-
1
-
-
0031770716
-
Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles
-
Azzam EI, de Toledo SM, Gooding T, et al. Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Radiat Res 1998;150:497-504.
-
(1998)
Radiat Res
, vol.150
, pp. 497-504
-
-
Azzam, E.I.1
De Toledo, S.M.2
Gooding, T.3
-
2
-
-
0035895240
-
Direct evidence for the participation of gap-junction mediated intercellular communication in the transmission of damage signals from alphaparticle irradiated to non-irradiated cells
-
Azzam EI, de Toledo SM, Little JB. Direct evidence for the participation of gap-junction mediated intercellular communication in the transmission of damage signals from alphaparticle irradiated to non-irradiated cells. Proc Natl Acad Sci USA 2001;98:473-8.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 473-478
-
-
Azzam, E.I.1
De Toledo, S.M.2
Little, J.B.3
-
3
-
-
0242392025
-
Gap junctional intercellular communication and cellular response to heat stress
-
Hamada N, Kodama S, Suzuki K, et al. Gap junctional intercellular communication and cellular response to heat stress. Carcinogenesis 2003;24:1723-8.
-
(2003)
Carcinogenesis
, vol.24
, pp. 1723-1728
-
-
Hamada, N.1
Kodama, S.2
Suzuki, K.3
-
4
-
-
0041709202
-
Bystander effect induced by counted high-LET particles in confluent human fibroblasts: A mechanistic study
-
Shao C, Furusawa Y, Kobayashi Y, et al. Bystander effect induced by counted high-LET particles in confluent human fibroblasts: a mechanistic study. FASEB J 2003;17:1422-7.
-
(2003)
FASEB J
, vol.17
, pp. 1422-1427
-
-
Shao, C.1
Furusawa, Y.2
Kobayashi, Y.3
-
5
-
-
84856625041
-
Gap junctions propagate opposite effects in normal and tumor testicular cells in response to cisplatin
-
Hong X, Wang Q, Yang Y, et al. Gap junctions propagate opposite effects in normal and tumor testicular cells in response to cisplatin. Cancer Lett 2011;317:165-71.
-
(2011)
Cancer Lett
, vol.317
, pp. 165-171
-
-
Hong, X.1
Wang, Q.2
Yang, Y.3
-
6
-
-
1942469377
-
Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions
-
Jensen R, Glazer PM. Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions. Proc Natl Acad Sci USA 2004;101:6134-9.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 6134-6139
-
-
Jensen, R.1
Glazer, P.M.2
-
7
-
-
0033027240
-
Evidence for pronounced bystander effects caused by nonuniform distributions of radioactivity using a novel three-dimensional tissue culture model
-
Bishayee A, Rao DV, Howell RW. Evidence for pronounced bystander effects caused by nonuniform distributions of radioactivity using a novel three-dimensional tissue culture model. Radiat Res 1999;152:88-97.
-
(1999)
Radiat Res
, vol.152
, pp. 88-97
-
-
Bishayee, A.1
Rao, D.V.2
Howell, R.W.3
-
8
-
-
77749273749
-
Year-long upregulation of connexin43 in rabbit hearts by heavy ion irradiation
-
Amino M, Yoshioka K, Fujibayashi D, et al. Year-long upregulation of connexin43 in rabbit hearts by heavy ion irradiation. Am J Physiol Heart Circ Physiol 2010;298:H1014-21.
-
(2010)
Am J Physiol Heart Circ Physiol
, vol.298
-
-
Amino, M.1
Yoshioka, K.2
Fujibayashi, D.3
-
9
-
-
67449102360
-
Heavy-ion-induced bystander killing of human lung cancer cells: Role of gap junctional intercellular communication
-
Harada K, Nonaka T, Hamada N, et al. Heavy-ion-induced bystander killing of human lung cancer cells: role of gap junctional intercellular communication. Cancer Sci 2009;100:684-8.
-
(2009)
Cancer Sci
, vol.100
, pp. 684-688
-
-
Harada, K.1
Nonaka, T.2
Hamada, N.3
-
10
-
-
50449107390
-
Oncogenic bystander radiation effects in Patched heterozygous mouse cerebellum
-
Mancuso M, Pasquali E, Leonardi S, et al. Oncogenic bystander radiation effects in Patched heterozygous mouse cerebellum. Proc Natl Acad Sci USA 2008;105:12445-50.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 12445-12450
-
-
Mancuso, M.1
Pasquali, E.2
Leonardi, S.3
-
11
-
-
20044363661
-
Heavy charged particles produce a bystander effect via cell-cell junctions
-
Suzuki M, Tsuruoka C. Heavy charged particles produce a bystander effect via cell-cell junctions. Biol Sci Space 2004;18:241-6.
