Syntaxin Binding Protein 1 Is Not Required for Allergic Inflammation via IgE-Mediated Mast Cell Activation

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Wu, Zhengli ^a   MacNeil, Adam J ^a   Berman, Jason N ^a   Lin, Tong Jun ^a  

^a IWK HEALTH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B; IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; SYNTAXIN; SYNTAXIN BINDING PROTEIN 1; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

ALLERGIC REACTION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ACTIVATION; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; IN VITRO STUDY; IN VIVO STUDY; LIVER DERIVED MAST CELL; MAST CELL; MAST CELL DEGRANULATION; MOUSE; NONHUMAN; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SKIN ANAPHYLAXIS;

ANIMALS; BLOTTING, WESTERN; CELL DEGRANULATION; DNA PRIMERS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOGLOBULIN E; LIVER; MAST CELLS; MICE; MICE, INBRED C57BL; MUNC18 PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 84874626702     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0058560     Document Type: Article

References (50)

1. Kirshenbaum AS, Goff JP, Semere T, Foster B, Scott LM, et al. (1999) Demonstration that human mast cells arise from a progenitor cell population that is CD34(+), c-kit(+), and expresses aminopeptidase N (CD13). Blood 94: 2333-2342.
2. Quackenbush EJ, Wershil BK, Aguirre V, Gutierrez-Ramos JC, (1998) Eotaxin modulates myelopoiesis and mast cell development from embryonic hematopoietic progenitors. Blood 92: 1887-1897.
3. Tkaczyk C, Okayama Y, Woolhiser MR, Hagaman DD, Gilfillan AM, et al. (2002) Activation of human mast cells through the high affinity IgG receptor. Mol Immunol 38: 1289-1293.
4. Bax HJ, Keeble AH, Gould HJ, (2012) Cytokinergic IgE Action in Mast Cell Activation. Front Immunol 3: 229.
5. Vercelli D, (2005) Genetic regulation of IgE responses: Achilles and the tortoise. J Allergy Clin Immunol 116: 60-64.
6. Galli SJ, Nakae S, Tsai M, (2005) Mast cells in the development of adaptive immune responses. Nat Immunol 6: 135-142.
7. Logan MR, Odemuyiwa SO, Moqbel R (2003) Understanding exocytosis in immune and inflammatory cells: the molecular basis of mediator secretion. J Allergy Clin Immunol 111: 923-932; quiz 933.
8. Alvarez de Toledo G, Fernandez JM, (1990) Compound versus multigranular exocytosis in peritoneal mast cells. J Gen Physiol 95: 397-409.
9. Martin-Verdeaux S, Pombo I, Iannascoli B, Roa M, Varin-Blank N, et al. (2003) Evidence of a role for Munc18-2 and microtubules in mast cell granule exocytosis. J Cell Sci 116: 325-334.
10. Hibi T, Hirashima N, Nakanishi M, (2000) Rat basophilic leukemia cells express syntaxin-3 and VAMP-7 in granule membranes. Biochem Biophys Res Commun 271: 36-41.
11. Paumet F, Le Mao J, Martin S, Galli T, David B, et al. (2000) Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment. J Immunol 164: 5850-5857.
12. Guo Z, Turner C, Castle D, (1998) Relocation of the t-SNARE SNAP-23 from lamellipodia-like cell surface projections regulates compound exocytosis in mast cells. Cell 94: 537-548.
13. Demo SD, Masuda E, Rossi AB, Throndset BT, Gerard AL, et al. (1999) Quantitative measurement of mast cell degranulation using a novel flow cytometric annexin-V binding assay. Cytometry 36: 340-348.
14. Hong W, (2005) SNAREs and traffic. Biochim Biophys Acta 1744: 120-144.
15. Ciufo LF, Barclay JW, Burgoyne RD, Morgan A, (2005) Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions. Mol Biol Cell 16: 470-482.
16. Han L, Jiang T, Han GA, Malintan NT, Xie L, et al. (2009) Rescue of Munc18-1 and-2 double knockdown reveals the essential functions of interaction between Munc18 and closed syntaxin in PC12 cells. Mol Biol Cell 20: 4962-4975.
17. Deak F, Xu Y, Chang WP, Dulubova I, Khvotchev M, et al. (2009) Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming. J Cell Biol 184: 751-764.
18. Shen J, Rathore SS, Khandan L, Rothman JE, (2010) SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion. J Cell Biol 190: 55-63.
19. Sharma VM, Shareef MM, Bhaskar K, Kalidas S, Shetty PA, et al. (2005) Nuclear localization of Munc18-1 (p67) in the adult rat brain and PC12 cells. Neurochem Int 47: 225-234.
20. Gulyas-Kovacs A, de Wit H, Milosevic I, Kochubey O, Toonen R, et al. (2007) Munc18-1: sequential interactions with the fusion machinery stimulate vesicle docking and priming. J Neurosci 27: 8676-8686.
21. Amin K, (2012) The role of mast cells in allergic inflammation. Respir Med 106: 9-14.
22. Houng A, Polgar J, Reed GL, (2003) Munc18-syntaxin complexes and exocytosis in human platelets. J Biol Chem 278: 19627-19633.
23. Voets T, Toonen RF, Brian EC, de Wit H, Moser T, et al. (2001) Munc18-1 promotes large dense-core vesicle docking. Neuron 31: 581-591.
24. Broeke JH, Roelandse M, Luteijn MJ, Boiko T, Matus A, et al. (2010) Munc18 and Munc13 regulate early neurite outgrowth. Biol Cell 102: 479-488.
