Arsenic bioaccessibility upon gastrointestinal digestion is highly determined by its speciation and lipid-bile salt interactions

Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering

Volumn 48, Issue 6, 2013, Pages 656-665

  Alava, Pradeep ^a   Du Laing, Gijs ^a   Odhiambo, Moses ^a   Verliefde, Arne ^b   Tack, Filip ^a   Van De Wiele, Tom R ^a  

^a GHENT UNIVERSITY   (Belgium)

^b Faculty of Bioscience Engineering   (Belgium)

Author keywords

arsenic; bile salts; Bioaccessibility; pH

Indexed keywords

AS SPECIES; BILE SALTS; BIOACCESSIBILITY; DIGESTIVE TRACT; FIBER CONTENTS; FOOD MATRIXES; GASTROINTESTINAL DIGESTION; INORGANIC ARSENIC; INORGANIC SPECIES;

ARSENIC; BIOCHEMISTRY; DIGESTIVE SYSTEM; PH; SALTS;

CHEMICAL CONTAMINATION;

ARSENIC; BILE SALT; IRON; LIPID; ORGANOARSENIC DERIVATIVE;

CHEMICAL INTERACTION; CONFERENCE PAPER; CONTROLLED STUDY; DIGESTION; SPECIES DIFFERENTIATION; STANDARD; STEREOCHEMISTRY; STOMACH PH;

ARSENIC; BILE ACIDS AND SALTS; COMPUTER SIMULATION; DIGESTION; FATTY ACIDS; FOOD-DRUG INTERACTIONS; GASTROINTESTINAL TRACT; HUMANS; HYDROGEN-ION CONCENTRATION; MODELS, BIOLOGICAL; ORYZA SATIVA; REFERENCE STANDARDS; RISK ASSESSMENT; SOIL POLLUTANTS; TRACE ELEMENTS;

EID: 84874584043     PISSN: 10934529     EISSN: 15324117     Source Type: Journal    
DOI: 10.1080/10934529.2013.732367     Document Type: Conference Paper

References (32)

