Mechanisms of fetal and neonatal renal impairment by pharmacologic inhibition of angiotensin

Current Medicinal Chemistry

Volumn 19, Issue 27, 2012, Pages 4572-4580

  Chevalier, Robert L ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Angiotensin; Anomalies; Development; Fetus; Hypertension; Kidney; Neonate

Indexed keywords

ANGIOTENSIN ANTAGONIST; ANGIOTENSIN RECEPTOR; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; RENIN INHIBITOR; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN DERIVATIVE; ANTIHYPERTENSIVE AGENT; DIPEPTIDYL CARBOXYPEPTIDASE;

ANGIOGENESIS; ARTICLE; CONGENITAL OBSTRUCTIVE NEPHROPATHY; DISEASE COURSE; EXPERIMENTAL STUDY; FETUS DEVELOPMENT; GESTATIONAL AGE; HUMAN; KIDNEY DEVELOPMENT; KIDNEY INJURY; KIDNEY MALFORMATION; NONHUMAN; PLACENTAL TRANSFER; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; TERATOGENESIS; URINARY TRACT OBSTRUCTION; ANIMAL; CHEMISTRY; CONGENITAL MALFORMATION; DRUG ANTAGONISM; DRUG EFFECT; EVOLUTION; FEMALE; GROWTH, DEVELOPMENT AND AGING; KIDNEY; METABOLISM; MOUSE; PREGNANCY; RAT;

ABNORMALITIES, DRUG-INDUCED; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANGIOTENSINS; ANIMALS; ANTIHYPERTENSIVE AGENTS; BIOLOGICAL EVOLUTION; FEMALE; FETAL DEVELOPMENT; GESTATIONAL AGE; HUMANS; KIDNEY; MICE; PEPTIDYL-DIPEPTIDASE A; PREGNANCY; RATS; RECEPTOR, ANGIOTENSIN, TYPE 1; RENIN-ANGIOTENSIN SYSTEM;

EID: 84874601820     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986712803306411     Document Type: Article

References (115)

1. Guignard, J. P.; Burgener, F.; Calame, A. Persistent anuria in a neonate: a side effect of captopril? Intl.J.Pediatr.Nephrol. 1981, 2133
2. Nishimura, H.: Angiotensin receptors-evolutionary overview and perspectives. Comp. Biochem. Physiol.[A] Mol. Integr. Physiol., 2001 128, 11-30.
3. Hollenberg, N. K.: Implications of species difference for clinical investigation: Studies on the renin-angiotensin system. Hypertension, 2000 35 [part2], 150-154.
4. Kuno, N.; Mizutani, S.; Ohno, Y.; Goto, K.; Itakura, A.; Kondo, I.; Kurauchi, O.; Kikkawa, F.; Tomoda, Y.: Possible involvement of placental proteases in bradykinin (BK) degradation. Reprod. Fertil. Dev., 1997 9, 633-639.
5. Fortin, J. P.; Gobeil, F., Jr.; Adam, A.; Regoli, D.; Marceau, F.: Do angiotensin-converting enzyme inhibitors directly stimulate the kinin B1 receptor? Am. J. Physiol., 2003 285, H277-H282.
6. Gomez, R. A.; Norwood, V. F.: Developmental consequences of the reninangiotensin system. Am. J. Kidney Dis., 1995 26, 409-431.
7. Yosypiv, I. V.: Renin-angiotensin system in ureteric bud branching morphogenesis: insights into the mechanisms. Pediatr. Nephrol., 2011 26, 1499-1512.
8. Ruster, C.; Wolf, G.: Renin-angiotensin-aldosterone system and progression of renal disease. J. Am. Soc. Nephrol., 2006 17, 2985-2991.
9. Takei, Y.; Joss, J. M. P.; Kloas, W.; Rankin, J. C.: Identification of angiotensin I in several vertebrate species: its structural and functional evolution. Gen. Comp. Endocrinol., 2004 135, 286-292.
