Single-Cell Analysis Reveals Isotype-Specific Autoreactive B Cell Repertoires in Sjögren's Syndrome

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Nguyen, Cuong Q ^a,b   Ogunniyi, Adebola O ^c   Karabiyik, Afife ^a   Love, J Christopher ^c,d  

^a University of Florida College of Veterinary Medicine   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF DENTISTRY   (United States)

^c Massachusetts Institute of Technology Cambridge   (United States)

^d KOCH INSTITUTE FOR INTEGRATIVE CANCER RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN; IMMUNOGLOBULIN G1 ANTIBODY; LYMPHOCYTE ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY DETECTION; ANTIBODY SPECIFICITY; ARTICLE; B LYMPHOCYTE; CELL SPECIFICITY; CELLULAR DISTRIBUTION; CERVICAL LYMPH NODE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MARKER; DISEASE PREDISPOSITION; FEMALE; IMMUNE RESPONSE; LYMPH NODE CELL; LYMPHOCYTE FUNCTION; MALE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PROCEDURES CONCERNING CELLS; SALIVARY GLAND; SIGNAL TRANSDUCTION; SINGLE CELL ANALYSIS; SJOEGREN SYNDROME; SPLEEN CELL;

ANIMALS; ANTIBODY SPECIFICITY; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNITY; B-LYMPHOCYTES; DISEASE MODELS, ANIMAL; FEMALE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN ISOTYPES; LYMPH NODES; MALE; MICE; RIBONUCLEOPROTEINS; SALIVARY GLANDS; SINGLE-CELL ANALYSIS; SJOGREN'S SYNDROME; SPLEEN;

EID: 84874894986     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0058127     Document Type: Article

References (33)