25. Dong Y, Wan Q, Yang X, Bai L, Xu P, (2007) Interaction of Munc18 and Syntaxin in the regulation of insulin secretion. Biochem Biophys Res Commun 360: 609-614.
26. Hamdan FF, Piton A, Gauthier J, Lortie A, Dubeau F, et al. (2009) De novo STXBP1 mutations in mental retardation and nonsyndromic epilepsy. Ann Neurol 65: 748-753.
27. Deprez L, Weckhuysen S, Holmgren P, Suls A, Van Dyck T, et al. (2010) Clinical spectrum of early-onset epileptic encephalopathies associated with STXBP1 mutations. Neurology 75: 1159-1165.
28. Saitsu H, Kato M, Okada I, Orii KE, Higuchi T, et al. (2010) STXBP1 mutations in early infantile epileptic encephalopathy with suppression-burst pattern. Epilepsia 51: 2397-2405.
29. Saitsu H, Kato M, Matsumoto N (2012) Haploinsufficiency of STXBP1 and Ohtahara syndrome. In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors Jasper's Basic Mechanisms of the Epilepsies [Internet] 4th edition Bethesda (MD): National Center for Biotechnology Information (US): 1-12.
30. Saitsu H, Hoshino H, Kato M, Nishiyama K, Okada I, et al. (2011) Paternal mosaicism of an STXBP1 mutation in OS. Clin Genet 80: 484-488.
31. Otsuka M, Oguni H, Liang JS, Ikeda H, Imai K, et al. (2010) STXBP1 mutations cause not only Ohtahara syndrome but also West syndrome-result of Japanese cohort study. Epilepsia 51: 2449-2452.
32. Hata Y, Slaughter CA, Sudhof TC, (1993) Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin. Nature 366: 347-351.
33. Misura KM, Scheller RH, Weis WI, (2000) Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex. Nature 404: 355-362.
34. Fujita Y, Sasaki T, Fukui K, Kotani H, Kimura T, et al. (1996) Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C: its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin. J Biol Chem 271: 7265-7268.
35. de Vries KJ, Geijtenbeek A, Brian EC, de Graan PN, Ghijsen WE, et al. (2000) Dynamics of munc18-1 phosphorylation/dephosphorylation in rat brain nerve terminals. Eur J Neurosci 12: 385-390.
36. Nechushtan H, Leitges M, Cohen C, Kay G, Razin E, (2000) Inhibition of degranulation and interleukin-6 production in mast cells derived from mice deficient in protein kinase Cbeta. Blood 95: 1752-1757.
37. Yang YJ, Chen W, Carrigan SO, Chen WM, Roth K, et al. (2008) TRAF6 specifically contributes to FcepsilonRI-mediated cytokine production but not mast cell degranulation. J Biol Chem 283: 32110-32118.
38. Li B, Power MR, Lin TJ, (2006) De novo synthesis of early growth response factor-1 is required for the full responsiveness of mast cells to produce TNF and IL-13 by IgE and antigen stimulation. Blood 107: 2814-2820.
39. Verhage M, Maia AS, Plomp JJ, Brussaard AB, Heeroma JH, et al. (2000) Synaptic assembly of the brain in the absence of neurotransmitter secretion. Science 287: 864-869.
40. Nigam R, Sepulveda J, Tuvim M, Petrova Y, Adachi R, et al. (2005) Expression and transcriptional regulation of Munc18 isoforms in mast cells. Biochim Biophys Acta 1728: 77-83.
41. Schraw TD, Lemons PP, Dean WL, Whiteheart SW, (2003) A role for Sec1/Munc18 proteins in platelet exocytosis. Biochem J 374: 207-217.
42. Suzuki Y, Yoshimaru T, Inoue T, Ra C, (2009) Discrete generations of intracellular hydrogen peroxide and superoxide in antigen-stimulated mast cells: reciprocal regulation of store-operated Ca2+ channel activity. Mol Immunol 46: 2200-2209.
43. Endo S, Hochman DJ, Midoro-Horiuti T, Goldblum RM, Brooks EG, (2011) Mountain cedar pollen induces IgE-independent mast cell degranulation, IL-4 production, and intracellular reactive oxygen species generation. Cell Immunol 271: 488-495.
44. Craig TJ, Evans GJ, Morgan A, (2003) Physiological regulation of Munc18/nSec1 phosphorylation on serine-313. J Neurochem 86: 1450-1457.
45. Fu J, Naren AP, Gao X, Ahmmed GU, Malik AB, (2005) Protease-activated receptor-1 activation of endothelial cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression. J Biol Chem 280: 3178-3184.
46. Hepp R, Puri N, Hohenstein AC, Crawford GL, Whiteheart SW, et al. (2005) Phosphorylation of SNAP-23 regulates exocytosis from mast cells. J Biol Chem 280: 6610-6620.
47. Nanamori M, Chen J, Du X, Ye RD, (2007) Regulation of leukocyte degranulation by cGMP-dependent protein kinase and phosphoinositide 3-kinase: potential roles in phosphorylation of target membrane SNARE complex proteins in rat mast cells. J Immunol 178: 416-427.
48. Yang YJ, Chen W, Edgar A, Li B, Molkentin JD, et al. (2009) Rcan1 negatively regulates Fc epsilonRI-mediated signaling and mast cell function. J Exp Med 206: 195-207.
49. MacNeil AJ, Yang YJ, Lin TJ, (2011) MAPK kinase 3 specifically regulates Fc epsilonRI-mediated IL-4 production by mast cells. J Immunol 187: 3374-3382.
50. Diao J, Su Z, Lu X, Yoon TY, Shin YK, et al. (2010) Single-Vesicle Fusion Assay Reveals Munc18-1 Binding to the SNARE Core Is Sufficient for Stimulating Membrane Fusion. ACS Chem Neurosci 1: 168-174.