Inhibition of human γ -glutamyl transpeptidase: Development of more potent, physiologically relevant, uncompetitive inhibitors

Biochemical Journal

Volumn 450, Issue 3, 2013, Pages 547-557

  Wickham, Stephanie ^a   Regan, Nicholas ^b   West, Matthew B ^a   Thai, Justin ^b   Cook, Paul F ^c   Terzyan, Simon S ^d   Li, Pui Kai ^b   Hanigan, Marie H ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c UNIVERSITY OF OKLAHOMA   (United States)

^d OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

glutamyl transpeptidase (GGT); Glutathione; OU749

Indexed keywords

ACIVICIN; ACYLTRANSFERASE INHIBITOR; BENZENE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; OU 749; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CYTOTOXICITY; DRUG POTENCY; ENZYME INHIBITION; ENZYME ISOLATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; PRIORITY JOURNAL; PROTEIN HYDROLYSIS; REDUCTION; SYNTHESIS;

ANIMALS; BINDING, COMPETITIVE; CELLS, CULTURED; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; GAMMA-GLUTAMYLTRANSFERASE; GLUTATHIONE; HUMANS; MICE; MODELS, BIOLOGICAL; NIH 3T3 CELLS; PROTEIN BINDING; SUBSTRATE SPECIFICITY; SULFONAMIDES; THIADIAZOLES;

EID: 84874613519     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20121435     Document Type: Article

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