10. Capelli, J. P.; Wesson, L. G.; Aponte, G. E.: A phylogenetic study of the renin-angiotensin system. Am. J. Physiol., 1970 218, 1171-1178.
11. Cobb, C. S.; Frankling, S. C.; Rankin, J. C.; Brown, J. A.: Angiotensin converting enzyme-like activity in tissues from the river lamprey or lampern, Lampetra fluviatilis, acclimated to freshwater and seawater. Gen. Comp. Endocrinol., 2002 127, 8-15.
12. Zimmerman, B. G.; Dunham, E. W.: Tissue renin-angiotensin system: A site of drug action? Annu. Rev. Pharmacol. Toxicol., 1997 37, 53-69.
13. Colombo, L.; Dalla Valle, L.; Armanini, D.; Belvedere, P.: Aldosterone and the conquest of land. J. Endocrinol. Invest., 2006 29, 373-379.
14. Liang, P.; Jones, C. A.; Bisgrove, B. W.; Song, L.; Glenn, S. T.; H.J.Yost; Gross, K. W.: Genomic characterization and expression analysis of the first nonmammalian renin genes from zebrafish and pufferfish. Physiol. Genomics, 2003 16, 314-322.
15. Lopez, M. L. S. S.; Pentz, E. S.; Robert, B.; Abrahamson, D. R.; Gomez, R. A.: Embryonic origin and lineage of juxtaglomerular cells. Am. J. Physiol. Renal Physiol., 2001 281, F345-F356.
16. Wilson, J. X.: The renin-angiotensin system in nonmammalian vertebrates. Endocr. Rev., 1984 5, 45-61.
17. Nagata, M.; Murakami, K.; Watanabe, T.: Renal manifestations in angiotensinogen-deficient mice: Unexpected phenotypes emerge. Exp. Nephrol, 1997 5, 445-448.
18. Spence, S. G.; Allen, H. L.; Cukierski, M. A.; Manson, J. M.; Robertson, R. T.; Eydelloth, R. S.: Defining the susceptible period of developmental toxicity for the AT1-selective angiotensin II receptor antagonist Losartan in rats. Teratology., 1995 51, 367-382.
19. Hilgers, K. F.; Reddi, V.; Krege, J. H.; Smithies, O.; Gomez, R. A.: Aberrant renal vascular morphology and renin expression in mutant mice lacking angiotensin-converting enzyme. Hypertension, 1997 29, 216-221.
20. Tsuchida, S.; Matsuzaka, T.; Chen, X.; Okubo, S.; Nimura, F.; Nishimura, H.; Fogo, A.; Utsunomiya, H.; Inagami, T.; Ichikawa, I.: Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes have all the major abnormal phenotypes of angiotensinogen nullizygotes. J. Clin. Invest., 1998 101, 755-760.
21. Takahashi, N.; Lopez, M. L.; Cowhig, J. E., Jr.; Taylor, M. A.; Hatada, T.; Riggs, E.; Lee, G.; Gomez, R. A.; Kim, H. S.; Smithies, O.: Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-type. J. Am. Soc. Nephol., 2005 16, 125-132.
22. Song, R.; van Buren, T.; Yosypiv, I. V.: Histone deacetylases are critical regulators of the renin-angiotensin system during ureteric bud branching morphogensis. Pediatr. Res., 2010 67, 573-578.
23. Gubler, M. C.; Antignac, C.: Renin-angioensin system in kidney development: renal tubular dysgenesis. Kidney Int., 2010 77, 400-406.
24. Cebrian, C.; Borodo, K.; Charles, N.; Herzlinger, D. A.: Morphometric index of the developing murine kidney. Devel. Dynam., 2004 231, 601-608.
25. Broughton Pipkin, F.: The renin-angiotensin system in mother and foetus. [Review] [44 refs]. Equine Veterinary Journal, 1984 16, 253-255.
26. Buttar, H. S.: An overview of the influence of ACE inhibitors on fetalplacental circulation and perinatal development. Mol. Cell Biochem., 1997 176, 61-71.
