Autocatalytic cleavage of human γ-glutamyl transpeptidase is highly dependent on N-glycosylation at asparagine 95

Journal of Biological Chemistry

Volumn 286, Issue 33, 2011, Pages 28876-28888

  West, Matthew B ^a   Wickham, Stephanie ^a   Quinalty, Leslie M ^a   Pavlovicz, Ryan E ^b   Li, Chenglong ^b   Hanigan, Marie H ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOCATALYTIC; AUTOCLEAVAGE; CLEAVAGE EFFICIENCY; DEGLYCOSYLATION; EXTRACELLULAR; GLUTATHIONES; HUMAN ENZYMES; KINETIC ANALYSIS; KINETIC BEHAVIOR; MEMBRANE ENZYMES; N-GLYCANS; N-GLYCOSYLATION; N-GLYCOSYLATION SITES; PROPEPTIDES; SINGLE SITES; SITE DIRECTED MUTAGENESIS; SMALL SUBUNITS; STRUCTURAL STABILITIES; WILD TYPES;

AMINO ACIDS; ENZYME ACTIVITY; GLYCOSYLATION; KINETICS; MUTAGENESIS; POLYPEPTIDES; THERMODYNAMIC STABILITY;

ESTERIFICATION;

ASPARAGINE; ENZYME PRECURSOR; GAMMA GLUTAMYLTRANSFERASE; GLYCAN;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DEGLYCOSYLATION; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME MODIFICATION; ENZYME STABILITY; HUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; SITE DIRECTED MUTAGENESIS; THERMOSTABILITY; WILD TYPE;

AMINO ACID SUBSTITUTION; ASPARAGINE; CATALYSIS; ENZYME STABILITY; GAMMA-GLUTAMYLTRANSFERASE; GLYCOSYLATION; HEK293 CELLS; HUMANS; KINETICS; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; PROTEIN FOLDING; PROTEIN MODIFICATION, TRANSLATIONAL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80051675493     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.248823     Document Type: Article

References (48)

