Hepatic steatosis and thyroid function tests in overweight and obese children

International Journal of Endocrinology

Volumn 2013, Issue , 2013, Pages

  Pacifico, L ^a   Bonci, E ^a   Ferraro, F ^a   Andreoli, G ^a   Bascetta, S ^a   Chiesa, C ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b INSTITUTE OF TRANSLATIONAL PHARMACOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; CHOLESTEROL; GLUCOSE; INSULIN; LIOTHYRONINE; LIPID; THYROTROPIN; THYROXINE; TRIACYLGLYCEROL;

ADOLESCENT; AGE; ARTICLE; BLOOD SAMPLING; BODY MASS; CHILD; CROSS-SECTIONAL STUDY; DIET RESTRICTION; DISEASE ASSOCIATION; DYSLIPIDEMIA; ECHOGRAPHY; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTRIGLYCERIDEMIA; HYPOTHYROIDISM; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; INTRAABDOMINAL FAT; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; NONALCOHOLIC FATTY LIVER; OBESITY; PREDICTION; PRESCHOOL CHILD; PRIORITY JOURNAL; PUBERTY; RISK ASSESSMENT; SCHOOL CHILD; SEX DIFFERENCE; THYROID FUNCTION TEST; WAIST CIRCUMFERENCE;

EID: 84874642810     PISSN: 16878337     EISSN: 16878345     Source Type: Journal    
DOI: 10.1155/2013/381014     Document Type: Article

References (48)

