메뉴 건너뛰기




Volumn 8, Issue , 2012, Pages 343-351

Profile of ranibizumab: Efficacy and safety for the treatment of wet age-related macular degeneration

Author keywords

Age related macular degeneration; Choroidal neovascularization; Efficacy; Ranibizumab; Safety

Indexed keywords

RANIBIZUMAB; VASCULOTROPIN A; VERTEPORFIN;

EID: 84874916844     PISSN: 11766336     EISSN: 1178203X     Source Type: Journal    
DOI: 10.2147/TCRM.S32801     Document Type: Review
Times cited : (15)

References (48)
  • 1
    • 6344241300 scopus 로고    scopus 로고
    • The epidemiology of age-related macular degeneration
    • Seddon JM, Chen CA. The epidemiology of age-related macular degeneration. Int Ophthalmol Clin. 2004;44:17-39.
    • (2004) Int Ophthalmol Clin , vol.44 , pp. 17-39
    • Seddon, J.M.1    Chen, C.A.2
  • 2
    • 1942542429 scopus 로고    scopus 로고
    • Age-related macular degeneration is the leading cause of blindness
    • Bressler NM. Age-related macular degeneration is the leading cause of blindness. JAMA. 2004;291:1900-1901.
    • (2004) JAMA , vol.291 , pp. 1900-1901
    • Bressler, N.M.1
  • 3
    • 0021752680 scopus 로고
    • Age-related macular degeneration and blindness due to neovascular maculopathy
    • Ferris FL 3rd, Fine SL, Hyman L. Age-related macular degeneration and blindness due to neovascular maculopathy. Arch Ophthalmol. 1984;102:1640-1642.
    • (1984) Arch Ophthalmol , vol.102 , pp. 1640-1642
    • Ferris III, F.L.1    Fine, S.L.2    Hyman, L.3
  • 4
    • 70649094281 scopus 로고    scopus 로고
    • Neovascular age-related macular degeneration: Intraocular cytokines and growth factors and the influence of therapy with ranibizumab
    • Funk M, Karl D, Georgopoulos M. Neovascular age-related macular degeneration: intraocular cytokines and growth factors and the influence of therapy with ranibizumab. Ophthalmology. 2009;116: 2393-2399.
    • (2009) Ophthalmology , vol.116 , pp. 2393-2399
    • Funk, M.1    Karl, D.2    Georgopoulos, M.3
  • 5
    • 0142122287 scopus 로고    scopus 로고
    • Retinal and choroidal angiogenesis: Pathophysiology and strategies for inhibition
    • Das A, McGuire PG. Retinal and choroidal angiogenesis: pathophysiology and strategies for inhibition. Prog Retin Eye Res. 2003;22:721-748.
    • (2003) Prog Retin Eye Res , vol.22 , pp. 721-748
    • Das, A.1    McGuire, P.G.2
  • 6
    • 33144456714 scopus 로고    scopus 로고
    • Aqueous humor levels of vascular endothelial growth factor and pigment epithelium-derived factor in polypoidal choroidal vasculopathy and choroidal neovascularization
    • Tong JP, Chan WM, Liu DT, et al. Aqueous humor levels of vascular endothelial growth factor and pigment epithelium-derived factor in polypoidal choroidal vasculopathy and choroidal neovascularization. Am J Ophthalmol. 2006;141:456-462.
    • (2006) Am J Ophthalmol , vol.141 , pp. 456-462
    • Tong, J.P.1    Chan, W.M.2    Liu, D.T.3
  • 7
    • 13944266313 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics of ranibizumab (rhuFabV2) after a single intravitreal administration
    • Gaudreault J, Fei D, Rusit J, et al. Preclinical pharmacokinetics of ranibizumab (rhuFabV2) after a single intravitreal administration. Invest Ophthalmol Vis Sci. 2005;46:726-733.
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , pp. 726-733
    • Gaudreault, J.1    Fei, D.2    Rusit, J.3
  • 9
    • 84875351707 scopus 로고    scopus 로고
    • Lucentis (ranibizumab injection). Full prescribing information. South San Francisco, CA: Genentech, Inc; Jun
    • Lucentis (ranibizumab injection). Full prescribing information. South San Francisco, CA: Genentech, Inc; Jun 2010.
    • (2010)
  • 10
    • 33749632278 scopus 로고    scopus 로고
    • Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration
    • Ferrara N, Damico L, Shams N, et al. Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration. Retina. 2006;26:859-870.
