메뉴 건너뛰기




Volumn 36, Issue 1, 2013, Pages 28-36

Neural restrictive silencer factor and choline acetyltransferase expression in cerebral tissue of Alzheimer's disease patients: A pilot study

Author keywords

Alzheimer's disease; Brain; Choline acetyltransferase; Neural restrictive silencer factor; Protein expression

Indexed keywords

CHOLINE ACETYLTRANSFERASE; ISOTHIOCYANIC ACID DERIVATIVE; NEURAL RESTRICTIVE SILENCER FACTOR; RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 84874824211     PISSN: 14154757     EISSN: 16784685     Source Type: Journal    
DOI: 10.1590/s1415-47572013000100005     Document Type: Article
Times cited : (17)

References (69)
  • 1
    • 75549087631 scopus 로고    scopus 로고
    • Treatment of Alzheimer's Disease cognitive symptoms
    • Abel C, Allegri RF, Garau L, Genovese O and Mangone CA (2008) Treatment of Alzheimer's Disease cognitive symptoms. Vertex 19(Suppl):39-47.
    • (2008) Vertex , vol.19 , Issue.SUPPL. , pp. 39-47
    • Abel, C.1    Allegri, R.F.2    Garau, L.3    Genovese, O.4    Mangone, C.A.5
  • 2
    • 0036810329 scopus 로고    scopus 로고
    • Alzheimer's disease and the basal forebrain cholinergic system: Relations to beta-amyloid peptides, cognition, and treatment strategies
    • Auld DS, Kornecook TJ, Bastianetto S and Quirion R (2002) Alzheimer's disease and the basal forebrain cholinergic system: Relations to beta-amyloid peptides, cognition, and treatment strategies. Prog Neurobiol 68:209-245.
    • (2002) Prog Neurobiol , vol.68 , pp. 209-245
    • Auld, D.S.1    Kornecook, T.J.2    Bastianetto, S.3    Quirion, R.4
  • 3
    • 0347052876 scopus 로고    scopus 로고
    • Distinct RE-1 silencing transcription factor-containing complexes interact with different target genes
    • Belyaev ND, Wood IC, Bruce AW, Street M, Trinh JB and Buckley NJ (2004) Distinct RE-1 silencing transcription factor-containing complexes interact with different target genes. J Biol Chem 279:556-561.
    • (2004) J Biol Chem , vol.279 , pp. 556-561
    • Belyaev, N.D.1    Wood, I.C.2    Bruce, A.W.3    Street, M.4    Trinh, J.B.5    Buckley, N.J.6
  • 4
    • 0029086418 scopus 로고
    • Coregulation of two embedded gene products, choline acetyltransferase and the vesicular acetylcholine transporter
    • Berrard S, Varoqui H, Cervini R, Israel M, Mallet J and Diebler MF (1995) Coregulation of two embedded gene products, choline acetyltransferase and the vesicular acetylcholine transporter. J Neurochem 65:939-942.
    • (1995) J Neurochem , vol.65 , pp. 939-942
    • Berrard, S.1    Varoqui, H.2    Cervini, R.3    Israel, M.4    Mallet, J.5    Diebler, M.F.6
  • 5
    • 0029082673 scopus 로고
    • Coordinated up-regulation of choline acetyltransferase and vesicular acetylcholine transporter gene expression by the retinoic acid receptor alpha, cAMP, and leukemia inhibitory factor/ciliary neurotrophic factor signaling pathways in a murine septal cell line
    • Berse B and Blusztajn JK (1995) Coordinated up-regulation of choline acetyltransferase and vesicular acetylcholine transporter gene expression by the retinoic acid receptor alpha, cAMP, and leukemia inhibitory factor/ciliary neurotrophic factor signaling pathways in a murine septal cell line. J Biol Chem 270:22101-22104.
    • (1995) J Biol Chem , vol.270 , pp. 22101-22104
    • Berse, B.1    Blusztajn, J.K.2
  • 6
    • 0028783665 scopus 로고
    • Promoter elements conferring neuron-specific expression of the beta 2-subunit of the neuronal NRSF & ChAT in brain tissue of AD nicotinic acetylcholine receptor studied in vitro and in transgenic mice
    • Bessis A, Salmon AM, Zoli M, Le Novere N, Picciotto M and Changeux JP (1995) Promoter elements conferring neuron-specific expression of the beta 2-subunit of the neuronal NRSF & ChAT in brain tissue of AD nicotinic acetylcholine receptor studied in vitro and in transgenic mice. Neuroscience 69:807-819.