1. Versantvoort, C.H.; Oomen, A.G.; Van de Kamp, E.; Rompelberg, C.J.; Sips, A.J. Applicability of an in vitro digestion model in assessing the bioaccessibility of mycotoxins from food. Food Chem Toxicol. 2005, 43(1), 31-40.
2. Ruby, M.V.; Davis, A.; Schoof, R.; Eberle, S.; Sellstone, C.M. Estimation of lead and arsenic bioavailability using a physiologically based extraction test. Environ. Sci. Technol. 1996, 30, 422-430.
3. NationalResearchCouncil. Arsenic inDrinkingWater-2001 Update. National Academy Press: Washington, DC, 2001.
4. Thomas, D.J.;Waters, S.B.; Styblo, M. Elucidating the pathway for arsenic methylation. Toxicol. Appl. Pharm. 2004, 198, 319-326.
5. Styblo, M.; Razo, L.M.D.; Vega, L.; Germolec, D.R.; LeCluyse, E.L.; Hamilton, G.A.; Reed, W.; Wang, C.; Cullen, W.R.; Thomas, D. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells. Arch. Toxicol. 2000, 74, 289.
6. Hughes, M.F.; Kenyon, E.M. Dose-dependent effects on the disposition of monomethylarsonic acid and dimethylarsinic acid in the mouse after intravenous administration. J. Toxicol. Env. Health 1998, 53, 95-112.
7. Hughes, M.F.; Devesa, V.; Adair, B.M.; Styblo, M.; Kenyon, E.M.; Thomas, D.J. Tissue dosimetry, metabolism and excretion of pentavalent and trivalent monomethylated arsenic in mice after oral administration. Toxicol. Appl. Pharm. 2005, 208, 186-197.
8. Hansen, H.R.; Raab, A.; Jaspars, M.; Milne, B.F.; Feldmann, J. Sulfur-containing arsenical mistaken for dimethylarsinous acid (DMA(III)) and identified as a natural metabolite in urine: Major implications for studies on arsenic metabolism and toxicity. Chem. Res. Toxicol. 2004, 17, 1086-1091.
9. Naranmandura, H.N.; Suzuki, K.I.; Hirano, S.; Suzuki, T. Arsenic metabolism and thioarsenicals in hamster and rats. Chem. Res. Toxicol. 2007, 20, 616-624.
10. Naranmandura, H.; Suzuki,K.T. Formation of dimethylthioarsenicals in red blood cells. Toxicol. Appl. Pharm. 2008, 227, 390-399.
11. Raml,R.; Goessler,W.; Traar, P.; Ochi, T.; Francesconi,K.A.Novel thioarsenic metabolites in human urine after ingestion of an arsenosugar, 2', 3'-dihydroxypropyl 5- deoxy-5-dimethylarsinoyl-b-Driboside. Chem. Res. Toxicol. 2005, 18, 1444-1450.
12. Raml, R.; Rumpler, A.; Goessler, W.; Vahter, M.; Li, L.; Ochi, T.; Francesconi, K.A. Thio-dimethylarsinate is a common metabolite in urine samples from arsenic-exposed women in Bangladesh. Toxicol. Appl. Pharm. 2007, 222, 374-380.
13. Suzuki, K.T.; Mandal, B.K.; Katagiri, A.; Sakuma, Y.; Kawakami, A.; Ogra,Y.; Yamaguchi, K.; Sei, Y.; Yamanaka, K.; Anzai, K.; Ohmichi, M.; Takayama, H.; Aimi, N. Dimethylthioarsenicals as arsenic metabolites and their chemical preparations. Chem. Res. Toxicol. 2004, 17, 914-921.
14. Wallschlager, J.; London, D. Determination of methylated arsenicsulfur compounds in ground water. Environ. Sci. Technol. 2008, 42, 228-234.
15. Hughes, M.F.; Vicenta, D.; Blakely, M.A.; Conklin, S.D.; Creed, J.T.; Styblo, M.; Kenyon, E.M.; Thomas, D.J. Tissue dosimetry, metabolism and excretion of pentavalent and trivalent monomethylated arsenic in mice after oral administration. Toxicol. Appl. Pharm. 2008, 227, 26-35.
16. Van de Wiele, T.; Christina, M.G.; Kubachka, K.M.; Creed, J.T.; Basta, N.; Dayton, E.A.; Whitacre, S.; Du Laing, G.; Bradham, K. Arsenic metabolism by human gut microbiota upon in Vitro digestion of contaminated soils. Environ. Health Persp. 2010, 118(7), 1004-1009.
17. Sun, G.X.; Van de Wiele, T.; Alava, P.; Tack, F.; Du Laing, G. Arsenic in cooked rice: Effect of chemical, enzymatic and microbial processes on bioaccessibility and speciation in the human gastrointestinal tract. Environ. Pollut. 2012, 162, 241-246.
18. Beak,D.G.; Basta,N.T.; Scheckel,K.G.; Traina, S.J. Bioaccessibility of arsenic(V) bound to ferrihydrite using a simulated gastrointestinal system. Environ. Sci. Technol. 2006, 40, 1364-1370.
19. Rodriguez, R.R.; Basta,N.T.; An in vitro gastrointestinalmethod to estimate bioavailable arsenic in contaminated soils and solid media. Environ. Sci. Technol. 1999, 33, 642-649.
20. Garbacz, G.; Klein, S. Dissolution testing of oral modifiedrelease dosage forms. J. Pharm. Pharmacol. 2012, doi: 10.1111/j. 2042-7158.2012.01477.x.
21. Schwarz, A.M.; Raith, K.; R? uttinger, H.H.; Dongowski, G.; Neubert, R.H.H. Investigation of the interactions between drugs andmixed bile salt/ lecithin micelles:Acharacterization bymicellar affinity capillary electrophoresis (MACE). Part III. J. Chromatogr. A 1997, 781(1-2), 377-389.
22. Alava, P.; Dulaing, G.; Tack, F.; Van De Wiele, T. HPLC ICP MS method development to monitor arsenic speciation changes by human gut micro biota. Biomed. Chromatogr. 2011, doi: 10.1002/bmc.1700.
23. Alava, P.; DuLaing, G.; Tack, F.; Van De Wiele, T. Towards an optimal sample preparation procedure: Arsenic speciation is preserved during extensive grinding and pressurized extraction from rice. Anal. Meth. 2012, doi:10.1039/C2AY25094B.
24. Schroder, L.; Basta, N.T.; Casteel, S.W.; Evans, T.J.; Payton, M.E.; Si, J. Validation of the in vitro gastrointestinal (IVG) method to estimate relative bioavailable lead in contaminated soils. J. Environ. Qual. 2004, 33(2), 513-521.
25. Zhao, L.; Suzanne, M.B.; Ghaly, A.E.; Brooks, M.S.; Dave, D. Extraction, purification and characterization of fish pepsin: A critical review. J. Food Process. Technol. 2011, 2(6). Available at http://dx.doi.org/10.4172/2157-7110. 1000126.
26. Odanaka, Y.; Matano, O.; Goto, S. Biomethylation of inorganic arsenic by the rat and some laboratory animals.B.Environ. Contam. Toxicol. 1980, 24, 452-459.
27. Lu, X.; Arnold, L.L.; Cohen, S.M.; Cullen, W.R.; Le, C. Speciation of dimethylarsinous acid and trimethylarsine oxide in rats fed with dimethylarsinic acid in the diet. Anal. Chem. 2003, 75, 6463-6468.
28. Lu, M.; Wang, H.; Arnold, L.L.; Cohen, S.M.; Li, X.F.; Lu, X.; Cullen,W.R.; Le, X.C. Binding of dimethylarsinous acid to cys-13a of rat hemoglobin is responsible for the retention of arsenic in rat blood. Chem. Res. Toxicol. 2007, 20, 27-37.
29. Laparra, J.M.; Velez, D.; Barbera, R.; Farre, R.; Montoro, R. Bioavailability of inorganic arsenic in cooked rice: Practical aspects for human health risk assessments. J. Agri. Food Chem. 2005, 53, 8829-8833.
30. Juhasz, A.L.; Smith, E.; Weber, J.; Rees, M.; Rofe, A.; Kuchel, T.; Sansom, L.; Naidu, R. In vivo assessment of arsenic bioavailability in rice and its significance for human health risk assessment. Environ. Health Persp. 2006, 114, 1826-1831.
31. Simonovic, R.B.; Momirovic, M. Determination of critical micelle concentration of Bile acis salts bi micro-calirometric titration. Mikrochim. Acta 1997, 127, 101-104.
32. Raposo, J.C.; Olazabal, M.A.; Madariaga, J.M. Complexation and precipitation of arsenate and iron species in sodium perchlorate solutions at 25 C. J. Sol. Chem. 2006, 35(1), 79-94.