27. Cooper, W. O.; Hernandez-Diaz, S.; Arbogast, P. G.; Dudley, J. A.; Dyer, S.; Gideon, P. S.; Hall, K.; Ray, W. A.: Major congenital malformations after first-trimester exposure to ACE inhibitors. N. Engl. J Med., 2006 354, 2443-2451.
28. Wolf, G.; Neilson, E. G.: Angiotensin II as a hypertrophogenic cytokine for proximal tubular cells. Kidney Int., 1993 43, S100-S107.
29. Yosypiv, I. V.: A new role for the renin-angiotensin system in the development of the ureteric bud and renal collecting system. Keio J. Med., 2008 57, 184-189.
30. Gibbons, G. H.; Pratt, R. E.; Dzau, V. J.: Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-Beta1 expression determines growth response to angiotensin II. J. Clin. Invest., 1992 90, 456-461.
31. Yoo, K. H.; Wolstenholme, J. T.; Chevalier, R. L.: Angiotensin-converting enzyme inhibition decreases growth factor expression in the neonatal rat kidney. Pediatr. Res., 1997 42, 588-592.
32. Yim, H. E.; Kim, M. K.; Bae, I. S.; Kim, J. H.; Choi, B. M.; Yoo, K. H.; Hong, Y. S.; Lee, J. W.: AT1 antagonist modulates activin-like kinase 5 and TGF-beta receptor II in the developing kidney. Pediatr. Nephrol., 2006 21, 1377-1388.
33. Miyazaki, Y.; Tsuchida, S.; Nishimura, H.; Pope, J. C.; Harris, R. C.; McKanna, J. M.; Inagami, T.; Hogan, B. M.; Fogo, A.; Ichikawa, I.: Angiotensin induces the urinary peristaltic machinery during the perinatal period. J Clin. Invest., 1998 102, 1489-1497.
34. Kakuchi, J.; Ichiki, T.; Kiyama, S.; Hogan, B. L. M.; Fogo, A.; Inagami, T.; Ichikawa, I.: Developmental expression of renal angiotensin II receptor genes in the mouse. Kidney Int., 1995 47, 140-147.
35. Aguilera, G.; Kapur, S.; Feuillan, P.; Sunar-Akbasak, B.; Bathia, A. J.: Developmental changes in angiotensin II receptor subtypes and AT1 receptor mRNA in rat kidney. Kidney Int., 1994 46, 973-979.
36. Oshima, K.; Miyazaki, Y.; Brock, J. W., III; Adams, M. C.; Ichikawa, I.; Pope, J. C.: Angiotensin type II receptor expression and ureteral budding. J. Urol., 2001 166, 1848-1852.
37. Nishimura, H.; Yerkes, E.; Hohenfellner, K.; Miyazaki, Y.; Ma, J.; Hunley, T. E.; Yoshida, H.; Ichiki, T.; Threadgill, D.; Phillips, J. A.; Hogan, B. M. L.; Fogo, A.; Brock, J. W.; Inagami, T.; Ichikawa, I.: Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men. Mol. Cell, 1999 3, 1-10.
38. Zhang, S. L.; Moini, B.; Ingelfinger, J. R.: Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor. J. Am. Soc. Nephrol., 2004 15, 1452-1465.
39. Song, R.; Spera, M.; Garrett, C.; El-Dahr, S. S.; Yosypiv, I. V.: Angiotensin II AT2 receptor regulates ureteric bud morphogenesis. Am. J. Physiol., 2010 298, F807-F817.
40. Nogueira-Silva, C.; Carvalho-Dias, E.; Piairao, P.; Nunes, S.; Baptista, M. J.; Moura, R. S.; Correia-Pinto, J.: Local fetal lung renin-angiotensin system as a target to treat congenital diaphragmatic hernia. Mol. Med., 2011 doi: 10.2119/molmed.2011.00210 [Epub ahead of print].