    • (1995) Neuroscience , vol.69 , pp. 807-819
    • Bessis, A.1    Salmon, A.M.2    Zoli, M.3    Le Novere, N.4    Picciotto, M.5    Changeux, J.P.6
  • 7
    • 0343417070 scopus 로고    scopus 로고
    • Choline acetyltransferase mRNA expression in the striatal neurons of patients with Alzheimer's disease
    • Boissiere F, Faucheux B, Agid Y and Hirsch EC (1997) Choline acetyltransferase mRNA expression in the striatal neurons of patients with Alzheimer's disease. Neurosci Lett 225:169-172.
    • (1997) Neurosci Lett , vol.225 , pp. 169-172
    • Boissiere, F.1    Faucheux, B.2    Agid, Y.3    Hirsch, E.C.4
  • 8
    • 45249108473 scopus 로고    scopus 로고
    • Structurefunction implications in Alzheimer's disease: Effect of Abeta oligomers at central synapses
    • Cerpa W, Dinamarca MC and Inestrosa NC (2008) Structurefunction implications in Alzheimer's disease: Effect of Abeta oligomers at central synapses. Curr Alzheimer Res 5:233-243.
    • (2008) Curr Alzheimer Res , vol.5 , pp. 233-243
    • Cerpa, W.1    Dinamarca, M.C.2    Inestrosa, N.C.3
  • 9
    • 0031694917 scopus 로고    scopus 로고
    • NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis
    • Chen ZF, Paquette AJ and Anderson DJ (1998) NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis. Nat Genet 20:136-142.
    • (1998) Nat Genet , vol.20 , pp. 136-142
    • Chen, Z.F.1    Paquette, A.J.2    Anderson, D.J.3
  • 10
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P and Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
    • (1987) Anal Biochem , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 12
    • 0020686674 scopus 로고
    • Alzheimer's disease: A disorder of cortical cholinergic innervation
    • Coyle JT, Price DL and DeLong MR (1983) Alzheimer's disease: A disorder of cortical cholinergic innervation. Science 219:1184-1190.
    • (1983) Science , vol.219 , pp. 1184-1190
    • Coyle, J.T.1    Price, D.L.2    Delong, M.R.3
  • 15
    • 0041125361 scopus 로고
    • The organization and some projections of cholinergic neurons of the mammalian forebrain
    • Fibiger HC (1982) The organization and some projections of cholinergic neurons of the mammalian forebrain. Brain Res 257:327-388.
    • (1982) Brain Res , vol.257 , pp. 327-388
    • Fibiger, H.C.1
  • 17
    • 0025267491 scopus 로고
    • Cortical projection patterns of the medial septum-diagonal band complex
    • Gaykema RP, Luiten PG, Nyakas C and Traber J (1990) Cortical projection patterns of the medial septum-diagonal band complex. J Comp Neurol 293:103-124.
    • (1990) J Comp Neurol , vol.293 , pp. 103-124
    • Gaykema, R.P.1    Luiten, P.G.2    Nyakas, C.3    Traber, J.4
  • 18
    • 41949104908 scopus 로고    scopus 로고
    • Cholinergic neuronal and axonal abnormalities are present early in aging and in Alzheimer disease
    • Geula C, Nagykery N, Nicholas A and Wu CK (2008) Cholinergic neuronal and axonal abnormalities are present early in aging and in Alzheimer disease. J Neuropathol Exp Neurol 67:309-318.
    • (2008) J Neuropathol Exp Neurol , vol.67 , pp. 309-318
    • Geula, C.1    Nagykery, N.2    Nicholas, A.3    Wu, C.K.4
  • 21
    • 33645858538 scopus 로고    scopus 로고
    • Alzheimer's disease - An interactive perspective
    • Heese K and Akatsu H (2006) Alzheimer's disease - An interactive perspective. Curr Alzheimer Res 3:109-121.
    • (2006) Curr Alzheimer Res , vol.3 , pp. 109-121
    • Heese, K.1    Akatsu, H.2
  • 22
    • 0037470636 scopus 로고    scopus 로고
    • Regulation of cholinergic gene expression by the neuron restrictive silencer factor/repressor element-1 silencing transcription factor
    • Hersh LB and Shimojo M (2003) Regulation of cholinergic gene expression by the neuron restrictive silencer factor/repressor element-1 silencing transcription factor. Life Sci 72:2021-2028.
