A Retrotransposon Insertion in the 5′ Regulatory Domain of Ptf1a Results in Ectopic Gene Expression and Multiple Congenital Defects in Danforth's Short Tail Mouse

PLoS Genetics

Volumn 9, Issue 2, 2013, Pages

  Lugani, Francesca ^a   Arora, Ripla ^a   Papeta, Natalia ^a   Patel, Ami ^a   Zheng, Zongyu ^a   Sterken, Roel ^a   Singer, Ruth A ^a   Caridi, Gianluca ^b   Mendelsohn, Cathy ^a   Sussel, Lori ^a   Papaioannou, Virginia E ^a   Gharavi, Ali G ^a  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

^b G GASLINI INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOME MAP; CONGENITAL DISORDER; CONTROLLED STUDY; ECTOPIC GENE EXPRESSION; EMBRYO; EMBRYO DEVELOPMENT; ENHANCER REGION; GENE; GENE EXPRESSION; GENE FUNCTION; GENE INSERTION; GENE LOCUS; GENE SEQUENCE; GENITAL MALFORMATION; HAPLOINSUFFICIENCY; HETEROZYGOTE; INTESTINE MALFORMATION; MOUSE; MUELLERIAN DUCT; NONHUMAN; PHENOTYPE; PTF1A GENE; RETROPOSON; SKELETON MALFORMATION; URINARY TRACT MALFORMATION; WILD TYPE;

ANIMALS; DNA-BINDING PROTEINS; EMBRYONIC DEVELOPMENT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MESODERM; MICE; MUTAGENESIS, INSERTIONAL; PANCREAS; RETROELEMENTS; SPINAL CORD; TAIL; TRANSCRIPTION FACTORS;

EID: 84874780737     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003206     Document Type: Article

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