Correlation of tissue-plasma partition coefficients between normal tissues and subcutaneous xenografts of human tumor cell lines in mouse as a prediction tool of drug penetration in tumors

Journal of Pharmaceutical Sciences

Volumn 102, Issue 4, 2013, Pages 1355-1369

  Poulin, Patrick ^a   Hop, Cornelis Eca ^b   Salphati, Laurent ^b   Liederer, Bianca M ^b  

^a Genentech ^*

^b GENENTECH INC   (United States)

Author keywords

ADME; Chemotherapy; Disposition; Distribution; Oncology; Partition coefficients; PBPK modeling; Pharmacokinetics; Xenograft

Indexed keywords

DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; DRUG PENETRATION; FEMALE; GLIOBLASTOMA; HUMAN; HUMAN CELL; LIVER; LUNG; MOUSE; MUSCLE; NONHUMAN; PARTITION COEFFICIENT; TUMOR XENOGRAFT;

EID: 84874669388     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23452     Document Type: Article

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