    • (2003) Life Sci , vol.72 , pp. 2021-2028
    • Hersh, L.B.1    Shimojo, M.2
  • 23
    • 14844311990 scopus 로고    scopus 로고
    • Reduction of choline acetyltransferase activity in primary visual cortex in mild to moderate Alzheimer's disease
    • Ikonomovic MD, Mufson EJ, Wuu J, Bennett DA and DeKosky ST (2005) Reduction of choline acetyltransferase activity in primary visual cortex in mild to moderate Alzheimer's disease. Arch Neurol 62:425-430.
    • (2005) Arch Neurol , vol.62 , pp. 425-430
    • Ikonomovic, M.D.1    Mufson, E.J.2    Wuu, J.3    Bennett, D.A.4    Dekosky, S.T.5
  • 25
    • 0344873128 scopus 로고    scopus 로고
    • Activity, modulation and role of basal forebrain cholinergic neurons innervating the cerebral cortex
    • Jones BE (2004) Activity, modulation and role of basal forebrain cholinergic neurons innervating the cerebral cortex. Prog Brain Res 145:157-169.
    • (2004) Prog Brain Res , vol.145 , pp. 157-169
    • Jones, B.E.1
  • 26
    • 0033135879 scopus 로고    scopus 로고
    • Knockout of REST/NRSF shows that the protein is a potent repressor of neuronally expressed genes in non-neural tissues
    • Jones FS and Meech R (1999) Knockout of REST/NRSF shows that the protein is a potent repressor of neuronally expressed genes in non-neural tissues. Bioessays 21:372-376
    • (1999) Bioessays , vol.21 , pp. 372-376
    • Jones, F.S.1    Meech, R.2
  • 27
    • 11344265672 scopus 로고    scopus 로고
    • Interactions between beta-amyloid and central cholinergic neurons: Implications for Alzheimer's disease
    • Kar S, Slowikowski SP, Westaway D and Mount HT (2004) Interactions between beta-amyloid and central cholinergic neurons: Implications for Alzheimer's disease. J Psychiatry Neurosci 29:427-441.
    • (2004) J Psychiatry Neurosci , vol.29 , pp. 427-441
    • Kar, S.1    Slowikowski, S.P.2    Westaway, D.3    Mount, H.T.4
  • 28
    • 0025009296 scopus 로고
    • Physiological cholinergic functions in the CNS
    • Karczmar AG (1990) Physiological cholinergic functions in the CNS. Prog Brain Res 84:437-466.
    • (1990) Prog Brain Res , vol.84 , pp. 437-466
    • Karczmar, A.G.1
  • 29
    • 0027524610 scopus 로고
    • Brief presentation of the story and present status of studies of the vertebrate cholinergic system
    • Karczmar AG (1993) Brief presentation of the story and present status of studies of the vertebrate cholinergic system. Neuropsychopharmacology 9:181-199.
    • (1993) Neuropsychopharmacology , vol.9 , pp. 181-199
    • Karczmar, A.G.1
  • 31
    • 1442339260 scopus 로고    scopus 로고
    • Transcription
    • Lewin B, (ed), Oxford University Press and Cell Press, New York
    • Lewin B (2000) Transcription. In: Lewin B (ed) Genes VII. Oxford University Press and Cell Press, New York, pp 233-271.
    • (2000) Genes VII , pp. 233-271
    • Lewin, B.1
  • 32
    • 0030451494 scopus 로고    scopus 로고
    • Cell type-specific regulation of choline acetyltransferase gene expression. Role of the neuron-restrictive silencer element and cholinergic-specific enhancer sequences
    • Lonnerberg P, Schoenherr CJ, Anderson DJ and Ibanez CF (1996) Cell type-specific regulation of choline acetyltransferase gene expression. Role of the neuron-restrictive silencer element and cholinergic-specific enhancer sequences. J Biol Chem 271:33358-33365.
