P38/NF-κB/Snail Pathway Is Involved in Caffeic Acid-Induced Inhibition of Cancer Stem Cells-Like Properties and Migratory Capacity in Malignant Human Keratinocyte

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Yang, Ye ^a   Li, Yuan ^b   Wang, Kebo ^a   Wang, Yu ^a   Yin, Wenqin ^a   Li, Lei ^a,b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b Nanjing Medical University   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CAFFEIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR SNAIL;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER STEM CELL; CELL ASSAY; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; KERATINOCYTE; PHENOTYPE; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SOUTHWESTERN BLOTTING; TRANSCRIPTION INITIATION; UPREGULATION; WESTERN BLOTTING;

ANTICARCINOGENIC AGENTS; CAFFEIC ACIDS; CELL LINE; CELL MOVEMENT; CELL TRANSDIFFERENTIATION; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; KERATINOCYTES; NEOPLASTIC STEM CELLS; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENOTYPE; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84874829556     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0058915     Document Type: Article

References (36)

1. Benitah SA, (2011) Tumour biology: Skin-cancer stem cells outwitted. Nature 478: 329-330.
2. Shaikh WR, Geller A, Alexander G, Asgari MM, Chanange GJ, et al. (2012) Developing an Interactive Web-Based Learning Program on Skin Cancer: the Learning Experiences of Clinical Educators. J Cancer Educ 27: 709-716.
3. Alonso SR, Tracey L, Ortiz P, Perez-Gomez B, Palacios J, et al. (2007) A high-throughput study in melanoma identifies epithelial-mesenchymal transition as a major determinant of metastasis. Cancer Res 67: 3450-3460.
4. Borden EC, (2007) Melanoma 2007: current state and preview of the future. Semin Oncol 34: 449-451.
5. Nagasaka R, Chotimarkorn C, Shafiqul IM, Hori M, Ozaki H, et al. (2007) Anti-inflammatory effects of hydroxycinnamic acid derivatives. Biochem Biophys Res Commun 358: 615-619.
6. Szliszka E, Zydowicz G, Mizgala E, Krol W, (2012) Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) sensitizes LNCaP prostate cancer cells to TRAIL-induced apoptosis. Int J Oncol 41: 818-828.
7. Jung JE, Kim HS. Lee CS, Park DH, Kim YN, et al. (2007) Caffeic acid and its synthetic derivative CADPE suppress tumor angiogenesis by blocking STAT3-mediated VEGF expression in human renal carcinoma cells. Carcinogenesis 28: 1780-1787.
8. Staniforth V, Chiu LT, Yang NS, (2006) Caffeic acid suppresses UVB radiation-induced expression of interleukin-10 and activation of mitogen-activated protein kinases in mouse. Carcinogenesis 27: 1803-1811.
9. Kang NJ, Lee KW, Shin BJ, Jung SK, Hwang MK, et al. (2009) Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression. Carcinogenesis 30: 321-330.
10. Nakamura M, Tokura Y, (2011) Epithelial-mesenchymal transition in the skin. J Dermatol Sci 61: 7-13.
11. Wu Y, Zhou BP, (2010) Snail: More than EMT. Cell Adh Migr 4: 199-203.
12. Takebe N, Warren RQ, Ivy SP, (2011) Breast cancer growth and metastasis: interplay between cancer stem cells, embryonic signaling pathways and epithelial-to-mesenchymal transition. Breast Cancer Res 13: 211.
13. Eaves CJ, (2008) Cancer stem cells: Here, there, everywhere? Nature 456: 581-582.
14. Kim HM, Haraguchi N, Ishii H, Ohkuma M, Okano M, et al. (2012) Increased CD13 Expression Reduces Reactive Oxygen Species, Promoting Survival of Liver Cancer Stem Cells via an Epithelial-Mesenchymal Transition-like Phenomenon. Ann Surg Onco 19: 539-548.
15. Nemoto Y, Maruo T, Sato T, Deguchi T, Ito T, et al. (2011) Identification of cancer stem cells derived from a canine lung adenocarcinoma cell line. Vet Pathol 48: 1029-1034.
16. Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, et al. (2008) The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133: 704-715.
17. Li Y, Ling M, Xu Y, Wang S, Li Z, et al. (2010) The repressive effect of NF-kappaB on p53 by mot-2 is involved in human keratinocyte transformation induced by low levels of arsenite. Toxicol Sci 116: 174-182.
18. Lencinas A, Broka DM, Konieczka JH, Klewer SE, Antin PB, et al. (2010) Arsenic exposure perturbs epithelial-mesenchymal cell transition and gene expression in a collagen gel assay. Toxicol Sci 116: 273-285.
19. Trempus CS, Morris RJ, Ehinger M, Elmore A, Bortner CD, et al. (2007) CD34 expression by hair follicle stem cells is required for skin tumor development in mice. Cancer Res 67: 4173-4181.
20. Liu Y, Lyle S, Yang Z, Cotsarelis G, (2003) Keratin 15 promoter targets putative epithelial stem cells in the hair follicle bulge. J Invest Dermatol 121: 963-968.
21. Tokar EJ, Diwan BA, Waalkes MP, (2010) Arsenic exposure transforms human epithelial stem/progenitor cells into a cancer stem-like phenotype. Environ Health Perspect 118: 108-115.
22. Zhu LF, Hu Y, Yang CC, Xu XH, Ning TY, et al. (2012) Snail overexpression induces an epithelial to mesenchymal transition and cancer stem cell-like properties in SCC9 cells. Lab Invest 92: 744-752.
23. Julien S, Puig I, Caretti E, Bonaventure J, Nelles L, et al. (2007) Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition. Oncogene 26: 7445-7456.
24. Dong R, Wang Q, He XL, Chu YK, Lu JG, et al. (2007) Role of nuclear factor kappa B and reactive oxygen species in the tumor necrosis factor-alpha-induced epithelial-mesenchymal transition of MCF-7 cells. Braz J Med Biol Res 40: 1071-1078.
25. Strippoli R, Benedicto I, Foronda M, Perez-Lozano ML, Sanchez-Perales S, et al. (2010) p38 maintains E-cadherin expression by modulating TAK1-NF-kappa B during epithelial-to-mesenchymal transition. J Cell Sci 123: 4321-4331.
26. Huang MT, Smart RC, Wong CQ, Conney AH, (1988) Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res 48: 5941-5946.
27. Wang Z, Yang J, Fisher T, Xiao H, Jiang Y, et al. (2012) Akt activation is responsible for enhanced migratory and invasive behavior of arsenic-transformed human bronchial epithelial cells. Environ Health Perspect 120: 92-97.
28. Tellez CS, Juri DE, Do K, Bernauer AM, Thomas CL, et al. (2011) EMT and stem cell-like properties associated with miR-205 and miR-200 epigenetic silencing are early manifestations during carcinogen-induced transformation of human lung epithelial cells. Cancer Res 71: 3087-3097.
29. Tokar EJ, Qu W, Liu J, Liu W, Webber MM, et al. (2010) Arsenic-specific stem cell selection during malignant transformation. J Natl Cancer Inst 102: 638-649.
30. Wu Y, Zhou BP, (2012) Snail: More than EMT. Cell Adh Migr 4: 199-203.
31. Montserrat N, Gallardo A, Escuin D, Catasus L, Prat J, et al. (2011) Repression of E-cadherin by SNAIL, ZEB1, and TWIST in invasive ductal carcinomas of the breast: a cooperative effort? Hum Pathol 42: 103-110.
32. Zhang K, Zhaos J, Liu X, Yan B, Chen D, et al. (2011) Activation of NF-B upregulates Snail and consequent repression of E-cadherin in cholangiocarcinoma cell invasion. Hepatogastroenterology 58: 1-7.
33. Chang L, Karin M, (2001) Mammalian MAP kinase signalling cascades. Nature 410: 37-40.
34. Wagner EF, Nebreda AR, (2009) Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer 9: 537-549.
35. Cuenda A, Rousseau S, (2007) p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim Biophys Acta 1773: 1358-1375.
36. Zavadil J, Bottinger EP, (2005) TGF-beta and epithelial-to-mesenchymal transitions. Oncogene 24: 5764-5774.