Novel inhibitors of protein arginine deiminase with potential activity in multiple sclerosis animal model

Journal of Medicinal Chemistry

Volumn 56, Issue 4, 2013, Pages 1715-1722

  Wei, Lianhu ^a,c   Wasilewski, Ewa ^a   Chakka, Sai Kumar ^a   Bello, Angelica M ^a,c   Moscarello, Mario A ^b   Kotra, Lakshmi P ^a,c  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1 [4 (2,3 DIHYDRO 3 METHYL 2 OXO 1H INDOL 5 YL) 2 THIAZOLYL] GUANIDINE; 2 [1 (3,3 DIMETHYL 1 CYCLOHEXEN 1 YL)ETHYLIDENE] HYDRAZINE CARBOXIMIDAMIDE ACETIC ACID SALT; 4 AMINO 5,8 DIHYDRO 2,6,6 TRIMETHYL 6H PYRANO[4',3':4,5]THIENO[2,3 B]PYRIDINE 3 CARBOXYLIC ACID HYDRAZIDE; 5,5 DIMETHYL 3 (1 PIPERAZINYLMETHYL) 2,4 IMIDAZOLIDINEDIONE; 5,6,7,8 TETRAHYDRO 4 IMINO 7 METHYL BENZOTHIENO[2,3 D]PYRIMIDIN 3(4H) AMINE; 6 (1H NAPHTH[2,3 D] 2 IMIDAZOLYL) 2 BENZOTHIAZOLAMINE; CITRULLINE; ENZYME INHIBITOR; LIGAND; MYELIN BASIC PROTEIN; PROTEIN ARGININE DEIMINASE; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL MODEL; ARTICLE; BINDING SITE; CATALYSIS; CITRULLINATION; COMPUTER MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG EFFICACY; ENZYME INHIBITION; HYDROLYSIS; IN VIVO STUDY; MOLECULAR LIBRARY; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PILOT STUDY; STRUCTURE ACTIVITY RELATION;

EID: 84874606482     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301755q     Document Type: Article

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