    • (1996) J Biol Chem , vol.271 , pp. 33358-33365
    • Lonnerberg, P.1    Schoenherr, C.J.2    Anderson, D.J.3    Ibanez, C.F.4
  • 34
    • 84874927995 scopus 로고    scopus 로고
    • Maduración del RNA o procesamiento postranscripcional
    • Harcourt/Gráficas Marte S.A, Madrid
    • Luque JH and Hernández A (2002) Maduración del RNA o procesamiento postranscripcional. In: Biología Molecular e Ingeniería Genética. Harcourt/Gráficas Marte S.A, Madrid, pp 275-284.
    • (2002) Biología Molecular E Ingeniería Genética , pp. 275-284
    • Luque, J.H.1    Hernández, A.2
  • 35
    • 0034831233 scopus 로고    scopus 로고
    • The protein kinase Cdk5. Structural aspects, roles in neurogenesis and involvement in Alzheimer's pathology
    • Maccioni RB, Otth C, Concha II and Munoz JP (2001) The protein kinase Cdk5. Structural aspects, roles in neurogenesis and involvement in Alzheimer's pathology. Eur J Biochem 268:1518-1527.
    • (2001) Eur J Biochem , vol.268 , pp. 1518-1527
    • Maccioni, R.B.1    Otth, C.2    Concha, I.I.3    Munoz, J.P.4
  • 36
    • 0033600301 scopus 로고    scopus 로고
    • Molecular basis of the neurodegenerative disorders
    • Martin JB (1999) Molecular basis of the neurodegenerative disorders. N Engl J Med 340:1970-1980.
    • (1999) N Engl J Med , vol.340 , pp. 1970-1980
    • Martin, J.B.1
  • 37
    • 0024519886 scopus 로고
    • Cholinergic somata and terminals in the rat substantia nigra: An immunocytochemical study with optical and electron microscopic techniques
    • Martinez-Murillo R, Villalba R, Montero-Caballero MI and Rodrigo J (1989) Cholinergic somata and terminals in the rat substantia nigra: An immunocytochemical study with optical and electron microscopic techniques. J Comp Neurol 281:397-415.
    • (1989) J Comp Neurol , vol.281 , pp. 397-415
    • Martinez-Murillo, R.1    Villalba, R.2    Montero-Caballero, M.I.3    Rodrigo, J.4
  • 38
    • 0030446775 scopus 로고    scopus 로고
    • The systems-level organization of cholinergic innervation in the human cerebral cortex and its alterations in Alzheimer's disease
    • Mesulam MM (1996) The systems-level organization of cholinergic innervation in the human cerebral cortex and its alterations in Alzheimer's disease. Prog Brain Res 109:285-297.
    • (1996) Prog Brain Res , vol.109 , pp. 285-297
    • Mesulam, M.M.1
  • 39
    • 0023715013 scopus 로고
    • Nucleus basalis (Ch4) and cortical cholinergic innervation in the human brain: Observations based on the distribution of acetylcholinesterase and choline acetyltransferase
    • Mesulam MM and Geula C (1988) Nucleus basalis (Ch4) and cortical cholinergic innervation in the human brain: Observations based on the distribution of acetylcholinesterase and choline acetyltransferase. J Comp Neurol 275:216-240.
    • (1988) J Comp Neurol , vol.275 , pp. 216-240
    • Mesulam, M.M.1    Geula, C.2
  • 40
    • 0031055065 scopus 로고    scopus 로고
    • Expression of the rat m4 muscarinic acetylcholine receptor gene is regulated by the neuron-restrictive silencer element/repressor element 1
    • Mieda M, Haga T and Saffen DW (1997) Expression of the rat m4 muscarinic acetylcholine receptor gene is regulated by the neuron-restrictive silencer element/repressor element 1. J Biol Chem 272:5854-5860.
    • (1997) J Biol Chem , vol.272 , pp. 5854-5860
    • Mieda, M.1    Haga, T.2    Saffen, D.W.3
  • 41
    • 0025278166 scopus 로고
    • A cell type-preferred silencer element that controls the neural-specific expression of the SCG10 gene
    • Mori N, Stein R, Sigmund O and Anderson DJ (1990) A cell type-preferred silencer element that controls the neural-specific expression of the SCG10 gene. Neuron 4:583-594.
    • (1990) Neuron , vol.4 , pp. 583-594
    • Mori, N.1    Stein, R.2    Sigmund, O.3    Anderson, D.J.4
  • 42
    • 0026651523 scopus 로고
    • A common silencer element in the SCG10 and type II Na+ channel genes binds a factor present in nonneuronal cells but not in neuronal cells
    • Mori N, Schoenherr C, Vandenbergh DJ and Anderson DJ (1992) A common silencer element in the SCG10 and type II Na+ channel genes binds a factor present in nonneuronal cells but not in neuronal cells. Neuron 9:45-54.
