Saccades during Attempted Fixation in Parkinsonian Disorders and Recessive Ataxia: From Microsaccades to Square-Wave Jerks

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Otero Millan, Jorge ^a,b   Schneider, Rosalyn ^c   Leigh, R John ^c   Macknik, Stephen L ^a   Martinez Conde, Susana ^a  

^a BARROW NEUROLOGICAL INSTITUTE   (United States)

^b UNIVERSITY OF VIGO   (Spain)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; ATAXIA; BASAL GANGLION; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE DURATION; EYE FIXATION; EYE MOVEMENT DISORDER; FEMALE; GAZE; HUMAN; INHIBITION (PSYCHOLOGY); LATENT PERIOD; MALE; NERVE CELL NETWORK; NEUROPATHOLOGY; NEUROPHYSIOLOGY; PARKINSONISM; PATIENT ASSESSMENT; PRESCHOOL CHILD; SACCADIC EYE MOVEMENT; SCHOOL CHILD; SQUARE WAVE JERK;

AGED; BRAIN; FEMALE; FIXATION, OCULAR; HUMANS; MALE; MIDDLE AGED; PARKINSONIAN DISORDERS; SACCADES; SPINOCEREBELLAR ATAXIAS; SUPRANUCLEAR PALSY, PROGRESSIVE;

EID: 84874822538     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0058535     Document Type: Article

References (61)

