Hypothyroidism in a patient with non-alcoholic fatty liver disease

BMJ

Volumn 342, Issue 7789, 2011, Pages 168-

  Gardner, C J ^a   Richardson, P ^b   Wong, C ^a   Polavarapu, N ^a   Kemp, G J ^c   Cuthbertson, D J ^a  

^a UNIVERSITY HOSPITAL AINTREE   (United Kingdom)

^b ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NONSTEROID ANTIINFLAMMATORY AGENT;

ADULT; ALCOHOL LIVER CIRRHOSIS; ANKLE SPRAIN; ARTICLE; BRADYCARDIA; CASE REPORT; HUMAN; HYPOTHYROIDISM; LETHARGY; MALE; NONALCOHOLIC FATTY LIVER; PERICARDIAL EFFUSION; PRIORITY JOURNAL;

ADULT; FATTY LIVER; HUMANS; HYPOTHYROIDISM; KIDNEY FUNCTION TESTS; LIVER FUNCTION TESTS; MALE;

EID: 78751692130     PISSN: None     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.c7199     Document Type: Article

References (19)

1. Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004;40:1387-95.
2. Yatsuji S, Hashimoto E. [Natural history of Japanese patients with non-alcoholic fatty liver disease (NAFLD), especially non-alcoholic steatohepatitis (NASH) patients with hepatocellular carcinoma (HCC)]. Nippon Rinsho 2006;64:1173-9.
3. Ludwig J, Viggiano TR, McGill DB, Oh BJ. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 1980;55:434-8.
4. Loria P, Carulli L, Bertolotti M, Lonardo A. Endocrine and liver interaction: the role of endocrine pathways in NASH. Nat Rev Gastroenterol Hepatol 2009;6:236-47.
5. Thomas EL, Hamilton G, Patel N, O'Dwyer R, Dore CJ, Goldin RD, et al. Hepatic triglyceride content and its relation to body adiposity: a magnetic resonance imaging and proton magnetic resonance spectroscopy study. Gut 2005;54:122-7.
6. Erickson AR, Enzenauer RJ, Nordstrom DM, Merenich JA. The prevalence of hypothyroidism in gout. Am J Med 1994;97:231-4.
7. Bhala N, Usherwood T, George J. Non-alcoholic fatty liver disease. BMJ 7. 2009;339:b2474.
8. Chidakel A, Mentuccia D, Celi FS. Peripheral metabolism of thyroid hormone and glucose homeostasis. Thyroid 2005;15:899-903.
9. Hashimoto K, Cohen RN, Yamada M, Markan KR, Monden T, Satoh T, et al. Cross-talk between thyroid hormone receptor and liver X receptor regulatory pathways is revealed in a thyroid hormone resistance mouse model. J Biol Chem 2006;281:295-302.
10. Liangpunsakul S, Chalasani N. Is hypothyroidism a risk factor for non-alcoholic steatohepatitis? J Clin Gastroenterol 2003;37:340-3.
11. Cable EE, Finn PD, Stebbins JW, Hou J, Ito BR, van Poelje PD, et al. Reduction of hepatic steatosis in rats and mice after treatment with a liver-targeted thyroid hormone receptor agonist. Hepatology 2009;49:407-17.
12. Erion MD, Cable EE, Ito BR, Jiang H, Fujitaki JM, Finn PD, et al. Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index. Proc Natl Acad Sci U S A 2007;104:15490-5.
13. Perra A, Simbula G, Simbula M, Pibiri M, Kowalik MA, Sulas P, et al. Thyroid hormone (T3) and TRbeta agonist GC-1 inhibit/reverse nonalcoholic fatty liver in rats. Faseb J 2008;22:2981-9.
14. Hassan MM, Kaseb A, Li D, Patt YZ, Vauthey JN, Thomas MB, et al. Association between hypothyroidism and hepatocellular carcinoma: a case-control study in the United States. Hepatology 2009;49:1563-70.
15. Marchesini G, Brizi M, Bianchi G, Tomassetti S, Bugianesi E, Lenzi M, et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 2001;50:1844-50.
16. Ichikawa T, Hamasaki K, Ishikawa H, Ejima E, Eguchi K, Nakao K. Non-alcoholic steatohepatitis and hepatic steatosis in patients with adult onset growth hormone deficiency. Gut 2003;52:914.
17. Nyenwe EA, Williamson-Baddorf S, Waters B, Wan JY, Solomon SS. Nonalcoholic Fatty liver disease and metabolic syndrome in hypopituitary patients. Am J Med Sci 2009;338:190-5.
18. Lonardo A, Loria P, Leonardi F, Ganazzi D, Carulli N. Growth hormone plasma levels in nonalcoholic fatty liver disease. Am J Gastroenterol 2002;97:1071-2.
19. Vuppalanchi R, Chalasani N. Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management. Hepatology 2009;49:306-17.