Local fetal lung renin-angiotensin system as a target to treat congenital diaphragmatic hernia

Molecular Medicine

Volumn 18, Issue 2, 2012, Pages 231-243

  Nogueira Silva, Cristina ^a,b,c   Carvalho Dias, Emanuel ^a,b,d   Piairo, Paulina ^a,b   Nunes, Susana ^d   Baptista, Maria J ^a,b,d   Moura, Rute S ^a,b   Correia Pinto, Jorge ^a,b,c  

^a UNIVERSITY OF MINHO   (Portugal)

^b UNIVERSITY OF MINHO   (Portugal)

^c HOSPITAL DE BRAGA   (Portugal)

^d HOSPITAL DE SÃO JOÃO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN I; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR; DIPEPTIDYL CARBOXYPEPTIDASE; NITROGEN; PROTEIN KINASE B; PROTEIN P42; PROTEIN P44; RENIN; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREEDING; CELL DIFFERENTIATION; CONGENITAL DIAPHRAGM HERNIA; CONTROLLED STUDY; DRUG TARGETING; EPITHELIUM CELL; FEMALE; FETUS; FETUS LUNG; FETUS LUNG MATURATION; GESTATION PERIOD; HEART RIGHT VENTRICLE HYPERTROPHY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INTRACELLULAR SIGNALING; LUNG DEVELOPMENT; LUNG FUNCTION; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PULMONARY HYPERTENSION; PUP (RODENT); RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SURVIVAL TIME; WESTERN BLOTTING;

ANGIOTENSIN II TYPE 2 RECEPTOR BLOCKERS; ANGIOTENSINOGEN; ANIMALS; FEMALE; FETUS; HERNIA, DIAPHRAGMATIC; IMIDAZOLES; IMMUNOHISTOCHEMISTRY; PEPTIDYL-DIPEPTIDASE A; PREGNANCY; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; RENIN-ANGIOTENSIN SYSTEM;

EID: 84856101074     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2011.00210     Document Type: Article

References (63)