1. Abadi RV, Gowen E, (2004) Characteristics of saccadic intrusions. Vision Res 44: 2675-2690.
2. Martinez-Conde S, Macknik SL, Hubel DH, (2004) The role of fixational eye movements in visual perception. Nat Rev Neurosci 5: 229-240.
3. Leigh RJ, Zee DS (2006) The neurology of eye movements. Oxford Univ Press.
4. Martinez-Conde S, Macknik SL, Troncoso XG, Dyar TA, (2006) Microsaccades counteract visual fading during fixation. Neuron 49: 297-305.
5. Martinez-Conde S, Macknik SL, Troncoso XG, Hubel DH, (2009) Microsaccades: a neurophysiological analysis. Trends Neurosci 32: 463-475.
6. Martinez-Conde S, Macknik SL, (2007) Windows on the mind. Sci Am 297: 56-63.
7. Troncoso XG, Macknik SL, Martinez-Conde S, (2008) Microsaccades counteract perceptual filling-in. J Vis 8: 1-9.
8. McCamy MB, Otero-Millan J, Macknik SL, Yang Y, Troncoso XG, et al. (2012) Microsaccadic Efficacy and Contribution to Foveal and Peripheral Vision. J Neurosci 32: 9194-9204.
9. Rascol O, Sabatini U, Simonetta-Moreau M, Montastruc JL, Rascol A, et al. (1991) Square wave jerks in parkinsonian syndromes. J Neurol Neurosurg Psychiatr 54: 599-602.
10. Fahey MC, Cremer PD, Aw ST, Millist L, Todd MJ, et al. (2008) Vestibular, saccadic and fixation abnormalities in genetically confirmed Friedreich ataxia. Brain 131: 1035-1045.
11. Chen AL, Riley DE, King SA, Joshi AC, Serra A, et al. (2010) The disturbance of gaze in progressive supranuclear palsy: implications for pathogenesis. Front Neur 1: 147.
12. Otero-Millan J, Serra A, Leigh RJ, Troncoso XG, Macknik SL, et al. (2011) Distinctive features of saccadic intrusions and microsaccades in progressive supranuclear palsy. J Neurosci 31: 4379-4387.
13. Gowen E, Abadi RV, Poliakoff E, Hansen PC, Miall RC, (2007) Modulation of saccadic intrusions by exogenous and endogenous attention. Brain Res 1141: 154-167.
14. Otero-Millan J, Macknik SL, Serra A, Leigh RJ, Martinez-Conde S, (2011) Triggering mechanisms in microsaccade and saccade generation: a novel proposal. Ann N Y Acad Sci 1233: 107-116.
15. Boxer AL, Garbutt S, Seeley WW, Jafari A, Heuer HW, et al. (2012) Saccade abnormalities in autopsy-confirmed frontotemporal lobar degeneration and Alzheimer disease. Arch Neurol 69: 509-517.
16. Watanabe M, Munoz DP, (2011) Probing basal ganglia functions by saccade eye movements. Eur J Neurosci 33: 2070-2090.
17. Litvan I, Agid Y, Calne D, Campbell G, Dubois B, et al. (1996) Clinical Research Criteria for the Diagnosis of Progressive Supranuclear Palsy (Steele-Richardson-Olszewski Syndrome) Report of the NINDS-SPSP International Workshop*. Neurology 47: 1-9.
18. Hoehn MM, Yahr MD, (1967) Parkinsonism: onset, progression, and mortality. Neurology 17: 427-442.
19. Boeve BF, Maraganore DM, Parisi JE, Ahlskog JE, Graff-Radford N, et al. (1999) Pathologic heterogeneity in clinically diagnosed corticobasal degeneration. Neurology 53: 795-795.
20. Gilman S, Wenning GK, Low PA, Brooks DJ, Mathias CJ, et al. (2008) Second consensus statement on the diagnosis of multiple system atrophy. Neurology 71: 670-676.
21. Swartz BE, Li S, Bespalova I, Burmeister M, Dulaney E, et al. (2003) Pathogenesis of clinical signs in recessive ataxia with saccadic intrusions. Ann Neurol 54: 824-828.
22. Otero-Millan J, Troncoso XG, Macknik SL, Serrano-Pedraza I, Martinez-Conde S, (2008) Saccades and microsaccades during visual fixation, exploration and search: foundations for a common saccadic generator. J Vis 8: 14-21.
23. Robinson DA, (1963) A method of measuring eye movements using a scleral coil in a magnetic field. IEEE Trans Biomed Eng 10: 137-145.
24. Ramat S, Somers JT, Das VE, Leigh RJ, (1999) Conjugate Ocular Oscillations During Shifts of the Direction and Depth of Visual Fixation. Invest Ophthalmol Vis Sci 40: 1681-1686.
25. Engbert R, Kliegl R, (2003) Microsaccades uncover the orientation of covert attention. Vision Res 43: 1035-1045.
26. Engbert R, (2006) Microsaccades: A microcosm for research on oculomotor control, attention, and visual perception. Prog Brain Res 154: 177-192.
27. Laubrock J, Engbert R, Kliegl R, (2005) Microsaccade dynamics during covert attention. Vision Res 45: 721-730.
28. Kapoula Z, Robinson DA, Hain TC, (1986) Motion of the eye immediately after a saccade. Exp Brain Res 61: 386-394.
29. Møller F, Laursen M, Tygesen J, Sjølie A, (2002) Binocular quantification and characterization of microsaccades. Graefes Arch Clin Exp Ophthalmol 240: 765-770.
30. Troncoso XG, Macknik SL, Martinez-Conde S, (2005) Novel visual illusions related to Vasarely's "nested squares" show that corner salience varies with corner angle. Perception 34: 409-420.
31. Troncoso XG, Macknik SL, Otero-Millan J, Martinez-Conde S, (2008) Microsaccades drive illusory motion in the Enigma illusion. Proc Natl Acad Sci USA 105: 16033-16038.
32. Bahill AT, Clark MR, Stark L, (1975) The main sequence, a tool for studying human eye movements. Math Biosci 24: 191-204.