    • (2006) Retina , vol.26 , pp. 859-870
    • Ferrara, N.1    Damico, L.2    Shams, N.3
  • 11
    • 77957764473 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and age-related macular degeneration: From basic science to therapy
    • Ferrara N. Vascular endothelial growth factor and age-related macular degeneration: from basic science to therapy. Nat Med. 2010;16:1107-1111.
    • (2010) Nat Med , vol.16 , pp. 1107-1111
    • Ferrara, N.1
  • 12
    • 35148885811 scopus 로고    scopus 로고
    • Ranibizumab inhibits multiple forms of biologically active vascular endothelial growth factor in vitro and in vivo
    • Lowe J, Araujo J, Yang J, et al. Ranibizumab inhibits multiple forms of biologically active vascular endothelial growth factor in vitro and in vivo. Exp Eye Res. 2007;85:425-430.
    • (2007) Exp Eye Res , vol.85 , pp. 425-430
    • Lowe, J.1    Araujo, J.2    Yang, J.3
  • 13
    • 84875324365 scopus 로고    scopus 로고
    • European Medicines Agency. Assessment report for Lucentis (ranibizumab). Procedure no: EMEA/H/C/000715/II/0020 [online]. Available from URL, Accessed May 17,
    • European Medicines Agency. Assessment report for Lucentis (ranibizumab). Procedure no: EMEA/H/C/000715/II/0020 [online]. Available from URL: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Assessment_Report_-_Variation/human/000715/WC500101009.pdf. Accessed May 17, 2012.
    • (2012)
  • 14
    • 79951525187 scopus 로고    scopus 로고
    • Systemic and ocular safety of intravitreal anti-VEGF therapies for ocular neovascular disease
    • Tolentino M. Systemic and ocular safety of intravitreal anti-VEGF therapies for ocular neovascular disease. Surv Ophthalmol. 2011;56(2):95-113.
    • (2011) Surv Ophthalmol , vol.56 , Issue.2 , pp. 95-113
    • Tolentino, M.1
  • 15
    • 84857107913 scopus 로고    scopus 로고
    • Center for Drug Evaluation and Research. BLA application number: 125156, [online]. Available from URL, Accessed September 16
    • Center for Drug Evaluation and Research. BLA application number: 125156. Clinical pharmacology and biopharmaceutics review(s) [online]. Available from URL: http://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/125156s0000_Lucentis_ClinPharmR.pdf. Accessed September 16, 2011.
    • (2011) Clinical Pharmacology and Biopharmaceutics Review
  • 16
    • 0024454362 scopus 로고
    • Growth features of choroidal neovascular membranes in age-related macular degeneration
    • Klein ML, Jorizzo PA, Watzke RC. Growth features of choroidal neovascular membranes in age-related macular degeneration. Ophthalmology. 1989;96:1416-1419.
    • (1989) Ophthalmology , vol.96 , pp. 1416-1419
    • Klein, M.L.1    Jorizzo, P.A.2    Watzke, R.C.3
  • 17
    • 60149107965 scopus 로고    scopus 로고
    • Delay in treating age-related macular degeneration in Spain is associated with progressive vision loss
    • Arias L, Armada F, Donate J, et al. Delay in treating age-related macular degeneration in Spain is associated with progressive vision loss. Eye. 2009;23:326-333.
    • (2009) Eye , vol.23 , pp. 326-333
    • Arias, L.1    Armada, F.2    Donate, J.3
  • 18
    • 79955590384 scopus 로고    scopus 로고
    • Delay between medical indication to anti-VEGF treatment in age-related macular degeneration can result in a loss of visual acuity
    • Muether PS, Hermann MM, Koch K, et al. Delay between medical indication to anti-VEGF treatment in age-related macular degeneration can result in a loss of visual acuity. Graefe's Arch Clin Exp Ophthalmol. 2011;249:633-637.
    • (2011) Graefe's Arch Clin Exp Ophthalmol , vol.249 , pp. 633-637
    • Muether, P.S.1    Hermann, M.M.2    Koch, K.3
  • 19
    • 79952993616 scopus 로고    scopus 로고
    • Early treatment of exudative age-related macular degeneration with ranibizumab (Lucentis): The key to success
    • Matthe E, Sandner D. Early treatment of exudative age-related macular degeneration with ranibizumab (Lucentis): the key to success. Ophthalmology. 2011;108:237-243.
