Structural and biochemical characterization of an atypical short-chain dehydrogenase/reductase reveals an unusual cofactor preference

FEBS Journal

Volumn 280, Issue 5, 2013, Pages 1358-1370

  Buysschaert, Géraldine ^a   Verstraete, Kenneth ^a   Savvides, Savvas N ^a   Vergauwen, Bjorn ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

atypical SDR; NADPH cofactor binding; short chain dehydrogenase reductase; structure function; Vibrio vulnificus

Indexed keywords

OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SHORT CHAIN DEHYDROGENASE REDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ANALYSIS; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; ISOTHERMAL TITRATION CALORIMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN MOTIF; PROTON TRANSPORT; ROSSMANN FOLD; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; VIBRIO VULNIFICUS;

AMINO ACID SEQUENCE; BINDING SITES; CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; FATTY ACID SYNTHETASE COMPLEX; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; NADH, NADPH OXIDOREDUCTASES; NADP; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROMETRY, FLUORESCENCE; SUBSTRATE SPECIFICITY; VIBRIO VULNIFICUS;

VIBRIO VULNIFICUS;

EID: 84874498856     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12128     Document Type: Article

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