Genome-wide association study reveals a complex genetic architecture underpinning-induced CYP3A4 enzyme activity

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 38, Issue 1, 2013, Pages 63-67

  Rahmioglu, Nilufer ^a,c   Heaton, James ^b   Clement, Gail ^a   Gill, Raj ^a   Surdulescu, Gabriela ^a   Zlobecka, Karolina ^a   Hodgkiss, Dylan ^a   Smith, Norman W ^b   Ahmadi, Kourosh R ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

CYP3A4; Drug drug interaction; Genome wide association study; Induction

Indexed keywords

3 HYDROQUININE; CYTOCHROME P450 3A; HEPATOCYTE NUCLEAR FACTOR 4; HYDROQUININE; MULTIDRUG RESISTANCE PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; QUININE; RETINOID X RECEPTOR ALPHA; STEROID RECEPTOR COACTIVATOR 1; UNCLASSIFIED DRUG;

ABCB1 GENE; ADULT; AGED; ARTICLE; CASEIN KINASE 2 ALPHA PRIME POLYPEPTIDE GENE; CONTROLLED STUDY; CYP3A GENE; DYNEIN AXONEMAL HEAVY CHAIN 11 GENE; ENZYME ACTIVITY; FEMALE; GENE; GENE LOCUS; GENE STRUCTURE; GENETIC ASSOCIATION; GENETIC VARIABILITY; HNF4 ALPHA GENE; HUMAN; NORMAL HUMAN; NR1I2 GENE; NUCLEAR TRANSCRIPTION FACTOR X BOX BINDING LIKE 1 GENE; PGC 1 ALPHA GENE; RXR ALPHA GENE; SORTILIN RELATED VSP10 DOMAIN RECEPTOR GENE; SRC 1 GENE; WNT SIGNALING PATHWAY;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BIOTRANSFORMATION; CYTOCHROME P-450 CYP3A; ENZYME INDUCTION; FEMALE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; HYDROXYLATION; HYPERICUM; LIVER; MIDDLE AGED; PHENOTYPE; PLANT PREPARATIONS; QUINIDINE; QUININE; SUBSTRATE SPECIFICITY; TWINS;

EID: 84874657473     PISSN: 03787966     EISSN: 21070180     Source Type: Journal    
DOI: 10.1007/s13318-012-0103-z     Document Type: Article

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