Functional cooperation of URAT1 (SLC22A12) and URATv1 (SLC2A9) in renal reabsorption of urate

Nephrology Dialysis Transplantation

Volumn 28, Issue 3, 2013, Pages 603-611

  Nakanishi, Takeo ^a   Ohya, Kouhei ^a   Shimada, Sho ^a   Anzai, Naohiko ^b   Tamai, Ikumi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Benzbromarone; Pyrazinecarboxylic acid; Urate reabsorption; URAT1; URATv1

Indexed keywords

BENZBROMARONE; CARRIER PROTEIN; LACTIC ACID; NICOTINIC ACID; PYRAZINOIC ACID; SALICYLIC ACID; UNCLASSIFIED DRUG; URATE; URATE TRANSPORTER 1; URATE TRANSPORTER V1;

ANIMAL CELL; APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY CELL; KIDNEY EPITHELIUM; KIDNEY TUBULE ABSORPTION; MEMBRANE PERMEABILITY; MEMBRANE TRANSPORT; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; XENOPUS;

ANIMALS; BENZBROMARONE; CELLS, CULTURED; DOGS; FLUORESCENT ANTIBODY TECHNIQUE; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; HUMANS; KIDNEY; LACTIC ACID; MADIN DARBY CANINE KIDNEY CELLS; NIACIN; OOCYTES; ORGANIC ANION TRANSPORTERS; ORGANIC CATION TRANSPORT PROTEINS; PYRAZINAMIDE; URIC ACID; URICOSURIC AGENTS; VASODILATOR AGENTS; XENOPUS LAEVIS;

EID: 84874851478     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfs574     Document Type: Article

References (30)

1. Anzai N, Enomoto A, Endou H. Renal urate handling: clinical relevance of recent advances. Curr Rheumatol Rep 2005; 7: 227-234
2. Hosomi A, Nakanishi T, Fujita T et al. Extra-renal elimination of uric acid via intestinal efflux transporter BCRP/ABCG2. PLoS ONE 2012; 7: e30456
3. Fang J, Alderman MH. Serum uric acid and cardiovascular mortality. JAMA 2000; 283: 2404-2410
4. Berger L, Yü TF. Renal function in gout IV. An analysis of 524 gouty subjects including long-term follow-up studies. Am J Med 1975; 59: 605-613
5. Alderman MH, Cohen H, Madhavan S et al. Serum uric acid and cardiovascular events in successfully treated hypertensive patients. Hypertension 1999; 34: 144-150
6. Campion EW, Glynn RJ, Delabry LO. Asymptomatic hyperuricemia. Risks and consequences in the normative aging study. Am J Med 1987; 82: 421-426
7. Selby J, Friedman G, Quesenberry CJ. Precursors of essential hypertension: pulmonary function, heart rate, uric acid, serum cholesterol, and other serum chemistries. Am J Epidemiol 1992; 131: 1017-1027
8. Taniguchi Y, Hayashi T, Tsumura K et al. Serum uric acid and the risk for hypertension and Type 2 diabetes in Japanese men: the Osaka Health Survey. J Hypertens 2001; 19: 1209-1215
9. Anzai N, Endou H. Drug discovery for hyperuricemia. Expert Opin Drug Discov 2007; 2: 1251-1261
10. Sato M, Iwanaga T, Mamada H et al. Involvement of uric acid transporters in alteration of serum uric acid level by angiotensin II receptor blockers. Pharm Res 2008; 25: 639-646
11. Enomoto A, Kimura H, Chairoungdua A et al. Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature 2002; 417: 447-452
12. Sato M, Mamada H, Anzai N et al. Renal secretion of uric acid by organic anion transporter 2 (OAT2/SLC22A7) in human. Biol Pharm Bull 2010; 33: 498-503
13. Iwanaga T, Sato M, Maeda T et al. Concentration-dependent mode of interaction of angiotensin II receptor blockers with uric acid transporter. J Pharmacol Exp Ther 2007; 320: 211-217
14. Li Y, Sato M, Yanagisawa Y et al. Effects of angiotensin II receptor blockers on renal handling of uric acid in rats. Drug Metab Pharmacokinet 2008; 23: 263-270
15. Daskalopoulou S, Tzovaras V, Mikhailidis D et al. Effect on serum uric acid levels of drugs prescribed for indications other than treating hyperuricaemia. Curr Pharm Des 2005; 11: 4161- 4175
16. Trost B, Weidmann P. Metabolic effects of calcium antagonists in humans, with emphasis on carbohydrate, lipid, potassium, and uric acid homeostases. J Cardiovasc Pharmacol 1988; 12: S86-S92
17. Vitart V, Rudan I, Hayward C et al. SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Nat Genet 2008; 40: 437-442
18. Anzai N, Ichida K, Jutabha P et al. Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans. J Biol Chem 2008; 283: 26834-26838
19. Preitner F, Bonny O, Laverrière A et al. Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy. Proc Natl Acad Sci USA 2009; 106: 15501-15506
20. McCarthy MI, Abecasis GR, Cardon LR et al. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet 2008; 9: 356-369
21. Iwanaga T, Kobayashi D, Hirayama M et al. Involvement of uric acid transporter in increased renal clearance of the xanthine oxidase inhibitor oxypurinol induced by a uricosuric agent, benzbromarone. Drug Metab Dispos 2005; 33: 1791-1795
22. Nakanishi T, Fukushi A, Sato M et al. Functional characterization of apical transporters expressed in rat proximal tubular cells (PTCs) in primary culture. Mol Pharm 2011; 8: 2142-2150
23. Yü TSF, Gutman AB. Study of the paradoxical effects of salicylate in low, intermediate and high dosage on the renal mechanisms for excretion of urate in man. J Clin Invest 1959; 38: 1298-1315
24. Sato M, Wakayama T, Mamada H et al. Identification and functional characterization of uric acid transporter Urat1 (Slc22a12) in rats. Biochim Biophys Acta Biomembr 2011; 1808: 1441-1447
25. Wakida N, Tuyen DG, Adachi M et al. Mutations in human urate transporter 1 gene in presecretory reabsorption defect type of familial renal hypouricemia. J Clin Endocrinol Metab 2005; 90: 2169-2174
26. Takahashi T, Tsuchida S, Oyamada T et al. Recurrent URAT1 gene mutations and prevalence of renal hypouricemia in Japanese. Pediat Nephrol 2005; 20: 576-578
27. Bahn A, Hagos Y, Reuter S et al. Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13). J Biol Chem 2008; 283: 16332-16341
28. Miura D, Anzai N, Jutabha P et al. Human urate transporter 1 (hURAT1) mediates the transport of orotate. J Physiol Sci 2011; 61: 253-257
29. Ohtsu N, Anzai N, Fukutomi T et al. Human renal urate transpoter URAT1 mediates the transport of salicylate. Nihon Jinzo Gakkai Shi 2010; 52: 499-504
30. Augustin R, Carayannopoulos MO, Dowd LO et al. Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking. J Biol Chem 2004; 279: 16229-16236