    • (1992) Neuron , vol.9 , pp. 45-54
    • Mori, N.1    Schoenherr, C.2    Vandenbergh, D.J.3    Anderson, D.J.4
  • 43
  • 44
    • 84861727534 scopus 로고    scopus 로고
    • Inhibition of choline acetyltransferase as a mechanism for cholinergic dysfunction induced by amyloid-peptide oligomers
    • Nunes-Tavares N, Santos LE, Stutz B, Brito-Moreira J, Kein WL, Ferreira ST and de Mello FG (2012) Inhibition of choline acetyltransferase as a mechanism for cholinergic dysfunction induced by amyloid-peptide oligomers. J Biol Chem 287:19377-19385.
    • (2012) J Biol Chem , vol.287 , pp. 19377-19385
    • Nunes-Tavares, N.1    Santos, L.E.2    Stutz, B.3    Brito-Moreira, J.4    Kein, W.L.5    Ferreira, S.T.6    de Mello, F.G.7
  • 45
    • 0027049178 scopus 로고
    • A complementary DNA for human choline acetyltransferase induces two forms of enzyme with different molecular weights in cultured cells
    • Oda Y, Nakanishi I and Deguchi T (1992) A complementary DNA for human choline acetyltransferase induces two forms of enzyme with different molecular weights in cultured cells. Brain Res Mol Brain Res 16:287-294.
    • (1992) Brain Res Mol Brain Res , vol.16 , pp. 287-294
    • Oda, Y.1    Nakanishi, I.2    Deguchi, T.3
  • 46
    • 0029980928 scopus 로고    scopus 로고
    • Translation initiation sites and relative activity of large and small forms of human choline acetyltransferase
    • Oda Y, Muroishi Y and Nakanishi I (1996) Translation initiation sites and relative activity of large and small forms of human choline acetyltransferase. Brain Res Mol Brain Res 38:135-138.
    • (1996) Brain Res Mol Brain Res , vol.38 , pp. 135-138
    • Oda, Y.1    Muroishi, Y.2    Nakanishi, I.3
  • 47
    • 4344583328 scopus 로고    scopus 로고
    • Comparative study of gene expression of cholinergic system-related molecules in the human spinal cord and term placenta
    • Oda Y, Muroishi Y, Misawa H and Suzuki S (2004) Comparative study of gene expression of cholinergic system-related molecules in the human spinal cord and term placenta. Neuroscience 128:39-49.
    • (2004) Neuroscience , vol.128 , pp. 39-49
    • Oda, Y.1    Muroishi, Y.2    Misawa, H.3    Suzuki, S.4
  • 48
    • 52049105166 scopus 로고    scopus 로고
    • Interactions between the amyloid and cholinergic mechanisms in Alzheimer's disease
    • Pakaski M and Kalman J (2008) Interactions between the amyloid and cholinergic mechanisms in Alzheimer's disease. Neurochem Int 53:103-111.
    • (2008) Neurochem Int , vol.53 , pp. 103-111
    • Pakaski, M.1    Kalman, J.2
  • 49
    • 0032519868 scopus 로고    scopus 로고
    • Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene
    • Palm K, Belluardo N, Metsis M and Timmusk T (1998) Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene. J Neurosci 18:1280-1296
    • (1998) J Neurosci , vol.18 , pp. 1280-1296
    • Palm, K.1    Belluardo, N.2    Metsis, M.3    Timmusk, T.4
  • 50
    • 0032846641 scopus 로고    scopus 로고
    • Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat
    • Palm K, Metsis M and Timmusk T (1999) Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat. Brain Res Mol Brain Res 72:30-39.
    • (1999) Brain Res Mol Brain Res , vol.72 , pp. 30-39
    • Palm, K.1    Metsis, M.2    Timmusk, T.3
  • 51
    • 0027443555 scopus 로고
    • Overview and future directions of CNS cholinergic mechanisms
    • Pepeu G (1993) Overview and future directions of CNS cholinergic mechanisms. Prog Brain Res 98:455-458.
