Ptf1a determines GABAergic over glutamatergic neuronal cell fate in the spinal cord dorsal horn

Development

Volumn 132, Issue 24, 2005, Pages 5461-5469

  Glasgow, Stacey M ^a   Henke, R Michael ^a   MacDonald, Raymond J ^a   Wright, Christopher V E ^b   Johnson, Jane E ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BHLH transcription factor; Dorsal horn inhibitory neurons; Mouse; Spinal cord development

Indexed keywords

HELIX LOOP HELIX PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PTF1A; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL FATE; CELL POPULATION; CEREBELLUM; CONTROLLED STUDY; EMBRYO; GABAERGIC SYSTEM; GENE MUTATION; INTERNEURON; MOUSE; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NEURAL TUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SPINAL CORD DORSAL HORN;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; CEREBELLUM; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; HOMEODOMAIN PROTEINS; INTERNEURONS; MICE; MICE, MUTANT STRAINS; MUTATION; NEURONS; PAX2 TRANSCRIPTION FACTOR; POSTERIOR HORN CELLS; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 29144516650     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.02167     Document Type: Article

References (38)

1. Artavanis-Tsakonas, S., Rand, M. D. and Lake, R. J. (1999). Notch signaling: cell fate control and signal integration in development. Science 284, 770-776.
2. Beres, T., Masui, T., Swift, G. H., Shi, L., Henke, R. M. and MacDonald, R. J. (2005). PTF1: an organ-specific and Notch-independent bHLH complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue RBP-L. Mol. Cell. Biol. (in press).
3. Bermingham, N. A., Hassan, B. A., Wang, V. Y., Fernandez, M., Banfi, S., Bellen, H. J., Fritzsch, B. and Zoghbi, H. Y. (2001). Proprioceptor pathway development is dependent on Math1. Neuron 30, 411-422.
4. Bertrand, N., Castro, D. S. and Guillemot, F. (2002). Proneural genes and the specification of neural cell types. Nat. Rev. Neurosci. 3, 517-530.
5. Birren, S. J., Lo, L. and Anderson, D. J. (1993). Sympathetic neuroblasts undergo a developmental switch in trophic dependence. Development 119, 597-610.
6. Bray, S. and Furriols, M. (2001). Notch pathway: Making sense of Suppressor of hairless. Curr. Biol. 11, R217-R221.
7. Caspary, T. and Anderson, K. V. (2003). Patterning cell types in the dorsal spinal cord: what the mouse mutants say. Nat. Rev. Neurosci. 4, 289-297.
8. Cheng, L., Arata, A., Mizuguchi, R., Qian, Y., Karunaratne, A., Gray, P. A., Arata, S., Shirasawa, S., Bouchard, M., Luo, P. et al. (2004). Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates. Nat. Neurosci. 7, 510-517.
9. Cheng, L., Abdel-Samad, O., Xu, Y., Mizuguchi, R., Luo, P., Shirasawa, S., Goulding, M. and Ma, Q. (2005). Lbx1 and Tlx3 act as opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes. Nat. Neurosci. 8, 1510-1515.
10. Cockell, M., Stevenson, B. J., Strubin, M., Hagenbuchle, O. and Wellauer, P. K. (1989). Identification of a cell-specific DNA-binding activity that interacts with a transcriptional activator of genes expressed in the acinar pancreas. Mol. Cell. Biol. 9, 2464-2476.
11. Fode, C., Ma, Q., Casarosa, S., Ang, S.-L., Anderson, D. J. and Guillemot, F. (2000). A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons. Genes Dev. 14, 67-80.
12. Gowan, K., Helms, A. W., Hunsaker, T. L., Collisson, T., Ebert, P. J., Odom, R. and Johnson, J. E. (2001). Cross inhibitory activities of Ngn1 and Math1 allow specification of distinct dorsal interneurons. Neuron 31, 219-232.
13. Gross, M. K., Dottori, M. and Goulding, M. (2002). Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord. Neuron 34, 535-549.
14. Helms, A. W. and Johnson, J. E. (2003). Specification of dorsal spinal cord interneurons. Curr. Opin. Neurobiol. 13, 42-49.
15. Helms, A. W., Battiste, J., Henke, R. M., Nakada, Y., Simplicio, N., Guillemot, F. and Johnson, J. E. (2005). Sequential roles for Mash1 and Ngn2 in the generation of dorsal spinal cord interneurons. Development 132, 2709-2719.
16. Hoshino, M., MNakamura, S., Mori, K., Kawauchi, T., Terao, M., Nishimura, Y., Fukuda, A., Fuse, T., Matsuo, N., Sone, M. et al. (2005). Ptf1a, a bHLH Transcriptional Gene, Defines GABAergic Neuronal Fates in Cerebellum. Neuron 47, 201-213.
