Changes in alternative brain-derived neurotrophic factor transcript expression in the developing human prefrontal cortex

European Journal of Neuroscience

Volumn 29, Issue 7, 2009, Pages 1311-1322

  Wong, Jenny ^a,b   Webster, Maree J ^c   Cassano, Hope ^d   Weickert, Cynthia S ^a,b,d  

^a SCHIZOPHRENIA RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c Stanley Medical Research Institute   (United States)

^d NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Brain derived neurotrophic factor; Developmental gene expression; Dorsolateral prefrontal cortex; Neurotrophin; Postmortem; TrkB

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; MESSENGER RNA;

ADOLESCENT; ADULT; ARTICLE; BIRTH; BRAIN DEVELOPMENT; BRAIN REGION; CHILD; EXON; FEMALE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GROUPS BY AGE; HUMAN; IN SITU HYBRIDIZATION; INFANCY; INFANT; MALE; NERVE CELL PLASTICITY; PREFRONTAL CORTEX; PRESCHOOL CHILD; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SCHOOL CHILD; TISSUE SECTION; TODDLER; TRANSCRIPTION INITIATION; UPREGULATION;

ADOLESCENT; ADULT; ALTERNATIVE SPLICING; ANALYSIS OF VARIANCE; BLOTTING, WESTERN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHILD; CHILD, PRESCHOOL; GENE EXPRESSION; HUMANS; IN SITU HYBRIDIZATION; INFANT; MIDDLE AGED; NEURONS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PREFRONTAL CORTEX; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; YOUNG ADULT;

EID: 64049085178     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2009.06669.x     Document Type: Article

References (47)