41. Forhead, A. J.; Jellyman, J. K.; Gillham, K.; Ward, J. W.; Blache, D.; Fowden, A. L.: Renal growth retardation following angiotensin II type 1 (AT1) receptor antagonism is associated with increased AT2 receptor protein in fetal sheep. J. Endocrinol., 2011 208, 137-145.
42. Tufro-McReddie, A.; Romano, L. M.; Harris, J. M.; Ferder, L.; Gomez, R. A.: Angiotensin II regulates nephrogenesis and renal vascular development. Am. J. Physiol., 1995 269, F110-F115.
43. Reddi, V.; Zaglul, A.; Pentz, E. S.; Gomez, R. A.: Renin-expressing cells are associated with branching of the developing kidney vasculature. J. Am. Soc. Nephrol, 1998 9, 63-71.
44. Madsen, K.; Marcussen, N.; Pedersen, M.; Kjaersgaard, G.; Facemire, C.; Coffman, T. M.; Jensen, B. L.: Angiotensin II promotes development of the renal microcirculation through AT1 receptors. J. Am. Soc. Nephrol., 2010 21, 448-459.
45. Li, X. C.; Shao, Y.; Zhuo, J. L.: AT1a receptor knockout in mice impairs urine concentration by reducing basal vasopressin levels and its receptor signaling proteins in the inner medulla. Kidney Int., 2009 76, 169-177.
46. Racasan, S.; Hahnel, B.; van der Giezen, D. M.; Blezer, E. L.; Goldschmeding, R.; Braam, B.; Kriz, W.; Koomans, H. A.; Joles, J. A.: TEmporary losartan or captopril in young SHR induces malignant hypertension despite initialnormotension. Kidney Int., 2004 65, 575-581.
47. Sequeira Lopez, M. L.; Gomez, R. A.: Development of the renal arterioles. J. Am. Soc. Nephrol., 2011 22, 2156-2165.
48. McCausland, J. E.; Ryan, G. B.; Alcorn, D.: Angiotensin converting enzyme inhibition in the postnatal rat results in decreased cell proliferation in the renal outer medulla. Clin. Exp. Pharmacol. Physiol., 1996 23, 552-554.
49. Kakinuma, Y.; Sugiyama, F.; Taniguchi, K.; Horiguchi, H.; Ogata, T.; Murakami, K.; Yagami, K.; Fukamizu, A.: Developmental stage-specific involvement of angiotensin in murine nephrogenesis. Pediatr. Nephrol., 1999 13, 792-799.
50. Niimura, F.; Labosky, P. A.; Kakuchi, J.; Okubo, S.; Yoshida, H.; Oikawa, T.; Ichiki, T.; Naftilan, A. J.; Fogo, A.; Inagami, T.; Hogan, B. L. M.; Ichikawa, I.: Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. J. Clin. Invest., 1995 96, 2947-2954.
51. Nilsson, A. B.; Nitescu, N.; Chen, Y.; Guron, G. S.; Marcussen, N.; Matejka, G. L.; Friberg, P.: IGF-I treatment attenuates renal abnormalities induced by neonatal ACE inhibition. Am. J. Physiol., 2000 279, R1050-R1060.
52. Nilsson, A. B. M.; Friberg, P.; Bönquist, L.; Lasaitiene, D.; Marcussen, N.; Chen, Y.: Growth hormone aggravates renal abnormalities induced by neonatal enalapril treatment. Pediatr. Nephrol., 2003 18, 878-886.
53. Lasaitiene, D.; Friberg, P.; Sundelin, B.; Chen, Y.: Neonatal RAS inhibition changes the phenotype of the developing thick ascending limb of Henle. Am. J. Physiol. Renal Physiol., 2004 286, F1144-F1153.
54. Ding, Y.; Stec, D. E.; Sigmund, C. D.: Genetic evidence that lethality in angiotensinogen-deficient mice is due to loss of systemic but not renal angiotensinogen. J. Biol. Chem., 2001 276, 7431-7436.
55. Lochard, N.; Silversides, D. W.; Van Kats, J. P.; Mercure, C.; Reudelhuber, T. L.: Brain-specific restoration of angiotensin II corrects renal defects seen in angiotensinogen-deficient mice. J. Biol. Chem., 2003 278, 2184-2189.