1. Angulo P., Nonalcoholic fatty liver disease. The New England Journal of Medicine 2002 346 16 1221 1231 2-s2.0-0037129380 10.1056/NEJMra011775 (Pubitemid 34984585)
2. Kotronen A., Yki-Järvinen H., Fatty liver: a novel component of the metabolic syndrome. Arteriosclerosis, Thrombosis, and Vascular Biology 2008 28 1 27 38 2-s2.0-37549047145 10.1161/ATVBAHA.107.147538
3. Pacifico L., Poggiogalle E., Cantisani V., Pediatric nonalcoholic fatty liver disease: a clinical and laboratory challenge. World Journal of Hepatology 2010 2 7 275 288
4. Liangpunsakul S., Chalasani N., Is hypothyroidism a risk factor for non-alcoholic steatohepatitis? Journal of Clinical Gastroenterology 2003 37 4 340 343 2-s2.0-0141790139 10.1097/00004836-200310000-00014 (Pubitemid 37158998)
5. Silveira M. G., Mendes F. D., Diehl N. N., Enders F. T., Lindor K. D., Thyroid dysfunction in primary biliary cirrhosis, primary sclerosing cholangitis and non-alcoholic fatty liver disease. Liver International 2009 29 7 1094 1100 2-s2.0-67650433921 10.1111/j.1478-3231.2009.02003.x
6. Xu C., Xu L., Yu C., Miao M., Li Y., Association between thyroid function and nonalcoholic fatty liver disease in euthyroid elderly Chinese. Clinical Endocrinology 2011 75 2 240 246 2-s2.0-79960189855 10.1111/j.1365-2265.2011. 04016.x
7. Chung G. E., Kim D., Kim W., Non-alcoholic fatty liver disease across the spectrum of hypothyroidism. Journal of Hepatology 2012 57 1 150 156
8. Pagadala M. R., Zein C. O., Dasarathy S., Yerian L. M., Lopez R., McCullough A. J., Prevalence of hypothyroidism in nonalcoholic fatty liver disease. Digestive Diseases and Sciences 2012 57 2 528 534
9. Ittermann T., Haring R., Wallaschofski H., Inverse association between serum free thyroxine levels and hepatic steatosis: results from the study of health in Pomerania. Thyroid 2012 22 6 568 574
10. Carulli L., Ballestri S., Lonardo A., Is nonalcoholic steatohepatitis associated with a high-though-normal thyroid stimulating hormone level and lower cholesterol levels? Internal and Emergency Medicine. In press
11. Gardner C. J., Richardson P., Wong C., Polavarapu N., Kemp G. J., Cuthbertson D. J., Hypothyroidism in a patient with non-alcoholic fatty liver disease. British Medical Journal 2011 342 7789 168 170 2-s2.0-78751692130 10.1136/bmj.c7199
12. Cole T. J., Bellizzi M. C., Flegal K. M., Dietz W. H., Establishing a standard definition for child overweight and obesity worldwide: international survey. British Medical Journal 2000 320 7244 1240 1243 2-s2.0-0034611996 (Pubitemid 30240471)
13. Pacifico L., Anania C., Ferraro F., Andreoli G. M., Chiesa C., Thyroid function in childhood obesity and metabolic comorbidity. Clinica Chimica Acta 2012 413 3-4 396 405
14. Hamilton T. E., Davis S., Onstad L., Kopecky K. J., Thyrotropin levels in a population with no clinical, autoantibody, or ultrasonographic evidence of thyroid disease: implications for the diagnosis of subclinical hypothyroidism. Journal of Clinical Endocrinology and Metabolism 2008 93 4 1224 1230 2-s2.0-42049093000 10.1210/jc.2006-2300 (Pubitemid 351519714)
15. Brabant G., Beck-Peccoz P., Jarzab B., Laurberg P., Orgiazzi J., Szabolcs I., Weetman A. P., Wiersinga W. M., Is there a need to redefine the upper normal limit of TSH? European Journal of Endocrinology 2006 154 5 633 637 2-s2.0-33744547660 10.1530/eje.1.02136 (Pubitemid 43810847)
16. Laurberg P., Andersen S., Carlé A., Karmisholt J., Knudsen N., Pedersen I. B., The TSH upper reference limit: where are we at? Nature Reviews Endocrinology 2011 7 4 232 239 2-s2.0-79953111833 10.1038/nrendo.2011.13
17. Zimmermann M. B., Hess S. Y., Molinari L., De Benoist B., Delange F., Braverman L. E., Fujieda K., Ito Y., Jooste P. L., Moosa K., Pearce E. N., Pretell E. A., Shishiba Y., New reference values for thyroid volume by ultrasound in iodine-sufficient schoolchildren: A World Health Organization/Nutrition for Health and Development Iodine Deficiency Study Group Report. American Journal of Clinical Nutrition 2004 79 2 231 237 2-s2.0-1342328585 (Pubitemid 41095975)
