Influence of long-term enteral nutrition on pharmacokinetics of digoxin in rats

Drug Metabolism and Pharmacokinetics

Volumn 28, Issue 1, 2013, Pages 44-52

  Higashi, Keiichiro ^a,b   Tanaka, Chihiro ^a   Imanishi, Kaori ^a   Sawamoto, Kazuki ^a,b   Horikawa, Takumi ^a   Ohkawa, Hiroko ^b   Matsushita, Ryo ^a   Sai, Yoshimichi ^a,b   Miyamoto, Ken Ichi ^a,b  

^a KANAZAWA UNIVERSITY   (Japan)

^b KANAZAWA UNIVERSITY HOSPITAL   (Japan)

Author keywords

Absorption; Cyp3a2; Digoxin; Enteral nutrition; Metabolism; Oatp; P gp; Pharmacokinetics

Indexed keywords

AMINE OXIDASE (COPPER CONTAINING); CYTOCHROME P450 3A2; DIGOXIN; MEMBRANE PROTEIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; ORGANIC ANION TRANSPORTER; PROTEIN ABCB1A; PROTEIN SLCO1A4; UNCLASSIFIED DRUG;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DIET; DIET SUPPLEMENTATION; DIGESTED DIET; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; ELEMENTAL DIET; ENTERIC FEEDING; ENZYME METABOLISM; FEMALE; FOOD DRUG INTERACTION; HUMAN; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; ORGAN WEIGHT; PROTEIN EXPRESSION; RAT; RETROSPECTIVE STUDY; SEMI DIGESTED DIET;

EID: 84874613468     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-11-RG-153     Document Type: Article

References (44)