-
(2004)
Biol Sci Space
, vol.18
, pp. 241-246
-
-
Suzuki, M.1
Tsuruoka, C.2
-
12
-
-
0032718304
-
Gap junction intercellular communication mediates the competitive cell proliferation disadvantage of irradiated mouse preimplantation embryos in aggregation chimeras
-
Vance MM, Wiley LM. Gap junction intercellular communication mediates the competitive cell proliferation disadvantage of irradiated mouse preimplantation embryos in aggregation chimeras. Radiat Res 1999;152:544-51.
-
(1999)
Radiat Res
, vol.152
, pp. 544-551
-
-
Vance, M.M.1
Wiley, L.M.2
-
13
-
-
79960875889
-
Intercellular communication amplifies stressful effects in high-charge, high-energy (HZE) particle-irradiated human cells
-
Autsavapromporn N, de Toledo SM, Buonanno M, et al. Intercellular communication amplifies stressful effects in high-charge, high-energy (HZE) particle-irradiated human cells. J Radiat Res (Tokyo) 2011;52:408-14.
-
(2011)
J Radiat Res (Tokyo)
, vol.52
, pp. 408-414
-
-
Autsavapromporn, N.1
De Toledo, S.M.2
Buonanno, M.3
-
14
-
-
79952122287
-
The role of gap junction communication and oxidative stress in the propagation of toxic effects among high-dose α-particle-irradiated human cells
-
Autsavapromporn N, de Toledo SM, Little JB, et al. The role of gap junction communication and oxidative stress in the propagation of toxic effects among high-dose α-particle-irradiated human cells. Radiat Res 2011;175:347-57.
-
(2011)
Radiat Res
, vol.175
, pp. 347-357
-
-
Autsavapromporn, N.1
De Toledo, S.M.2
Little, J.B.3
-
15
-
-
0035144598
-
Free-radical initiated and gap junction-mediated bystander effect due to nonuniform distribution of incorporated radioactivity in a three-dimensional tissue culture model
-
Bishayee A, Hill HZ, Stein D, et al. Free-radical initiated and gap junction-mediated bystander effect due to nonuniform distribution of incorporated radioactivity in a three-dimensional tissue culture model. Radiat Res 2001;155:335-44.
-
(2001)
Radiat Res
, vol.155
, pp. 335-344
-
-
Bishayee, A.1
Hill, H.Z.2
Stein, D.3
-
16
-
-
79959614066
-
Increased frequency of spontaneous neoplastic transformation in progeny of bystander cells from cultures exposed to densely-ionizing radiation
-
Buonanno M, de Toledo SM, Azzam EI. Increased frequency of spontaneous neoplastic transformation in progeny of bystander cells from cultures exposed to densely-ionizing radiation. PLoS One 2011;6:e21540.
-
(2011)
PLoS One
, vol.6
-
-
Buonanno, M.1
De Toledo, S.M.2
Azzam, E.I.3
-
17
-
-
0041317777
-
Role of gap junctional intercellular communication in radiation-induced bystander effects in human fibroblasts
-
Shao C, Furusawa Y, Aoki M, et al. Role of gap junctional intercellular communication in radiation-induced bystander effects in human fibroblasts. Radiat Res 2003;160:318-23.
-
(2003)
Radiat Res
, vol.160
, pp. 318-323
-
-
Shao, C.1
Furusawa, Y.2
Aoki, M.3
-
18
-
-
34247250263
-
Effect of gap junctional intercellular communication on radiation responses in neoplastic human cells
-
Shao C, Furusawa Y, Matsumoto Y, et al. Effect of gap junctional intercellular communication on radiation responses in neoplastic human cells. Radiat Res 2007;167:283-8.
-
(2007)
Radiat Res
, vol.167
, pp. 283-288
-
-
Shao, C.1
Furusawa, Y.2
Matsumoto, Y.3
-
19
-
-
0034007865
-
Induction of a bystander mutagenic effect of alpha particles in mammalian cells
-
Zhou H, Randers-Pehrson G, Waldren CA, et al. Induction of a bystander mutagenic effect of alpha particles in mammalian cells. Proc Natl Acad Sci USA 2000;97:2099-104.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 2099-2104
-
-
Zhou, H.1
Randers-Pehrson, G.2
Waldren, C.A.3
-
20
-
-
79953793768
-
Radiation induced nontargeted response: Mechanism and potential clinical implications
-
Hei TK, Zhou H, Chai Y, et al. Radiation induced nontargeted response: mechanism and potential clinical implications. Curr Mol Pharmacol 2011;4:96-105.