1. Aid, T., Kazantseva, A., Piirsoo, M., Palm, K. Timmusk, T. (2007) Mouse and rat BDNF gene structure and expression revisited. J. Neurosci. Res., 85, 525 535.
2. An, J.J., Gharami, K., Liao, G.Y., Woo, N.H., Lau, A.G., Vanevski, F., Torre, E.R., Jones, K.R., Feng, Y., Lu, B. Xu, B. (2008) Distinct role of long 3′ UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neurons. Cell, 134, 175 187.
3. Barde, Y.A., Edgar, D. Thoenen, H. (1982) Purification of a new neurotrophic factor from mammalian brain. EMBO J., 1, 549 553.
4. Berchtold, N.C., Oliff, H.S., Isackson, P. Cotman, C.W. (1999) Hippocampal BDNF mRNA shows a diurnal regulation, primarily in the exon III transcript. Brain Res. Mol. Brain Res., 71, 11 22.
5. Bourgeois, J.P., Goldman-Rakic, P.S. Rakic, P. (1994) Synaptogenesis in the prefrontal cortex of rhesus monkeys. Cereb. Cortex, 4, 78 96.
6. Cabelli, R.J., Hohn, A. Shatz, C.J. (1995) Inhibition of ocular dominance column formation by infusion of NT-4/5 or BDNF. Science, 267, 1662 1666.
7. Cabelli, R.J., Shelton, D.L., Segal, R.A. Shatz, C.J. (1997) Blockade of endogenous ligands of trkB inhibits formation of ocular dominance columns. Neuron, 19, 63 76.
8. Chiaruttini, C., Sonego, M., Baj, G., Simonato, M. Tongiorgi, E. (2008) BDNF mRNA splice variants display activity-dependent targeting to distinct hippocampal laminae. Mol. Cell. Neurosci., 37, 11 19.
9. Dennis, K.E. Levitt, P. (2005) Regional expression of brain derived neurotrophic factor (BDNF) is correlated with dynamic patterns of promoter methylation in the developing mouse forebrain. Brain Res. Mol. Brain Res., 140, 1 9.
10. Dwivedi, Y., Rizavi, H.S. Pandey, G.N. (2006) Antidepressants reverse corticosterone-mediated decrease in brain-derived neurotrophic factor expression: differential regulation of specific exons by antidepressants and corticosterone. Neuroscience, 139, 1017 1029.
11. Ernfors, P., Ibanez, C.F., Ebendal, T., Olson, L. Persson, H. (1990) Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain. Proc. Natl Acad. Sci. USA, 87, 5454 5458.
12. Friedman, W.J., Ernfors, P. Persson, H. (1991) Transient and persistent expression of NT-3/HDNF mRNA in the rat brain during postnatal development. J. Neurosci., 11, 1577 1584.
13. Giedd, J.N., Blumenthal, J., Jeffries, N.O., Castellanos, F.X., Liu, H., Zijdenbos, A., Paus, T., Evans, A.C. Rapoport, J.L. (1999) Brain development during childhood and adolescence: a longitudinal MRI study. Nat. Neurosci., 2, 861 863.
14. Glantz, L.A., Gilmore, J.H., Hamer, R.M., Lieberman, J.A. Jarskog, L.F. (2007) Synaptophysin and postsynaptic density protein 95 in the human prefrontal cortex from mid-gestation into early adulthood. Neuroscience, 149, 582 591.
15. Gorski, J.A., Zeiler, S.R., Tamowski, S. Jones, K.R. (2003) Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites. J. Neurosci., 23, 6856 6865.
16. Hayashi, M., Yamashita, A. Shimizu, K. (1997) Somatostatin and brain-derived neurotrophic factor mRNA expression in the primate brain: decreased levels of mRNAs during aging. Brain Res., 749, 283 289.
17. Hofer, M., Pagliusi, S.R., Hohn, A., Leibrock, J. Barde, Y.A. (1990) Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain. EMBO J., 9, 2459 2464.
18. Huntley, G.W., Benson, D.L., Jones, E.G. Isackson, P.J. (1992) Developmental expression of brain derived neurotrophic factor mRNA by neurons of fetal and adult monkey prefrontal cortex. Brain Res. Dev. Brain Res., 70, 53 63.
19. Huttenlocher, P.R. (1990) Morphometric study of human cerebral cortex development. Neuropsychologia, 28, 517 527.
20. Huttenlocher, P.R. Dabholkar, A.S. (1997) Regional differences in synaptogenesis in human cerebral cortex. J. Comp. Neurol., 387, 167 178.
21. Huttenlocher, P.R., de Courten, C., Garey, L.J. Van der Loos, H. (1982) Synaptogenesis in human visual cortex - evidence for synapse elimination during normal development. Neurosci. Lett., 33, 247 252.
22. Katoh-Semba, R., Takeuchi, I.K., Semba, R. Kato, K. (1997) Distribution of brain-derived neurotrophic factor in rats and its changes with development in the brain. J. Neurochem., 69, 34 42.
23. Katoh-Semba, R., Semba, R., Takeuchi, I.K. Kato, K. (1998) Age-related changes in levels of brain-derived neurotrophic factor in selected brain regions of rats, normal mice and senescence-accelerated mice: a comparison to those of nerve growth factor and neurotrophin-3. Neurosci. Res., 31, 227 234.
24. Kozlovsky, N., Shanon-Weickert, C., Tomaskovic-Crook, E., Kleinman, J.E., Belmaker, R.H. Agam, G. (2004) Reduced GSK-3beta mRNA levels in postmortem dorsolateral prefrontal cortex of schizophrenic patients. J. Neural Transm., 111, 1583 1592.