56. Massiera, F.; Bloch-Faure, M.; Ceiler, D.; Murakami, K.; Fukamizu, A.; Gasc, J. M.; Quignard-Boulange, A.; Negrel, R.; Ailhaud, G.; Seydoux, J.; Meneton, P.; Teboul, M.: Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB Journal, 2001 15, 2427-2729.
57. Davisson, R. L.; Kim, H. S.; Krege, J. H.; Lager, D. J.; Smithies, O.; Sigmund, C. D.: Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen genes. J. Clin. Invest., 1997 99, 1258-1264.
58. Hughson, M. D.; Farris, A. B.; Douglas-Denton, R.; Hoy, W. E.; Bertram, J. F.: Glomerular number and size in autopsy kidneys: The relationship to birth weight. Kidney Int., 2003 63, 2113-2122.
59. Gluckman, P. D.; Hanson, M. A.; Cooper, C.; Thornburg, K. L.: Effect of in utero and early-life conditions on adult health and disease. New Engl. J. Med., 2008 359, 61-73.
60. Darby, I. A.; Sernia, C.: In situ hybridization and immunohistochemistry of renal angiotensinogen in neonatal and adult rat kidneys. Cell. Tissue. Res., 1995 281, 197-206.
61. Yosipiv, I. V.; El-Dahr, S. S.: Activation of angiotensin-generating systems in the developing rat kidney. Hypertension, 1996 27, 281-286.
62. Yosipiv, I. V.; Dipp, S.; El-Dahr, S. S.: Ontogeny of somatic angiotensinconverting enzyme. Hypertension., 1994 23, 369-374.
63. Fiselier, T.; Monnens, L.; van Munster, P.; Jansen, M.; Peer, P.; Lignen, P.: The renin angiotensin aldosterone system in infancy and childhood in basal conditions and after stimulation. Eur. J. Pediatr., 1984 143, 18-24.
64. Wallace, K. B.; Hook, J. B.; Bailie, M. D.: Postnatal development of the renin-angiotensin system in rats. Am. J. Physiol., 1980 238, R432-R437.
65. Broughton Pipkin, F.; Turner, S. R.; Symonds, E. M.: Possible risk with captopril in pregnancy: some animal data. Lancet, 1980 1, 1256.
66. Hanssens, M.; Keirse, M. J. N. C.; Vankelecom, F.; Van Assche, F. A.: Fetal and neonatal effects of treatment with angiotensin-converting enzyme inhibitors in pregnancy. Obstetrics Gynecology, 1991 78, 128-135.
67. Pryde, P. G.; Sedman, A. B.; Nugent, C. E.; Barr, M.: Angiotensinconverting enzyme inhibitor fetopathy. J. Am. Soc. Nephrol., 1993 3, 1575-1582.
68. Shotan, A.; Widerhorn, J.; Hurst, A.; Elkayam, U.: Risks of angiotensinconverting enzyme inhibition during pregnancy: Experimental and clinical evidence, potential mechanisms, and recommendations for use. Am. J. Med., 1994 96, 451-456.
69. Harewood, W. J.; Phippard, A. F.; Duggin, G. G.; Horvath, J. S.; Tiller, D. J.: Fetotoxicity of angiotensin-converting enzyme inhibition in primate pregnancy: A prospective, placebo-controlled study in baboons (Papio hamadryas). Am. J. Obstet. Gynecol., 1994 171, 633-642.
70. Yagami, H.; Kurauchi, O.; Murata, Y.; Okamoto, T.; Mizutani, S.; Tomoda, Y.: Expression of angiotensin-converting enzyme in human placenta and its physiologic role in the fetal circulation. Obstet. Gynecol., 1994 84, 453-457.
71. Reisenberger, K.; Egarter, C.; Sternberger, B.; Eckenberger, P.; Eberle, E.; Weissenbacher, E. R.: Placental passage of angiotensin-converting enzyme inhibitors. Am. J. Obstet. Gynecol., 1996 174, 1450-1455.