1. van den Hout L, et al. (2009) Can we improve outcome of congenital diaphragmatic hernia? Pediatr. Surg. Int. 25:733-43.
2. Keller RL, et al. (2010) Congenital diaphragmatic hernia: endothelin-1, pulmonary hypertension, and disease severity. Am. J. Respir. Crit. Care Med. 182:555-61.
3. Luong C, et al. (2011) Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia. Circulation. 123:2120-31.
4. Puri P, Wester T. (1997) Historical aspects of congenital diaphragmatic hernia. Pediatr. Surg. Int. 12:95-100.
5. Harrison MR, et al. (2003) A randomized trial of fetal endoscopic tracheal occlusion for severe fetal congenital diaphragmatic hernia. N. Engl. J. Med. 349:1916-24.
6. Jani JC, et al. (2009) Severe diaphragmatic hernia treated by fetal endoscopic tracheal occlusion. Ultrasound Obstet. Gynecol. 34:304-10.
7. Nogueira-Silva C, Moura RS, Esteves N, Gonzaga S, Correia-Pinto J. (2008) Intrinsic catch-up growth of hypoplastic fetal lungs is mediated by interleukin-6. Pediatr. Pulmonol. 43:680-9.
8. Santos M, et al. (2006) Ghrelin expression in human and rat fetal lungs and the effect of ghrelin administration in nitrofen-induced congenital diaphragmatic hernia. Pediatr. Res. 59:531-7.
9. Baptista MJ, et al. (2005) Antenatal vitamin A administration attenuates lung hypoplasia by interfering with early instead of late determinants of lung underdevelopment in congenital diaphragmatic hernia. J. Pediatr. Surg. 40:658-65.
10. Thébaud B, et al. (1999) Vitamin A decreases the incidence and severity of nitrofen-induced congenital diaphragmatic hernia in rats. Am. J. Physiol. 277:L423-9.
11. Lavoie JL, Sigmund CD. (2003) Minireview: overview of the renin-angiotensin system-an endocrine and paracrine system. Endocrinology. 144:2179-83.
12. Paul M, Poyan Mehr A, Kreutz R. (2006) Physiology of local renin-angiotensin systems. Physiol. Rev. 86:747-803.
13. Goyal R, Leitzke A, Goyal D, Gheorghe CP, Longo LD. (2011) Antenatal maternal hypoxic stress: adaptations in fetal lung renin-angiotensin system. Reprod. Sci. 18:180-9.
14. Morrell NW, Grieshaber SS, Danilov SM, Majack RA, Stenmark KR. (1996) Developmental regulation of angiotensin converting enzyme and angiotensin type 1 receptor in the rat pulmonary circulation. Am. J. Respir. Cell Mol. Biol. 14:526-37.
15. Shanmugam S, Corvol P, Gasc JM. (1996) Angiotensin II type 2 receptor mRNA expression in the developing cardiopulmonary system of the rat. Hypertension. 28:91-7.
16. o 1005/92 [of 1992 Oct 23]. [cited 2012 Mar 8]. Available from: http://www. dre. pt/cgi/dr1s.exe?t=dr&cap=1-1200&doc= 1992343 0%20&v02=&v01=2&v03=1900-01-01& v04 = 3000-12-21&v05=&v06=&v07=&v08=&v09= &v10 =&v 11=Portaria&v12=&v13=&v14= &v15=& sort=0& submit=Pesquisar
17. World Medical Association [WMA]. (1964) WMA declaration of Helsinki-ethical principles for medical research involving humans. Last amended 2008 Oct. [cited 2012 Mar 8]. Available from: http://www.wma.net/en/30publications/10policies/b3/index.html
18. Institute of Laboratory Animal Resources; Commission on Life Sciences; National Research Council. (1996) Guide for the Care and Use of Laboratory Animals. Washington (DC): National Academy Press. [cited 2012 Mar 8]. Available from: http://www.nap.edu/openbook.php?record_id= 5140
19. Tenbrinck R, et al. (1990) Experimentally induced congenital diaphragmatic hernia in rats. J. Pediatr. Surg. 25:426-9.
20. Eskildsen-Helmond YE, Mulvany MJ. (2003) Pressure-induced activation of extracellular signal-regulated kinase 1/2 in small arteries. Hypertension. 41:891-7.
21. Levy BI, et al. (1996) Chronic blockade of AT2-subtype receptors prevents the effect of an giotensin II on the rat vascular structure. J. Clin. Invest. 98:418-25.
22. Nogueira-Silva C, Santos M, Baptista MJ, Moura RS, Correia-Pinto J. (2006) IL-6 is constitutively expressed during lung morphogenesis and enhances fetal lung explant branching. Pediatr. Res. 60:530-6.
23. Dauger S, et al. (2001) MASH-1/RET pathway involvement in development of brain stem control of respiratory frequency in newborn mice. Physiol. Genomics. 7:149-57.
24. Bradford MM. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding. Anal. Biochem. 72:248-54.
25. Cooney TP, Thurlbeck WM. (1982) The radial alveolar count method of Emery and Mithal: a reappraisal 2-intrauterine and early postnatal lung growth. Thorax. 37:580-3.
26. Pires NM, et al. (2007) Activation of nuclear receptor Nur77 by 6-mercaptopurine protects against neointima formation. Circulation. 115:493-500.
27. Baptista MJ, Nogueira-Silva C, Areias JC, Correia-Pinto J. (2008) Perinatal profile of ventricular overload markers in congenital diaphragmatic hernia. J. Pediatr. Surg. 43:627-33.
28. Shanmugam S, Monnot C, Corvol P, Gasc JM. (1994) Distribution of type 1 angiotensin II receptor subtype messenger RNAs in the rat fetus. Hypertension. 23:137-41.
29. Acosta JM, et al. (2001) Novel mechanisms in murine nitrofen-induced pulmonary hypoplasia: FGF-10 rescue in culture. Am. J. Physiol. Lung Cell Mol. Physiol. 281:L250-7.
30. Sarah A, Gebb B, Shannon JM. (2000) Tissue interactions mediate early events in pulmonary vasculogenesis. Dev. Dyn. 217:159-69.
31. Thébaud B, et al. (2005) Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization. Circulation. 112:2477-86.
32. Jakkula M, et al. (2000) Inhibition of angiogenesis decreases alveolarization in the developing rat lung. Am. J. Physiol. Lung Cell Mol. Physiol. 279:L600-7.
