Development and characterization of PLGA nanocapsules of grandisin isolated from Virola surinamensis: In vitro release and cytotoxicity studies

Revista Brasileira de Farmacognosia

Volumn 23, Issue 1, 2013, Pages 153-159

  Stecanella, Luciano Aparecido ^a   Taveira, Stephânia Fleury ^a   Marreto, Ricardo Neves ^a   Valadares, Marize C ^a   Vieira, Marcelo de Sousa ^a   Kato, Massuo Jorge ^b   Lima, Eliana Martins ^a  

^a FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Cytotoxicity; Grandisin; PLGA nanocapsules; Sustained release

Indexed keywords

NANOCAPSULE; NEOLIGNAN GRANDISIN; NEUTRAL RED; POLOXAMER; POLYGLACTIN; UNCLASSIFIED DRUG; VIROLA SURINAMENSIS EXTRACT;

ANIMAL CELL; ARTICLE; COLUMN CHROMATOGRAPHY; CYTOTOXICITY; DRUG RELEASE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PARTICLE SIZE; PHASE CONTRAST MICROSCOPY; SPECTROPHOTOMETRY; ZETA POTENTIAL;

EID: 84874511869     PISSN: 0102695X     EISSN: None     Source Type: Journal    
DOI: 10.1590/S0102-695X2012005000128     Document Type: Article

References (18)

1. Budhian A, Siegel SJ, Winey KI 2007. Haloperidol-loaded PLGA nanoparticles: systematic study of particle size and drug content. Int J Pharm 336: 367-375.
2. Cabral MM, Kato MJ, Alencar JA, Guimarães AE 2009. Larvicidal activity of grandisin against Aedes aegypti. J Am Mosquito Contr 25: 103-105.
3. Carvalho AA, Galdino PM, Nascimento MV, Kato MJ, Valadares MC, Cunha LC, Costa EA 2010. Antinociceptive and anti-inflammatory activities of grandisin extracted from Virola surinamensis. Phytother Res 24: 113-118.
4. Fessi H, Puisieux F, Devissaguet JP, Ammoury N, Benita S 1989. Nanocapsules formation by interfacial polymer deposition following solvente displacement. Int J Pharm 55: R1-R4.
5. Liu P, Rong X, Laru J, Veen BV, Kiesvaara J, Hirvonen J, Laaksonen T, Peltonen L 2011. Nanosuspensions of poorly soluble drugs: Preparation and development by wet milling. Int J Pharm 411: 215-222.
6. Lopes NP, Blumenthal EEA, Cavalheiro AJ, Kato MJ, Yoshida M 1996. Lignans, g-lactones and propiophenones of Virola surinamensis. Phytochemistry 43: 1089-1092.
7. Lopes NP, Chicaro P, Kato MJ, Albuquerque S, Yoshida M 1998. Flavonoids and lignans from Virola surinamensis twigs and their in vitro activity against Trypanosoma cruzi. Planta Med 64: 667-669.
8. Martins RCC, Latorre LR, Sartorelli P, Kato MJ 2000. Phenylpropanoids and tetrahydrofuranlignans from Piper solmsianum. Phytochemistry 55: 843-6.
9. Mathias K, Ismail B, Crovalan CM, Hayes KD 2006. Heat and pH effects on the conjugated forms of genistein and daidzein isoflavovones. J Agr Food Chem 54: 7495-7502.
10. Melo NFSM, Grillo R, Guilherme VA, Araujo DR, Paula E, Rosa AH, Fraceto LF 2011. Poly (Lactide-co- Glycolide) nanocapsules containing benzocaine: influence of the composition of the oily nucleus on physico-chemical properties and anesthetic activity. Pharm Res 28: 1984-1994.
11. Nogueira CD, de Mello RP, Kato MJ, Cabral MM 2009. Disruption of Chrysomyamegacephala growth caused by lignin grandisin. J Med Entomol 46: 281-283.
12. Oh JE, Nam YS, Lee KH, Park TG 1999. Conjugation of drug to poly(D, latic-co-glycolic acid) for controlled release from biodegradable microspheres. J Control Release 57: 269-280.
13. Schultes RE, Holmstedt B 1971. Miscellaneous notes of Myristicaceous plants of South America. Lloyd 34: 61-68.
14. Souza LG, Silva EJ, Martins ALL, Mota MF, Braga RC, Lima EM, Valadares MC, Taveira SF, Marreto RN 2011. Development of topotecan loaded lipid nanoparticles for chemical stabilization and prolonged release. Eur J PharmSci 79: 189-196.
15. Valadares MC, de Carvalho IC, de Oliveira Junior L, Vieira MS, de Carvalho FS, Andrade LV, Lima EM, Kato MJ 2009. Cytotoxicity and antiangiogenic activity of grandisin. J Pharm Pharmacol 61: 1709-1714.
16. Valadares MC, de Oliveira LM Jr, de Carvalho FS, Andrade LV, dos Santos AP, de Oliveira V, Gil ES, Kato MG 2011. Chemoprotective effect of the tetrahydrofuranlignan grandisin in the in vivo rodent micronucleus assay. J Pharm Pharmacol 63: 447-451.
17. Wong HL, Rauth AM, Bendayan R, Wu XY 2007. In vivo evaluation of a new polymer-lipid hybrid nanoparticles (PLN) formulation of doxorubicin in a murine solid tumor model. Eur J Pharm Biopharm 65: 300-308.
18. Zhao YZ, Sun CZ, Lu CT, Dai DD, Lv HF, Wu Y, Wan CW, Chen LJ, Lin M, Li XK 2011. Characterization and antitumor activity of chemical conjugation of doxorubicin in polymeric micelles (DOX-P) in vitro. CancerLett 311: 187-194.