18. Grundy S. M., Metabolic syndrome scientific statement by the American Heart Association and the National Heart, Lung, and Blood Institute. Arteriosclerosis, Thrombosis, and Vascular Biology 2005 25 11 2243 2244 2-s2.0-27644519985 10.1161/01.ATV.0000189155.75833.c7 (Pubitemid 41552637)
19. Goodman E., Daniels S. R., Meigs J. B., Dolan L. M., Instability in the diagnosis of metabolic syndrome in adolescents. Circulation 2007 115 17 2316 2322 2-s2.0-34247571404 10.1161/CIRCULATIONAHA.106.669994 (Pubitemid 46691226)
20. Matthews D. R., Hosker J. P., Rudenski A. S., Naylor B. A., Treacher D. F., Turner R. C., Homeostasis model assessment: insulin resistance and β -cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985 28 7 412 419 2-s2.0-0021813187 (Pubitemid 15018832)
21. Pacifico L., Anania C., Martino F., Cantisani V., Pascone R., Marcantonio A., Chiesa C., Functional and morphological vascular changes in pediatric nonalcoholic fatty liver disease. Hepatology 2010 52 5 1643 1651 2-s2.0-78049523237 10.1002/hep.23890
22. Schwimmer J. B., Dunn W., Norman G. J., Pardee P. E., Middleton M. S., Kerkar N., Sirlin C. B., SAFETY study: alanine aminotransferase cutoff values are set too high for reliable detection of pediatric chronic liver disease. Gastroenterology 2010 138 4 1357 1364 2-s2.0-77949816251 10.1053/j.gastro.2009. 12.052
23. Targher G., Montagnana M., Salvagno G., Moghetti P., Zoppini G., Muggeo M., Lippi G., Association between serum TSH, free T4 and serum liver enzyme activities in a large cohort of unselected outpatients. Clinical Endocrinology 2008 68 3 481 484 2-s2.0-39149088669 10.1111/j.1365-2265.2007.03068.x (Pubitemid 351257870)
24. Rochon C., Tauveron I., Dejax C., Benoit P., Capitan P., Fabricio A., Berry C., Champredon C., Thieblot P., Grizard J., Response of glucose disposal to hyperinsulinaemia in human hypothyroidism and hyperthyroidism. Clinical Science 2003 104 1 7 15 2-s2.0-0037284933 10.1042/CS20020154 (Pubitemid 36249918)
25. Dimitriadis G., Mitrou P., Lambadiari V., Boutati E., Maratou E., Panagiotakos D. B., Koukkou E., Tzanela M., Thalassinos N., Raptis S. A., Insulin action in adipose tissue and muscle in hypothyroidism. Journal of Clinical Endocrinology and Metabolism 2006 91 12 4930 4937 2-s2.0-33845495428 10.1210/jc.2006-0478 (Pubitemid 44917329)
26. Pucci E., Chiovato L., Pinchera A., Thyroid and lipid metabolism. International Journal of Obesity and Related Metabolic Disorders 2000 24 supplement 2 S109 S112 2-s2.0-0033913054 10.1038/sj/ijo/0801292 (Pubitemid 30461962)
27. O'Brien T., Dinneen S. F., O'Brien P. C., Palumbo P. J., Hyperlipidemia in patients with primary and secondary hypothyroidism. Mayo Clinic Proceedings 1993 68 9 860 866 2-s2.0-0027162504 (Pubitemid 23266121)
28. Michalaki M. A., Vagenakis A. G., Leonardou A. S., Argentou M. N., Habeos I. G., Makri M. G., Psyrogiannis A. I., Kalfarentzos F. E., Kyriazopoulou V. E., Thyroid function in humans with morbid obesity. Thyroid 2006 16 1 73 78 2-s2.0-33644803211 10.1089/thy.2006.16.73 (Pubitemid 43348719)
29. Raftopoulos Y., Gagné D. J., Papasavas P., Hayetian F., Maurer J., Bononi P., Caushaj P. F., Improvement of hypothyroidism after laparoscopic Roux-en-Y gastric bypass for morbid obesity. Obesity Surgery 2004 14 4 509 513 2-s2.0-2342639057 10.1381/096089204323013514 (Pubitemid 38570291)
30. Dimitriadis G., Parry-Billings M., Bevan S., Leighton B., Krause U., Piva T., Tegos K., Challiss R. A. J., Wegener G., Newsholme E. A., The effects of insulin on transport and metabolism of glucose in skeletal muscle from hyperthyroid and hypothyroid rats. European Journal of Clinical Investigation 1997 27 6 475 483 2-s2.0-8544245733 (Pubitemid 27288357)
31. Dimitriadis G. D., Leighton B., Parry-Billings M., West D., Newsholme E. A., Effects of hypothyroidism on the sensitivity of glycolysis and glycogen synthesis to insulin in the soleus muscle of the rat. Biochemical Journal 1989 15 2 369 373 (Pubitemid 19040906)
32. Maratou E., Hadjidakis D. J., Kollias A., Tsegka K., Peppa M., Alevizaki M., Mitrou P., Lambadiari V., Boutati E., Nikzas D., Tountas N., Economopoulos T., Raptis S. A., Dimitriadis G., Studies of insulin resistance in patients with clinical and subclinical hypothyroidism. European Journal of Endocrinology 2009 160 5 785 790 2-s2.0-65549135659 10.1530/EJE-08-0797