1. Allison, R. D. (1985) Methods Enzymol. 113, 419-437
2. Hanigan, M. H., and Ricketts, W. A. (1993) Biochemistry 32, 6302-6306
3. Hanigan, M. H., and Frierson, H. F., Jr. (1996) J. Histochem. Cytochem. 44, 1101-1108
4. Hiramatsu, K., Asaba, Y., Takeshita, S., Nimura, Y., Tatsumi, S., Katagiri, N., Niida, S., Nakajima, T., Tanaka, S., Ito, M., Karsenty, G., and Ikeda, K. (2007) Endocrinology 148, 2708-2715
5. Hanigan, M. H., Frierson, H. F., Jr., Swanson, P. E., and De Young, B. R. (1999) Hum. Pathol. 30, 300-305
6. Lieberman, M. W., Wiseman, A. L., Shi, Z. Z., Carter, B. Z., Barrios, R., Ou, C. N., Chévez-Barrios, P., Wang, Y., Habib, G. M., Goodman, J. C., Huang, S. L., Lebovitz, R. M., and Matzuk, M. M. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 7923-7926
7. Hanigan, M. H., Gallagher, B. C., Townsend, D. M., and Gabarra, V. (1999) Carcinogenesis 20, 553-559
8. Brannigan, J. A., Dodson, G., Duggleby, H. J., Moody, P. C., Smith, J. L., Tomchick, D. R., and Murzin, A. G. (1995) Nature 378, 416-419
9. Suzuki, H., and Kumagai, H. (2002) J. Biol. Chem. 277, 43536-43543
10. Kinlough, C. L., Poland, P. A., Bruns, J. B., and Hughey, R. P. (2005) Methods Enzymol. 401, 426-449
11. Inoue, M., Hiratake, J., Suzuki, H., Kumagai, H., and Sakata, K. (2000) Biochemistry 39, 7764-7771
12. Castonguay, R., Halim, D., Morin, M., Furtos, A., Lherbet, C., Bonneil, E., Thibault, P., and Keillor, J. W. (2007) Biochemistry 46, 12253-12262
13. Angele, C., Oster, T., Visvikis, A., Michels, J. M., Wellman, M., and Siest, G. (1991) Clin. Chem. 37, 662-666
14. Nemesánszky, E., and Lott, J. A. (1985) Clin. Chem. 31, 797-803
15. Rademacher, T. W., Parekh, R. B., and Dwek, R. A. (1988) Annu. Rev. Biochem. 57, 785-838
16. West, M. B., Segu, Z. M., Feasley, C. L., Kang, P., Klouckova, I., Li, C., Novotny, M. V., West, C. M., Mechref, Y., and Hanigan, M. H. (2010) J. Biol. Chem. 285, 29511-29524
17. Meredith, M. J. (1991) Biochem. Int. 25, 321-330
18. Helenius, A., and Aebi, M. (2004) Annu. Rev. Biochem. 73, 1019-1049
19. Skropeta, D. (2009) Bioorg. Med. Chem. 17, 2645-2653
20. McCracken, A. A., and Brodsky, J. L. (2003) BioEssays 25, 868-877
21. Williams, D. B. (2006) J. Cell Sci. 119, 615-623
22. King, J. B., West, M. B., Cook, P. F., and Hanigan, M. H. (2009) J. Biol. Chem. 284, 9059-9065
23. Graham, F. L., and van der Eb, A. J. (1973) Virology 52, 456-467
24. Hochstenbach, F., David, V., Watkins, S., and Brenner, M. B. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 4734-4738
25. Sali, A., and Blundell, T. L. (1993) J. Mol. Biol. 234, 779-815
26. Okada, T., Suzuki, H., Wada, K., Kumagai, H., and Fukuyama, K. (2007) J. Biol. Chem. 282, 2433-2439
27. Wada, K., Irie, M., Suzuki, H., and Fukuyama, K. (2010) FEBS J. 277, 1000-1009
28. Shen, M. Y., and Sali, A. (2006) Protein Sci. 15, 2507-2524
29. Case, D. A., Cheatham, T. E., 3rd, Darden, T., Gohlke, H., Luo, R., Merz, K. M., Jr., Onufriev, A., Simmerling, C., Wang, B., and Woods, R. J. (2005) J. Comput. Chem. 26, 1668-1688
30. Lindorff-Larsen, K., Piana, S., Palmo, K., Maragakis, P., Klepeis, J. L., Dror, R. O., and Shaw, D. E. (2010) Proteins Struct. Funct. Bioinformat. 78, 1950-1958
31. Kirschner, K. N., Yongye, A. B., Tschampel, S. M., González- Outeiriño, J., Daniels, C. R., Foley, B. L., and Woods, R. J. (2008) J. Comput. Chem. 29, 622-655
32. Shaw, L. M., London, J. W., and Petersen, L. E. (1978) Clin. Chem. 24, 905-915
33. Sener, A., and Yardimci, T. (2005) J. Biochem. Mol. Biol. 38, 343-349
34. Elce, J. S., and Broxmeyer, B. (1976) Biochem. J. 153, 223-232
35. Curthoys, N. P., and Hughey, R. P. (1979) Enzyme 24, 383-403
36. Thompson, G. A., and Meister, A. (1976) Biochem. Biophys. Res. Commun. 71, 32-36
37. Keillor, J. W., Castonguay, R., and Lherbet, C. (2005) Methods Enzymol. 401, 449-467
38. Gross, V., Tran-Thi, T. A., Schwarz, R. T., Elbein, A. D., Decker, K., and Heinrich, P. C. (1986) Biochem. J. 236, 853-860
39. Herscovics, A. (1999) Biochim. Biophys. Acta 1473, 96-107
40. Elbein, A. D. (1987) Annu. Rev. Biochem. 56, 497-534
41. Hebert, D. N., Zhang, J. X., Chen, W., Foellmer, B., and Helenius, A. (1997) J. Cell Biol. 139, 613-623
42. Bosques, C. J., and Imperiali, B. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 7593-7598
43. Barouki, R., Finidori, J., Chobert, M. N., Aggerbeck, M., Laperche, Y., and Hanoune, J. (1984) J. Biol. Chem. 259, 7970-7974
44. Wei, W., Hackmann, K., Xu, H., Germino, G., and Qian, F. (2007) J. Biol. Chem. 282, 21729-21737
45. Nakajima, M., Koga, T., Sakai, H., Yamanaka, H., Fujiwara, R., and Yokoi, T. (2010) Biochem. Pharmacol. 79, 1165-1172
46. Smith, T. K., and Meister, A. (1994) FASEB J. 8, 661-664
47. Rudd, P. M., Elliott, T., Cresswell, P., Wilson, I. A., and Dwek, R. A. (2001) Science 291, 2370-2376
48. Thompson, J. D., Higgins, D. G., and Gibson, T. J. (1994) Nucleic Acids Res. 22, 4673-4680