A new mouse mutant of the Cdh23 gene with early-onset hearing loss facilitates evaluation of otoprotection drugs

Pharmacogenomics Journal

Volumn 12, Issue 1, 2012, Pages 30-44

  Han, F ^a   Yu, H ^a   Tian, C ^a   Chen, H E ^a   Benedict Alderfer, C ^a   Zheng, Y ^a   Wang, Q ^a   Han, X ^a   Zheng, Q Y ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

apoptosis; Cdh23; hearing loss; mouse model; mutation; Z VAD FMK

Indexed keywords

BENZYLOXYCARBONYLVALYLALANYLASPARTYL(OME) FLUOROMETHYL KETONE; CASPASE; CASPASE INHIBITOR; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CDH23 GENE; COCHLEA; CONTROLLED STUDY; DRUG RESPONSE; EAR PROTECTION; ERL GENE; GENE; GENE MUTATION; GENE SEQUENCE; GENETIC ANALYSIS; HAIR CELL; HEARING IMPAIRMENT; HEARING LOSS; INNER EAR; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

AGE FACTORS; AMINO ACID CHLOROMETHYL KETONES; AMINO ACID SEQUENCE; ANIMALS; CADHERINS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; GENETIC COMPLEMENTATION TEST; HAIR CELLS, AUDITORY, OUTER; HEARING LOSS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; NEUROPROTECTIVE AGENTS; POINT MUTATION;

MUS;

EID: 84856225799     PISSN: 1470269X     EISSN: 14731150     Source Type: Journal    
DOI: 10.1038/tpj.2010.60     Document Type: Article

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