Primary cilia act as mechanosensors during bone healing around an implant

Medical Engineering and Physics

Volumn 35, Issue 3, 2013, Pages 392-402

  Leucht, P ^a   Monica, S D ^a   Temiyasathit, S ^b,c   Lenton, K ^a   Manu, A ^a   Longaker, M T ^a   Jacobs, C R ^b,c   Spilker, R L ^d   Guo, H ^d   Brunski, J B ^a   Helms, J A ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

^c Columbia University ^*  (United States)

^d RENSSELAER POLYTECHNIC INSTITUTE   (United States)

Author keywords

Implant: Osteogenesis; Mechanotransduction; Osteoblast

Indexed keywords

BONE HEALING; CELL BEHAVIORS; COLLAGEN FIBER; GENETIC BACKGROUNDS; INTERFACIAL STRAIN; LIVING TISSUES; LOCAL ENVIRONMENTS; MECHANICAL STIMULUS; MECHANOSENSORS; MECHANOTRANSDUCTION; MOLECULAR SIGNALS; MOTION DEVICES; MULTISCALES; OSTEOGENESIS; OSTEOGENIC DIFFERENTIATION; PERI-IMPLANT CELLS; PRIMARY CILIUM; STRAIN FIELDS;

BONE; CYTOLOGY; MAMMALS; TISSUE;

OSTEOBLASTS;

CELL PROTEIN; COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 1A1; PROTEIN KIF3A; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEFECT; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; EUKARYOTIC FLAGELLUM; FRACTURE HEALING; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IMPLANT; IN SITU HYBRIDIZATION; MALE; MECHANOTRANSDUCTION; MORPHOMETRICS; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; STIMULUS RESPONSE; TIBIA;

ANIMALS; BONE AND BONES; CELL PROLIFERATION; CILIA; COLLAGEN TYPE I; KINESIN; MALE; MICE; MICE, KNOCKOUT; OSTEOBLASTS; OSTEOGENESIS; POISSON DISTRIBUTION; PROSTHESES AND IMPLANTS; REGENERATIVE MEDICINE; SIGNAL TRANSDUCTION; STRESS, MECHANICAL; TIBIA;

EID: 84874518190     PISSN: 13504533     EISSN: 18734030     Source Type: Journal    
DOI: 10.1016/j.medengphy.2012.06.005     Document Type: Article

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