The -144C/A Polymorphism in the Promoter of HSP90beta Is Associated with Multiple Organ Dysfunction Scores

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Zhao, Yan ^a   Tao, Liju ^b   Jiang, Dongpo ^a   Chen, Xingyun ^a   Li, Ping ^a   Ning, Yalei ^a   Xiong, Renping ^a   Liu, Ping ^a   Peng, Yizhi ^b   Zhou, Yuan Guo ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 90BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CHINESE; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; GENOTYPE; HEAT SHOCK PROTEIN 90BETA GENE; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; MULTIPLE ORGAN DYSFUNCTION SCORE; NUCLEOTIDE SEQUENCE; ORGAN INJURY; POLYMERASE CHAIN REACTION; PROMOTER REGION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SCORING SYSTEM; SEPSIS; SINGLE NUCLEOTIDE POLYMORPHISM; WESTERN BLOTTING; WILD TYPE;

ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; ETHNIC GROUPS; FEMALE; GENE EXPRESSION REGULATION; GENE FREQUENCY; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LEUKOCYTES; MALE; MIDDLE AGED; MULTIPLE ORGAN FAILURE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA; WOUNDS AND INJURIES; YOUNG ADULT;

EID: 84874853282     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0058646     Document Type: Article

References (47)

1. Chen KH, Zeng L, Gu W, Zhou J, Du DY, et al. (2011) Polymorphisms in the toll-like receptor 9 gene associated with sepsis and multiple organ dysfunction after major blunt trauma. Br J Surg 98: 1252-1259.
2. Chen KH, Gu W, Zeng L, Jiang DP, Zhang LY, et al. (2011) Identification of haplotype tag SNPs within the entire TLR2 gene and their clinical relevance in patients with major trauma. Shock 35: 35-41.
3. Waterer GW, Bruns AH, (2010) Genetic risk of acute pulmonary infections and sepsis. Expert Rev Respir Med 4: 229-238.
4. Duan ZX, Gu W, Zhang LY, Jiang DP, Zhou J, et al. (2011) Tumor necrosis factor alpha gene polymorphism is associated with the outcome of trauma patients in Chinese Han population. J Trauma 70: 954-958.
5. Gu W, Zeng L, Zhang LY, Jiang DP, Du DY, et al. (2011) Association of Interleukin 4-589T/C Polymorphism With TH1 and TH2 Bias and Sepsis in Chinese Major Trauma Patients. J Trauma.
6. Wong HR, (2012) Genetics and genomics in pediatric septic shock. Crit Care Med 40: 1618-1626.
7. Tsantes AE, Tsangaris I, Bonovas S, Kopterides P, Rapti E, et al. (2010) The effect of four hemostatic gene polymorphisms on the outcome of septic critically ill patients. Blood Coagul Fibrinolysis 21: 175-181.
8. Madach K, Aladzsity I, Szilagyi A, Fust G, Gal J, et al. (2010) 4G/5G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis: prospective, observational, genetic study. Crit Care 14: R79.
9. Garcia-Segarra G, Espinosa G, Tassies D, Oriola J, Aibar J, et al. (2007) Increased mortality in septic shock with the 4G/4G genotype of plasminogen activator inhibitor 1 in patients of white descent. Intensive Care Med 33: 1354-1362.
10. Glushkova OV, Novoselova TV, Khrenov MO, Parfenyuk SB, Lunin SM, et al. (2010) Role of heat shock protein hsp90 in formation of protective reactions in acute toxic stress. Biochemistry (Mosc) 75: 702-707.
11. Broemer M, Krappmann D, Scheidereit C, (2004) Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation. Oncogene 23: 5378-5386.
12. Taiyab A, Rao CM, (2010) HSP90 modulates actin dynamics: Inhibition of HSP90 leads to decreased cell motility and impairs invasion. Biochim Biophys Acta.
13. Chatterjee A, Dimitropoulou C, Drakopanayiotakis F, Antonova G, Snead C, et al. (2007) Heat shock protein 90 inhibitors prolong survival, attenuate inflammation, and reduce lung injury in murine sepsis. Am J Respir Crit Care Med 176: 667-75.
14. Millson SH, Truman AW, Racz A, Hu B, Panaretou B, et al. (2007) Expressed as the sole Hsp90 of yeast, the alpha and beta isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90beta generates sensitivity to the Hsp90 inhibitor radicicol. FEBS J 274: 4453-4463.
15. MacLean MJ, Llordella MM, Bot N, Picard D, (2005) A yeast-based assay reveals a functional defect of the Q488H polymorphism in human Hsp90alpha. Biochem Biophys Res Commun 337: 133-137.
16. Duina AA, Kalton HM, Gaber RF, (1998) Requirement for Hsp90 and a CyP-40-type cyclophilin in negative regulation of the heat shock response. J Biol Chem 273: 18974-18978.
17. Nathan DF, Lindquist S, (1995) Mutational analysis of Hsp90 function: interactions with a steroid receptor and a protein kinase. Mol Cell Biol 15: 3917-3925.
18. Bohen SP, (1995) Hsp90 mutants disrupt glucocorticoid receptor ligand binding and destabilize aporeceptor complexes. J Biol Chem 270: 29433-29438.
19. Passarino G, Cavalleri GL, Stecconi R, Franceschi C, Altomare K, et al. (2003) Molecular variation of human HSP90alpha and HSP90beta genes in Caucasians. Hum Mutat 21: 554-555.