17. Hoveyda, N., Shield, J. P., Garrett, C., Chong, W. K., Beardsall, K., Bentsi-Enchill, E., Mallya, H. and Thompson, M. H. (1999). Neonatal diabetes mellitus and cerebellar hypoplasia/agenesis: report of a new recessive syndrome. J. Med. Genet. 36, 700-744.
18. Ibuki, T., Hama, A. T., Wang, X. T., Pappas, G. D. and Sagen, J. (1997). Loss of GABA-immunoreactivity in the spinal dorsal horn of rats with peripheral nerve injury and promotion of recovery by adrenal medullary grafts. Neuroscience 76, 845-858.
19. Jessell, T. M. (2000). Neuronal specification in the spinal cord: inductive signals and transcriptional codes. Nat. Rev. Genetics 1, 20-29.
20. Kawaguchi, Y., Cooper, B., Gannon, M., Ray, M., MacDonald, R. J. and Wright, C. V. E. (2002). The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat. Genetics 32, 128-134.
21. Krapp, A., Knofler, M., Ledermann, B., Burki, K., Berney, C., Zoerkler, N., Hagenbuchle, O. and Wellauer, P. K. (1998). The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. Genes Dev. 12, 3752-3763.
22. Kriks, S., Lanuza, G. M., Mizuguchi, R., Nakafuku, M. and Goulding, M. (2005). Gsh2 is required for the repression of Ngn1 and specification of dorsal interneuron fate in the spinal cord. Development 132, 2991-3002.
23. Lee, S. K. and Pfaff, S. L. (2001). Transcriptional networks regulating neuronal identity in the developing spinal cord. Nat. Neurosci. 4, 1183-1191.
24. Li, H. and Edlund, H. (2001). Persistent expression of Hlxb9 in the pancreatic epithelium impairs pancreatic development. Dev. Biol. 240, 247-253.
25. Liu, Y., Helms, A. W. and Johnson, J. E. (2004). Distinct activities of Msx1 and Msx3 in dorsal neural tube development. Development 131, 1017-1028.
26. Lo, L.-C., Johnson, J. E., Wuenschell, C. W., Saito, T. and Anderson, D. J. (1991). Mammalian achaete-scute homolog 1 is transiently expressed by spatially-restricted subsets of early neuroepithelial and neural crest cells. Genes Dev. 5, 1524-1537.
27. Mann, R. S. and Carroll, S. B. (2002). Molecular mechanisms of selector gene function and evolution. Curr. Opin. Genet. Dev. 12, 592-600.
28. Miyoshi, G., Bessho, Y., Yamada, S. and Kageyama, R. (2004). Identification of a novel basic helix-loop-helix gene, Heslike, and its role in GABAergic neurogenesis. J. Neurosci. 24, 3672-3682.
29. Müller, T., Brohmann, H., Pierani, A., Heppenstall, P. A., Lewin, G. R., Jessell, T. M. and Birchmeier, C. (2002). The homeodomain factor Lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord. Neuron 34, 551-562.
30. Müller, T., Anlag, K., Wildner, H., Britsch, S., Treier, M. and Birchmeier, C. (2005). The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord. Genes Dev. 19, 733-743.
31. Obata, J., Yano, M., Mimura, H., Goto, T., Nakayama, R., Mibu, Y., Oka, C. and Kawaichi, M. (2001). p48 subunit of mouse PTF1 binds to RBP-Jk/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos. Genes Cells 6, 345-360.
32. Rose, S. D., Swift, G. H., Peyton, M. J., Hammer, R. E. and MacDonald, R. J. (2001). The role of PTF1-P48 in pancreatic acinar gene expression. J. Biol. Chem. 276, 44018-44026.
33. Rudomin, P. and Schmidt, R. F. (1999). Presynaptic inhibition in the vertebrate spinal cord revisited. Exp. Brain Res. 129, 1-37.
34. Sellick, G. S., Barker, K. T., Stolte-Dijkstra, I., Fleischmann, C., Coleman, R. J., Garrett, C., Gloyn, A. L., Edghill, E. L., Hattersley, A. T., Wellauer, P. K. et al. (2004). Mutations in PTF1A cause pancreatic and cerebellar agenesis. Nat. Genet. 36, 1301-1305.
35. Soriano, P. (1999). Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21, 70-71.
36. Srinivas, S., Watanabe, T., Lin, C. S., William, C. M., Tanabe, Y., Jessell, T. M. and Costantini, F. (2001). Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev. Biol. 1, 4.
37. Tsuchida, T., Ensini, M., Morton, S. B., Baldassare, M., Edlund, T., Jessell, T. M. and Pfaff, S. L. (1994). Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes. Cell 79, 957-970.
38. Wiesenfeld-Hallin, Z., Aldskogius, H., Grant, G., Hao, J. X., Hokfelt, T. and Xu, X. J. (1997). Central inhibitory dysfunctions: mechanisms and clinical implications. Behav. Brain Sci. 20, 420-425; discussion 435-513.