1. Martin F, Chan AC, (2006) B cell immunobiology in disease: evolving concepts from the clinic. Annual review of immunology 24: 467-496.
2. Chan AC, Carter PJ, (2010) Therapeutic antibodies for autoimmunity and inflammation. Nature reviews Immunology 10: 301-316.
3. Dwyer DS, Bradley RJ, Urquhart CK, Kearney JF, (1983) Naturally occurring anti-idiotypic antibodies in myasthenia gravis patients. Nature 301: 611-614.
4. Cha S, Singson E, Cornelius J, Yagna JP, Knot HJ, et al. (2006) Muscarinic acetylcholine type-3 receptor desensitization due to chronic exposure to Sjogren's syndrome-associated autoantibodies. J Rheumatol 33: 296-306.
5. Teng CS, Smith BR, Clayton B, Evered DC, Clark F, et al. (1977) Thyroid-stimulating immunoglobulins in ophthalmic Graves' disease. Clinical endocrinology 6: 207-211.
6. Smith BR, Hall R, (1974) Thyroid-stimulating immunoglobulins in Graves' disease. Lancet 2: 427-431.
7. Lernmark A, (2001) Autoimmune diseases: are markers ready for prediction? The Journal of clinical investigation 108: 1091-1096.
8. Ogunniyi AO, Story CM, Papa E, Guillen E, Love JC, (2009) Screening individual hybridomas by microengraving to discover monoclonal antibodies. Nature protocols 4: 767-782.
9. Love JC, Ronan JL, Grotenbreg GM, van der Veen AG, Ploegh HL, (2006) A microengraving method for rapid selection of single cells producing antigen-specific antibodies. Nature biotechnology 24: 703-707.
10. Story CM, Papa E, Hu CC, Ronan JL, Herlihy K, et al. (2008) Profiling antibody responses by multiparametric analysis of primary B cells. Proceedings of the National Academy of Sciences of the United States of America 105: 17902-17907.
11. Nguyen CQ, Cha SR, Peck AB, (2007) Sjögren's syndrome (SjS)-like disease of mice: the importance of B lymphocytes and autoantibodies. Frontiers in Bioscience 12: 1767-1789.
12. Nguyen CQ, Peck AB, (2009) Unraveling the pathophysiology of Sjogren syndrome-associated dry eye disease. Ocul Surf 7: 11-27.
13. Gordon TP, Bolstad AI, Rischmueller M, Jonsson R, Waterman SA, (2001) Autoantibodies in primary Sjogren's syndrome: new insights into mechanisms of autoantibody diversification and disease pathogenesis. Autoimmunity 34: 123-132.
14. Jonsson R, Haga HJ, Gordon TP, (2000) Current concepts on diagnosis, autoantibodies and therapy in Sjogren's syndrome. Scand J Rheumatol 29: 341-348.
15. Sugai S, Masaki Y, Dong L, (2004) Lymphoproliferative disorders in patients with Sjogren's syndrome. Autoimmun Rev 3Suppl 1: S67-69.
16. Lavoie TN, Lee BH, Nguyen CQ, (2011) Current concepts: mouse models of Sjogren's syndrome. Journal of biomedicine & biotechnology 2011: 549107.
17. Fox RI, Kang HI, (1992) Pathogenesis of Sjogren's syndrome. Rheum Dis Clin North Am 18: 517-538.
18. Hardin JA, Mimori T, (1985) Autoantibodies to ribonucleoproteins. Clin Rheum Dis 11: 485-505.
19. Harley JB, Alexander EL, Bias WB, Fox OF, Provost TT, et al. (1986) Anti-Ro (SS-A) and anti-La (SS-B) in patients with Sjogren's syndrome. Arthritis Rheum 29: 196-206.
20. Routsias JG, Tzioufas AG, (2007) Sjogren's syndrome-study of autoantigens and autoantibodies. Clin Rev Allergy Immunol 32: 238-251.
21. Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, et al. (2002) Classification criteria for Sjogren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 61: 554-558.
22. Novljan MP, Rozman B, Jerse M, Rotar Z, Vidmar G, et al. (2006) Comparison of the different classification criteria sets for primary Sjogren's syndrome. Scand J Rheumatol 35: 463-467.
23. Shiboski SC, Shiboski CH, Criswell L, Baer A, Challacombe S, et al. (2012) American College of Rheumatology classification criteria for Sjogren's syndrome: a data-driven, expert consensus approach in the Sjogren's International Collaborative Clinical Alliance cohort. Arthritis care & research 64: 475-487.
24. Gao J, Cha S, Jonsson R, Opalko J, Peck AB, (2004) Detection of anti-type 3 muscarinic acetylcholine receptor autoantibodies in the sera of Sjogren's syndrome patients by use of a transfected cell line assay. Arthritis Rheum 50: 2615-2621.
25. Cha S, Nagashima H, Brown VB, Peck AB, Humphreys-Beher MG, (2002) Two NOD Idd-associated intervals contribute synergistically to the development of autoimmune exocrinopathy (Sjögren's syndrome) on a healthy murine background. Arthritis Rheum 46: 1390-1398.
26. Ronan JL, Story CM, Papa E, Love JC, (2009) Optimization of the surfaces used to capture antibodies from single hybridomas reduces the time required for microengraving. Journal of immunological methods 340: 164-169.
27. Nguyen CQ, Gao JH, Kim H, Saban DR, Cornelius JG, et al. (2007) IL-4-STAT6 signal transduction-dependent induction of the clinical phase of Sjogren's syndrome-like disease of the nonobese diabetic mouse. J Immunol 179: 382-390.
28. Gao J, Killedar S, Cornelius JG, Nguyen C, Cha S, et al. (2006) Sjogren's syndrome in the NOD mouse model is an interleukin-4 time-dependent, antibody isotype-specific autoimmune disease. J Autoimmun 26: 90-103.
29. Hayakawa K, Asano M, Shinton SA, Gui M, Allman D, et al. (1999) Positive selection of natural autoreactive B cells. Science 285: 113-116.
30. Casola S, Otipoby KL, Alimzhanov M, Humme S, Uyttersprot N, et al. (2004) B cell receptor signal strength determines B cell fate. Nat Immunol 5: 317-327.
31. Gauld SB, Dal Porto JM, Cambier JC, (2002) B cell antigen receptor signaling: roles in cell development and disease. Science 296: 1641-1642.
32. Satoh M, Chan EK, Ho LA, Rose KM, Parks CG, et al. (2012) Prevalence and sociodemographic correlates of antinuclear antibodies in the United States. Arthritis and rheumatism 64: 2319-2327.
33. Hayashi N, Koshiba M, Nishimura K, Sugiyama D, Nakamura T, et al. (2008) Prevalence of disease-specific antinuclear antibodies in general population: estimates from annual physical examinations of residents of a small town over a 5-year period. Modern rheumatology/the Japan Rheumatism Association 18: 153-160.