Probing the donor and acceptor substrate specificity of the γ-glutamyl transpeptidase

Biochemistry

Volumn 51, Issue 6, 2012, Pages 1199-1212

  Hu, Xin ^a,d   Legler, Patricia M ^b   Khavrutskii, Ilja ^a   Scorpio, Angelo ^c   Compton, Jaimee R ^b   Robertson, Kelly L ^b   Friedlander, Arthur M ^c   Wallqvist, Anders ^a  

^a U S ARMY MEDICAL RESEARCH AND MATERIEL COMMAND   (United States)

^b NAVAL RESEARCH LABORATORY   (United States)

^c UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^d NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCEPTOR SITES; BACILLUS ANTHRACIS; BINDING SPECIFICITIES; BURKHOLDERIA; COMPUTATIONAL APPROACH; DONOR AND ACCEPTOR; DONOR SUBSTRATES; DRUG DESIGN; FRANCISELLA TULARENSIS; GLUTATHIONE METABOLISM; HELICOBACTER PYLORI; KINETIC ANALYSIS; L-AMINO ACIDS; MD SIMULATION; PROTEIN-LIGAND INTERACTIONS; SITE DIRECTED MUTAGENESIS; STEREOSPECIFICITY; STRUCTURAL BASIS; SUBSTRATE BINDING; SUBSTRATE SPECIFICITY; YERSINIA PESTIS;

AMINO ACIDS; BINDING ENERGY; CATALYSIS; ENZYMES; ESCHERICHIA COLI;

SUBSTRATES;

ACYLTRANSFERASE INHIBITOR; AMINO ACID; GAMMA GLUTAMYLTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BACILLUS ANTHRACIS; BURKHOLDERIA MALLEI; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; FRANCISELLA TULARENSIS; GENETIC CONSERVATION; HELICOBACTER PYLORI; IC 50; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR MODEL; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STEADY STATE; STEREOSPECIFICITY; YERSINIA PESTIS;

ANIMALS; BACILLUS ANTHRACIS; BACTERIAL CAPSULES; BACTERIAL PROTEINS; CATALYTIC DOMAIN; COMPUTATIONAL BIOLOGY; GAMMA-GLUTAMYLTRANSFERASE; GLUTATHIONE; HUMANS; LIGANDS; MICE; PROTEIN BINDING; RATS; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; SULFONAMIDES; SWINE; THIADIAZOLES;

BACILLUS ANTHRACIS; BACTERIA (MICROORGANISMS); BURKHOLDERIA MALLEI; ESCHERICHIA COLI; FRANCISELLA TULARENSIS; HELICOBACTER PYLORI; RATTUS; YERSINIA PESTIS;

EID: 84863171498     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200987b     Document Type: Article

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