Prevalence of thyroid dysfunction in obese children and adolescents before and after weight reduction and its relation to other metabolic parameters

Hormone Research

Volumn 71, Issue 3, 2009, Pages 155-161

  Shalitin, S ^a   Yackobovitch Gavan, M ^b   Phillip, M ^b  

^a SCHNEIDER CHILDREN S MEDICAL CENTER OF ISRAEL   (Israel)

^b NONE

Author keywords

Metabolic profile; Obesity; Thyroid function

Indexed keywords

ADIPONECTIN; C REACTIVE PROTEIN; CHOLESTEROL; GHRELIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN; HOMOCYSTEINE; INSULIN; INTERLEUKIN 6; LEPTIN; LOW DENSITY LIPOPROTEIN; THYROTROPIN; THYROXINE; TRIACYLGLYCEROL;

ADOLESCENT; ADULT; ARTICLE; BLOOD SAMPLING; BODY FAT DISTRIBUTION; BODY MASS; CHILD; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; EUTHYROIDISM; FEMALE; FREE THYROXINE INDEX; GLUCOSE BLOOD LEVEL; HUMAN; HYPERTHYROTROPINEMIA; INSULIN BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; METABOLIC PARAMETERS; OBESITY; PRESCHOOL CHILD; PREVALENCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SCHOOL CHILD; THYROID DISEASE; THYROID GLAND; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE; WEIGHT REDUCTION;

ADOLESCENT; BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; COMBINED MODALITY THERAPY; DIET THERAPY; EXERCISE THERAPY; FEMALE; HUMANS; INSULIN RESISTANCE; MALE; OBESITY; PREVALENCE; RETROSPECTIVE STUDIES; THYROID DISEASES; THYROID FUNCTION TESTS; THYROTROPIN; WEIGHT LOSS;

EID: 59749106641     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000197872     Document Type: Article

References (25)

1. Ebbeling CB, Pawlak DB, Ludwig DS: Childhood obesity: public-health crisis, common sense cure. Lancet 2002;360:473-482.
2. Nathan BM, Moran A: Metabolic complications of obesity in childhood and adolescence: more than just diabetes. Curr Opin Endocrinol Diabetes Obes 2008;15:21-29.
3. Stichel H, I'Allemand D, Gruters A: Thyroid function and obesity in children and adolescents. Horm Res 2000;54:14-19.
4. Bhowmick SK, Dasari G, Levens KL, Rettig KR: The prevalence of elevated serum thyroid-stimulating hormone in childhood/adolescent obesity and of autoimmune thyroid diseases in a subgroup. J Natl Med Assoc 2007;99:773-776.
5. Kuczmarski RJ, Ogden CL, Guo SS, Grummer-Strawn LM, Flegal KM, Mei Z, Wei R, Curtin LR, Roche AF, Johnson CL:2000 CDC growth charts for the United States: methods and development. Vital Health Stat 11 2002;246:1-190.
6. Marshall WA, Tanner JM: Variations in the pattern of pubertal changes in boys. Arch Dis Child 1970;45:12-23.
7. Marshall WA, Tanner JM: Variations in the pattern of pubertal changes in girls. Arch Dis Child 1969;44:291-303.
8. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-419.
9. SPSS: Statistical Package for the Social Sciences, version 14.0. SPSS, Inc, Chicago.
10. Reinehr T, Andler W: Changes in the atherogenic risk-factor profile according to degree of reduction of overweight. Arch Dis Child 2004;89:419-422.
11. Eliakim A, Barzilai M, Walach B, Nemet D: Should we treat elevated thyroid stimulating hormone levels in obese children and adolescents? Int J Pediatr Obes 2006;1:217-221.
12. Gross AR, Kushner J: Obesity, nutrition and the thyroid. Endocrinology 1996;6:392-403.
13. Lima N, Cavaliere H, Medeiros-Neto G: A retrospective study of thyroid autoimmunity and hypothyroidism in a random obese population. Med Sci Res 1987;15:31-32.
14. Mihali E, Fekete C, Tatro JB, Liposits Z, Stopa EG, Lecha RM: Hypophysio-tropic thyrotroin-releasing hormone-synthesizing neurons in the human hypothalamus are innervated by neuropeptide Y, agouti-related protein, and alpha-melanocyte-stimulating hormone. J Clin Endocrinol Metab 2000;85:2596-2603.
15. Pinkney JH, Goodrick SJ, Katz J, Johnson AB, Lightman SL, Coppack SW, Mohamed-Ali V: Leptin and the pituitary-thyroid axis: a comparative study in lean, obese, hypothyroid and hyperthyroid subjects. Clin Endocrinol (Oxf) 1998;49:583-588.
16. Reinehr T, Andler W: Thyroid hormones before and after weight loss in obesity. Arch Dis Child 2002;87:320-323.
17. Michalaki MA, Vagenakis AG, Leonardou AS, Argentou MN, Habeos IG, Makri MG, Psyrogiannis AI, Kalfarentzos FE, Kyriazopoulou VE: Thyroid function in humans with morbid obesity. Thyroid 2006;16:73-78.
18. Burman KD, Latham KR, Djuh YY, Smallridge RC, Tseng YC, Lukes YG, Maunder R, Wartofsky L: Solubilized nuclear thyroid hormone receptors in circulating human mononuclear cells. J Clin Endocrinol Metab 1980;51:106-116.
19. Reinehr T, De Sousa G, Andler W: Hyperthyrotropinemia in obese children is reversible after weight loss and is not related to lipids. J Clin Endocrinol Metab 2006;91:3088-3091.
20. Tagliaferri M, Berselli ME, CalòG, Minocci A, Savia G, Petroni ML, Viberti GC, Liuzzi A: Subclinical hypothyroidism in obese patients: relation to resting energy expenditure, serum leptin, body composition, and lipid profile. Obes Res 2001;9:196-201.
21. Rodondi N, Aujesky D, Vittinghoff E, Cornuz J, Bauer DC: Subclinical hypothyroidism and the risk of coronary heart disease: a meta-analysis. Am J Med 2006;119:541-551.
22. Hueston WJ, King DE, Geesey ME: Serum biomarkers for cardiovascular inflammation in subclinical hypothyroidism. Clin Endocrinol (Oxf) 2005;63:582-587.
23. Klein I, Biondi B: Hypothyroidism as a risk factor for cardiovascular disease. Endocrine 2004;24:1-13.
24. Fadeyev VV, Sytch J, Kalashnikov V, Rojtman A, Syrkin A, Melnichenko G: Levothyroxine replacement therapy in patients with subclinical hypothyroidism and coronary artery disease. Endocr Pract 2006;12:5-17.
25. Serter R, Demirbas B, Korukluoglu B, Culha C, Cakal E, Aral Y: The effect of L-thyroxine replacement therapy on lipid based cardiovascular risk in subclinical hypothyroidism. Invest J Endocrinol 2004;27:897-903.