72. Irani, R. A.; Xia, Y.: The functional role of the renin-angiotensin system in pregnancy and preeclampsia. Placenta, 2008 29, 763-771.
73. Tabacova, S. A.; Kimmel, C. A.: Enalapril: pharmacokinetic/dynamic inferences for comparative developmental toxicity. A review. [Review] [95 refs]. Reprod. Toxicol., 2001 15, 467-478.
74. Wintour, E. M.: The renin-angiotensin system and the development of the kidney. Trends. Endocrinol. Metab., 1997 8, 199-207.
75. Guron, G.; Friberg, P.: An intact renin-angiotensin system is a prerequisite for normal renal development. J. Hypertension, 2000 18, 123-137.
76. Larsson, L.; Aperia, A.; Wilton, P.: Effect of normal development on compensatory renal growth. Kidney Int, 1980 18, 29-35.
77. Larsson, L.; Maunsbach, A. B.: The ultrastructural development of the glomerular filtration barrier in the rat kidney: A morphometric analysis. J. Ultrastr. Res., 1980 72, 392-406.
78. Moritz, K. M.; Wintour, E. M.: Functional development of the meso-and metanephros. Pediatr. Nephrol., 1999 13, 171-178.
79. MacDonald, M. S.; Emery, J. L.: The late intrauterine and postnatal development of human renal glomeruli. J. Anat., 1959 93, 331-340.
80. Huttunen, K.; Gronhagen-Riska, C.; Fyhrquist, F.: Enalapril treatment of a nursing with slightly impaired renal function. Clin. Nephrol., 1989 31, 278.
81. Bennett PN: Drugs and Human Lactation. 1 ed. Amsterdam, Elsevier Science Publishers, 1988
82. Tack, E. D.; Perlman, J. M.: Renal failure in sick hypertensive premature infants receiving captopril therapy. J. Pediatr., 1988 112, 805-810.
83. O'Dea, R. F.; Mirkin, B. L.; Alward, C. T.; Sinaiko, A. R.: Treatment of neonatal hypertension with captopril. J. Pediatr., 1988 113, 403-406.
84. Schilder, J. L. A. M.; Van den Anker, J. N.: Use of enalapril in neonatal hypertension. Acta Paediatr., 1995 84, 1426-1428.
85. Charbit, M.; Dechaux, M.; Blazy, I.; Vargas, R.; Laouari, D.; Brocart, D.; Lacoste, M.; Gubler, M. C.; Sachs, C.: Deleterious effects of inhibition of the renin-angiotensin system in neonatal rats. Pediatr. Nephrol., 1995 9, 303-308.
86. Chevalier, R. L.; Thornhill, B. A.; Belmonte, D. C.; Baertschi, A. J.: Endogenous angiotensin II inhibits natriuresis following acute volume expansion in the neonatal rat. Am. J. Physiol., 1996 270, R393-R397.
87. Guron, G.; Marcussen, N.; Nilsson, A.; Sundelin, B.; Friberg, P.: Postnatal time frame for renal vulnerability to enalapril in rats. J. Am. Soc. Nephrol., 1999 10, 1550-1560.
88. Daikha-Dahmane, F.; Levy-Beff, E.; Jugie, M.; Lenclen, R.: Foetal kidney maldevelopment in maternal use of angiotensin II type I receptor antagonists. Pediatr. Nephrol., 2006 21, 729-732.
89. Seikaly, M. G.; Ho, P. L.; Emmett, L.; Fine, R. N.; Tejani, A.: Chronic renal insufficiency in children: The 2001 annual report of the NAPRTCS. Pediatr. Nephrol., 2003 18, 796-804.
90. Norwood, V. F.; Carey, R. M.; Geary, K. M.; Jose, P. A.; Gomez, R. A.; Chevalier, R. L.: Neonatal ureteral obstruction stimulates recruitment of renin-secreting renal cortical cells. Kidney Int., 1994 45, 1333-1339.