    • (1993) Prog Brain Res , vol.98 , pp. 455-458
    • Pepeu, G.1
  • 52
    • 0141552123 scopus 로고    scopus 로고
    • Aging of the brain and dementia of the Alzheimer type
    • In: Kandel ER and Jessel TM, McGraw-Hill, New York
    • Price DL (2000) Aging of the brain and dementia of the Alzheimer type. In: Kandel ER and Jessel TM (ed) Principles of Neural Sciences. McGraw-Hill, New York, pp 1149-1168.
    • (2000) Principles of Neural Sciences , pp. 1149-1168
    • Price, D.L.1
  • 53
    • 0034001908 scopus 로고    scopus 로고
    • Transcriptional repression by neuron-restrictive silencer factor is mediated via the Sin3-histone deacetylase complex
    • Roopra A, Sharling L, Wood IC, Briggs T, Bachfischer U, Paquette AJ and Buckley NJ (2000) Transcriptional repression by neuron-restrictive silencer factor is mediated via the Sin3-histone deacetylase complex. Mol Cell Biol 20:2147-2157.
    • (2000) Mol Cell Biol , vol.20 , pp. 2147-2157
    • Roopra, A.1    Sharling, L.2    Wood, I.C.3    Briggs, T.4    Bachfischer, U.5    Paquette, A.J.6    Buckley, N.J.7
  • 54
    • 0028968802 scopus 로고
    • The neuron-restrictive silencer factor (NRSF): A coordinate repressor of multiple neuron-specific genes
    • Schoenherr CJ and Anderson DJ (1995) The neuron-restrictive silencer factor (NRSF): A coordinate repressor of multiple neuron-specific genes. Science 267:1360-1363.
    • (1995) Science , vol.267 , pp. 1360-1363
    • Schoenherr, C.J.1    Anderson, D.J.2
  • 55
    • 0029796093 scopus 로고    scopus 로고
    • Identification of potential target genes for the neuron-restrictive silencer factor
    • Schoenherr CJ, Paquette AJ and Anderson DJ (1996) Identification of potential target genes for the neuron-restrictive silencer factor. Proc Natl Acad Sci USA 93:9881-9886.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9881-9886
    • Schoenherr, C.J.1    Paquette, A.J.2    Anderson, D.J.3
  • 56
    • 0031743552 scopus 로고    scopus 로고
    • Trajectories of cholinergic pathways within the cerebral hemispheres of the human brain
    • Selden NR, Gitelman DR, Salamon-Murayama N, Parrish TB and Mesulam MM (1998) Trajectories of cholinergic pathways within the cerebral hemispheres of the human brain. Brain 121:2249-2257.
    • (1998) Brain , vol.121 , pp. 2249-2257
    • Selden, N.R.1    Gitelman, D.R.2    Salamon-Murayama, N.3    Parrish, T.B.4    Mesulam, M.M.5
  • 57
    • 0024373897 scopus 로고
    • Brainstem projecting neurons in the rat basal forebrain: Neurochemical, topographical, and physiological distinctions from cortically projecting cholinergic neurons
    • Semba K, Reiner PB, McGeer EG and Fibiger HC (1989) Brainstem projecting neurons in the rat basal forebrain: Neurochemical, topographical, and physiological distinctions from cortically projecting cholinergic neurons. Brain Res Bull 22:501-509.
    • (1989) Brain Res Bull , vol.22 , pp. 501-509
    • Semba, K.1    Reiner, P.B.2    McGeer, E.G.3    Fibiger, H.C.4
  • 58
    • 0032875467 scopus 로고    scopus 로고
    • Protein kinase A regulates cholinergic gene expression in PC12 cells: REST4 silences the silencing activity of neuron-restrictive silencer factor/REST
    • Shimojo M, Paquette AJ, Anderson DJ and Hersh LB (1999) Protein kinase A regulates cholinergic gene expression in PC12 cells: REST4 silences the silencing activity of neuron-restrictive silencer factor/REST. Mol Cell Biol 19:6788-6795.
    • (1999) Mol Cell Biol , vol.19 , pp. 6788-6795
    • Shimojo, M.1    Paquette, A.J.2    Anderson, D.J.3    Hersh, L.B.4
  • 59
    • 0031844540 scopus 로고    scopus 로고
    • The cholinergic gene locus is coordinately regulated by protein kinase A II in PC12 cells
    • Shimojo M, Wu D and Hersh LB (1998) The cholinergic gene locus is coordinately regulated by protein kinase A II in PC12 cells. J Neurochem 71:1118-1126.