20. Csermely P, Schnaider T, Soti C, Prohaszka Z, Nardai G, (1998) The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review. Pharmacol Ther 79: 129-168.
21. Chen B, Piel WH, Gui L, Bruford E, Monteiro A, (2005) The HSP90 family of genes in the human genome: insights into their divergence and evolution. Genomics 86: 627-637.
22. Voss AK, Thomas T, Gruss P, (2000) Mice lacking HSP90beta fail to develop a placental labyrinth. Development 127: 1-11.
23. Shen HY, Zhao Y, Chen XY, Xiong RP, Lu JL, et al. (2010) Differential alteration of heat shock protein 90 in mice modifies glucocorticoid receptor function and susceptibility to trauma. J Neurotrauma 27: 373-381.
24. Zhao Y, Shen HY, Chen XY, Xiong RP, Li P, et al. (2010) Genetic variations of heat shock protein 84 in mice mediate cellular glucocorticoid response. Cell Physiol Biochem 25: 359-366.
25. Scale TAI, (2005) Barrington. Illinois: Association for the Advancement of Automotive Medicine.
26. Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL, et al. (1995) Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med 23: 1638-1652.
27. Hsu HY, Wu HL, Tan SK, Li VP, Wang WT, et al. (2007) Geldanamycin interferes with the 90-kDa heat shock protein, affecting lipopolysaccharide-mediated interleukin-1 expression and apoptosis within macrophages. Mol Pharmacol 71: 344-356.
28. Yoshida M, Xia Y, (2003) Heat shock protein 90 as an endogenous protein enhancer of inducible nitric-oxide synthase. J Biol Chem 278: 36953-36958.
29. Garcia-Cardena G, Fan R, Shah V, Sorrentino R, Cirino G, et al. (1998) Dynamic activation of endothelial nitric oxide synthase by Hsp90. Nature 392: 821-824.
30. Padmini E, Venkatraman U, Srinivasan L, (2012) Mechanism of JNK signal regulation by placental HSP70 and HSP90 in endothelial cell during preeclampsia. Toxicol Mech Methods 22: 367-374.
31. Padmini E, Uthra V, Lavanya S, (2012) Effect of HSP70 and 90 in Modulation of JNK, ERK Expression in Preeclamptic Placental Endothelial Cell. Cell Biochem Biophys.
32. Sonna LA, Gaffin SL, Pratt RE, Cullivan ML, Angel KC, et al. (2002) Effect of acute heat shock on gene expression by human peripheral blood mononuclear cells. J Appl Physiol 92: 2208-2220.
33. Karmazyn M, Mailer K, Currie RW, (1990) Acquisition and decay of heat-shock-enhanced postischemic ventricular recovery. Am J Physiol 259: H424-431.
34. Currie RW, Karmazyn M, Kloc M, Mailer K, (1988) Heat-shock response is associated with enhanced postischemic ventricular recovery. Circ Res 63: 543-549.
35. Latchman DS, (2001) Heat shock proteins and cardiac protection. Cardiovasc Res 51: 637-646.
36. Amrani M, Latif N, Morrison K, Gray CC, Jayakumar J, et al. (1998) Relative induction of heat shock protein in coronary endothelial cells and cardiomyocytes: implications for myocardial protection. J Thorac Cardiovasc Surg 115: 200-209.
37. Nielsen ER, Eskildsen-Helmond YE, Rattan SI, (2006) MAP kinases and heat shock-induced hormesis in human fibroblasts during serial passaging in vitro. Ann N Y Acad Sci 1067: 343-348.
38. Tominaga M, Ohta M, Kai S, Iwaki K, Shibata K, et al. (2009) Increased heat-shock protein 90 expression contributes to impaired adaptive cytoprotection in the gastric mucosa of portal hypertensive rats. J Gastroenterol and Hepatol 24: 1136-1141.
39. Latchman DS, (2004) Protective effect of heat shock proteins in the nervous system. Curr Neurovasc Res 1: 21-27.
40. Pribenszky C, Vajta G, Molnar M, Du Y, Lin L, et al. (2010) Stress for stress tolerance? A fundamentally new approach in mammalian embryology. Biol Reprod 83: 690-697.
41. Yang C, Gao J, Wang HY, Liu Q, Xu MH, et al. (2011) Effects of hypothalamus destruction on the level of plasma corticosterone after blast injury and its relation to interleukin-6 in rats. Cytokine 54: 29-35.
42. Vandevyver S, Dejager L, Van Bogaert T, Kleyman A, Liu Y, et al. (2012) Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation. J Clin Invest 122: 2130-2140.
43. Lannan EA, Galliher-Beckley AJ, Scoltock AB, Cidlowski JA, (2012) Proinflammatory Actions of Glucocorticoids: Glucocorticoids and TNFalpha Coregulate Gene Expression In Vitro and In Vivo. Endocrinology.
44. Bhattacharyya S, Ratajczak CK, Vogt SK, Kelley C, Colonna M, et al. (2010) TAK1 targeting by glucocorticoids determines JNK and IkappaB regulation in Toll-like receptor-stimulated macrophages. Blood 115: 1921-1931.
45. Busillo JM, Azzam KM, Cidlowski JA, (2011) Glucocorticoids sensitize the innate immune system through regulation of the NLRP3 inflammasome. J Biol Chem 286: 38703-38713.
46. Kainuma E, Watanabe M, Tomiyama-Miyaji C, Inoue M, Kuwano Y, et al. (2009) Association of glucocorticoid with stress-induced modulation of body temperature, blood glucose and innate immunity. Psychoneuroendocrinology 34: 1459-1468.
47. Echeverria PC, Mazaira G, Erlejman A, Gomez-Sanchez C, Piwien Pilipuk G, et al. (2009) Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta. Mol Cell Biol 29: 4788-4797.