-
(2011)
Curr Mol Pharmacol
, vol.4
, pp. 96-105
-
-
Hei, T.K.1
Zhou, H.2
Chai, Y.3
-
21
-
-
64649084383
-
Radiation-induced bystander signalling in cancer therapy
-
Prise KM, O'Sullivan JM. Radiation-induced bystander signalling in cancer therapy. Nat Rev Cancer 2009;9:351-60.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 351-360
-
-
Prise, K.M.1
O'Sullivan, J.M.2
-
23
-
-
33845352897
-
Adaptive responses to low-dose/low-dose-rate gamma rays in normal human fibroblasts: The role of growth architecture and oxidative metabolism
-
de Toledo SM, Asaad N, Venkatachalam P, et al. Adaptive responses to low-dose/low-dose-rate gamma rays in normal human fibroblasts: the role of growth architecture and oxidative metabolism. Radiat Res 2006;166:849-57.
-
(2006)
Radiat Res
, vol.166
, pp. 849-857
-
-
De Toledo, S.M.1
Asaad, N.2
Venkatachalam, P.3
-
24
-
-
0029968876
-
Participation of gap-junctional cell communication on the adaptive response in human cells induced by low dose of X-rays
-
Ishii K, Watanabe M. Participation of gap-junctional cell communication on the adaptive response in human cells induced by low dose of X-rays. Int J Radiat Biol 1996;69:291-9.
-
(1996)
Int J Radiat Biol
, vol.69
, pp. 291-299
-
-
Ishii, K.1
Watanabe, M.2
-
25
-
-
84870565831
-
Induction of lethal bystander effects in human breast cancer cell cultures by DNA-incorporated iodine-125 depends on phenotype
-
May 16 [Epub ahead of print]
-
Akudugu JM, Azzam EI, Howell RW. Induction of lethal bystander effects in human breast cancer cell cultures by DNA-incorporated iodine-125 depends on phenotype. Int J Radiat Biol 2012;May 16 [Epub ahead of print].
-
(2012)
Int J Radiat Biol
-
-
Akudugu, J.M.1
Azzam, E.I.2
Howell, R.W.3
-
26
-
-
1642319697
-
The radiation-induced bystander effect: Evidence and significance
-
Azzam EI, Little JB. The radiation-induced bystander effect: evidence and significance. Hum Exp Toxicol 2004;23:61-5.
-
(2004)
Hum Exp Toxicol
, vol.23
, pp. 61-65
-
-
Azzam, E.I.1
Little, J.B.2
-
27
-
-
0242658550
-
Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect
-
Azzam EI, de Toledo SM, Little JB. Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect. Oncogene 2003;22:7050-7.
-
(2003)
Oncogene
, vol.22
, pp. 7050-7057
-
-
Azzam, E.I.1
De Toledo, S.M.2
Little, J.B.3
-
28
-
-
79953802454
-
Signaling pathways underpinning the manifestations of ionizing radiation-induced bystander effects
-
Hamada N, Maeda M, Otsuka K, et al. Signaling pathways underpinning the manifestations of ionizing radiation-induced bystander effects. Curr Mol Pharmacol 2011;4:79-95.
-
(2011)
Curr Mol Pharmacol
, vol.4
, pp. 79-95
-
-
Hamada, N.1
Maeda, M.2
Otsuka, K.3
-
29
-
-
0035704411
-
Emerging issues of connexin channels: Biophysics fills the gap
-
Harris AL. Emerging issues of connexin channels: biophysics fills the gap. Q Rev Biophys 2001;34:325-472.
-
(2001)
Q Rev Biophys
, vol.34
, pp. 325-472
-
-
Harris, A.L.1
-
30
-
-
34249082403
-
Connexin channel permeability to cytoplasmic molecules
-
Harris AL. Connexin channel permeability to cytoplasmic molecules. Prog Biophys Mol Biol 2007;94:120-43.
-
(2007)
Prog Biophys Mol Biol
, vol.94
, pp. 120-143
-
-
Harris, A.L.1
-
31
-
-
0035985057
-
Structural and functional diversity of connexin genes in the mouse and human genome
-
Willecke K, Eiberger J, Degen J, et al. Structural and functional diversity of connexin genes in the mouse and human genome. Biol Chem 2002;383:725-37.
-
(2002)
Biol Chem
, vol.383
, pp. 725-737
-
-
Willecke, K.1
Eiberger, J.2
Degen, J.3
-
32
-
-
33646586079
-
Selective permeability of different connexin channels to the second messenger cyclic AMP
-
Bedner P, Niessen H, Odermatt B, et al. Selective permeability of different connexin channels to the second messenger cyclic AMP. J Biol Chem 2005;281:6673-81.
