Noddy, a mouse harboring a missense mutation in protocadherin-15, reveals the impact of disrupting a critical interaction site between tip-link cadherins in inner ear hair cells

Journal of Neuroscience

Volumn 33, Issue 10, 2013, Pages 4395-4404

  Geng, Ruishuang ^a   Sotomayor, Marcos ^b   Kinder, Kimberly J ^a   Gopal, Suhasini R ^a   Gerka Stuyt, John ^a   Chen, Daniel ^a   Hardisty Hughes, Rachel E ^c   Ball, Greg ^c   Parker, Andy ^c   Gaudet, Rachelle ^d   Furness, David ^e   Brown, Steve D ^c   Corey, David P ^b   Alagramam, Kumar N ^a,f  

^a UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c MRC MAMMALIAN GENETICS UNIT   (United Kingdom)

^d HARVARD UNIVERSITY   (United States)

^e KEELE UNIVERSITY   (United Kingdom)

^f CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; CADHERIN; CADHERIN 23; ISOLEUCINE; PROTOCADHERIN 15; UNCLASSIFIED DRUG;

ALLELE; AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ARTICLE; CHEMICAL MUTAGENESIS; CIRCLING BEHAVIOR; CONTROLLED STUDY; FEMALE; GEL PERMEATION CHROMATOGRAPHY; GENE MAPPING; GENE SEQUENCE; GENOTYPE; HAIR CELL; HEARING IMPAIRMENT; HUMAN; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE TEST; MALE; MECHANOTRANSDUCTION; MISSENSE MUTATION; MOUSE; NEWBORN; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCANNING ELECTRON MICROSCOPY; STEREOCILIUM; VESTIBULAR DISORDER;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; CADHERINS; CALCIUM; CELLS, CULTURED; ELECTROENCEPHALOGRAPHY; ETHYLNITROSOUREA; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; GENOTYPE; HAIR CELLS, AUDITORY; HEARING LOSS; LABYRINTH DISEASES; MECHANOTRANSDUCTION, CELLULAR; MICE; MICE, TRANSGENIC; MICROSCOPY, ATOMIC FORCE; MUTAGENS; MUTATION, MISSENSE; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN BINDING; PROTEIN PRECURSORS; PYRIDINIUM COMPOUNDS; QUATERNARY AMMONIUM COMPOUNDS;

EID: 84874618199     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4514-12.2013     Document Type: Article

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