    • (2011) Ophthalmology , vol.108 , pp. 237-243
    • Matthe, E.1    Sandner, D.2
  • 20
    • 33749445317 scopus 로고    scopus 로고
    • Ranibizumab for neovascular age-related macular degeneration
    • Rosenfeld PJ, Brown DM, Heier JS, et al. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med. 2006;355: 1419-1431.
    • (2006) N Engl J Med , vol.355 , pp. 1419-1431
    • Rosenfeld, P.J.1    Brown, D.M.2    Heier, J.S.3
  • 21
    • 36249002808 scopus 로고    scopus 로고
    • Ranibizumab for predominantly classic neovascular age-related macular degeneration: Subgroup analysis of first-year ANCHOR results
    • Kaiser PK, Brown DM, Zhang K, et al. Ranibizumab for predominantly classic neovascular age-related macular degeneration: subgroup analysis of first-year ANCHOR results. Am J Ophthalmol. 2007;144: 850-857.
    • (2007) Am J Ophthalmol , vol.144 , pp. 850-857
    • Kaiser, P.K.1    Brown, D.M.2    Zhang, K.3
  • 22
    • 57949094834 scopus 로고    scopus 로고
    • Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: Two-year results of the ANCHOR study
    • Brown DM, Michels M, Kaiser PK, et al. Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: two-year results of the ANCHOR study. Ophthalmology. 2009;116:57-65.
    • (2009) Ophthalmology , vol.116 , pp. 57-65
    • Brown, D.M.1    Michels, M.2    Kaiser, P.K.3
  • 23
    • 38349172455 scopus 로고    scopus 로고
    • Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER study year 1
    • Regillo CD, Brown DM, Abraham P, et al. Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER study year 1. Am J Ophthalmol. 2008;145:239-248.
    • (2008) Am J Ophthalmol , vol.145 , pp. 239-248
    • Regillo, C.D.1    Brown, D.M.2    Abraham, P.3
  • 24
    • 77956056292 scopus 로고    scopus 로고
    • Randomized, double-masked, sham- controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER Study Year 2
    • Abraham P, Yue H, Wilson L, et al. Randomized, double-masked, sham- controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER Study Year 2. Am J Ophthalmol. 2010;150: 315-324.
    • (2010) Am J Ophthalmol , vol.150 , pp. 315-324
    • Abraham, P.1    Yue, H.2    Wilson, L.3
  • 25
    • 69249222585 scopus 로고    scopus 로고
    • A phase IIIb study to evaluate the safety of ranibizumab in subjects with neovascular age-related macular degeneration
    • Boyer DS, Heier JS, Brown DM, et al. A phase IIIb study to evaluate the safety of ranibizumab in subjects with neovascular age-related macular degeneration. Ophthalmology. 2009;116: 1731-1739.
    • (2009) Ophthalmology , vol.116 , pp. 1731-1739
    • Boyer, D.S.1    Heier, J.S.2    Brown, D.M.3
  • 26
    • 79955631484 scopus 로고    scopus 로고
    • Efficacy and safety of monthly versus quarterly ranibizumab treatment in neovascular age-related macular degeneration: The EXCITE study
    • Schmidt-Erfurth U, Eldem B, Guymet R, et al. Efficacy and safety of monthly versus quarterly ranibizumab treatment in neovascular age-related macular degeneration: the EXCITE study. Ophthalmology. 2011;118:831-839.
    • (2011) Ophthalmology , vol.118 , pp. 831-839
    • Schmidt-Erfurth, U.1    Eldem, B.2    Guymet, R.3
  • 27
    • 33947403618 scopus 로고    scopus 로고
    • An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration
    • Fung AE, Lalwani GA, Rosenfeld PJ, et al. An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration. Am J Ophthalmol. 2007;143:566-583.
    • (2007) Am J Ophthalmol , vol.143 , pp. 566-583
    • Fung, A.E.1    Lalwani, G.A.2    Rosenfeld, P.J.3
  • 28
    • 79953295148 scopus 로고    scopus 로고
    • Safety and efficacy of a flexible dosing regimen of ranibizumab in neovascular age-related macular degeneration: The SUSTAIN study
    • Safety and efficacy of a flexible dosing regimen of ranibizumab in neovascular age-related macular degeneration: the SUSTAIN study. Ophthalmology. 2011;118:663-671.