33. Evinger C, Manning KA, Sibony PA, (1991) Eyelid movements. Mechanisms and normal data. Invest Ophthalmol Vis Sci 32: 387-400.
34. Gruart A, Blazquez P, Delgado-Garcia JM, (1995) Kinematics of spontaneous, reflex, and conditioned eyelid movements in the alert cat. J Neurophysiol 74: 226-248.
35. Martinez-Conde S, (2006) Fixational eye movements in normal and pathological vision. Visual Perception- Fundamentals of Vision: Low and Mid-Level Processes in Perception. Elsevier, Vol. Volume 154, Part 1: 151-176.
36. McLachlan GJ (2005) Discriminant Analysis and Statistical Pattern Recognition. Discriminant Analysis and Statistical Pattern Recognition. John Wiley & Sons, Inc. p. i-xv.
37. Arlot S, (2010) A survey of cross-validation procedures for model selection. Statist Surv 4: 40-79.
38. Cornsweet TN, (1956) Determination of the stimuli for involuntary drifts and saccadic eye movements. J Opt Soc Am 46: 987-988.
39. Pinnock R, McGivern R, Forbes R, Gibson J, (2010) An exploration of ocular fixation in Parkinson's disease, multiple system atrophy and progressive supranuclear palsy. J Neurol 257: 533-539.
40. Rolfs M, Kliegl R, Engbert R, (2008) Toward a model of microsaccade generation: The case of microsaccadic inhibition. J Vis 8: 1-23.
41. Hafed ZM, Goffart L, Krauzlis RJ, (2009) A neural mechanism for microsaccade generation in the primate superior colliculus. Science 323: 940-943.
42. Sparks D, Rohrer WH, Zhang Y, (2000) The role of the superior colliculus in saccade initiation: a study of express saccades and the gap effect. Vision Res 40: 2763-2777.
43. Bergeron A, Guitton D, (2002) In Multiple-Step Gaze Shifts: Omnipause (OPNs) and Collicular Fixation Neurons Encode Gaze Position Error; OPNs Gate Saccades. J Neurophysiol 88: 1726-1742.
44. Cullen KE, Guitton D, (1997) Analysis of Primate IBN Spike Trains Using System Identification Techniques. I. Relationship to Eye Movement Dynamics During Head-Fixed Saccades. J Neurophysiol 78: 3259-3282.
45. Evinger C, Kaneko CR, Fuchs AF, (1982) Activity of omnipause neurons in alert cats during saccadic eye movements and visual stimuli. J Neurophysiol 47: 827-844.
46. Bergeron A, Guitton D, (2001) The superior colliculus and its control of fixation behavior via projections to brainstem omnipause neurons. Prog Brain Res 134: 97-107.
47. Shinoda Y, Sugiuchi Y, Takahashi M, Izawa Y, (2011) Neural substrate for suppression of omnipause neurons at the onset of saccades. Ann N Y Acad Sci 1233: 100-106.
48. Chan F, Armstrong IT, Pari G, Riopelle RJ, Munoz DP, (2005) Deficits in saccadic eye-movement control in Parkinson's disease. Neuropsychologia 43: 784-796.
49. Pinkhardt EH, Kassubek J, (2011) Ocular motor abnormalities in Parkinsonian syndromes. Parkinsonism Relat Disord 17: 223-230.
50. Averbuch-Heller L, Stahl JS, Hlavin ML, Leigh RJ, (1999) Square-wave jerks induced by pallidotomy in parkinsonian patients. Neurology 52: 185-188.
51. O'Sullivan JD, Maruff P, Tyler P, Peppard RF, McNeill P, et al. (2003) Unilateral pallidotomy for Parkinson's disease disrupts ocular fixation. J Clin Neurosci 10: 181-185.
52. Bhidayasiri R, Riley DE, Somers JT, Lerner AJ, Buttner-Ennever JA, et al. (2001) Pathophysiology of slow vertical saccades in progressive supranuclear palsy. Neurology 57: 2070-2077.
53. Robinson FR, Straube A, Fuchs AF, (1993) Role of the caudal fastigial nucleus in saccade generation. II. Effects of muscimol inactivation. J Neurophysiol 70: 1741-1758.
54. Goffart L, Pélisson D, (1998) Orienting Gaze Shifts During Muscimol Inactivation of Caudal Fastigial Nucleus in the Cat. I. Gaze Dysmetria. J Neurophysiol 79: 1942-1958.
55. Goffart L, Chen LL, Sparks DL, (2004) Deficits in Saccades and Fixation During Muscimol Inactivation of the Caudal Fastigial Nucleus in the Rhesus Monkey. J Neurophysiol 92: 3351-3367.
56. Serra A, Liao K, Martinez-Conde S, Optican LM, Leigh RJ, (2008) Suppression of saccadic intrusions in hereditary ataxia by memantine. Neurology 70: 810-812.
57. Weber H, Fischer B, Rogal L, Spatz WB, Illing RB, (1989) Macro square wave jerks in a rhesus monkey: physiological and anatomical findings in a case of selective impairment of attentive fixation. J Hirnforsch 30: 603-611.
58. Cui J, Wilke M, Logothetis NK, Leopold DA, Liang H, (2009) Visibility states modulate microsaccade rate and direction. Vision Res 49: 228-236.
59. Gandhi NJ, Keller EL, (1997) Spatial distribution and discharge characteristics of superior colliculus neurons antidromically activated from the omnipause region in monkey. J Neurophysiol 78: 2221-2225.
60. Moschovakis AK, Kitama T, Dalezios Y, Petit J, Brandi AM, et al. (1998) An Anatomical Substrate for the Spatiotemporal Transformation. J Neurosci 18: 10219-10229.
61. Büttner-Ennever JA, Horn AKE, Henn V, Cohen B, (1999) Projections from the superior colliculus motor map to omnipause neurons in monkey. J Comp Neurol 413: 55-67.