Melody, an ENU mutation in Caspase 3, alters the catalytic cysteine residue and causes sensorineural hearing loss in mice

Mammalian Genome

Volumn 21, Issue 11-12, 2010, Pages 565-576

  Parker, Andrew ^a   Hardisty Hughes, Rachel E ^a   Wisby, Laura ^a   Joyce, Susan ^a   Brown, Steve D M ^a  

^a MRC MAMMALIAN GENETICS UNIT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CYSTEINE; ETHYLNITROSOUREA; SERINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CATALYSIS; CELL LOSS; CHROMOSOME 8; CONTROLLED STUDY; DISEASE SEVERITY; EMBRYO; ENZYME ACTIVE SITE; ENZYME BINDING; GENE; GENE MAPPING; HAIR CELL; HETEROZYGOTE; HISTOPATHOLOGY; HOMOZYGOTE; MELODY GENE; MOUSE; MUTATIONAL ANALYSIS; NERVE CELL DEGENERATION; NONHUMAN; NULL ALLELE; PERCEPTION DEAFNESS; POINT MUTATION; RETINA GANGLION CELL;

AMINO ACID SEQUENCE; ANIMALS; CASPASE 3; CHROMOSOME MAPPING; COCHLEA; CYSTEINE PROTEASES; DEAFNESS; ETHYLNITROSOUREA; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; FEMALE; GENE EXPRESSION REGULATION; HAIR CELLS, AUDITORY; HEARING LOSS, SENSORINEURAL; HETEROZYGOTE; HOMOZYGOTE; MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MUTAGENESIS; POINT MUTATION; SPIRAL GANGLION;

MUS;

EID: 78650979005     PISSN: 09388990     EISSN: 14321777     Source Type: Journal    
DOI: 10.1007/s00335-010-9306-2     Document Type: Article

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