-
(2005)
J Biol Chem
, vol.281
, pp. 6673-6681
-
-
Bedner, P.1
Niessen, H.2
Odermatt, B.3
-
33
-
-
0037184068
-
Gap junctions between cells expressing connexin 43 or 32 show inverse permselectivity to adenosine and ATP
-
Goldberg GS, Moreno AP, Lampe PD. Gap junctions between cells expressing connexin 43 or 32 show inverse permselectivity to adenosine and ATP. J Biol Chem 2002;277:36725-30.
-
(2002)
J Biol Chem
, vol.277
, pp. 36725-36730
-
-
Goldberg, G.S.1
Moreno, A.P.2
Lampe, P.D.3
-
34
-
-
0034106797
-
Selective permeability of different connexin channels to the second messenger inositol 1,4,5-trisphosphate
-
Niessen H, Harz H, Bedner P, et al. Selective permeability of different connexin channels to the second messenger inositol 1,4,5-trisphosphate. J Cell Sci 2000;113:1365-72.
-
(2000)
J Cell Sci
, vol.113
, pp. 1365-1372
-
-
Niessen, H.1
Harz, H.2
Bedner, P.3
-
35
-
-
0032579554
-
Isoform composition of connexin channels determines selectivity among second messengers and uncharged molecules
-
Bevans CG, Kordel M, Rhee SK, et al. Isoform composition of connexin channels determines selectivity among second messengers and uncharged molecules. J Biol Chem 1998;273: 2808-16.
-
(1998)
J Biol Chem
, vol.273
, pp. 2808-2816
-
-
Bevans, C.G.1
Kordel, M.2
Rhee, S.K.3
-
36
-
-
3242729342
-
Altered permeability and modulatory character of connexin channels during mammary gland development
-
Locke D, Stein T, Davies C, et al. Altered permeability and modulatory character of connexin channels during mammary gland development. Exp Cell Res 2004;298:643-60.
-
(2004)
Exp Cell Res
, vol.298
, pp. 643-660
-
-
Locke, D.1
Stein, T.2
Davies, C.3
-
37
-
-
33745190968
-
Heteromeric, but not homomeric, connexin channels are selectively permeable to inositol phosphates
-
Ayad WA, Locke D, Koreen IV, et al. Heteromeric, but not homomeric, connexin channels are selectively permeable to inositol phosphates. J Biol Chem 2006;281:16727-39.
-
(2006)
J Biol Chem
, vol.281
, pp. 16727-16739
-
-
Ayad, W.A.1
Locke, D.2
Koreen, I.V.3
-
38
-
-
0028939358
-
Negative growth control of HeLa cells by connexin genes: Connexin species specificity
-
Mesnil M, Krutovskikh V, Piccoli C, et al. Negative growth control of HeLa cells by connexin genes: connexin species specificity. Cancer Res 1995;55:629-39.
-
(1995)
Cancer Res
, vol.55
, pp. 629-639
-
-
Mesnil, M.1
Krutovskikh, V.2
Piccoli, C.3
-
39
-
-
0242442576
-
Expression of connexin43 is highly sensitive to ionizing radiation and environmental stresses
-
Azzam EI, de Toledo SM, Little JB. Expression of connexin43 is highly sensitive to ionizing radiation and environmental stresses. Cancer Res 2003;63:7128-35.
-
(2003)
Cancer Res
, vol.63
, pp. 7128-7135
-
-
Azzam, E.I.1
De Toledo, S.M.2
Little, J.B.3
-
40
-
-
16644392770
-
Tetracycline-regulated expression enables purification and functional analysis of recombinant connexin channels from mammalian cells
-
Koreen IV, Elsayed WA, Liu YJ, et al. Tetracycline-regulated expression enables purification and functional analysis of recombinant connexin channels from mammalian cells. Biochem J 2004;383:111-9.
-
(2004)
Biochem J
, vol.383
, pp. 111-119
-
-
Koreen, I.V.1
Elsayed, W.A.2
Liu, Y.J.3
-
41
-
-
3042677247
-
A multi-port lowfluence alpha-particle irradiator: Fabrication, testing and benchmark radiobiological studies
-
Neti PV, de Toledo SM, Perumal V, et al. A multi-port lowfluence alpha-particle irradiator: fabrication, testing and benchmark radiobiological studies. Radiat Res 2004;161:732-8.
