The free fatty acid receptor G protein-coupled receptor 40 (GPR40) protects from bone loss through inhibition of osteoclast differentiation

Journal of Biological Chemistry

Volumn 288, Issue 9, 2013, Pages 6542-6551

  Wauquier, Fabien ^a,b,c   Philippe, Claire ^a,b,c   Léotoing, Laurent ^a,b,c   Mercier, Sylvie ^a,b,c   Davicco, Marie Jeanne ^a,b,c   Lebecque, Patrice ^a,b,c   Guicheux, Jérôme ^d,e   Pilet, Paul ^d,e   Miot Noirault, Elisabeth ^b,d   Poitout, Vincent ^f,g   Alquier, Thierry ^f,g   Coxam, Véronique ^a,b,c   Wittrant, Yohann ^a,b,c,h  

^a CEMAGREF   (France)

^b UNIVERSITÉ CLERMONT AUVERGNE   (France)

^c Universite de Nantes   (France)

^d INSERM   (France)

^e Laboratoire d'Acoustique Environnementale)   (France)

^f CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^g UNIVERSITÉ DE MONTRÉAL   (Canada)

^h INRA and University of Auvergne   (France)

Author keywords

[No Author keywords available]

Indexed keywords

, INHIBITOR; AGE-RELATED; BONE CELLS; BONE DENSITY; BONE LOSS; BONE MARROW; BONE REMODELING; CELL DIFFERENTIATION; FREE FATTY ACID; G PROTEIN COUPLED RECEPTORS; IN-VIVO; MICRO CT; NUCLEAR FACTOR OF ACTIVATED T-CELLS; NUCLEAR FACTORS; OSTEOCLAST DIFFERENTIATION; OSTEOCLAST PRECURSOR; OSTEOPOROTIC; PRIMARY CELL CULTURES; PRIMARY CULTURE; PROTEIN RECEPTORS; RECEPTOR ACTIVATOR; RELEVANT TARGET; SIGNALING PATHWAYS; THERAPEUTIC STRATEGY; WILD TYPES;

CELL CULTURE; CHEMICAL ACTIVATION; COMPUTERIZED TOMOGRAPHY; GENE EXPRESSION; MAMMALS; PHOSPHORYLATION;

BONE;

BONE DENSITY CONSERVATION AGENT; G PROTEIN COUPLED RECEPTOR 40; GW 9508; I KAPPA B ALPHA; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OSTEOCLAST DIFFERENTIATION FACTOR; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE MARROW CULTURE; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; FEMALE; IN VIVO STUDY; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REPORTER GENE; SIGNAL TRANSDUCTION; WILD TYPE;

ANIMALS; BONE RESORPTION; CELL DIFFERENTIATION; CELL LINE; METHYLAMINES; MICE; MICE, KNOCKOUT; NFATC TRANSCRIPTION FACTORS; OSTEOCLASTS; OSTEOPOROSIS; PROPIONATES; RANK LIGAND; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84874781809     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.429084     Document Type: Article

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