    • (2011) Ophthalmology , vol.118 , pp. 663-671
  • 29
    • 84863320414 scopus 로고    scopus 로고
    • Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: 2-year results
    • CATT Research Group, May 1, Epub ahead of print
    • CATT Research Group. Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: 2-year results. Ophthalmology. May 1, 2012. [Epub ahead of print.]
    • (2012) Ophthalmology
  • 30
    • 77957727640 scopus 로고    scopus 로고
    • A review of ranibizumab clinical trial data in exudative age-related macular degeneration and how to translate it into daily practice
    • Monés J. A review of ranibizumab clinical trial data in exudative age-related macular degeneration and how to translate it into daily practice. Ophthalmologica. 2011;225:112-119.
    • (2011) Ophthalmologica , vol.225 , pp. 112-119
    • Monés, J.1
  • 31
    • 36249002808 scopus 로고    scopus 로고
    • Ranibizumab for predominantly classic neovascular age-related macular degeneration: Subgroup analysis of first-year ANCHOR results
    • Kaiser PK, Brown DM, Zhang K, et al. Ranibizumab for predominantly classic neovascular age-related macular degeneration: subgroup analysis of first-year ANCHOR results. Am J Ophthalmol. 2007;144: 850-857.
    • (2007) Am J Ophthalmol , vol.144 , pp. 850-857
    • Kaiser, P.K.1    Brown, D.M.2    Zhang, K.3
  • 32
    • 70450201592 scopus 로고    scopus 로고
    • National Institute for Health and Clinical Excellence. Ranibizumab: The clinician's guide to commencing, continuing, and discontinuing treatment
    • W, National Institute for Health and Clinical Excellence. Ranibizumab: the clinician's guide to commencing, continuing, and discontinuing treatment. Eye (Lond). 2009;23:2140-2142.
    • (2009) Eye (Lond) , vol.23 , pp. 2140-2142
  • 33
    • 43049176776 scopus 로고    scopus 로고
    • Ranibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration
    • Antoszyk AN, Tuomi L, Chung CY, et al. Ranibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration. Am J Ophthalmol. 2008;145:862-874.
    • (2008) Am J Ophthalmol , vol.145 , pp. 862-874
    • Antoszyk, A.N.1    Tuomi, L.2    Chung, C.Y.3
  • 34
    • 57149115612 scopus 로고    scopus 로고
    • Same-day administration of verteporfin and ranibizumab 0.5 mg in patients with choroidal neovascularization due to age-related macular degeneration
    • Schmidt-Erfurth U, Wolf S. Same-day administration of verteporfin and ranibizumab 0.5 mg in patients with choroidal neovascularization due to age-related macular degeneration. Br J Ophthalmol. 2008;92: 1628-1635.
    • (2008) Br J Ophthalmol , vol.92 , pp. 1628-1635
    • Schmidt-Erfurth, U.1    Wolf, S.2
  • 36
    • 58949083350 scopus 로고    scopus 로고
    • Incidence of endophthalmitis related to intravitreal injection of bevacizumab and ranibizumab
    • Fintak DR, Shah GK, Blinder KJ, et al. Incidence of endophthalmitis related to intravitreal injection of bevacizumab and ranibizumab. Retina. 2008;28:1395-1399.
    • (2008) Retina , vol.28 , pp. 1395-1399
    • Fintak, D.R.1    Shah, G.K.2    Blinder, K.J.3
  • 37
    • 79958262185 scopus 로고    scopus 로고
    • Optimising the management of choroidal neovascularization in Asian patients: Consensus on treatment recommendations for anti-VEGF therapy
    • Koh A, Lim TH, Au Eong K, et al. Optimising the management of choroidal neovascularization in Asian patients: consensus on treatment recommendations for anti-VEGF therapy. Singapore Med J. 2011;52: 232-240.
    • (2011) Singapore Med J , vol.52 , pp. 232-240
    • Koh, A.1    Lim, T.H.2    Au, E.K.3
  • 38
    • 34250166159 scopus 로고    scopus 로고
    • Tears of the retinal pigment epithelium: An old problem in a new era
    • Chang LK, Sarraf D. Tears of the retinal pigment epithelium: an old problem in a new era. Retina. 2007;27:523-534.