25. Lauterborn, J.C., Rivera, S., Stinis, C.T., Hayes, V.Y., Isackson, P.J. Gall, C.M. (1996) Differential effects of protein synthesis inhibition on the activity-dependent expression of BDNF transcripts: evidence for immediate-early gene responses from specific promoters. J. Neurosci., 16, 7428 7436.
26. Levitt, J.B., Lewis, D.A., Yoshioka, T. Lund, J.S. (1993) Topography of pyramidal neuron intrinsic connections in macaque monkey prefrontal cortex (areas 9 and 46). J. Comp. Neurol., 338, 360 376.
27. Lipska, B.K., Deep-Soboslay, A., Weickert, C.S., Hyde, T.M., Martin, C.E., Herman, M.M. Kleinman, J.E. (2006) Critical factors in gene expression in postmortem human brain: focus on studies in schizophrenia. Biol. Psychiatry, 60, 650 658.
28. Liu, Q.R., Walther, D., Drgon, T., Polesskaya, O., Lesnick, T.G., Strain, K.J., de Andrade, M., Bower, J.H., Maraganore, D.M. Uhl, G.R. (2005) Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's disease. Am. J. Med. Genet. B Neuropsychiatr. Genet., 134, 93 103.
29. Liu, Q.R., Lu, L., Zhu, X.G., Gong, J.P., Shaham, Y. Uhl, G.R. (2006) Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine. Brain Res., 1067, 1 12.
30. Livak, K.J. Schmittgen, T.D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods, 25, 402 408.
31. Malkovska, I., Kernie, S.G. Parada, L.F. (2006) Differential expression of the four untranslated BDNF exons in the adult mouse brain. J. Neurosci. Res., 83, 211 221.
32. Mandolesi, G., Menna, E., Harauzov, A., von Bartheld, C.S., Caleo, M. Maffei, L. (2005) A role for retinal brain-derived neurotrophic factor in ocular dominance plasticity. Curr. Biol., 15, 2119 2124.
33. McAllister, A.K., Lo, D.C. Katz, L.C. (1995) Neurotrophins regulate dendritic growth in developing visual cortex. Neuron, 15, 791 803.
34. Pattabiraman, P.P., Tropea, D., Chiaruttini, C., Tongiorgi, E., Cattaneo, A. Domenici, L. (2005) Neuronal activity regulates the developmental expression and subcellular localization of cortical BDNF mRNA isoforms in vivo. Mol. Cell. Neurosci., 28, 556 570.
35. Pruunsild, P., Kazantseva, A., Aid, T., Palm, K. Timmusk, T. (2007) Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters. Genomics, 90, 397 406.
36. Romanczyk, T.B., Weickert, C.S., Webster, M.J., Herman, M.M., Akil, M. Kleinman, J.E. (2002) Alterations in trkB mRNA in the human prefrontal cortex throughout the lifespan. Eur. J. Neurosci., 15, 269 280.
37. Sathanoori, M., Dias, B.G., Nair, A.R., Banerjee, S.B., Tole, S. Vaidya, V.A. (2004) Differential regulation of multiple brain-derived neurotrophic factor transcripts in the postnatal and adult rat hippocampus during development, and in response to kainate administration. Brain Res. Mol. Brain Res., 130, 170 177.
38. Sowell, E.R., Thompson, P.M., Holmes, C.J., Jernigan, T.L. Toga, A.W. (1999) In vivo evidence for post-adolescent brain maturation in frontal and striatal regions. Nat. Neurosci., 2, 859 861.
39. Timmusk, T., Palm, K., Metsis, M., Reintam, T., Paalme, V., Saarma, M. Persson, H. (1993) Multiple promoters direct tissue-specific expression of the rat BDNF gene. Neuron, 10, 475 489.
40. Timmusk, T., Belluardo, N., Persson, H. Metsis, M. (1994a) Developmental regulation of brain-derived neurotrophic factor messenger RNAs transcribed from different promoters in the rat brain. Neuroscience, 60, 287 291.
41. Timmusk, T., Persson, H. Metsis, M. (1994b) Analysis of transcriptional initiation and translatability of brain-derived neurotrophic factor mRNAs in the rat brain. Neurosci. Lett., 177, 27 31.
42. Tongiorgi, E., Armellin, M., Giulianini, P.G., Bregola, G., Zucchini, S., Paradiso, B., Steward, O., Cattaneo, A. Simonato, M. (2004) Brain-derived neurotrophic factor mRNA and protein are targeted to discrete dendritic laminas by events that trigger epileptogenesis. J. Neurosci., 24, 6842 6852.
43. Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A. Speleman, F. (2002) Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol., 3, RESEARCH0034.1 RESEARCH0034.11.
44. Webster, M.J., Weickert, C.S., Herman, M.M. Kleinman, J.E. (2002) BDNF mRNA expression during postnatal development, maturation and aging of the human prefrontal cortex. Brain Res. Dev. Brain Res., 139, 139 150.
45. Webster, M.J., Herman, M.M., Kleinman, J.E. Shannon Weickert, C. (2006) BDNF and trkB mRNA expression in the hippocampus and temporal cortex during the human lifespan. Gene Expr. Patterns, 6, 941 951.
46. Weickert, C.S., Hyde, T.M., Lipska, B.K., Herman, M.M., Weinberger, D.R. Kleinman, J.E. (2003) Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia. Mol. Psychiatry, 8, 592 610.
47. Wetmore, C., Ernfors, P., Persson, H. Olson, L. (1990) Localization of brain-derived neurotrophic factor mRNA to neurons in the brain by in situ hybridization. Exp. Neurol., 109, 141 152.