , vol.20 , pp. 813-818
    • Chen, N.Y.1    Holle, L.2    Li, W.3    Peirce, S.K.4    Beck, M.T.5    Chen, W.Y.6
  • 43
    • 0345257112 scopus 로고    scopus 로고
    • Inhibition of prolactin (PRL)-induced proliferative signals in breast cancer cells by a molecular mimic of phosphorylated PRL
    • Schroeder MD, Brockman JL, Walker AM, Schuler LA. Inhibition of prolactin (PRL)-induced proliferative signals in breast cancer cells by a molecular mimic of phosphorylated PRL, S179D-PRL. Endocrinology 2003;144: 5300-7.
    • (2003) S179D-PRL. Endocrinology , vol.144 , pp. 5300-5307
    • Schroeder, M.D.1    Brockman, J.L.2    Walker, A.M.3    Schuler, L.A.4
  • 44
    • 9544220647 scopus 로고    scopus 로고
    • Long-acting growth hormones produced by conjugation with polyethylene glycol
    • Clark R, Olson K, Fuh G, Marian M, Mortensen D, Teshima G, et al. Long-acting growth hormones produced by conjugation with polyethylene glycol. J Biol Chem 1996;271: 21969-77.
    • (1996) J Biol Chem , vol.271 , pp. 21969-21977
    • Clark, R.1    Olson, K.2    Fuh, G.3    Marian, M.4    Mortensen, D.5    Teshima, G.6
  • 46
    • 37549011436 scopus 로고    scopus 로고
    • Elements related to heterogeneity of antibody-dependent cell cytotoxicity in patients under trastuzumab therapy for primary operable breast cancer overexpressing Her2
    • Varchetta S, Gibelli N, Oliviero B, Nardini E, Gennari R, Gatti G, et al. Elements related to heterogeneity of antibody-dependent cell cytotoxicity in patients under trastuzumab therapy for primary operable breast cancer overexpressing Her2. Cancer Res 2007;67: 11991-9.
    • (2007) Cancer Res , vol.67 , pp. 11991-11999
    • Varchetta, S.1    Gibelli, N.2    Oliviero, B.3    Nardini, E.4    Gennari, R.5    Gatti, G.6
  • 47
    • 61449239114 scopus 로고    scopus 로고
    • Impact of Fc{gamma}RIIa-Fc{gamma}RIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan
    • Bibeau F, Lopez-Crapez E, Di FF, Thezenas S, Ychou M, Blanchard F, et al. Impact of Fc{gamma}RIIa-Fc{gamma}RIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan. J Clin Oncol 2009;27: 1122-9.
    • (2009) J Clin Oncol , vol.27 , pp. 1122-1129
    • Bibeau, F.1    Lopez-Crapez, E.2    Di, F.F.3    Thezenas, S.4    Ychou, M.5    Blanchard, F.6
  • 48
    • 8544242334 scopus 로고    scopus 로고
    • Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse
    • Ormandy CJ, Camus A, Barra J, Damotte D, Lucas B, Buteau H, et al. Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes Dev 1997;11: 167-78.
    • (1997) Genes Dev , vol.11 , pp. 167-178
    • Ormandy, C.J.1    Camus, A.2    Barra, J.3    Damotte, D.4    Lucas, B.5    Buteau, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.