91. Chevalier, R. L.; Kim, A.; Thornhill, B. A.; Wolstenholme, J. T.: Recovery following relief of unilateral ureteral obstruction in the neonatal rat. Kidney Int., 1999 55, 793-807.
92. El-Dahr, S. S.; Gee, J.; Dipp, S.; Hanss, B. G.; Vari, R. C.; Chao, J.: Upregulation of renin-angiotensin system and downregulation of kallikrein in obstructive nephropathy. Am. J. Physiol., 1993 264, F874-F881.
93. Yoo, K. H.; Norwood, V. F.; El-Dahr, S. S.; Yosipiv, I.; Chevalier, R. L.: Regulation of angiotensin II AT1 and AT2 receptors in neonatal ureteral obstruction. Am. J. Physiol., 1997 273, R503-R509.
94. Gobet, R.; Park, J. M.; Nguyen, H. T.; Chang, B.; Cisek, L. J.; Peters, C. A.: Renal renin-angiotensin system dysregulation caused by partial bladder outlet obstruction in fetal sheep. Kidney Int., 1999 56, 1654-1661.
95. Bhaskaran, M.; Reddy, K.; Radhakrishanan, N.; Franki, N.; Ding, G.; Singhal, P. C.: Angiotensin II induces apoptosis in renal proximal tubular cells. Am. J. Physiol., 2003 284, F955-F965.
96. Chevalier, R. L.; Thornhill, B. A.; Wolstenholme, J. T.: Renal cellular response to ureteral obstruction: role of maturation and angiotensin II. Am. J. Physiol., 1999 277, F41-F47.
97. Fern, R. J.; Yesko, C. M.; Thornhill, B. A.; Kim, H.-S.; Smithies, O.; Chevalier, R. L.: Reduced angiotensinogen expression attenuates renal interstitial fibrosis in obstructive nephropathy in mice. J. Clin. Invest., 1999 103, 39-46.
98. Beharrie, A.; Franc-Guimond, J.; Rodriguez, M. M.; Au, J.; Zilleruelo, G.; Abitbol, C. L.: A functional immature model of chronic partial ureteral obstruction. Kidney Int., 2004 65, 1155-1161.
99. Klahr, S.; Ishidoya, S.; Morrissey, J.: Role of angiotensin II in the tubulointerstitial fibrosis of obstructive nephropathy. Am. J. Kidney Dis., 1995 26, 141-146.
100. Kaneto, H.; Morrissey, J.; McCracken, R.; Reyes, A.; Klahr, S.: Enalapril reduces collagen type IV synthesis and expansion of the interstitium in the obstructed rat kidney. Kidney Int., 1994 45, 1637-1647.
101. Chen, C. O.; Park, M. H.; Forbes, M. S.; Thornhill, B. A.; Kiley, S. C.; Yoo, K. H.; Chevalier, R. L.: Angiotensin converting enzyme inhibition aggravates renal interstitial injury resulting from partial unilateral ureteral obstruction in the neonatal rat. Am. J. Physiol. Renal Physiol., 2007 292, F946-F955.
102. Cachat, F.; Lange-Sperandio, B.; Chang, A. Y.; Kiley, S. C.; Thornhill, B. A.; Forbes, M. S.; Chevalier, R. L.: Ureteral obstruction in neonatal mice elicits segment-specific tubular cell responses leading to nephron loss. Kidney Int., 2003 63, 564-575.
103. Vanpee, M.; Blennow, M.; Linne, T.; Herin, P.; Aperia, A.: Renal function in very low birth weight infants: Normal maturity reached during early childhood. J. Pediatr., 1992 121, 784-788.
104. Coleman, C. M.; Minor, J. J.; Burt, L. E.; Thornhill, B. A.; Forbes, M. S.; Chevalier, R. L.: Angiotensin AT1 receptor inhibition exacerbates renal injury resulting from partial unilateral ureteral obstruction in the neonatal rat. Am. J. Physiol., 2007 293, F262-F268.