    • (1998) J Neurochem , vol.71 , pp. 1118-1126
    • Shimojo, M.1    Wu, D.2    Hersh, L.B.3
  • 60
    • 0025994795 scopus 로고
    • The medial temporal lobe memory system
    • Squire LR and Zola-Morgan S (1991) The medial temporal lobe memory system. Science 253:1380-1386.
    • (1991) Science , vol.253 , pp. 1380-1386
    • Squire, L.R.1    Zola-Morgan, S.2
  • 61
    • 0031958783 scopus 로고    scopus 로고
    • The use of DNase I hypersensitivity site mapping to identify regulatory regions of the human cholinergic gene locus
    • Tanaka H, Zhao Y, Wu D and Hersh LB (1998) The use of DNase I hypersensitivity site mapping to identify regulatory regions of the human cholinergic gene locus. J Neurochem 70:1799-1808.
    • (1998) J Neurochem , vol.70 , pp. 1799-1808
    • Tanaka, H.1    Zhao, Y.2    Wu, D.3    Hersh, L.B.4
  • 62
    • 0028283543 scopus 로고
    • Regulation of synapsin I gene expression by the zinc finger transcription factor zif268/egr-1
    • Thiel G, Schoch S and Petersohn D (1994) Regulation of synapsin I gene expression by the zinc finger transcription factor zif268/egr-1. J Biol Chem 269:15294-15301.
    • (1994) J Biol Chem , vol.269 , pp. 15294-15301
    • Thiel, G.1    Schoch, S.2    Petersohn, D.3
  • 63
    • 0033534468 scopus 로고    scopus 로고
    • Brainderived neurotrophic factor expression in vivo is under the control of neuron-restrictive silencer element
    • Timmusk T, Palm K, Lendahl U and Metsis M (1999) Brainderived neurotrophic factor expression in vivo is under the control of neuron-restrictive silencer element. J Biol Chem 274:1078-1084.
    • (1999) J Biol Chem , vol.274 , pp. 1078-1084
    • Timmusk, T.1    Palm, K.2    Lendahl, U.3    Metsis, M.4
  • 65
    • 0026630567 scopus 로고
    • Hippocampus, fimbria-fornix, amygdala, and memory: Object discriminations in rats
    • Wible CG, Shiber JR and Olton DS (1992) Hippocampus, fimbria-fornix, amygdala, and memory: Object discriminations in rats. Behav Neurosci 106:751-761.
    • (1992) Behav Neurosci , vol.106 , pp. 751-761
    • Wible, C.G.1    Shiber, J.R.2    Olton, D.S.3
  • 66
    • 0020397384 scopus 로고
    • Alzheimer's disease. Correlation of cortical choline acetyltrans-ferase activity with the severity of dementia and histological abnormalities
    • Wilcock GK, Esiri MM, Bowen DM and Smith CC (1982) Alzheimer's disease. Correlation of cortical choline acetyltrans-ferase activity with the severity of dementia and histological abnormalities. J Neurol Sci 57:407-417.
    • (1982) J Neurol Sci , vol.57 , pp. 407-417
    • Wilcock, G.K.1    Esiri, M.M.2    Bowen, D.M.3    Smith, C.C.4
  • 67
    • 0344441724 scopus 로고    scopus 로고
    • Interaction of the repressor element 1-silencing transcription factor (REST) with target genes
    • Wood IC, Belyaev ND, Bruce AW, Jones C, Mistry M, Roopra A and Buckley NJ (2003) Interaction of the repressor element 1-silencing transcription factor (REST) with target genes. J Mol Biol 334:863-874.
    • (2003) J Mol Biol , vol.334 , pp. 863-874
    • Wood, I.C.1    Belyaev, N.D.2    Bruce, A.W.3    Jones, C.4    Mistry, M.5    Roopra, A.6    Buckley, N.J.7
  • 69
    • 22144444924 scopus 로고    scopus 로고
    • Alzheimer's disease: Interactions between cholinergic functions and beta-amyloid
    • Yan Z and Feng J (2004) Alzheimer's disease: Interactions between cholinergic functions and beta-amyloid. Curr Alzheimer Res 1:241-248.
    • (2004) Curr Alzheimer Res , vol.1 , pp. 241-248
    • Yan, Z.1    Feng, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.