-
(2004)
Radiat Res
, vol.161
, pp. 732-738
-
-
Neti, P.V.1
De Toledo, S.M.2
Perumal, V.3
-
42
-
-
0021317766
-
Modification by anisotonic treatment of repair and fixation of radiation damage in cell killing and transformation
-
Raaphorst GP, Azzam EI, Borsa J, et al. Modification by anisotonic treatment of repair and fixation of radiation damage in cell killing and transformation. Br J Cancer Suppl 1984;6:239-42.
-
(1984)
Br J Cancer Suppl
, vol.6
, pp. 239-242
-
-
Raaphorst, G.P.1
Azzam, E.I.2
Borsa, J.3
-
43
-
-
0000596925
-
Effect of oxygen tension on HeLa cell growth
-
Rueckert RR, Mueller GC. Effect of oxygen tension on HeLa cell growth. Cancer Res 1960;20:944-9.
-
(1960)
Cancer Res
, vol.20
, pp. 944-949
-
-
Rueckert, R.R.1
Mueller, G.C.2
-
44
-
-
0025963431
-
A relationship between microdosimetric spectra and cell survival for high-LET irradiation
-
Charlton DE, Sephton R. A relationship between microdosimetric spectra and cell survival for high-LET irradiation. Int J Radiat Biol 1991;59:447-57.
-
(1991)
Int J Radiat Biol
, vol.59
, pp. 447-457
-
-
Charlton, D.E.1
Sephton, R.2
-
45
-
-
0021987630
-
Measurement of micronuclei in lymphocytes
-
Fenech M, Morley AA. Measurement of micronuclei in lymphocytes. Mutat Res 1985;147:29-36.
-
(1985)
Mutat Res
, vol.147
, pp. 29-36
-
-
Fenech, M.1
Morley, A.A.2
-
46
-
-
0025270365
-
Use of the tetrazolium assay in measuring the response of human tumor cells to ionizing radiation
-
Price P, McMillan TJ. Use of the tetrazolium assay in measuring the response of human tumor cells to ionizing radiation. Cancer Res 1990;50:1392-6.
-
(1990)
Cancer Res
, vol.50
, pp. 1392-1396
-
-
Price, P.1
McMillan, T.J.2
-
48
-
-
69949090953
-
Connexins: A myriad of functions extending beyond assembly of gap junction channels
-
Dbouk HA, Mroue RM, El-Sabban ME, et al. Connexins: a myriad of functions extending beyond assembly of gap junction channels. Cell Commun Signal 2009;7:4.
-
(2009)
Cell Commun Signal
, vol.7
, pp. 4
-
-
Dbouk, H.A.1
Mroue, R.M.2
El-Sabban, M.E.3
-
49
-
-
84867483822
-
Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury
-
Azzam EI, Jay-Gerin JP, Pain D. Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury. Cancer Lett 2012;327:48-60.
-
(2012)
Cancer Lett
, vol.327
, pp. 48-60
-
-
Azzam, E.I.1
Jay-Gerin, J.P.2
Pain, D.3
-
50
-
-
20444369494
-
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation
-
Laird DW. Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation. Biochim Biophys Acta 2005;1711:172-82.
-
(2005)
Biochim Biophys Acta
, vol.1711
, pp. 172-182
-
-
Laird, D.W.1
-
51
-
-
33645238079
-
S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: Induction by oxidant stress and reversal by reducing agents
-
Retamal MA, Cortes CJ, Reuss L, et al. S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: induction by oxidant stress and reversal by reducing agents. Proc Natl Acad Sci USA 2006;103:4475-80.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 4475-4480
-
-
Retamal, M.A.1
Cortes, C.J.2
Reuss, L.3
-
52
-
-
80755140180
-
Role of connexin43 and ATP in long-range bystander radiation damage and oncogenesis in vivo
-
Mancuso M, Pasquali E, Leonardi S, et al. Role of connexin43 and ATP in long-range bystander radiation damage and oncogenesis in vivo. Oncogene 2011;30:4601-8.
-
(2011)
Oncogene
, vol.30
, pp. 4601-4608
-
-
Mancuso, M.1
Pasquali, E.2
Leonardi, S.3
-
53
-
-
77952329911
-
Regulation of lens gap junctions by Transforming Growth Factor beta
-
Boswell BA, VanSlyke JK, Musil LS. Regulation of lens gap junctions by Transforming Growth Factor beta. Mol Biol Cell 2010;21:1686-97.
-
(2010)
Mol Biol Cell
, vol.21
, pp. 1686-1697
-
-
Boswell, B.A.1
Vanslyke, J.K.2
Musil, L.S.3
|