Comparative analysis of human CYP3A4 and rat CYP3A1 induction and relevant gene expression by bisphenol A and diethylstilbestrol: Implications for toxicity testing paradigms

Reproductive Toxicology

Volumn 37, Issue , 2013, Pages 24-30

  Kuzbari, Oumar ^a   Peterson, C Matthew ^a   Franklin, Michael R ^b   Hathaway, Laura B ^b   Johnstone, Erica B ^a   Hammoud, Ahmad O ^a   Lamb, John G ^b  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

Bisphenol A; BPA; CYP3A1; CYP3A4; DES; Diethylstilbestrol; PXR

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; CYTOCHROME P450 3A1; CYTOCHROME P450 3A4; DIETHYLSTILBESTROL; LUCIFERIN; MESSENGER RNA; PREGNANE X RECEPTOR;

ANIMAL CELL; ARTICLE; BIOLUMINESCENCE; CELL ASSAY; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYP3A4 GENE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HEPATOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PROMOTER REGION; RAT; REPORTER GENE; SAFETY; TOXICITY TESTING;

ANIMALS; BENZHYDRYL COMPOUNDS; CELL LINE, TUMOR; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DIETHYLSTILBESTROL; ENDOCRINE DISRUPTORS; ENZYME INDUCTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MICROSOMES, LIVER; PHENOLS; RATS; RECEPTORS, STEROID; TOXICITY TESTS;

EID: 84874567538     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2013.01.005     Document Type: Article

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