1. Cangelosi, M. J., Auerbach, H. R. and Cohen, J. T.: A clinical and economic evaluation of enteral nutrition. Curr. Med. Res. Opin., 27: 413-422 (2011).
2. Pritchard, C, Duffy, S., Edington, J. and Pang, E: Enteral nutrition and oral nutrition supplements: A review of the economic literature. JPEN J. Parenter. EnteralNutr, 30: 52-59 (2006).
3. A.S.P.E.N. Board of Directors: Guidelines for the use of parenteral and enteral nutrition in adult and pediatric patients. J.P.E.N. J. Parenter. Enteral Nutr, 26(1 Suppl): 1SA-138SA (2002).
4. Young, E. A., Cioletti, L. A., Winborne, W. B., Traylor, J. B. and Weser, E.: Comparative study of nutritional adaptation to denned formula diets in rats. Am. J. Clin. Nutr, 33: 2106-2118 (1980).
5. Young, E. A., Cioletti, L. A., Traylor, J. B. and Balderas, V.: Gastrointestinal response to oral versus gastric feeding of denned formula diets. Am. J. Clin. Nutr, 35: 715-726 (1982).
6. Shou, J., Lappin, J., Minnard, E. A., Daly, J. M., Fischer, J. E. and Meguid, M. M.: Total parenteral nutrition, bacterial translocation, and host immune function. Am. J. Surg., 167: 145-150 (1994).
7. Alverdy, J. C, Aoys, E. and Moss, G. S.: Total parenteral nutrition promotes bacterial translocation from the gut. Surgery, 104: 185-190 (1988).
8. Berg, R. D.: Bacterial translocation from the gastrointestinal tract. J Med., 23: 217-244 (1992).
9. Shen, T. Y, Qin, H. L., Gao, Z. G., Fan, X. B., Hang, X. M. and Jiang, Y Q.: Influences of enteral nutrition combined with probiotics on gut microflora and barrier function of rats with abdominal infection. World J. Gastroenterol, 12: 4352-4358 (2006).
10. Lipman, T. O.: Bacterial translocation and enteral nutrition in humans: an outsider looks in. JPEN J. Parenter. Enteral Nutr, 19: 156-165 (1995).
11. Mosenthal, A. C, Xu, D. and Deitch, E. A.: Elemental and intravenous total parenteral nutrition diet-induced gut barrier failure is intestinal site specific and can be prevented by feeding nonfermentable fiber. Crit. Care Med, 30: 396-02 (2002).
12. Fay, M. A., Sheth, R. D. and Gidal, B. E.: Oral absorption kinetics of levetiracetam: the effect of mixing with food or enteral nutrition formulas. Clin. Ther, 27: 594-598 (2005).
13. Burkhardt, O., Stass, H., Thuss, U., Borner, K. and Welte, T.: Effects of enteral feeding on the oral bioavailability of moxifioxacin in healthy volunteers. Clin. Pharmacokinet., 44: 969-976 (2005).
14. Iseki, K., Kawabata, S., Kaneuchi, M. and Miyazaki, K.: Changes in the absorption behavior of drugs when combined with oral nutrition support. Jpn. J. Hosp. Pharm., 25: 15-21 (1999).
15. Rathore, S. S., Curtis, J. P., Wang, Y, Bristow, M. R. and Krumholz, H. M.: Association of serum digoxin concentration and outcomes in patients with heart failure. JAMA, 289: 871-878 (2003).
16. Prindle, K. H., Jr., Skelton, C. L., Epstein, S. E. and Marcus, F. I.: Influence of extracellular potassium concentration on myocardial uptake and inotropic effect of tritiated digoxin. Circ. Res., 28: 337-345 (1971).
17. Steiness, E.: Digoxin toxicity compared with myocardial digoxin and potassium concentration. Br J. Pharmacol., 63: 233-237 (1978).
18. Jelliffe, R.: Goal-oriented, model-based drug regimens: setting individualized goals for each patient. Ther. Drug Monit., 22: 325-329 (2000).
19. Takagi, K., Nakao, M., Ogura, Y, Nabeshima, T. andKunii, A.: Sensitive colorimetric assay of serum diamine oxidase. Clin. Chim. Acta, 226: 67-75 (1994).
20. Sai, Y, Kaneko, Y, Ito, S., Mitsuoka, K., Kato, Y, Tamai, I., Artursson, P. and Tsuji, A.: Predominant contribution of organic anion transporting polypeptide OATP-B (OATP2B1) to apical uptake of estrone-3-sulfate by human intestinal Caco-2 cells. Drug Metab. Dispos., 34(8): 1423-1431 (2006).
21. McCullagh, K. J., Poole, R. C, Halestrap, A. P., O'Brien, M. and Bonen, A.: Role of the lactate transporter (MCT1) in skeletal muscles. Am. J. Physiol, 271(1 Pt 1): E143-E150 (1996).
22. Nussbaum, M. S. and Fisher, J.: Pathogenesis of hepatic steatosis during total parenteral nutrition. Surg. Annu., 23: 1-11 (1991
23. Werner, A., Rick, H., Trijnie, B., Vincent, W B., Folkert, K. and Henkjan, J. V.: Essential fatty acid deficiency in mice is associated with hepatic steatosis and secretion of large VLDL particles. Am. J. Physiol. Gastrointest. Liver Physiol., 288: G1150-G1158 (2005).