105. Chevalier, R. L.: Obstructive nephropathy and the developing kidney: Too little or too much angiotensin? Kidney Int., 2004 65, 1517-1518.
106. Ardissino, G.; Vigano, S.; Testa, S.; Dacco, V.; Paglialonga, F.; Leoni, A.; Belingheri, M.; Avolio, L.; Ciofani, A.; Claris-Appiani, A.; Cusi, D.; Edefonti, A.; Ammenti, A.; Cecconi, M.; Fede, C.; Ghio, L.; La Manna, A.; Maringhini, S.; Papalia, T.; Pela, I.; Pisanello, L.; Ratsch, I. M.: No clear evidence of ACEi efficacy on the progression of chronic kidney disease in children with hypodysplastic nephropathy-report from the ItalKid project database. Nephrol. Dial. Transplant, 2007 22, 2525-2530.
107. Mayer, G.: ACE genotype and ACE inhibitor response in kidney disease: A perspective. Am. J. Kidney Dis., 2002 40, 227-235.
108. Hohenfellner, K.; Hunley, T. E.; Brezinska, R.; Brodhag, P.; Shyr, Y.; Brenner, W.; Habermehl, P.; Kon, V.: ACE I/D gene polymorphism predicts renal damage in congenital uropathies. Pediatr. Nephrol., 1999 13, 514-518.
109. Hohenfellner, K.; Wingen, A.-M.; Nauroth, O.; Wuhl, E.; Mehls, O.; Schaefer, F.: Impact of ACE I/D gene polymorphism on congenital renal malformations. Pediatr. Nephrol., 2001 16, 356-361.
110. Rigoli, L.; Chimenz, R.; di Bella, C.; Cavallaro, E.; Caruso, R.; Briuglia, S.; Fede, C.; Salpietro, C. D.: Angiotensin-converting enzyme and angiotensin type 2 receptor gene genotype distributions in Italian children with congenital uropathies. Pediatr. Res., 2004 56, 988-993.
111. Siomou, E.; Bouba, I.; Kollios, K. D.; Papadopoulou, F.; Syrrou, M.; Georgiou, I.; Siamopoulou, A.: Angiotensin II type 2 receptor gene polymorphism in Caucasian children with a wide spectrum of congenital anomalies of the kidney and urinary tract. Pediatr. Res., 2007 62, 83-87.
112. Huang, X. R.; Chen, W. Y.; Truong, L. D.; Lan, H. Y.: Chymase is upregulated in diabetic nephropathy: implications for an alternative pathway of angiotensin II-mediated diabetic renal and vascular disease. J. Am. Soc. Nephrol., 2003 14, 1738-1747.
113. Ma, J.; Nishimura, H.; Fogo, A.; Kon, V.; Inagami, T.; Ichikawa, I.: Accelerated fibrosis and collagen deposition develop in the renal interstitium of angiotensin type 2 receptor null mutant mice during ureteral obstruction. Kidney Int., 1998 53, 937-944.
114. Benndorf, R. A.; Krebs, C.; Hirsch-Hoffmann, b.; Schwedhelm, E.; Cieslar, G.; Schmidt-Haupt, R.; Steinmetz, O. M.; Meyer-Schwesinger, C.; Thaiss, F.; Haddad, M.; Fehr, S.; Heilmann, A.; Helmchen, U.; Hein, L.; Ehmke, H.; Stahl, R. A.; Boger, R. H.; Wenzel, U. O.: Angiotensin II type 2 receptor deficiency aggravates renal injury and reduces survival in chronic kidney disease in mice. Kidney Int., 2009 75, 1039-1049.
115. Hashimoto, N.; Maeshima, Y.; Satoh, M.; Odawara, M.; Sugiyama, H.; Kashihara, N.; Matsubara, H.; Yamasaki, Y.; Makino, H.: Overexpression of angiotensin type 2 receptor ameliorates glomerular injury in a mouse remnant kidney model. Am. J. Physiol. Renal Physiol., 2004 286, F516-F525.