33. Pearce E. N., Hypothyroidism and dyslipidemia: modern concepts and approaches. Current Cardiology Reports 2004 6 6 451 456 2-s2.0-9744263284 (Pubitemid 39585763)
34. Pearce E. N., Update in lipid alterations in subclinical hypothyroidism. Journal of Clinical Endocrinology and Metabolism 2012 97 2 326 333
35. Aeberli I., Jung A., Murer S. B., Wildhaber J., Wildhaber-Brooks J., Knöpfli B. H., Zimmermann M. B., During rapid weight loss in obese children, reductions in TSH predict improvements in insulin sensitivity independent of changes in body weight or fat. Journal of Clinical Endocrinology and Metabolism 2010 95 12 5412 5418 2-s2.0-78650070497 10.1210/jc.2010-1169
36. Nader N. S., Bahn R. S., Johnson M. D., Weaver A. L., Singh R., Kumar S., Relationships between thyroid function and lipid status or insulin resistance in a pediatric population. Thyroid 2010 20 12 1333 1339 2-s2.0-78649710228 10.1089/thy.2010.0180
37. Carreras M. C., Peralta J. G., Converso D. P., Finocchietto P. V., Rebagliati I., Zaninovich A. A., Poderoso J. J., Modulation of liver mitochondrial NOS is implicated in thyroid-dependent regulation of O2 uptake. American Journal of Physiology 2001 281 6 H2282 H2288 2-s2.0-0035658447
38. Skulachev V. P., Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants. Quarterly Reviews of Biophysics 1996 29 2 169 202 2-s2.0-0029765443 (Pubitemid 26280789)
39. Rotondi M., Leporati P., La Manna A., Pirali B., Mondello T., Fonter R., Magri F., Chiovato L., Raised serum TSH levels in patients with morbid obesity: is it enough to diagnose subclinical hypothyroidism? European Journal of Endocrinology 2009 160 3 403 408 2-s2.0-62649137175 10.1530/EJE-08-0734
40. Sari R., Balci M. K., Altunbas H., Karayalcin U., The effect of body weight and weight loss on thyroid volume and function in obese women. Clinical Endocrinology 2003 59 2 258 262 2-s2.0-0041664877 10.1046/j.1365-2265.2003. 01836.x (Pubitemid 36918663)
41. De Pergola G., Ciampolillo A., Paolotti S., Trerotoli P., Giorgino R., Free triiodothyronine and thyroid stimulating hormone are directly associated with waist circumference, independently of insulin resistance, metabolic parameters and blood pressure in overweight and obese women. Clinical Endocrinology 2007 67 2 265 269 2-s2.0-34447518842 10.1111/j.1365-2265.2007. 02874.x (Pubitemid 47076304)
42. Reinehr T., Obesity and thyroid function. Molecular and Cellular Endocrinology 2010 316 2 165 171 2-s2.0-72449142627 10.1016/j.mce.2009.06.005
43. Reinehr T., de Sousa G., Andler W., Hyperthyrotropinemia in obese children is reversible after weight loss and is not related to lipids. Journal of Clinical Endocrinology and Metabolism 2006 91 8 3088 3091 2-s2.0-33747635927 10.1210/jc.2006-0095 (Pubitemid 44271761)
44. Shalitin S., Yackobovitch-Gavan M., Phillip M., Prevalence of thyroid dysfunction in obese children and adolescents before and after weight reduction and its relation to other metabolic parameters. Hormone Research 2009 71 3 155 161 2-s2.0-59749106641 10.1159/000197872
45. Reinehr T., Andler W., Thyroid hormones before and after weight loss in obesity. Archives of Disease in Childhood 2002 87 4 320 323 2-s2.0-0036787235 10.1136/adc.87.4.320
46. Duntas L. H., Wartofsky L., Cardiovascular risk and subclinical hypothyroidism: focus on lipids and new emerging risk factors. What is the evidence? Thyroid 2007 17 11 1075 1084 2-s2.0-36749100869 10.1089/thy.2007.0116 (Pubitemid 350207760)
47. Rodondi N., Aujesky D., Vittinghoff E., Cornuz J., Bauer D. C., Subclinical hypothyroidism and the risk of coronary heart disease: a meta-analysis. The American Journal of Medicine 2006 119 7 541 551 2-s2.0-33745924975 10.1016/j.amjmed.2005.09.028 (Pubitemid 44041257)
48. Walsh J. P., Setpoints and susceptibility: do small differences in thyroid function really matter? Clinical Endocrinology 2011 75 2 158 159 2-s2.0-79960152355 10.1111/j.1365-2265.2011.04036.x