24. Werner, A., Deanna, M. M., Rick, H., Vincent, B., Harry, V G., Folkert, K. and Henkjan, J. V: Fat malabsorption in essential fatty acid-deficient mice is not due to impaired bile formation. Am. J. Physiol. Gastrointest. Liver Physiol., 283: G900-G908 (2002).
25. Luk, G. D., Bayless, T. M. and Baylin, S. B.: Plasma postheparin diamine oxidase. Sensitive provocative test for quantitating length of acute intestinal mucosal injury in the rat. J. Clin. Invest., 71: 1308-1315 (1983).
26. Luk, G. D., Bayless, T. M. and Baylin, S. B.: Diamine oxidase (histaminase). A circulating marker for rat intestinal mucosal maturation and integrity. J. Clin. Invest., 66: 66-70 (1980).
27. Lisalo, E.: Clinical pharmacokinetics of digoxin. Clin. Pharmacokinet., 2: 1-16 (1977).
28. Caldwell, J. H., Martin, J. F., Dutta, S. and Greenberger, N. J.: Intestinal absorption of digoxin-3H in the rat. Am. J. Physiol., 217: 1747-1751 (1969).
29. Yao, H.-M. and Chiou, W L.: The complexity of intestinal absorption and exsorption of digoxin in rats. Int. J. Clin. Pharmacol., 322: 79-86 (2006).
30. Mayer, U., Wagenaar, E., Beijnen, J. H., Smit, J. W., Meijer, D. K., Van Asperen, J., Borst, P. and Schinkel, A. H.: Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr la P-glycoprotein. Br. J. Pharmacol., 119: 1038-1044 (1996).
31. Salphati, L. and Benet, L. Z.: Metabolism of digoxin and digoxigenin digitoxosides in rat livermicrosomes: involvement of cytochrome P4503A. Xenobiotica, 29(2): 171-185 (1999).
32. Johnson, B. F., O'Grady, J., Sabey, G. A. and Bye, C: Effect of a standard breakfast on digoxin absorption in normal subjects. Clin. Pharmacol. Ther, 23(3): 315-319 (1978).
33. Greenblatt, D. J., Duhme, D. W, Koch-Weser, J. and Smith, T. W.: Bioavailability of digoxin tablets and elixir in the fasting and postprandial states. Clin. Pharmacol. Ther, 16(3): 444-448 (1974).
34. Lembcke, B., Hasler, K., Kramer, P., Caspary, W. F. and Creutzfeldt, W.: Plasma digoxin concentrations during administration of dietary fibre (guar gum) in man. Z. Gastroenterol., 20(3): 164-167 (1982).
35. Zilly, W., Kuhlmann, J., Kasper, H. and Richter, E.: Effect of a fiber-rich diet on digoxin resorption. Med. Klin. Prax, 77(19): 42-8 (1982).
36. Schick, D. and Scheuer, J.: Current concepts therapy with digitalis glycosides. Am. Heart J, 87: 253-258 (1974).
37. Greenberger, N. J., MacDermott, R. P., Martin, J. F. and Dutta, S.: Intestinal absorption of six tritium-labeled digitalis glycosides in rats and guinea pigs. J. Pharmacol. Exp. Ther, 167(2): 265-273 (1969).
38. Hall, W. H. and Doherty, J. E.: Tritiated digoxin XVI. Gastric absorption. Am. J. Dig. Dis., 16(10): 903-908 (1971).
39. Beermann, B., Hellstrom, K. and Rosen, A.: The absorption of orally administered (12-3H)digoxin in man. Clin. Sci., 43(4): 507-518 (1972).
40. Ochs, H., Bodem, G., Schafer, P. K., Kodrat, G. and Dengler, H. J.: Absorption of digoxin from the distal parts of the intestine in man. Eur J. Clin. Pharmacol, 9(2-3): 95-97 (1975).
41. Yamaguchi, M., Yamauchi, A., Nishimura, M., Ueda, N. and Naito, S.: Soy bean oil fat emulsion prevents Cytochrome P450 mRNA down-regulation induced by fat-free overdose total parenteral nutrition in infant rats. Biol. Pharm. Bull, 28(1): 143-147 (2005).
42. Donato, M. T., Lahoz, A., Jimenez, N., Perez, G., Serralta, A., Mir, J., Castell, J. V and Gomez-Lechon, M. J.: Potential impact of steatosis on cytochrome P450 enzymes of human hepatocytes isolated from fatty liver grafts. Drug Metab. Dispos., 34(9): 1556-1562 (2006).
43. Fisher, C. D., Lickteig, A. J., Augustine, L. M., Ranger-Moore, J., Jackson, J. P., Ferguson, S. S. and Cherrington, N. J.: Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease. Drug Metab. Dispos., 37(10): 2087-2094 (2009).
44. Taub, M. E., Mease, K., Sane, R. S., Watson, C. A., Chen, L., Ellens, H., Hirakawa, B., Reyner, E. L., Jani, M. and Lee, C. A.: Digoxin is not a substrate for organic anion-transporting polypeptide transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a substrate for a sodium-dependent transporter expressed in HEK293 cells. Drug Metab. Dispos., 39(11): 2093-2102 (2011).