    • (2007) Retina , vol.27 , pp. 523-534
    • Chang, L.K.1    Sarraf, D.2
  • 39
    • 67649171066 scopus 로고    scopus 로고
    • Predictors of anti-VEGF-associated retinal pigment epithelial tear using FA and OCT analysis
    • Chiang A, Chang LK, Yu F, et al. Predictors of anti-VEGF-associated retinal pigment epithelial tear using FA and OCT analysis. Retina. 2008;28:1265-1269.
    • (2008) Retina , vol.28 , pp. 1265-1269
    • Chiang, A.1    Chang, L.K.2    Yu, F.3
  • 40
    • 0031039243 scopus 로고    scopus 로고
    • The biology of vascular endothelial growth factor
    • Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev. 1997;18:4-25.
    • (1997) Endocr Rev , vol.18 , pp. 4-25
    • Ferrara, N.1    Davis-Smyth, T.2
  • 41
    • 33846973644 scopus 로고    scopus 로고
    • Ranibizumab for neovascular age-related macular degeneration
    • author reply 749-750
    • Gillies MC, Wong TY. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med. 2007;356:748-749; author reply 749-750.
    • (2007) N Engl J Med , vol.356 , pp. 748-749
    • Gillies, M.C.1    Wong, T.Y.2
  • 43
    • 58849084256 scopus 로고    scopus 로고
    • Cerebrovascular accidents in ranibizumab
    • Ueta T, Yanagi Y, Tamaki Y, et al. Cerebrovascular accidents in ranibizumab. Ophthalmology. 2009;116:362.
    • (2009) Ophthalmology , vol.116 , pp. 362
    • Ueta, T.1    Yanagi, Y.2    Tamaki, Y.3
  • 44
    • 38349126811 scopus 로고    scopus 로고
    • Cardiovascular risk factors and age-related macular degeneration: The Los Angeles Latino Eye Study
    • Fraser-Bell S, Wu J, Klein R, et al. Cardiovascular risk factors and age-related macular degeneration: the Los Angeles Latino Eye Study. Am J Ophthalmol. 2008;145:308-316.
    • (2008) Am J Ophthalmol , vol.145 , pp. 308-316
    • Fraser-Bell, S.1    Wu, J.2    Klein, R.3
  • 45
    • 0032510639 scopus 로고    scopus 로고
    • Prediction of coronary heart disease using risk factor categories
    • Wilson PW, D'Agostino RB, Levy D, et al. Prediction of coronary heart disease using risk factor categories. Circulation. 1998;97: 1837-1847.
    • (1998) Circulation , vol.97 , pp. 1837-1847
    • Wilson, P.W.1    D'agostino, R.B.2    Levy, D.3
  • 46
    • 84859400504 scopus 로고    scopus 로고
    • HORIZON: An open-label extension trial of ranibizumab for choroidal neovascularization secondary to age-related macular degeneration
    • February 4, Epub ahead of print
    • Singer MA, Awh CC, Sadda S, et al. HORIZON: an open-label extension trial of ranibizumab for choroidal neovascularization secondary to age-related macular degeneration. Ophthalmology. February 4, 2012. [Epub ahead of print.]
    • (2012) Ophthalmology
    • Singer, M.A.1    Awh, C.C.2    Sadda, S.3
  • 47
    • 77952910606 scopus 로고    scopus 로고
    • Significant improvements in near vision, reading speed, central visual field and related quality of life after ranibizumab treatment of wet age-related macular degeneration
    • Frennesson C, Nilsson UL, Peebo BB, et al. Significant improvements in near vision, reading speed, central visual field and related quality of life after ranibizumab treatment of wet age-related macular degeneration. Acta Ophthalmol. 2010;88:420-425.
    • (2010) Acta Ophthalmol , vol.88 , pp. 420-425
    • Frennesson, C.1    Nilsson, U.L.2    Peebo, B.B.3
  • 48
    • 67650446559 scopus 로고    scopus 로고
    • Evaluating patient discomfort, anxiety, and fear before and after ranibizumab intravitreous injection for wet age-related macular degeneration
    • Chua PY, Mitrut I, Armbrecht AM, et al. Evaluating patient discomfort, anxiety, and fear before and after ranibizumab intravitreous injection for wet age-related macular degeneration. Arch Ophthalmol. 2009;127:939-940.
    • (2009) Arch Ophthalmol , vol.127 , pp. 939-940
    • Chua, P.Y.1    Mitrut, I.2    Armbrecht, A.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.