33. Healy AM, Morgenthau L, Zhu X, Farber HW, Cardoso WV. (2000) VEGF is deposited in the subepithelial matrix at the leading edge of branching airways and stimulates neovascularization in the murine embryonic lung. Dev. Dyn. 21:341-52.
34. Yosypiv IV, El-Dahr SS. (2005) Role of the reninangiotensin system in the development of the ureteric bud and renal collecting system. Pediatr. Nephrol. 20:1219-29.
35. Stoll M, et al. (1995) The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells. J. Clin. Invest. 95:651-7.
36. Nakajima M, et al. (1995) The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer. Proc. Natl. Acad. Sci. U. S. A. 92:10663-7.
37. Inagami T, Senbonmatsu T. (2001) Dual effects of angiotensin II type 2 receptor on cardiovascular hypertrophy. Trends Cardiovasc. Med. 11:324-8.
38. Gyurko R, Kimura B, Kurian P, Crews FT, Phillips MI. (1992) Angiotensin II receptor subtypes play opposite roles in regulating phosphatidylinositol hydrolysis in rat skin slices. Biochem. Biophys. Res. Commun. 186:285-92.
39. Maric C, Aldred GP, Harris PJ, Alcorn D. (1998) Angiotensin II inhibits growth of cultured embryonic renomedullary interstitial cells through the AT2 receptor. Kidney Int. 53:92-9.
40. Kling DE, et al. (2002) Pre-and postnatal lung development, maturation, and plasticity: MEK-1/2 inhibition reduces branching morphogenesis and causes mesenchymal cell apoptosis in fetal rat lungs. Am. J. Physiol. Lung Cell Mol. Physiol. 282:L370-8.
41. Kaschina E, Unger T. (2003) Angiotensin AT1/AT2 receptors: regulation, signalling and function. Blood Press. 12:70-88.
42. Kling DE, Schnitzer JJ. (2007) Vitamin A deficiency (VAD), teratogenic, and surgical models of congenital diaphragmatic hernia (CDH). Am. J. Med. Genet. C Semin. Med. Genet. 145C:139-57.
43. Montedonico S, Nakazawa N, Puri P. (2008) Congenital diaphragmatic hernia and retinoids: searching for an etiology. Pediatr. Surg. Int. 24:755-61.
44. Gallot D, et al. (2005) Congenital diaphragmatic hernia: a retinoid-signaling pathway disruption during lung development? Birth Defects Res. A Clin. Mol. Teratol. 73:523-31.
45. Greer JJ, Babiuk RP, Thebaud B. (2003) Etiology of congenital diaphragmatic hernia: the retinoid hypothesis. Pediatr. Res. 53:726-30.
46. Major D, et al. (1998) Retinol status of newborn infants with congenital diaphragmatic hernia. Pediatr. Surg. Int. 13:547-9.
47. Mey J, Babiuk RP, Clugston R, Zhang W, Greer JJ. (2003) Retinal dehydrogenase-2 is inhibited by compounds that induce congenital diaphragmatic hernias in rodents. Am. J. Pathol. 162:673-9.
48. Babiuk RP, Thebaud B, Greer JJ. (2004) Reductions in the incidence of nitrofen-induced diaphragmatic hernia by vitamin A and retinoic acid. Am. J. Physiol. Lung Cell Mol. Physiol. 286:L970-3.
49. Guleria RS, Choudhary R, Tanaka T, Baker KM, Pan J. (2011) Retinoic acid receptor-mediated signaling protects cardiomyocytes from hyperglycemia induced apoptosis: role of the reninangiotensin system. J. Cell Physiol. 226:1292-307.
50. Choudhary R, et al. (2008) All-trans retinoic acid prevents development of cardiac remodeling in aortic banded rats by inhibiting the reninangiotensin system. Am. J. Physiol. Heart Circ. Physiol. 294:H633-44.
51. Thébaud B, et al. (2001) Restoring effects of vitamin A on surfactant synthesis in nitrofen-induced congenital diaphragmatic hernia in rats. Am. J. Respir. Crit. Care Med. 164:1083-9.
52. Keijzer R, Liu J, Deimling J, Tibboel D, Post M. (2000) Dual-hit hypothesis explains pulmonary hypoplasia in the nitrofen model of congenital diaphragmatic hernia. Am. J. Pathol. 156:1299-306.
53. Asabe K, Tsuji K, Handa N, Kajiwara M, Suita S. (1998) Expression of clara cell 10-kDa protein (CC10) in congenital diaphragmatic hernia. Pediatr. Surg. Int. 14:36-9.
54. Boucherat O, et al. (2007) Surfactant maturation is not delayed in human fetuses with diaphragmatic hernia. PLoS Med. 4:e237.
55. Van Tuyl M, et al. (2003) Pulmonary surfactant protein A, B, and C mRNA and protein expression in the nitrofen-induced congenital diaphragmatic hernia rat model. Pediatr. Res. 54:641-52.
56. Chapin CJ, et al. (2005) Congenital diaphragmatic hernia, tracheal occlusion, thyroid transcription factor-1, and fetal pulmonary epithelial maturation. Am. J. Physiol. Lung Cell Mol. Physiol. 289:L44-52.
57. Santos M, et al. (2007) Pulmonary epithelial cell differentiation in the nitrofen-induced congenital diaphragmatic hernia. J. Pediatr. Surg. 42:1231-7.
58. Mohseni-Bod H, Bohn D. (2007) Pulmonary hypertension in congenital diaphragmatic hernia. Semin. Pediatr. Surg. 16:126-33.
59. Kanai M, et al. (2001) Fetal tracheal occlusion in the rat model of nitrofen-induced congenital diaphragmatic hernia: tracheal occlusion reverses the arterial structural abnormality. J. Pediatr. Surg. 36:839-45.
60. Karamanoukian HL, et al. (1995) Pathophysiology of congenital diaphragmatic hernia. XI: Anatomic and biochemical characterization of the heart in the fetal lamb CDH model. J. Pediatr. Surg. 30:925-8.
61. González-Reyes S, Martínez L, Tovar JA. (2005) Effects of prenatal vitamins A, E, and C on the hypoplastic hearts of fetal rats with diaphragmatic hernia. J. Pediatr. Surg. 40:1269-74.
62. Montedonico S, Nakazawa N, Shinkai T, Bannigan J, Puri P. (2007) Kidney development in the nitrofen-induced pulmonary hypoplasia and congenital diaphragmatic hernia in rats. J. Pediatr. Surg. 42:239-43.
63. Correia-Pinto J, et al. (2003) Fetal heart development in the nitrofen-induced CDH rat model: the role of mechanical and nonmechanical factors. J. Pediatr. Surg. 38:1444-51.